Roy C Levitt

Professor of Clinical

  • 6788 Citations
1975 …2020

Research output per year

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Research Output

115 Scopus citations

A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction

Zhou, Y., Shapiro, M., Dong, Q., Louahed, J., Weiss, C., Wan, S., Chen, Q., Dragwa, C., Savio, D., Huang, M., Fuller, C., Tomer, Y., Nicolaides, N. C., McLane, M. & Levitt, R. C., Dec 1 2002, Novartis Foundation Symposium. Vol. 248. p. 150-170 21 p. (Novartis Foundation Symposium; vol. 248).

Research output: Chapter in Book/Report/Conference proceedingChapter

59 Scopus citations

Adult muscle sodium channel α-subunit is a gene candidate for malignant hyperthermia susceptibility

Olckers, A., Meyers, D. A., Meyers, S., Taylor, E. W., Fletcher, J. E., Rosenberg, H., Isaacs, H. & Levitt, R. C., Nov 1992, In : Genomics. 14, 3, p. 829-831 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

A genetic approach to the study of lung physiology: Understanding biological variability in airway responsiveness

Levitt, R. C., Mitzner, W. & Kleeberger, S. R., Jan 1 1990, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 258, 3 2-2, p. L157-L164

Research output: Contribution to journalReview article

40 Scopus citations

A genetic model for evaluation of susceptibility to ozone-induced inflammation

Kleeberger, S. R., Bassett, D. J. P., Jakab, G. J. & Levitt, R. C., Jan 1 1990, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 258, 6 2-3, p. L313-L320

Research output: Contribution to journalArticle

88 Scopus citations

Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression

Erasso, D., Tender, G., Levitt, R. C. & Cui, J. G., Nov 2014, In : Experimental neurology. 261, p. 646-653 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Airway Hyperresponsiveness to Acetylcholine: Segregation Analysis and Evidence for Linkage to Murine Chromosome 6

Ewart, S. L., Mitzner, W., DiSilvestre, D. A., Meyers, D. A. & Levitt, R. C., Jan 1 1996, In : American journal of respiratory cell and molecular biology. 14, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Allelic loss of chromosome 18q and prognosis in colorectal cancer

Jen, J., Kim, H., Piantadosi, S., Liu, Z. F., Levitt, R. C., Sistonen, P., Kinzler, K. W., Vogelstein, B. & Hamilton, S. R., Jul 28 1994, In : New England Journal of Medicine. 331, 4, p. 213-221 9 p.

Research output: Contribution to journalArticle

644 Scopus citations

An emerging new paradigm in opioid withdrawal: A critical role for glia-neuron signaling in the periaqueductal gray

Ouyang, H., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A. & Hao, S., Sep 18 2012, In : The Scientific World Journal. 2012, 940613.

Research output: Contribution to journalReview article

13 Scopus citations

A new ventilator for monitoring lung mechanics in small animals [2]

Volgyesi, G. A., Tremblay, L. N., Webster, P., Zamel, N., Slutsky, A. S., Ewart, S., Levitt, R. & Mitzner, W., May 3 2001, In : Journal of applied physiology. 90, 5, p. 2016-2017 2 p.

Research output: Contribution to journalLetter

A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma

Niimi, T., Munakata, M., Keck-Waggoner, C. L., Popescu, N. C., Levitt, R. C., Hisada, M. & Kimura, S., Mar 2002, In : American journal of human genetics. 70, 3, p. 718-725 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

A single-gene difference associated with theophylline toxicity in mice

Levitt, R. C., Levitt, D. S., Shum, S. & Nebert, D. W., Jan 1 1979, In : Clinical Research. 27, 2, p. 445A

Research output: Contribution to journalArticle

1 Scopus citations

A single gene difference in early death caused by hypoplastic anemia in mice receiving oral benzo[a]pyrene daily

Levitt, R. C., Felton, J. S., Robinson, J. R. & Nebert, D. W., Jan 1 1975, In : Pharmacologist. 17, 2, p. No.207

Research output: Contribution to journalArticle

7 Scopus citations

Assessment of somatosensory function in patients with idiopathic dry eye symptoms

Galor, A., Levitt, R. C., McManus, K. T., Kalangara, J. P., Seiden, B. E., Park, J. J., Covington, D. B., Sarantopoulos, K. D. & Felix, E., Nov 1 2016, In : JAMA Ophthalmology. 134, 11, p. 1290-1298 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region

Holroyd, K. J., Martinati, L. C., Trabetti, E., Scherpbier, T., Eleff, S. M., Boner, A. L., Pignatti, P. F., Kiser, M. B., Dragwa, C. R., Hubbard, F., Sullivan, C. D., Grasso, L., Messler, C. J., Huang, M., Hu, Y., Nicolaides, N. C., Buetow, K. H. & Levitt, R. C., Sep 1 1998, In : Genomics. 52, 2, p. 233-235 3 p.

