Roy C Levitt

Professor of Clinical

  • 6788 Citations
1975 …2020

Research output per year

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Research Output

2014

Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression

Erasso, D., Tender, G., Levitt, R. C. & Cui, J. G., Nov 2014, In : Experimental neurology. 261, p. 646-653 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

Huang, W., Zheng, W., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Mar 1 2014, In : Gene Therapy. 21, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Jul 30 2014, In : Molecular Pain. 10, 1, 49.

Research output: Contribution to journalArticle

23 Scopus citations

Interleukin 10 mediated by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Jan 1 2014, In : Anesthesia and analgesia. 119, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1 alpha/CXCR4 system in rats

Huang, W., Zheng, W., Ouyang, H., Yi, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. A. & Hao, S., Mar 1 2014, In : Anesthesia and analgesia. 118, 3, p. 671-680 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10

Zhang, Y. P., Song, C. Y., Yuan, Y., Eber, A., Rodriguez, Y., Levitt, R. C., Takacs, P., Yang, Z., Goldberg, R. & Candiotti, K. A., Oct 1 2013, In : Neurobiology of Disease. 58, p. 169-178 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Prophylactic and antinociceptive effects of coenzyme q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes

Zhang, Y. P., Eber, A., Yuan, Y., Yang, Z., Rodriguez, Y., Levitt, R. C., Takacs, P. & Candiotti, K. A., Apr 1 2013, In : Anesthesiology. 118, 4, p. 945-954 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

An emerging new paradigm in opioid withdrawal: A critical role for glia-neuron signaling in the periaqueductal gray

Ouyang, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A. & Hao, S., Sep 18 2012, In : The Scientific World Journal. 2012, 940613.

Research output: Contribution to journalReview article

13 Scopus citations

Crosstalk between JNK and NF-κB in the KDO2-mediated production of TNFα in HAPI cells.

Zheng, X., Zheng, W., Liu, S., Patel, H. M., Xia, X., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., 2012, In : Cellular and Molecular Neurobiology. 32, 8, p. 1375-1383 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

TNFα and IL-1β are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS

Zheng, W., Zheng, X., Liu, S., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., Apr 20 2012, In : Biochemical and biophysical research communications. 420, 4, p. 762-767 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Glial NF-kappa B inhibition alters neuropeptide expression after sciatic nerve injury in mice

Zhang, Y. P., Fu, E. S., Sagen, J., Levitt, R. C., Candiotti, K. A., Bethea, J. R. & Brambilla, R., Apr 18 2011, In : Brain Research. 1385, p. 38-46 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2010

Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways

Hauber, H. P., Lavigne, F., Hung, H. L., Levitt, R. C. & Hamid, Q., Jul 1 2010, In : Journal of Cystic Fibrosis. 9, 4, p. 277-279 3 p.

Research output: Contribution to journalArticle

14 Scopus citations
2007

IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells

Steenwinckel, V., Louahed, J., Orabona, C., Huaux, F., Warnier, G., McKenzie, A., Lison, D., Levitt, R. & Renauld, J. C., Mar 1 2007, In : Journal of Immunology. 178, 5, p. 3244-3251 8 p.

Research output: Contribution to journalArticle

Open Access
78 Scopus citations

LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors

Hauber, H. P., Goldmann, T., Vollmer, E., Wollenberg, B., Hung, H. L., Levitt, R. C. & Zabel, P., Apr 1 2007, In : Journal of Endotoxin Research. 13, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Up-regulation of interleukin-9 and the interleukin-9-associated calcium-activated chloride channel hCLCA1 in nasal mucosa following in vivo allergen challenge

Hauber, H. P., Bergeron, C., Toda, M., Kontolemos, M., Holroyd, K. J., Levitt, R. C. & Hamid, Q., Mar 1 2007, In : Allergy, Asthma and Clinical Immunology. 3, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome

Walker, N. M., Simpson, J. E., Levitt, R. C., Boyle, K. T. & Clarke, L. L., Apr 1 2006, In : Journal of Pharmacology and Experimental Therapeutics. 317, 1, p. 275-283 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis

Hauber, H. P., Bergeron, C., Tsicopoulos, A., Wallaert, B., Olivenstein, R., Holroyd, K. J., Levitt, R. C. & Hamid, Q., Apr 2005, In : Canadian Respiratory Journal. 12, 3, p. 143-146 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Niflumic acid and MSI-2216 reduce TNF-α-induced mucin expression in human airway mucosa

Hauber, H. P., Daigneault, P., Frenkiel, S., Lavigne, F., Hung, H. L., Levitt, R. C. & Hamid, Q., Feb 2005, In : Journal of Allergy and Clinical Immunology. 115, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction

Hauber, H. P., Tsicopoulos, A., Wallaert, B., Griffin, S., McElvaney, N. G., Daigneault, P., Mueller, Z., Olivenstein, R., Holroyd, K. J., Levitt, R. C. & Hamid, Q., Jun 2004, In : European Respiratory Journal. 23, 6, p. 846-850 5 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Involvement of IL-9 in the bronchial phenotype of patients with nasal polyposis

Tsicopoulos, A., Shimbara, A., De Nadai, P., Aldewachi, O., Lamblin, C., Lassalle, P., Walls, A. F., Sénéchal, S., Levitt, R. C., Darras, J., Hamid, Q. & Wallaert, B., Mar 2004, In : Journal of Allergy and Clinical Immunology. 113, 3, p. 462-469 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2003

Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis

Hauber, H. P., Manoukian, J. J., Nguyen, L. H. P., Sobol, S. E., Levitt, R. C., Holroyd, K. J., McElvaney, N. G., Griffin, S. & Hamid, Q., Jun 1 2003, In : Laryngoscope. 113, 6, p. 1037-1042 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Interleukin-9 induces mucous cell metaplasia independent of inflammation

Reader, J. R., Hyde, D. M., Schelegle, E. S., Aldrich, M. C., Stoddard, A. M., McLane, M. P., Levitt, R. C. & Tepper, J. S., Jun 1 2003, In : American journal of respiratory cell and molecular biology. 28, 6, p. 664-672 9 p.

Research output: Contribution to journalArticle

61 Scopus citations
2002
115 Scopus citations

A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction

Zhou, Y., Shapiro, M., Dong, Q., Louahed, J., Weiss, C., Wan, S., Chen, Q., Dragwa, C., Savio, D., Huang, M., Fuller, C., Tomer, Y., Nicolaides, N. C., McLane, M. & Levitt, R. C., Dec 1 2002, Novartis Foundation Symposium. Vol. 248. p. 150-170 21 p. (Novartis Foundation Symposium; vol. 248).

Research output: Chapter in Book/Report/Conference proceedingChapter

59 Scopus citations

A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma

Niimi, T., Munakata, M., Keck-Waggoner, C. L., Popescu, N. C., Levitt, R. C., Hisada, M. & Kimura, S., Mar 2002, In : American journal of human genetics. 70, 3, p. 718-725 8 p.

Research output: Contribution to journalArticle

52 Scopus citations
2001

A new ventilator for monitoring lung mechanics in small animals [2]

Volgyesi, G. A., Tremblay, L. N., Webster, P., Zamel, N., Slutsky, A. S., Ewart, S., Levitt, R. & Mitzner, W., May 3 2001, In : Journal of applied physiology. 90, 5, p. 2016-2017 2 p.

