Shuanglin Hao

Professor

  • 1501 Citations
1994 …2023

Research output per year

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Research Output

  • 1501 Citations
  • 46 Article
  • 6 Review article
  • 2 Chapter
  • 1 Comment/debate
2020

Viral vector-mediated gene transfer of glutamic acid decarboxylase for chronic pain treatment: A literature review

Kanao-Kanda, M., Kanda, H., Liu, S., Roy, S., Toborek, M. & Hao, S., Apr 2020, In : Human gene therapy. 31, 7-8, p. 405-414 10 p.

Research output: Contribution to journalReview article

2019

Mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn

Takahashi, K., Yi, H., Gu, J., Ikegami, D., Liu, S., Iida, T., Kashiwagi, Y., Dong, C., Kunisawa, T. & Hao, S., Jan 1 2019, In : British Journal of Anaesthesia.

Research output: Contribution to journalArticle

1 Scopus citations

Ryanodine Receptor to Mitochondrial Reactive Oxygen Species Pathway Plays an Important Role in Chronic Human Immunodeficiency Virus gp120MN-Induced Neuropathic Pain in Rats

Godai, K., Takahashi, K., Kashiwagi, Y., Liu, C. H., Yi, H., Liu, S., Dong, C., Lubarsky, D. A. & Hao, S., Jul 1 2019, In : Anesthesia and analgesia. 129, 1, p. 276-286 11 p.

Research output: Contribution to journalArticle

2018

Phosphorylated CCAAT/enhancer binding protein β Contributes to rat HIV-related neuropathic pain: In vitro and in vivo studies

Yi, H., Liu, S., Kashiwagi, Y., Ikegami, D., Huang, W., Kanda, H., Iida, T., Liu, C. H., Takahashi, K., Lubarsky, D. & Hao, S., Jan 17 2018, In : Journal of Neuroscience. 38, 3, p. 555-574 20 p.

Research output: Contribution to journalArticle

2 Scopus citations

Spinal bromodomain-containing protein 4 contributes to neuropathic pain induced by HIV glycoprotein 120 with morphine in rats

Takahashi, K., Yi, H., Liu, C. H., Liu, S., Kashiwagi, Y., Patin, D. & Hao, S., Jan 1 2018, In : NeuroReport. 29, 6, p. 441-446 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFα, NR2B, and pC/EBPβ in the periaqueductal gray in rats

Yi, H., Iida, T., Liu, S., Ikegami, D., Liu, Q., Iida, A., Lubarsky, D. & Hao, S., Mar 16 2017, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

4 Scopus citations

MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats

Iida, T., Yi, H., Liu, S., Ikegami, D., Zheng, W., Liu, Q., Takahashi, K., Kashiwagi, Y., Goins, W. F., Glorioso, J. C. & Hao, S., May 1 2017, In : Gene Therapy. 24, 5, p. 314-324 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a

Kanda, H., Kanao, M., Liu, S., Yi, H., Iida, T., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jan 11 2016, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

11 Scopus citations
14 Scopus citations

Pain

Chen, J., Han, J. S., Zhao, Z. Q., Wei, F., Hsieh, J. C., Bao, L., Chen, A. C. N., Dai, Y., Fan, B. F., Gu, J. G., Hao, S. L., Hu, S. J., Ji, Y. H., Li, Y. J., Li, Y. Q., Lin, Q., Liu, X. G., Liu, Y. Q., Lu, Y., Luo, F. & 23 others, Ma, C., Qiu, Y. H., Rao, Z. R., Shi, L., Shyu, B. C., Song, X. J., Tang, J. S., Tao, Y. X., Wan, Y., Wang, J. S., Wang, K. W., Wang, Y., Xu, G. Y., Xu, T. L., You, H. J., Yu, L. C., Yu, S. Y., Zhang, D. Y., Zhang, D. R., Zhang, J. M., Zhang, X., Zhang, Y. Q. & Zhuo, M., Jan 1 2016, Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, p. 1091-1149 59 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spinal CPEB-mtROS-CBP signaling pathway contributes to perineural HIV gp120 with ddC-related neuropathic pain in rats

Iida, T., Yi, H., Liu, S., Huang, W., Kanda, H., Lubarsky, D. & Hao, S., Jul 1 2016, In : Experimental Neurology. 281, p. 17-27 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway

Zhuang, G. Z., Keeler, B., Grant, J., Bianchi, L., Fu, E. S., Zhang, Y. P., Erasso, D. M., Cui, J. G., Wiltshire, T., Li, Q., Hao, S., Sarantopoulos, K. D., Candiotti, K., Wishnek, S. M., Smith, S. B., Maixner, W., Diatchenko, L., Martin, E. R. & Levitt, R. C., Mar 3 2015, In : PloS one. 10, 3, e0118273.

Research output: Contribution to journalArticle

14 Scopus citations

Current gene therapy using viral vectors for chronic pain

Guedon, J. M. G., Wu, S., Zheng, X., Churchill, C. C., Glorioso, J. C., Liu, C. H., Liu, S., Vulchanova, L., Bekker, A., Tao, Y. X., Kinchington, P. R., Goins, W. F., Fairbanks, C. A. & Hao, S., May 13 2015, In : Molecular Pain. 11, 1, 27.

