Shuanglin Hao

Professor

  • 1456 Citations
1994 …2023
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Research Output 1994 2019

  • 1456 Citations
  • 52 Article
  • 2 Chapter
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Article
2019
1 Citation (Scopus)

Mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn

Takahashi, K., Yi, H., Gu, J., Ikegami, D., Liu, S., Iida, T., Kashiwagi, Y., Dong, C., Kunisawa, T. & Hao, S., Jan 1 2019, In : British Journal of Anaesthesia.

Research output: Contribution to journalArticle

Polyadenylation
Morphine
Carrier Proteins
Oligodeoxyribonucleotides
Opioid Analgesics

Ryanodine Receptor to Mitochondrial Reactive Oxygen Species Pathway Plays an Important Role in Chronic Human Immunodeficiency Virus gp120MN-Induced Neuropathic Pain in Rats

Godai, K., Takahashi, K., Kashiwagi, Y., Liu, C. H., Yi, H., Liu, S., Dong, C., Lubarsky, D. A. & Hao, S., Jul 1 2019, In : Anesthesia and analgesia. 129, 1, p. 276-286 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Neuralgia
Reactive Oxygen Species
Superoxides
Glycoproteins
2018
2 Citations (Scopus)

Phosphorylated CCAAT/enhancer binding protein β Contributes to rat HIV-related neuropathic pain: In vitro and in vivo studies

Yi, H., Liu, S., Kashiwagi, Y., Ikegami, D., Huang, W., Kanda, H., Iida, T., Liu, C. H., Takahashi, K., Lubarsky, D. & Hao, S., Jan 17 2018, In : Journal of Neuroscience. 38, 3, p. 555-574 20 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Neuralgia
HIV Envelope Protein gp120
HIV
Hyperalgesia
3 Citations (Scopus)

Spinal bromodomain-containing protein 4 contributes to neuropathic pain induced by HIV glycoprotein 120 with morphine in rats

Takahashi, K., Yi, H., Liu, C. H., Liu, S., Kashiwagi, Y., Patin, D. & Hao, S., Jan 1 2018, In : NeuroReport. 29, 6, p. 441-446 6 p.

Research output: Contribution to journalArticle

Neuralgia
Morphine
Glycoproteins
HIV
Opiate Alkaloids
2017
4 Citations (Scopus)

IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFα, NR2B, and pC/EBPβ in the periaqueductal gray in rats

Yi, H., Iida, T., Liu, S., Ikegami, D., Liu, Q., Iida, A., Lubarsky, D. & Hao, S., Mar 16 2017, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

Periaqueductal Gray
Interleukin-4
Morphine
Substance Withdrawal Syndrome
Cytokines
2 Citations (Scopus)

MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats

Iida, T., Yi, H., Liu, S., Ikegami, D., Zheng, W., Liu, Q., Takahashi, K., Kashiwagi, Y., Goins, W. F., Glorioso, J. C. & Hao, S., May 1 2017, In : Gene Therapy. 24, 5, p. 314-324 11 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Simplexvirus
Morphine
Superoxide Dismutase
Activating Transcription Factor 6
2016
9 Citations (Scopus)

HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a

Kanda, H., Kanao, M., Liu, S., Yi, H., Iida, T., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jan 11 2016, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Neuralgia
HIV
Human Herpesvirus 1
Superoxides
14 Citations (Scopus)
Mitochondrial Dynamics
Mitochondrial Proteins
Hyperalgesia
Superoxides
Oligodeoxyribonucleotides
12 Citations (Scopus)

Spinal CPEB-mtROS-CBP signaling pathway contributes to perineural HIV gp120 with ddC-related neuropathic pain in rats

Iida, T., Yi, H., Liu, S., Huang, W., Kanda, H., Lubarsky, D. & Hao, S., Jul 1 2016, In : Experimental Neurology. 281, p. 17-27 11 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Polyadenylation
Neuralgia
Carrier Proteins
HIV
2015
13 Citations (Scopus)

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway

Zhuang, G. Z., Keeler, B., Grant, J., Bianchi, L., Fu, E., Zhang, Y. P., Erasso, D. M., Cui, J. G., Wiltshire, T., Li, Q., Hao, S., Sarantopoulos, K. D., Candiotti, K. A., Wishnek, S. M., Smith, S. B., Maixner, W., Diatchenko, L., Martin, E. R. & Levitt, R. C., Mar 3 2015, In : PLoS One. 10, 3, e0118273.

Research output: Contribution to journalArticle

Carbonic Anhydrases
carbonate dehydratase
Inositol
pain
Calcium
27 Citations (Scopus)

Current gene therapy using viral vectors for chronic pain

Guedon, J. M. G., Wu, S., Zheng, X., Churchill, C. C., Glorioso, J. C., Liu, C. H., Liu, S., Vulchanova, L., Bekker, A., Tao, Y. X., Kinchington, P. R., Goins, W. F., Fairbanks, C. A. & Hao, S., May 13 2015, In : Molecular Pain. 11, 1, 27.