Research output: Contribution to journalLetter

Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma

Zhou, Y., Dong, Q., Louahed, J., Dragwa, C., Savio, D., Huang, M., Weiss, C., Tomer, Y., McLane, M. P., Nicolaides, N. C. & Levitt, R. C., Jan 1 2001, In : American journal of respiratory cell and molecular biology. 25, 4, p. 486-491 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: Role in IL-8 release

Abdelilah, S. G., Latifa, K., Esra, N., Cameron, L., Bouchaib, L., Nicolaides, N. C., Levitt, R. C. & Hamid, Q., Feb 15 2001, In : Journal of Immunology. 166, 4, p. 2768-2774 7 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Interleukin 9 promotes influx and local maturation of eosinophils

Louahed, J., Zhou, Y., Lee Maloy, W., Rani, P. U., Weiss, C., Tomer, Y., Vink, A., Renauld, J. C., Van Snick, J., Nicolaides, N. C., Levitt, R. C. & Haczku, A., Feb 15 2001, In : Blood. 97, 4, p. 1035-1042 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma

Zhuo, Y., McLane, M. & Levitt, R. C., Dec 1 2001, In : Respiratory research. 2, 2, p. 80-84 5 p.

Research output: Contribution to journalReview article

66 Scopus citations

UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 Homeodomain transcription factor

Niimi, T., Keck-Waggoner, C. L., Popescu, N. C., Zhou, Y., Levitt, R. C. & Kimura, S., Jan 1 2001, In : Molecular Endocrinology. 15, 11, p. 2021-2036 16 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Ventilation in mice with a solenoid-controlled airflow.

Ewart, S., Levitt, R. & Mitzner, W., May 1 2001, In : Journal of applied physiology (Bethesda, Md. : 1985). 90, 5, p. 2016-2017 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2000

IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma

Shimbara, A., Christodoulopoulos, P., Soussi-Gounni, A., Olivenstein, R., Nakamura, Y., Levitt, R. C., Nicolaides, N. C., Holroyd, K. J., Tsicopoulos, A., Lafitte, J. J., Wallaert, B. & Hamid, Q. A., Jan 1 2000, In : Journal of Allergy and Clinical Immunology. 105, 1 I, p. 108-115 8 p.

Research output: Contribution to journalArticle

214 Scopus citations

IL-9 expression by human eosinophils: Regulation by IL-1β and TNF-α

Gounni, A. S., Nutku, E., Koussih, L., Aris, F., Louahed, J., Levitt, R. C., Nicolaides, N. C. & Hamid, Q., Jan 1 2000, In : Journal of Allergy and Clinical Immunology. 106, 3, p. 460-466 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Interleukin-9 upregulates mucus expression in the airways

Louahed, J., Toda, M., Jen, J., Hamid, Q., Renauld, J. C., Levitt, R. C. & Nicolaides, N. C., Jan 1 2000, In : American journal of respiratory cell and molecular biology. 22, 6, p. 649-656 8 p.

Research output: Contribution to journalArticle

219 Scopus citations

Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children

Malerba, G., Lauciello, M. C., Scherpbier, T., Trabetti, E., Galavotti, R., Cusin, V., Pescollderungg, L., Zanoni, G., Martinati, L. C., Boner, A. L., Levitt, R. C. & Pignatti, P. F., Jan 1 2000, In : American journal of respiratory and critical care medicine. 162, 4 I, p. 1587-1590 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Role of insulin receptor substrate-2 in interleukin-9-dependent proliferation

Demoulin, J. B., Grasso, L., Atkins, J. M., Stevens, M., Louahed, J., Levitt, R. C., Nicolaides, N. C. & Renauld, J. C., Oct 6 2000, In : FEBS letters. 482, 3, p. 200-204 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
1999

Emerging therapeutic targets in asthma: A role for interleukin-9

Levitt, R. C. & Nicolaides, N. C., Mar 1 1999, In : Expert Opinion on Therapeutic Targets. 3, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice

Dong, Q., Louahed, J., Vink, A., Sullivan, C. D., Messler, C. J., Zhou, Y., Haczku, A., Huaux, F., Arras, M., Holroyd, K. J., Renauld, J. C., Levitt, R. C. & Nicolaides, N. C., Jul 17 1999, In : European Journal of Immunology. 29, 7, p. 2130-2139 10 p.

