Roy C Levitt

Professor of Clinical

  • 6788 Citations
1975 …2020

Research output per year

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Research Output

1975

A single gene difference in early death caused by hypoplastic anemia in mice receiving oral benzo[a]pyrene daily

Levitt, R. C., Felton, J. S., Robinson, J. R. & Nebert, D. W., Jan 1 1975, In : Pharmacologist. 17, 2, p. No.207

Research output: Contribution to journalArticle

7 Scopus citations

Relationship between 'aromatic hydrocarbon responsiveness' and the survival times in mice treated with various drugs and environmental compounds

Robinson, J. R., Felton, J. S., Levitt, R. C., Thorgeirsson, S. S. & Nebert, D. W., Dec 1 1975, In : Molecular Pharmacology. 11, 6, p. 850-865 16 p.

Research output: Contribution to journalArticle

62 Scopus citations
1977

Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

Nebert, D. W., Levitt, R. C., Jensen, N. M., Lambert, G. H. & Felton, J. S., Mar 1 1977, In : Archives of Toxicology. 39, 1-2, p. 109-132 24 p.

Research output: Contribution to journalArticle

39 Scopus citations

Effects of environmental chemicals on the genetic regulation of microsomal enzyme systems

Nebert, D. W., Levitt, R. C., Orlando, M. M. & Felton, J. S., Nov 1977, In : Clinical Pharmacology and Therapeutics. 22, 5 PART 2, p. 640-658 19 p.

Research output: Contribution to journalArticle

18 Scopus citations
56 Scopus citations
1979

A single-gene difference associated with theophylline toxicity in mice

Levitt, R. C., Levitt, D. S., Shum, S. & Nebert, D. W., Jan 1 1979, In : Clinical Research. 27, 2, p. 445A

Research output: Contribution to journalArticle

1 Scopus citations
19 Scopus citations

Genetic differences in the metabolic activation of benzo[a]pyrene in mice. Attempts to correlate tumorigenesis with binding of reactive intermediates to DNA and with mutagenesis in vitro

Pelkonen, O., Boobis, A. R., Levitt, R. C., Kouri, R. E. & Nebert, D. W., Jan 1 1979, In : Pharmacology. 18, 6, p. 281-293 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

The Ah locus: Biochemical basis for genetic differences in brain tumor formation in mice

Levitt, R. C., Fysh, J. M., Jensen, N. M. & Nebert, D. W., Dec 1 1979, In : Genetics. 92, 4, p. 1205-1210 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
1980

Toxic chemical depression of the bone marrow and possible aplastic anemia explainable on a genetic basis

Nebert, D. W., Jensen, N. M., Levitt, R. C. & Felton, J. S., Jan 1 1980, In : Clinical Toxicology. 16, 1, p. 99-122 24 p.

Research output: Contribution to journalArticle

29 Scopus citations
1981

Preleukemia

Levitt, R. C. & Stuart, R. K., Jan 1 1981, Johns Hopkins Medical Journal. 5 ed. Vol. 148. p. 200-204 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
1982

Genetic differences in theophylline (THEO) toxicity associated with the Ah locus: Effects of cimetidine in vitro and in vivo

Lazarte, R. A., Nebert, D. W. & Levitt, R. C., Jan 1 1982, In : Pediatric Research. 16, 4 II, p. No. 284

Research output: Contribution to journalArticle

Prader-Willi syndrome associated with an interstitial deletion of chromosome 15

Bonuccelli, C. M., Stetten, G., Levitt, R. C., Levin, L. S. & Pyeritz, R. E., Dec 1 1982, Johns Hopkins Medical Journal. 5 ed. Vol. 151. p. 237-242 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
1983

Screening of 16 common therapeutic drugs. Possible association with the Ah locus

Chen, Y. T., Bigelow, S. W., Levitt, R. C. & Nebert, D. W., Jan 1 1983, In : Developmental Pharmacology and Therapeutics. 6, 4, p. 269-283 15 p.

Research output: Contribution to journalArticle

1984

Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse

Lazarte, R. A., bigelow, S. W., Nebert, D. W. & Levitt, R. C., Jan 1 1984, In : Developmental Pharmacology and Therapeutics. 7, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
1988

Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice

Levitt, R. C. & Mitzner, W., Jan 1 1988, In : FASEB Journal. 2, 10, p. 2605-2608 4 p.

Research output: Contribution to journalArticle

143 Scopus citations
1989

Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytyptamine

Levitt, R. C. & Mitzner, W., Jan 1 1989, In : Journal of applied physiology. 67, 3, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Foramen magnum decompression in an infant with homozygous achondroplasia. Case report.