Research output: Contribution to journalArticle

Chronic Pain
Genetic Therapy
Neuralgia
Herpes Simplex
Cytokines
12 Citations (Scopus)

Gene transfer of glutamic acid decarboxylase 67 by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 combined with ddC in rats

Kanao, M., Kanda, H., Huang, W., Liu, S., Yi, H., Candiotti, K. A., Lubarsky, D., Levitt, R. C. & Hao, S., Jun 25 2015, In : Anesthesia and Analgesia. 120, 6, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Neuralgia
Simplexvirus
HIV
Genes
2014
16 Citations (Scopus)

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

Huang, W., Zheng, W., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Mar 1 2014, In : Gene Therapy. 21, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

Neuralgia
Simplexvirus
Tumor Necrosis Factor-alpha
HIV
Spinal Ganglia
22 Citations (Scopus)

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jul 30 2014, In : Molecular Pain. 10, 1, 49.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Neuralgia
Simplexvirus
Interleukin-10
HIV
14 Citations (Scopus)

Interleukin 10 mediated by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jan 1 2014, In : Anesthesia and Analgesia. 119, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

Neuralgia
Simplexvirus
Interleukin-10
HIV
Spinal Ganglia
14 Citations (Scopus)

Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1 alpha/CXCR4 system in rats

Huang, W., Zheng, W., Ouyang, H., Yi, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Mar 1 2014, In : Anesthesia and Analgesia. 118, 3, p. 671-680 10 p.

Research output: Contribution to journalArticle

CXC Chemokines
Reverse Transcriptase Inhibitors
Chemokine Receptors
Hyperalgesia
Neuralgia
2013
10 Citations (Scopus)

Single-nucleotide polymorphism C3435T in the ABCB1 gene is associated with opioid consumption in postoperative pain

Candiotti, K. A., Yang, Z., Xue, L., Zhang, Y., Rodriguez, Y., Wang, L., Hao, S. & Gitlin, M., Dec 1 2013, In : Pain Medicine (United States). 14, 12, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

Postoperative Pain
Opioid Analgesics
Single Nucleotide Polymorphism
Genotype
Genes
39 Citations (Scopus)

The molecular and pharmacological mechanisms of HIV-related neuropathic pain

Hao, S., Sep 1 2013, In : Current Neuropharmacology. 11, 5, p. 499-512 14 p.

Research output: Contribution to journalArticle

Neuralgia
HIV
Pharmacology
Polyneuropathies
Poisons
2012
13 Citations (Scopus)

An emerging new paradigm in opioid withdrawal: A critical role for glia-neuron signaling in the periaqueductal gray

Ouyang, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A. & Hao, S., Sep 18 2012, In : The Scientific World Journal. 2012, 940613.

Research output: Contribution to journalArticle

Periaqueductal Gray
Neuroglia
Opioid Analgesics
Neurons
brain
1 Citation (Scopus)

Bi-directional interaction of NF-κB in nervous system damage, learning and memory

Liu, Q. F., Yang, Z., Li, J. C., Wang, S. R., Wang, X. & Hao, S., Oct 1 2012, In : Neurology Psychiatry and Brain Research. 18, 4, p. 186-190 5 p.

Research output: Contribution to journalArticle

NF-kappa B
Nervous System
Learning
B-Cell Leukemia
Inhibitor of Apoptosis Proteins
4 Citations (Scopus)

Crosstalk between JNK and NF-κB in the KDO2-mediated production of TNFα in HAPI cells.

Zheng, X., Zheng, W., Liu, S., Patel, H. M., Xia, X., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., 2012, In : Cellular and Molecular Neurobiology. 32, 8, p. 1375-1383 9 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
NF-kappa B
Phosphorylation
Cell Line
Cell Death
49 Citations (Scopus)

Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy

Chattopadhyay, M., Zhou, Z., Hao, S., Mata, M. & Fink, D. J., Mar 22 2012, In : Molecular Pain. 8, 17.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Diabetic Neuropathies
Spinal Ganglia
MicroRNAs
Pain
20 Citations (Scopus)

TNFα and IL-1β are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS

Zheng, W., Zheng, X., Liu, S., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., Apr 20 2012, In : Biochemical and Biophysical Research Communications. 420, 4, p. 762-767 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Interleukin-1
Lipopolysaccharides
CD14 Antigens
Neurodegenerative diseases
28 Citations (Scopus)

Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats

Sun, J., Liu, S., Mata, M., Fink, D. J. & Hao, S., Jan 1 2012, In : Gene Therapy. 19, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Transgenes
Morphine
Simplexvirus
Interleukin-1
2011
68 Citations (Scopus)

Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats

Zheng, W., Ouyang, H., Zheng, X., Liu, S., Mata, M., Fink, D. J. & Hao, S., May 20 2011, In : Molecular Pain. 7, 40.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Neuralgia
Neuroglia
Spinal Cord
Diagnosis-Related Groups
47 Citations (Scopus)

The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats

Hao, S., Liu, S., Zheng, X., Zheng, W., Ouyang, H., Mata, M. & Fink, D. J., Feb 1 2011, In : Neuropsychopharmacology. 36, 3, p. 664-676 13 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Naloxone
Morphine
Tumor Necrosis Factor-alpha
Phosphorylation
19 Citations (Scopus)

TNFα is involved in neuropathic pain induced by nucleoside reverse transcriptase inhibitor in rats

Zheng, X., Ouyang, H., Liu, S., Mata, M., Fink, D. J. & Hao, S., Nov 1 2011, In : Brain, Behavior, and Immunity. 25, 8, p. 1668-1676 9 p.

Research output: Contribution to journalArticle

Reverse Transcriptase Inhibitors
Neuralgia
Nucleosides
Hyperalgesia
Zalcitabine
2009
44 Citations (Scopus)

Effects of transgene-mediated endomorphin-2 in inflammatory pain

Hao, S., Wolfe, D., Glorioso, J. C., Mata, M. & Fink, D. J., Apr 1 2009, In : European Journal of Pain. 13, 4, p. 380-386 7 p.

Research output: Contribution to journalArticle

Transgenes
Pain
Freund's Adjuvant
Analgesics
Diagnosis-Related Groups
18 Citations (Scopus)

Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain

Hao, S., Hu, J. & Fink, D. J., Jan 30 2009, In : Behavioural Brain Research. 197, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

Enkephalins
Neuralgia
Naloxone
Transgenes
Morphine
2008
22 Citations (Scopus)

Applications of gene therapy to the treatment of chronic pain

Mata, M., Hao, S. & Fink, D. J., Feb 1 2008, In : Current Gene Therapy. 8, 1, p. 42-48 7 p.

Research output: Contribution to journalArticle

Chronic Pain
Genetic Therapy
Pain
Meninges
Simplexvirus
20 Citations (Scopus)

Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNFα

Mata, M., Hao, S. & Fink, D. J., Jun 6 2008, In : Neuroscience Letters. 437, 3, p. 209-213 5 p.

Research output: Contribution to journalArticle

Chronic Pain
Genetic Therapy
Interleukin-10
Anti-Inflammatory Agents
Genes
63 Citations (Scopus)

HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor α in spinal cord microglia

Zhou, Z., Peng, X., Hao, S., Fink, D. J. & Mata, M., Feb 1 2008, In : Gene Therapy. 15, 3, p. 183-190 8 p.

Research output: Contribution to journalArticle

Microglia
Interleukin-10
Spinal Cord
Tumor Necrosis Factor-alpha
Pain
2007
52 Citations (Scopus)

Engineering an endomorphin-2 gene for use in neuropathic pain therapy

Wolfe, D., Hao, S., Hu, J., Srinivasan, R., Goss, J., Mata, M., Fink, D. J. & Glorioso, J. C., Dec 15 2007, In : Pain. 133, 1-3, p. 29-38 10 p.

Research output: Contribution to journalArticle

Neuralgia
Hyperalgesia
Analgesics
Peptides
Spinal Ganglia
83 Citations (Scopus)

Gene transfer to interfere with TNFα signaling in neuropathic pain

Hao, S., Mata, M., Glorioso, J. C. & Fink, D. J., Jul 1 2007, In : Gene Therapy. 14, 13, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

Hyperalgesia
Neuralgia
Tumor Necrosis Factor-alpha
Ligation
Genes
11 Citations (Scopus)

Viral vector-based gene transfer for treatment of chronic pain

Hao, S., Mata, M. & Fink, D. J., Mar 1 2007, In : International Anesthesiology Clinics. 45, 2, p. 59-71 13 p.

Research output: Contribution to journalArticle

Genetic Vectors
Simplexvirus
Adenoviridae
Chronic Pain
Genetic Therapy
2006
106 Citations (Scopus)

HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain

Hao, S., Mata, M., Glorioso, J. C. & Fink, D. J., Feb 17 2006, In : Molecular Pain. 2, 6.