Research output: Contribution to journalArticle

108 Scopus citations

IL-9 pathway in asthma: New therapeutic targets for allergic inflammatory disorders

Levitt, R. C., McLane, M. R., MacDonald, D., Ferrante, V., Weiss, C., Zhou, T., Holroyd, K. J. & Nicolaides, N. C., Jan 1 1999, In : Journal of Allergy and Clinical Immunology. 103, 5 SUPPL., p. S485-S491

Research output: Contribution to journalArticle

98 Scopus citations

Interieukin 9: A candidate gene for asthma

Nicolaides, N. C., Holroyd, K. J., Ewart, S. L., Eleff, S. M., Kiser, M. B., Dragwa, C. R., Sullivan, C. D., Grasso, L., Zhang, L. Y., Messler, C. J., Zhou, T., Kleeberger, S. R., Buetow, K. H. & Levitt, R. C., Dec 1 1999, In : Pneumologie. 53, 9, p. M77

Research output: Contribution to journalArticle

Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones

Louahed, J., Grasso, L., De Smet, C., Van Roost, E., Wildmann, C., Nicolaides, N. C., Levitt, R. C. & Renauld, J. C., Sep 1 1999, In : Blood. 94, 5, p. 1701-1710 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
1998

Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region

Holroyd, K. J., Martinati, L. C., Trabetti, E., Scherpbier, T., Eleff, S. M., Boner, A. L., Pignatti, P. F., Kiser, M. B., Dragwa, C. R., Hubbard, F., Sullivan, C. D., Grasso, L., Messler, C. J., Huang, M., Hu, Y., Nicolaides, N. C., Buetow, K. H. & Levitt, R. C., Sep 1 1998, In : Genomics. 52, 2, p. 233-235 3 p.

Research output: Contribution to journalArticle

52 Scopus citations

Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice

McLane, M. P., Haczku, A., Van De Rijn, M., Weiss, C., Ferrante, V., MacDonald, D., Renauld, J. C., Nicolaides, N. C., Holroyd, K. J. & Levitt, R. C., Jan 1 1998, In : American journal of respiratory cell and molecular biology. 19, 5, p. 713-720 8 p.

Research output: Contribution to journalArticle

163 Scopus citations

Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor

Grasso, L., Huang, M., Sullivan, C. D., Messler, C. J., Kiser, M. B., Dragwa, C. R., Holroyd, K. J., Renauld, J. C., Levitt, R. C. & Nicolaides, N. C., Sep 11 1998, In : Journal of Biological Chemistry. 273, 37, p. 24016-24024 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
1997

Genetic control of differential baseline breathing pattern

Tankersley, C. G., Fitzgerald, R. S., Levitt, R. C., Mitzner, W. A., Ewart, S. L. & Kleeberger, S. R., Mar 1997, In : Journal of applied physiology. 82, 3, p. 874-881 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Interleukin 9: A candidate gene for asthma

Nicolaides, N. C., Holroyd, K. J., Ewart, S. L., Eleff, S. M., Kiser, M. B., Dragwa, C. R., Sullivan, C. D., Grasso, L., Zhang, L. Y., Messler, C. J., Zhou, T., Kleeberger, S. R., Buetow, K. H. & Levitt, R. C., Nov 25 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 24, p. 13175-13180 6 p.

Research output: Contribution to journalArticle

214 Scopus citations

Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice

Kleeberger, S. R., Levitt, R. C., Zhang, L. Y., Longphre, M., Harkema, J., Jedlicka, A., Eleff, S. M., DiSilvestre, D. & Holroyd, K. J., Jan 1 1997, In : Nature genetics. 17, 4, p. 475-478 4 p.

Research output: Contribution to journalArticle

157 Scopus citations
1996

Airway Hyperresponsiveness to Acetylcholine: Segregation Analysis and Evidence for Linkage to Murine Chromosome 6

Ewart, S. L., Mitzner, W., DiSilvestre, D. A., Meyers, D. A. & Levitt, R. C., Jan 1 1996, In : American journal of respiratory cell and molecular biology. 14, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
1995

Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice

Zhang, L. Y., Levitt, R. C. & Kleeberger, S. R., Jan 1 1995, In : Experimental Lung Research. 21, 4, p. 503-518 16 p.

Research output: Contribution to journalArticle

53 Scopus citations