Research output: Contribution to journalArticle

52 Scopus citations

Atopy and bronchial hyperresponsiveness: Exclusion of linkage to markers on chromosomes 11q and 6p

Amelung, P. J., Panhuysen, C. I. M., Postma, D. S., Levitt, R. C., Koeter, G. H., Francomano, C. A., Bleecker, E. R. & Meyers, D. A., Dec 1 1992, In : Clinical and Experimental Allergy. 22, 12, p. 1077-1084 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytyptamine

Levitt, R. C. & Mitzner, W., Jan 1 1989, In : Journal of applied physiology. 67, 3, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

Nebert, D. W., Levitt, R. C., Jensen, N. M., Lambert, G. H. & Felton, J. S., Mar 1 1977, In : Archives of Toxicology. 39, 1-2, p. 109-132 24 p.

Research output: Contribution to journalArticle

39 Scopus citations

Botulinum Toxin A for the Treatment of Photophobia and Dry Eye

Diel, R. J., Kroeger, Z. A., Levitt, R. C., Sarantopoulos, K. D., Sered, H., Martinez-Barrizonte, J. & Galor, A., Jan 1 2018, In : Ophthalmology. 125, 1, p. 139-140 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Bulbar conjunctival microvascular responses in dry eye

Chen, W., Batawi, H. I. M., Alava, J. R., Galor, A., Yuan, J., Sarantopoulos, K. D., McClellan, A. L., Feuer, W. J., Levitt, R. C. & Wang, J., Apr 1 2017, In : Ocular Surface. 15, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Burning Eye Syndrome: Do Neuropathic Pain Mechanisms Underlie Chronic Dry Eye?

Kalangara, J. P., Galor, A., Levitt, R. C., Felix, E., Alegret, R. & Sarantopoulos, K. D., Apr 1 2016, In : Pain medicine (Malden, Mass.). 17, 4, p. 746-755 10 p.

Research output: Contribution to journalReview article

15 Scopus citations

Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice

Levitt, R. C., Zhuang, G. Y., Kang, Y., Erasso, D. M., Upadhyay, U., Ozdemir, M., Fu, E., Sarantopoulos, K. D., Smith, S. B., Maixner, W., Diatchenko, L., Martin, E. R. & Wiltshire, T., May 25 2017, (Accepted/In press) In : Mammalian Genome. p. 1-9 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway

Zhuang, G. Z., Keeler, B., Grant, J., Bianchi, L., Fu, E. S., Zhang, Y. P., Erasso, D. M., Cui, J. G., Wiltshire, T., Li, Q., Hao, S., Sarantopoulos, K. D., Candiotti, K., Wishnek, S. M., Smith, S. B., Maixner, W., Diatchenko, L., Martin, E. R. & Levitt, R. C., Mar 3 2015, In : PloS one. 10, 3, e0118273.

Research output: Contribution to journalArticle

14 Scopus citations

Characteristics of Ocular Pain Complaints in Patients With Idiopathic Dry Eye Symptoms

Kalangara, J. P., Galor, A., Levitt, R. C., Covington, D. B., McManus, K. T., Sarantopoulos, K. D. & Felix, E., Feb 29 2016, (Accepted/In press) In : Eye and Contact Lens.

Research output: Contribution to journalArticle

25 Scopus citations

Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma

Zhou, Y., Dong, Q., Louahed, J., Dragwa, C., Savio, D., Huang, M., Weiss, C., Tomer, Y., McLane, M. P., Nicolaides, N. C. & Levitt, R. C., Jan 1 2001, In : American journal of respiratory cell and molecular biology. 25, 4, p. 486-491 6 p.

Research output: Contribution to journalArticle

118 Scopus citations
49 Scopus citations

Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques

Schwengel, D. A., Jedlicka, A. E., Nanthakumar, E. J., Weber, J. L. & Levitt, R. C., Jul 1 1994, In : Genomics. 22, 1, p. 46-54 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Corneal mechanical thresholds negatively associate with dry eye and ocular pain symptoms

Spierer, O., Felix, E., McClellan, A. L., Parel, J-M. A., Gonzalez, A., Feuer, W. J., Sarantopoulos, K. D., Levitt, R. C., Ehrmann, K. & Galor, A., Feb 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 617-625 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Crosstalk between JNK and NF-κB in the KDO2-mediated production of TNFα in HAPI cells.

Zheng, X., Zheng, W., Liu, S., Patel, H. M., Xia, X., Ouyang, H., Levitt, R. C., Candiotti, K. A. & Hao, S., 2012, In : Cellular and Molecular Neurobiology. 32, 8, p. 1375-1383 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10

Zhang, Y. P., Song, C. Y., Yuan, Y., Eber, A., Rodriguez, Y., Levitt, R. C., Takacs, P., Yang, Z., Goldberg, R. & Candiotti, K. A., Oct 1 2013, In : Neurobiology of Disease. 58, p. 169-178 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice

Zhang, L. Y., Levitt, R. C. & Kleeberger, S. R., Jan 1 1995, In : Experimental Lung Research. 21, 4, p. 503-518 16 p.