Research output: Contribution to journalArticle

Hyperalgesia
Spinal Ganglia
Neuralgia
Simplexvirus
Interleukin-4
2005

Erratum: Gene transfer of glutamic acid decarboxylase reduces neuropathic pain (Annals of Neurology (2005) 57 (914-918))

Hao, S., Mata, M., Wolf, D., Huang, S., Glorioso, J. C. & Fink, D. J., Nov 1 2005, In : Annals of Neurology. 58, 5

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Neuralgia
Neurology
Genes
78 Citations (Scopus)

Gene transfer of glutamic acid decarboxylase reduces neuropathic pain

Hao, S., Mata, M., Wolfe, D., Glorioso, J. C. & Fink, D. J., Jun 1 2005, In : Annals of Neurology. 57, 6, p. 914-918 5 p.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Hyperalgesia
Neuralgia
Simplexvirus
Genes
2004
19 Citations (Scopus)

Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation

Hu, J., Mata, M., Hao, S., Zhang, G. & Fink, D. J., Oct 1 2004, In : European Journal of Neuroscience. 20, 7, p. 1705-1712 8 p.

Research output: Contribution to journalArticle

Spinal Nerves
Wheat Germ Agglutinins
Horseradish Peroxidase
Chronic Pain
Ligation
119 Citations (Scopus)

Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain

Liu, J., Wolfe, D., Hao, S., Huang, S., Glorioso, J. C., Mata, M. & Fink, D. J., Jul 1 2004, In : Molecular Therapy. 10, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Neuralgia
Spinal Cord Injuries
Genetic Therapy
Hyperalgesia
2003
84 Citations (Scopus)

HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain

Hao, S., Mata, M., Wolfe, D., Huang, S., Glorioso, J. C. & Fink, D. J., Sep 1 2003, In : Molecular Therapy. 8, 3, p. 367-375 9 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Neuralgia
Simplexvirus
Neuroglia
Genes
11 Citations (Scopus)

Nifedipine potentiates the antinociceptive effect of endomorphin-1 microinjected into the periaqueductal gray in rats

Hao, S., Mamiya, K., Takahata, O., Iwasaki, H., Mata, M. & Fink, D. J., Apr 1 2003, In : Anesthesia and Analgesia. 96, 4, p. 1065-1071 7 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Nifedipine
Tail
Pressure
Microinjections
112 Citations (Scopus)

Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain

Hao, S., Mata, M., Goins, W., Glorioso, J. C. & Fink, D. J., Mar 1 2003, In : Pain. 102, 1-2, p. 135-142 8 p.

Research output: Contribution to journalArticle

Enkephalins
Neuralgia
Transgenes
Morphine
Analgesics
2002
30 Citations (Scopus)

Sevoflurane suppresses noxious stimulus-evoked expression of Fos-like immunoreactivity in the rat spinal cord via activation of endogenous opioid systems

Hao, S., Takahata, O., Mamiya, K. & Iwasaki, H., Jun 21 2002, In : Life Sciences. 71, 5, p. 571-580 10 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Rats
Spinal Cord
Chemical activation
Formaldehyde
2001
20 Citations (Scopus)

Antinociceptive interaction between spinal clonidine and lidocaine in the rat formalin test: An isobolographic analysis

Hao, S., Takahata, O. & Iwasaki, H., Mar 13 2001, In : Anesthesia and Analgesia. 92, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Clonidine
Pain Measurement
Lidocaine
Formaldehyde
Adrenergic Agonists
2000
17 Citations (Scopus)

Electroacupuncture potentiates the antinociceptive effect of intrathecal endomorphin-1 in the rat formalin test

Hao, S., Takahata, O. & Iwasaki, H., Jun 16 2000, In : Neuroscience Letters. 287, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

Electroacupuncture
Pain Measurement
Tail
Naltrexone
Opioid Peptides
43 Citations (Scopus)
Pain Measurement
Adrenergic Receptors
Formaldehyde
Tail
Rats
1999
10 Citations (Scopus)

Isobolographic analysis of interaction between spinal endomorphin-1, a newly isolated endogenous opioid peptide, and lidocaine in the rat formalin test

Hao, S., Takahata, O. & Iwasaki, H., Dec 10 1999, In : Neuroscience Letters. 276, 3, p. 177-180 4 p.

Research output: Contribution to journalArticle

Opioid Peptides
Pain Measurement
Lidocaine
mu Opioid Receptor
Local Anesthetics
1998
10 Citations (Scopus)

Naltrexone, but not atropine or yohimbine, antagonizes suppression of formalin-induced spinal sensitization by intrathecal nociceptin

Hao, S. & Ogawa, H., Aug 7 1998, In : Life Sciences. 63, 11, p. 167-173 7 p.

Research output: Contribution to journalArticle

Naltrexone
Yohimbine
Atropine
Formaldehyde
Cholinergic Receptors
12 Citations (Scopus)
Pain Measurement
Lidocaine
Inhalation
Drug Interactions
Formaldehyde