Moskowitz, N., Carson, B., Kopits, S., Levitt, R. & Hart, G., Jan 1989, In : Journal of neurosurgery. 70, 1, p. 126-128 3 p.

Research output: Contribution to journalArticle

28 Scopus citations
1990

A genetic approach to the study of lung physiology: Understanding biological variability in airway responsiveness

Levitt, R. C., Mitzner, W. & Kleeberger, S. R., Jan 1 1990, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 258, 3 2-2, p. L157-L164

Research output: Contribution to journalReview article

40 Scopus citations

A genetic model for evaluation of susceptibility to ozone-induced inflammation

Kleeberger, S. R., Bassett, D. J. P., Jakab, G. J. & Levitt, R. C., Jan 1 1990, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 258, 6 2-3, p. L313-L320

Research output: Contribution to journalArticle

88 Scopus citations

Gene candidate [2]

Levitt, R. C., McKusick, V. A., Fletcher, J. E. & Rosenberg, H., Jan 1 1990, In : Nature. 345, 6273, p. 297-298 2 p.

Research output: Contribution to journalLetter

15 Scopus citations

In vitro tracheal responses from mice chosen for in vivo lung cholinergic sensitivity

Weinmann, G. G., Black, C. M., Levitt, R. C. & Hirshman, C. A., Jan 1 1990, In : Journal of applied physiology. 69, 1, p. 274-280 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Succinylcholine potentiates responses to intravenous acetylcholine in the canine lung periphery

Kaise, A., Weinmann, G. G., Levitt, R. C. & Hirshman, C. A., Jan 1 1990, In : Journal of applied physiology. 69, 3, p. 1137-1142 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
1991

Evidence for genetic heterogeneity in malignant hyperthermia susceptibility

Levitt, R. C., Nouri, N., Jedlicka, A. E., McKusick, V. A., Marks, A. R., Shutack, J. G., Fletcher, J. E., Rosenberg, H. & Meyers, D. A., Nov 1991, In : Genomics. 11, 3, p. 543-547 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Molecular genetics and malignant hyperthermia

Levitt, R. C., Meyers, D., Fletcher, J. E. & Rosenberg, H., Jan 1 1991, In : Anesthesiology. 75, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

8 Scopus citations

Polymorphisms in the transcribed 3′ untranslated region of eukaryotic genes

Levitt, R. C., Oct 1991, In : Genomics. 11, 2, p. 484-489 6 p.

Research output: Contribution to journalShort survey

33 Scopus citations

Understanding biological variability in susceptibility to respiratory disease

Levitt, R. C., Nov 1991, In : Pharmacogenetics. 1, 2, p. 94-97 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1992

Adult muscle sodium channel α-subunit is a gene candidate for malignant hyperthermia susceptibility

Olckers, A., Meyers, D. A., Meyers, S., Taylor, E. W., Fletcher, J. E., Rosenberg, H., Isaacs, H. & Levitt, R. C., Nov 1992, In : Genomics. 14, 3, p. 829-831 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

Atopy and bronchial hyperresponsiveness: Exclusion of linkage to markers on chromosomes 11q and 6p

Amelung, P. J., Panhuysen, C. I. M., Postma, D. S., Levitt, R. C., Koeter, G. H., Francomano, C. A., Bleecker, E. R. & Meyers, D. A., Dec 1 1992, In : Clinical and Experimental Allergy. 22, 12, p. 1077-1084 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Dinucleotide repeat polymorphism at the hormone sensitive lipase (LIPE) locus

Levitt, R. C., Jedlicka, A. E. & Nouri, N., May 1 1992, In : Human molecular genetics. 1, 2, 1 p.

Research output: Contribution to journalComment/debate

11 Scopus citations

Evidence for the localization of a malignant hyperthermia susceptibility locus (MHS2) to human chromosome 17q

Levitt, R. C., Olckers, A., Meyers, S., Fletcher, J. E., Rosenberg, H., Isaacs, H. & Meyers, D. A., Nov 1992, In : Genomics. 14, 3, p. 562-566 5 p.

Research output: Contribution to journalArticle

117 Scopus citations

Prospects for the diagnosis of malignant hyperthermia susceptibility using molecular genetic approaches

Levitt, R. C., Jan 1 1992, In : Anesthesiology. 76, 6, p. 1039-1048 10 p.