Research output: Contribution to journalArticle

29 Scopus citations

Gene transfer of glutamic acid decarboxylase 67 by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 combined with ddC in rats

Kanao, M., Kanda, H., Huang, W., Liu, S., Yi, H., Candiotti, K. A., Lubarsky, D., Levitt, R. C. & Hao, S., Jun 25 2015, In : Anesthesia and Analgesia. 120, 6, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

Huang, W., Zheng, W., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Mar 1 2014, In : Gene Therapy. 21, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Jul 30 2014, In : Molecular Pain. 10, 1, 49.

Research output: Contribution to journalArticle

23 Scopus citations

Interleukin 10 mediated by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Jan 1 2014, In : Anesthesia and analgesia. 119, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1 alpha/CXCR4 system in rats

Huang, W., Zheng, W., Ouyang, H., Yi, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Mar 1 2014, In : Anesthesia and analgesia. 118, 3, p. 671-680 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Pain

Chen, J., Han, J. S., Zhao, Z. Q., Wei, F., Hsieh, J. C., Bao, L., Chen, A. C., Dai, Y., Fan, B. F., Gu, J. G., Hao, S. L., Hu, S. J., Ji, Y. H., Li, Y. J., Li, Y. Q., Lin, Q., Liu, X. G., Liu, Y. Q., Lu, Y., Luo, F. & 23 others, Ma, C., Qiu, Y. H., Rao, Z. R., Shi, L., Shyu, B. C., Song, X. J., Tang, J. S., Tao, Y. X., Wan, Y., Wang, J. S., Wang, K. W., Wang, Y., Xu, G. Y., Xu, T. L., You, H. J., Yu, L. C., Yu, S. Y., Zhang, D. Y., Zhang, D. R., Zhang, J. M., Zhang, X., Zhang, Y. Q. & Zhuo, M., Nov 1 2013, Neuroscience in the 21st Century: From Basic to Clinical. Springer New York, p. 965-1023 59 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Single-nucleotide polymorphism C3435T in the ABCB1 gene is associated with opioid consumption in postoperative pain

Candiotti, K., Yang, Z., Xue, L., Zhang, Y., Rodriguez, Y., Wang, L., Hao, S. & Gitlin, M., Dec 2013, In : Pain Medicine (United States). 14, 12, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

The molecular and pharmacological mechanisms of HIV-related neuropathic pain

Hao, S., Sep 1 2013, In : Current Neuropharmacology. 11, 5, p. 499-512 14 p.

Research output: Contribution to journalReview article

42 Scopus citations
2012

An emerging new paradigm in opioid withdrawal: A critical role for glia-neuron signaling in the periaqueductal gray

Ouyang, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A. & Hao, S., Sep 18 2012, In : The Scientific World Journal. 2012, 940613.

Research output: Contribution to journalReview article

13 Scopus citations

Bi-directional interaction of NF-κB in nervous system damage, learning and memory

Liu, Q. F., Yang, Z., Li, J. C., Wang, S. R., Wang, X. & Hao, S. L., Oct 2012, In : Neurology Psychiatry and Brain Research. 18, 4, p. 186-190 5 p.

Research output: Contribution to journalReview article

1 Scopus citations

Crosstalk between JNK and NF-κB in the KDO2-mediated production of TNFα in HAPI cells.

Zheng, X., Zheng, W., Liu, S., Patel, H. M., Xia, X., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., 2012, In : Cellular and Molecular Neurobiology. 32, 8, p. 1375-1383 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy

Chattopadhyay, M., Zhou, Z., Hao, S., Mata, M. & Fink, D. J., Mar 22 2012, In : Molecular Pain. 8, 17.

Research output: Contribution to journalArticle

51 Scopus citations

TNFα and IL-1β are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS

Zheng, W., Zheng, X., Liu, S., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., Apr 20 2012, In : Biochemical and biophysical research communications. 420, 4, p. 762-767 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats

Sun, J., Liu, S., Mata, M., Fink, D. J. & Hao, S., Jan 1 2012, In : Gene Therapy. 19, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats

Zheng, W., Ouyang, H., Zheng, X., Liu, S., Mata, M., Fink, D. J. & Hao, S., May 20 2011, In : Molecular Pain. 7, 40.

Research output: Contribution to journalArticle

70 Scopus citations

The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats

Hao, S., Liu, S., Zheng, X., Zheng, W., Ouyang, H., Mata, M. & Fink, D. J., Feb 1 2011, In : Neuropsychopharmacology. 36, 3, p. 664-676 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

TNFα is involved in neuropathic pain induced by nucleoside reverse transcriptase inhibitor in rats

Zheng, X., Ouyang, H., Liu, S., Mata, M., Fink, D. J. & Hao, S., Nov 1 2011, In : Brain, Behavior, and Immunity. 25, 8, p. 1668-1676 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Effects of transgene-mediated endomorphin-2 in inflammatory pain

Hao, S., Wolfe, D., Glorioso, J. C., Mata, M. & Fink, D. J., Apr 1 2009, In : European Journal of Pain. 13, 4, p. 380-386 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain

Hao, S., Hu, J. & Fink, D. J., Jan 30 2009, In : Behavioural Brain Research. 197, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Applications of gene therapy to the treatment of chronic pain

Mata, M., Hao, S. & Fink, D. J., Feb 1 2008, In : Current Gene Therapy. 8, 1, p. 42-48 7 p.

