Sandra M Merscher-gomez

Research Associate Professor

  • 2627 Citations
19942019

Research output per year

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Research Output

2019

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

Ryu, J. H., Ge, M., Merscher, S., Rosenberg, A. Z., Marco, D., Hila, R., Okamoto, K., Shin, M. K., Hoek, M., Fornoni, A. & Jeffrey, B. K. ID., Apr 2019, In : PloS one. 14, 4, e0211559.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

Ducasa, G. M., Mitrofanova, A., Mallela, S. K., Liu, X., Molina, J., Sloan, A., Pedigo, C. E., Ge, M., Santos, J. V., Hernandez, Y., Kim, J. J., Maugeais, C., Mendez, A. J., Nair, V., Kretzler, M., Burke, G. W., Nelson, R. G., Ishimoto, Y., Inagi, R., Banerjee, S. & 5 others, Liu, S., Szeto, H. H., Merscher, S., Fontanesi, F. & Fornoni, A., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3387-3400 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Detection and quantification of lipid droplets in differentiated human podocytes

Mallela, S. K., Patel, D. M., Ducasa, G. M., Merscher, S., Fornoni, A. & Al-Ali, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 199-206 8 p. (Methods in Molecular Biology; vol. 1996).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Identification of glomerular and podocyte-specific genes and pathways activated by sera of patients with focal segmental glomerulosclerosis

Otalora, L., Chavez, E., Watford, D., Tueros, L., Correa, M., Nair, V., Ruiz, P., Wahl, P., Eddy, S., Martini, S., Kretzler, M., Burke, G. W., Fornoni, A. & Merscher, S., 2019, In : PloS one. 14, 10, e0222948.

Research output: Contribution to journalArticle

Open Access

Regulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes

Mallela, S. K., Mitrofanova, A., Merscher, S. & Fornoni, A., Dec 1 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 12, 158517.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Mitrofanova, A., Mallela, S. K., Ducasa, G. M., Yoo, T. H., Rosenfeld-Gur, E., Zelnik, I. D., Molina, J., Varona Santos, J., Ge, M., Sloan, A., Kim, J. J., Pedigo, C., Bryn, J., Volosenco, I., Faul, C. H., Zeidan, Y., Garcia Hernandez, C., Mendez, A. J., Leibiger, I., Burke, G. W. & 6 others, Futerman, A. H., Barisoni, L., Ishimoto, Y., Inagi, R., Merscher, S. & Fornoni, A., Dec 1 2019, In : Nature communications. 10, 1, 2692.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2018

Editorial: Molecular mechanisms of proteinuria

Merscher, S., 2018, In : Frontiers in Medicine. 5, NOV, 00300.

Research output: Contribution to journalEditorial

Open Access

Hydroxypropyl-β-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis

Mitrofanova, A., Molina, J., Varona Santos, J., Guzman, J., Morales, X. A., Ducasa, G. M., Bryn, J., Sloan, A., Volosenco, I., Kim, J. J., Ge, M., Mallela, S. K., Kretzler, M., Eddy, S., Martini, S., Wahl, P., Pastori, S., Mendez, A. J., Burke, G. W., Merscher-gomez, S. M. & 1 others, Fornoni, A., Jan 1 2018, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Direct measurement of free and esterified cholesterol mass in differentiated human podocytes: A TLC and enzymatic assay-based method

Pedigo, C. E., Merscher-gomez, S. M. & Fornoni, A., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1609. p. 51-56 6 p. (Methods in Molecular Biology; vol. 1609).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury

Pedigo, C. E., Ducasa, G. M., Leclercq, F., Sloan, A., Mitrofanova, A., Hashmi, T., Molina-David, J., Ge, M., Lassenius, M. I., Forsblom, C., Lehto, M., Groop, P. H., Kretzler, M., Eddy, S., Martini, S., Reich, H., Wahl, P., Ghiggeri, G. M., Faul, C., Burke, G. W. & 5 others, Kretz, O., Huber, T. B., Mendez, A. J., Merscher, S. & Fornoni, A., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3336-3350 15 p.

Research output: Contribution to journalArticle

40 Scopus citations

Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor

Villarreal, R., Mitrofanova, A., Maiguel, D., Morales, X., Jeon, J., Grahammer, F., Leibiger, I. B., Guzman, J., Fachado, A., Yoo, T. H., Busher Katin, A., Gellermann, J., Merscher, S., Burke, G. W., Berggren, P-O. Y., Oh, J., Huber, T. B. & Fornoni, A., Apr 1 2016, In : Journal of the American Society of Nephrology : JASN. 27, 4, p. 1029-1041 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

Schiffer, M., Teng, B., Gu, C., Shchedrina, V. A., Kasaikina, M., Pham, V. A., Hanke, N., Rong, S., Gueler, F., Schroder, P., Tossidou, I., Park, J. K., Staggs, L., Haller, H., Erschow, S., Hilfiker-Kleiner, D., Wei, C., Chen, C., Tardi, N., Hakroush, S. & 5 others, Selig, M. K., Vasilyev, A., Merscher, S., Reiser, J. & Sever, S., Jun 9 2015, In : Nature medicine. 21, 6, p. 601-609 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Sphingomyelinase-like phosphodiesterase 3b expression levels determine podocyte injury phenotypes in glomerular disease