Research output: Contribution to journalArticle

53 Scopus citations

Dinucleotide repeat polymorphism at the hormone sensitive lipase (LIPE) locus

Levitt, R. C., Jedlicka, A. E. & Nouri, N., May 1 1992, In : Human molecular genetics. 1, 2, 1 p.

Research output: Contribution to journalComment/debate

11 Scopus citations

Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients

Lanza, N. L., McClellan, A. L., Batawi, H., Felix, E., Sarantopoulos, K. D., Levitt, R. C. & Galor, A., Apr 1 2016, In : Ocular Surface. 14, 2, p. 216-223 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters

Galor, A., Felix, E., Feuer, W. J., Shalabi, N., Martin, E. R., Margolis, T. P., Sarantopoulos, K. D. & Levitt, R. C., Aug 1 2015, In : British Journal of Ophthalmology. 99, 8, p. 1126-1129 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain

Galor, A., Zlotcavitch, L., Walter, S. D., Felix, E., Feuer, W. J., Martin, E. R., Margolis, T. P., Sarantopoulos, K. D. & Levitt, R. C., May 1 2015, In : British Journal of Ophthalmology. 99, 5, p. 665-668 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Effect of non-invasive intranasal neurostimulation on tear volume, dryness and ocular pain

Farhangi, M., Cheng, A. M., Baksh, B., Sarantopoulos, C. D., Felix, E. R., Levitt, R. C. & Galor, A., Jan 1 2019, (Accepted/In press) In : British Journal of Ophthalmology. 315065.

Research output: Contribution to journalArticle

Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways

Hauber, H. P., Lavigne, F., Hung, H. L., Levitt, R. C. & Hamid, Q., Jul 1 2010, In : Journal of Cystic Fibrosis. 9, 4, p. 277-279 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse

Lazarte, R. A., bigelow, S. W., Nebert, D. W. & Levitt, R. C., Jan 1 1984, In : Developmental Pharmacology and Therapeutics. 7, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of environmental chemicals on the genetic regulation of microsomal enzyme systems

Nebert, D. W., Levitt, R. C., Orlando, M. M. & Felton, J. S., Nov 1977, In : Clinical Pharmacology and Therapeutics. 22, 5 PART 2, p. 640-658 19 p.

Research output: Contribution to journalArticle

18 Scopus citations
56 Scopus citations

Emerging therapeutic targets in asthma: A role for interleukin-9

Levitt, R. C. & Nicolaides, N. C., Mar 1 1999, In : Expert Opinion on Therapeutic Targets. 3, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

Epidemiology of discordance between symptoms and signs of dry eye

Ong, E. S., Felix, E. R., Levitt, R. C., Feuer, W. J., Sarantopoulos, C. D. & Galor, A., May 1 2018, In : British Journal of Ophthalmology. 102, 5, p. 674-679 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Epidemiology of Persistent Dry Eye-Like Symptoms After Cataract Surgery

Iglesias, E., Sajnani, R., Levitt, R. C., Sarantopoulos, K. D. & Galor, A., Jul 1 2018, In : Cornea. 37, 7, p. 893-898 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Epidemiology of Persistent Postsurgical Pain Manifesting as Dry Eye-Like Symptoms after Cataract Surgery

Sajnani, R., Raia, S., Gibbons, A., Chang, V., Karp, C. L., Sarantopoulos, C. D., Levitt, R. C. & Galor, A., Jan 1 2018, In : Cornea. 37, 12, p. 1535-1541 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Evidence for a locus regulating total serum ige levels mapping to chromosome 5

Meyers, D. A., Postma, D. S., Panhuysen, C. I. M., Xu, J., Amelung, P. J., Levitt, R. C. & Bleecker, E. R., Sep 15 1994, In : Genomics. 23, 2, p. 464-470 7 p.

Research output: Contribution to journalArticle

345 Scopus citations

Evidence for genetic heterogeneity in malignant hyperthermia susceptibility

Levitt, R. C., Nouri, N., Jedlicka, A. E., McKusick, V. A., Marks, A. R., Shutack, J. G., Fletcher, J. E., Rosenberg, H. & Meyers, D. A., Nov 1991, In : Genomics. 11, 3, p. 543-547 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Evidence for the localization of a malignant hyperthermia susceptibility locus (MHS2) to human chromosome 17q

Levitt, R. C., Olckers, A., Meyers, S., Fletcher, J. E., Rosenberg, H., Isaacs, H. & Meyers, D. A., Nov 1992, In : Genomics. 14, 3, p. 562-566 5 p.

Research output: Contribution to journalArticle

117 Scopus citations

Evidence for two unlinked loci regulating total serum IgE levels

Xu, J., Levitt, R. C., Panhuysen, C. I. M., Postma, D. S., Taylor, E. W., Amelung, P. J., Holroyd, K. J., Bleecker, E. R. & Meyers, D. A., Jan 1 1995, In : American journal of human genetics. 57, 2, p. 425-430 6 p.

Research output: Contribution to journalArticle

80 Scopus citations
20 Scopus citations