Research output: Contribution to journalReview article

24 Scopus citations

Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNFα

Mata, M., Hao, S. & Fink, D. J., Jun 6 2008, In : Neuroscience Letters. 437, 3, p. 209-213 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor α in spinal cord microglia

Zhou, Z., Peng, X., Hao, S., Fink, D. J. & Mata, M., Feb 1 2008, In : Gene Therapy. 15, 3, p. 183-190 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
2007

Engineering an endomorphin-2 gene for use in neuropathic pain therapy

Wolfe, D., Hao, S., Hu, J., Srinivasan, R., Goss, J., Mata, M., Fink, D. J. & Glorioso, J. C., Dec 15 2007, In : Pain. 133, 1-3, p. 29-38 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Gene transfer to interfere with TNFα signaling in neuropathic pain

Hao, S., Mata, M., Glorioso, J. C. & Fink, D. J., Jul 1 2007, In : Gene Therapy. 14, 13, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Viral vector-based gene transfer for treatment of chronic pain

Hao, S., Mata, M. & Fink, D. J., Mar 1 2007, In : International Anesthesiology Clinics. 45, 2, p. 59-71 13 p.

Research output: Contribution to journalReview article

12 Scopus citations
2006

HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain

Hao, S., Mata, M., Glorioso, J. C. & Fink, D. J., Feb 17 2006, In : Molecular Pain. 2, 6.

Research output: Contribution to journalArticle

110 Scopus citations
2005

Erratum: Gene transfer of glutamic acid decarboxylase reduces neuropathic pain (Annals of Neurology (2005) 57 (914-918))

Hao, S., Mata, M., Wolf, D., Huang, S., Glorioso, J. C. & Fink, D. J., Nov 1 2005, In : Annals of neurology. 58, 5, 1 p.

Research output: Contribution to journalComment/debate

Gene transfer of glutamic acid decarboxylase reduces neuropathic pain

Hao, S., Mata, M., Wolfe, D., Glorioso, J. C. & Fink, D. J., Jun 1 2005, In : Annals of neurology. 57, 6, p. 914-918 5 p.

Research output: Contribution to journalArticle

80 Scopus citations
2004

Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation

Hu, J., Mata, M., Hao, S., Zhang, G. & Fink, D. J., Oct 1 2004, In : European Journal of Neuroscience. 20, 7, p. 1705-1712 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain

Liu, J., Wolfe, D., Hao, S., Huang, S., Glorioso, J. C., Mata, M. & Fink, D. J., Jul 1 2004, In : Molecular Therapy. 10, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

121 Scopus citations
2003

HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain

Hao, S., Mata, M., Wolfe, D., Huang, S., Glorioso, J. C. & Fink, D. J., Sep 1 2003, In : Molecular Therapy. 8, 3, p. 367-375 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Nifedipine potentiates the antinociceptive effect of endomorphin-1 microinjected into the periaqueductal gray in rats

Hao, S., Mamiya, K., Takahata, O., Iwasaki, H., Mata, M. & Fink, D. J., Apr 1 2003, In : Anesthesia and analgesia. 96, 4, p. 1065-1071 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain

Hao, S., Mata, M., Goins, W., Glorioso, J. C. & Fink, D. J., Mar 2003, In : Pain. 102, 1-2, p. 135-142 8 p.

Research output: Contribution to journalArticle

114 Scopus citations
2002

Sevoflurane suppresses noxious stimulus-evoked expression of Fos-like immunoreactivity in the rat spinal cord via activation of endogenous opioid systems

Hao, S., Takahata, O., Mamiya, K. & Iwasaki, H., Jun 21 2002, In : Life Sciences. 71, 5, p. 571-580 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2001

Antinociceptive interaction between spinal clonidine and lidocaine in the rat formalin test: An isobolographic analysis

Hao, S., Takahata, O. & Iwasaki, H., Jan 1 2001, In : Anesthesia and analgesia. 92, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2000

Electroacupuncture potentiates the antinociceptive effect of intrathecal endomorphin-1 in the rat formalin test

Hao, S., Takahata, O. & Iwasaki, H., Jun 16 2000, In : Neuroscience Letters. 287, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Intrathecal endomorphin-1 produces antinociceptive activities modulated by alpha 2-adrenoceptors in the rat tail flick, tail pressure and formalin tests

Hao, S., Takahata, O. & Iwasaki, H., Mar 3 2000, In : Life Sciences. 66, 15, p. 195-204 10 p.

Research output: Contribution to journalArticle

46 Scopus citations