Yoo, T. H., Pedigo, C. E., Guzman, J., Correa-Medina, M., Wei, C., Villarreal, R., Mitrofanova, A., Leclercq, F., Faul, C., Li, J., Kretzler, M., Nelson, R. G., Lehto, M., Forsblom, C., Groop, P. H., Reiser, J., Burke, G. W., Fornoni, A. & Merscher, S., Jan 1 2015, In : Journal of the American Society of Nephrology. 26, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

59 Scopus citations
2014

Lipid biology of the podocyte-new perspectives offer new opportunities

Fornoni, A., Merscher, S. & Kopp, J. B., Jul 2014, In : Nature Reviews Nephrology. 10, 7, p. 379-388 10 p.

Research output: Contribution to journalReview article

42 Scopus citations
17 Scopus citations

Podocyte pathology and nephropathy - sphingolipids in glomerular diseases

Merscher, S. & Fornoni, A., 2014, In : Frontiers in Endocrinology. 5, JUL, 127.

Research output: Contribution to journalReview article

37 Scopus citations

Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy

Guzman, J., Jauregui, A. N., Merscher-Gomez, S., Maiguel, D., Muresan, C., Mitrofanova, A., Diez-Sampedro, A., Szust, J., Yoo, T. H., Villarreal, R., Pedigo, C., Molano, R. D., Johnson, K., Kahn, B., Hartleben, B., Huber, T. B., Saha, J., Burke, G. W., Abel, E. D., Brosius, F. C. & 1 others, Fornoni, A., Feb 1 2014, In : Diabetes. 63, 2, p. 701-714 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Podocytopathy in diabetes: A metabolic disorder

Merscher, S., Lenz, O. & Fornoni, A., Jan 1 2014, In : Contributions to nephrology. 183, p. 157-173 17 p.

Research output: Contribution to journalArticle

Podocytopathy in diabetes: A metabolic disorder

Merscher-gomez, S. M., Lenz, O. & Fornoni, A., May 16 2014, Podocytopathy. S. Karger AG, Vol. 183. p. 157-173 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Cyclodextrin protects podocytes in diabetic kidney disease

Merscher-Gomez, S., Guzman, J., Pedigo, C. E., Lehto, M., Aguillon-Prada, R., Mendez, A., Lassenius, M. I., Forsblom, C., Yoo, T. H., Villarreal, R., Maiguel, D., Johnson, K., Goldberg, R., Nair, V., Randolph, A., Kretzler, M., Nelson, R. G., Burke, G. W., Groop, P. H. & Fornoni, A., Nov 1 2013, In : Diabetes. 62, 11, p. 3817-3827 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Dynamin-mediated nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells (Journal of Biological Chemistry (2012) 287, (28932-28942))

Jeon, J., Leibiger, I., Moede, T., Walter, B., Faul, C., Maiguel, D., Villarreal, R., Guzman, J., Berggren, P. O., Mundel, P., Ricordi, C., Merscher-Gomez, S. & Fornoni, A., Jan 11 2013, In : Journal of Biological Chemistry. 288, 2, 1 p.

Research output: Contribution to journalComment/debate

Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome

Ravani, P., Ponticelli, A., Siciliano, C., Fornoni, A., Magnasco, A., Sica, F., Bodria, M., Caridi, G., Wei, C., Belingheri, M., Ghio, L., Merscher-Gomez, S., Edefonti, A., Pasini, A., Montini, G., Murtas, C., Wang, X., Muruve, D., Vaglio, A., Martorana, D. & 4 others, Pani, A., Scolari, F., Reiser, J. & Ghiggeri, G. M., Nov 2013, In : Kidney international. 84, 5, p. 1025-1033 9 p.

Research output: Contribution to journalArticle

71 Scopus citations
2012

Dynamin-mediated nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells

Jeon, J., Leibiger, I., Moede, T., Walter, B., Faul, C., Maiguel, D., Villarreal, R., Guzman, J., Berggren, P. O., Mundelp, P., Ricordi, C., Merscher-Gomezs, S. & Fornoni, A., Aug 17 2012, In : Journal of Biological Chemistry. 287, 34, p. 28932-28942 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2011

Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis

Fornoni, A., Sageshima, J., Wei, C., Merscher-Gomez, S., Aguillon-Prada, R., Jauregui, A. N., Li, J., Mattiazzi, A., Ciancio, G., Chen, L., Zilleruelo, G., Abitbol, C., Chandar, J., Seeherunvong, W., Ricordi, C., Ikehata, M., Rastaldi, M. P., Reiser, J. & Burke, G. W., Jun 1 2011, In : Science Translational Medicine. 3, 85, 85ra46.