Research output: Contribution to journalReview article

19 Scopus citations
1993

G to A polymorphism in the CACNLG gene

Dickers, A., Jedlicka, A. E., Powers, P. A., Hogan, K., Gregg, R. G. & Levitt, R. C., Dec 1 1993, In : Human Molecular Genetics. 2, 12

Research output: Contribution to journalArticle

G to A polymorphism in the CACNLG gene

Dickers, A., Jedlicka, A. E., Powers, P. A., Hogan, K., Gregg, R. G. & Levitt, R. C., Dec 1 1993, In : Human molecular genetics. 2, 12, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Linkage mapping of the human thromboxane a2 receptor (tbxa2r) to chromosome 19p13.3 using transcribed 3′ untranslated dna sequence polymorphisms

Schwengel, D. A., Nouri, N., Meyers, D. A. & Levitt, R. C., Nov 1993, In : Genomics. 18, 2, p. 212-215 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Localization of the highly polymorphic locus D19S120 to 19p13.3 by linkage

Jedlicka, A. E., Taylor, E. W., Meyers, D. A., Liu, Z. & Levitt, R. C., Jan 1 1993, In : Cytogenetics and cell genetics. 65, 1-2, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mast cells modulate acute ozone-induced inflammation of the murine lung

Kleeberger, S. R., Seiden, J. E., Levitt, R. C. & Zhang, L. Y., Jan 1 1993, In : American Review of Respiratory Disease. 148, 5, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Susceptibility to ozone-induced inflammation. I. Genetic control of the response to subacute exposure

Kleeberger, S. R., Levitt, R. C. & Zhang, L. Y., Jan 1 1993, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 264, 1 8-1, p. L15-L20

Research output: Contribution to journalArticle

50 Scopus citations
41 Scopus citations
1994

Allelic loss of chromosome 18q and prognosis in colorectal cancer

Jen, J., Kim, H., Piantadosi, S., Liu, Z. F., Levitt, R. C., Sistonen, P., Kinzler, K. W., Vogelstein, B. & Hamilton, S. R., Jul 28 1994, In : New England Journal of Medicine. 331, 4, p. 213-221 9 p.

Research output: Contribution to journalArticle

644 Scopus citations

Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques

Schwengel, D. A., Jedlicka, A. E., Nanthakumar, E. J., Weber, J. L. & Levitt, R. C., Jul 1 1994, In : Genomics. 22, 1, p. 46-54 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Evidence for a locus regulating total serum ige levels mapping to chromosome 5

Meyers, D. A., Postma, D. S., Panhuysen, C. I. M., Xu, J., Amelung, P. J., Levitt, R. C. & Bleecker, E. R., Sep 15 1994, In : Genomics. 23, 2, p. 464-470 7 p.

Research output: Contribution to journalArticle

345 Scopus citations

Fluorescence-based resource for semiautomated genomic analyses using microsatellite markers

Levitt, R. C., Kiser, M. B., Dragwa, C., Jedlicka, A. E., Xu, J., Meyers, D. A. & Hudson, J. R., Nov 15 1994, In : Genomics. 24, 2, p. 361-365 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genetic counseling by the anesthesiologist

Levitt, R. C. & Bernhardt, B. A., Jan 1 1994, In : Anesthesiology Clinics of North America. 12, 3, p. 599-606 8 p.

Research output: Contribution to journalReview article

Molecular genetic methods for mapping disease genes

Levitt, R. C., Nov 1 1994, In : American journal of respiratory and critical care medicine. 150, 5 II, p. S94-S99

Research output: Contribution to journalArticle

5 Scopus citations
1995

Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice

Zhang, L. Y., Levitt, R. C. & Kleeberger, S. R., Jan 1 1995, In : Experimental Lung Research. 21, 4, p. 503-518 16 p.

Research output: Contribution to journalArticle

53 Scopus citations

Evidence for two unlinked loci regulating total serum IgE levels

Xu, J., Levitt, R. C., Panhuysen, C. I. M., Postma, D. S., Taylor, E. W., Amelung, P. J., Holroyd, K. J., Bleecker, E. R. & Meyers, D. A., Jan 1 1995, In : American journal of human genetics. 57, 2, p. 425-430 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Fine-structure mapping of genes providing susceptibility to asthma on chromosome 5q31-q33

Levitt, R. C. & Holroyd, K. J., Jan 1 1995, In : Clinical and Experimental Allergy, Supplement. 25, 2, p. 119-123 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic susceptibility to asthma – bronchial hyperresponsiveness coinherited with a major gene for atopy

Postma, D. S., Bleecker, E. R., Amelung, P. J., Holroyd, K. J., Xu, J., Panhuysen, C. I. M., Meyers, D. A. & Levitt, R. C., Oct 5 1995, In : New England Journal of Medicine. 333, 14, p. 894-900 7 p.

Research output: Contribution to journalArticle

681 Scopus citations