Research output: Contribution to journalArticle

295 Scopus citations
2008

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

Faul, C., Donnelly, M., Merscher-Gomez, S., Chang, Y. H., Franz, S., Delfgaauw, J., Chang, J. M., Choi, H. Y., Campbell, K. N., Kim, K., Reiser, J. & Mundel, P., Sep 1 2008, In : Nature medicine. 14, 9, p. 931-938 8 p.

Research output: Contribution to journalArticle

627 Scopus citations
2007

New Insights into the Role of Tbx1 in the Digeorge Mouse Model

Kochilas, L., Liao, J., Merscher-Gomez, S., Kucherlapati, R., Morrow, B. & Epstein, J. A., Nov 16 2007, Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms. Blackwell Publishing Ltd, p. 135-136 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2006

Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome

Long, J. M., LaPorte, P., Merscher, S., Funke, B., Saint-Jore, B., Puech, A., Kucherlapati, R., Morrow, B. E., Skoultchi, A. I. & Wynshaw-Boris, A., Nov 1 2006, In : Neurogenetics. 7, 4, p. 247-257 11 p.

Research output: Contribution to journalArticle

66 Scopus citations
2002

Role of neural crest during cardiac development in a mouse model of DiGeorge syndrome

Kochilas, L., Merscher-Gomez, S., Lu, M. M., Potluri, V., Liao, J., Kucherlapati, R., Morrow, B. & Epstein, J. A., Jan 1 2002, In : Developmental Biology. 251, 1, p. 157-166 10 p.

Research output: Contribution to journalArticle

68 Scopus citations
2001

TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome

Merscher, S., Funke, B., Epstein, J. A., Heyer, J., Puech, A., Lu, M. M., Xavier, R. J., Demay, M. B., Russell, R. G., Factor, S., Tokooya, K., Jore, B. S., Lopez, M., Pandita, R. K., Lia, M., Carrion, D., Xu, H., Schorle, H., Kobler, J. B., Scambler, P. & 4 others, Wynshaw-Boris, A., Skoultchi, A. I., Morrow, B. E. & Kucherlapati, R., Feb 23 2001, In : Cell. 104, 4, p. 619-629 11 p.

Research output: Contribution to journalArticle

698 Scopus citations
2000

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region

Puech, A., Saint-Jore, B., Merscher, S., Russell, R. G., Cherif, D., Sirotkin, H., Xu, H., Factor, S., Kucherlapati, R. & Skoultchi, A. I., Aug 29 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 18, p. 10090-10095 6 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations
1999

Der(22) syndrome and velo-cardio-facial syndrome/DiGeorge syndrome share a 1.5-Mb region of overlap on chromosome 22q11

Funke, B., Edelmann, L., McCain, N., Pandita, R. K., Ferreira, J., Merscher, S., Zohouri, M., Cannizzaro, L., Shanske, A. & Morrow, B. E., Jan 1 1999, In : American journal of human genetics. 64, 3, p. 747-758 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
1997

A 5.5-Mb high-resolution integrated map of distal 11q13

Merscher, S., Bekri, S., De Leeuw, B., Pedeutour, F., Grosgeorge, J., Shows, T. B., Müllenbach, R., Le Paslier, D., Nowak, N. J. & Gaudray, P., Feb 1 1997, In : Genomics. 39, 3, p. 340-347 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma

Bekri, S., Adélaide, J., Merscher, S., Grosgeorge, J., Caroli-Bosc, F., Perucca-Lostanlen, D., Kelley, P. M., Pébusque, M. J., Theillet, C., Birnbaum, D. & Gaudray, P., Jan 1 1997, In : Cytogenetic and Genome Research. 79, 1-2, p. 125-131 7 p.

Research output: Contribution to journalArticle

127 Scopus citations

Identification of new translocation breakpoints at 12q13 in lipomas

Merscher, S., Marondel, I., Pedeutour, F., Gaudray, P., Kucherlapati, R. & Turc-Carel, C., Nov 15 1997, In : Genomics. 46, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
1995

Cloning, Chromosomal Localization, and Physical Linkage of the β and γ Subunits (SCNN1B and SCNN1G) of the Human Epithelial Amiloride-Sensitive Sodium Channel

Voilley, N., Bassilana, F., Mignon, C., Merscher, S., Mattéi, M. G., Carle, G. F., Lazdunski, M. & Barbry, P., Aug 10 1995, In : Genomics. 28, 3, p. 560-565 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
1994

Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints

Pedeutour, F., Merscher, S., Durieux, E., Montgomery, K., Krauter, K., Clevy, J. P., Barcelo, G., Kucherlapati, R., Gaudray, P. & Turc-Carel, C., Aug 1994, In : Genomics. 22, 3, p. 512-518 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Nuclear runoff transcription analysis using chemiluminescent detection

Merscher, S., Hanselmann, R., Welter, C. & Dooley, S., Jan 1 1994, In : BioTechniques. 16, 6, p. 1024+1026

Research output: Contribution to journalArticle

21 Scopus citations