Roy C Levitt

Professor of Clinical

  • 6681 Citations
1975 …2020
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Research Output 1975 2019

2019

Effect of non-invasive intranasal neurostimulation on tear volume, dryness and ocular pain

Farhangi, M., Cheng, A. M., Baksh, B., Sarantopoulos, C. D., Felix, E. R., Levitt, R. C. & Galor, A., Jan 1 2019, (Accepted/In press) In : British Journal of Ophthalmology. 315065.

Research output: Contribution to journalArticle

Eye Pain
Tears
Phenolsulfonphthalein
Pain
Autoimmune Diseases

Individuals with migraine have a different dry eye symptom profile than individuals without migraine

Farhangi, M., Diel, R. J., Buse, D. C., Huang, A. M., Levitt, R. C., Sarantopoulos, K. D., Felix, E. & Galor, A., Jan 1 2019, In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Migraine Disorders
Eye Pain
Eye Abnormalities
Headache Disorders
Eye Diseases
3 Citations (Scopus)

Modification of the Neuropathic Pain Symptom Inventory for use in eye pain (NPSI-Eye)

Farhangi, M., Feuer, W., Galor, A., Bouhassira, D., Levitt, R. C., Sarantopoulos, C. D. & Felix, E. R., Jul 1 2019, In : Pain. 160, 7, p. 1541-1550 10 p.

Research output: Contribution to journalArticle

Eye Pain
Neuralgia
Equipment and Supplies
Anesthetics
Pain
1 Citation (Scopus)

Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL

Upadhyay, U., Zhuang, G. Z., Diatchenko, L., Parisien, M., Kang, Y., Sarantopoulos, K. D., Martin, E. R., Smithid, S. B., Maixner, W. & Levitt, R. C., Jun 1 2019, In : PLoS genetics. 15, 6, e1008226.

Research output: Contribution to journalArticle

Open Access
Carbonic Anhydrases
carbonate dehydratase
alternative splicing
Alternative Splicing
Spinal Ganglia
1 Citation (Scopus)
Open Access
Eye Pain
Intraocular Injections
Chronic Pain
Nerve Block
Pain
1 Citation (Scopus)

The Genetics of Neuropathic Pain from Model Organisms to Clinical Application

Calvo, M., Davies, A. J., Hébert, H. L., Weir, G. A., Chesler, E. J., Finnerup, N. B., Levitt, R. C., Smith, B. H., Neely, G. G., Costigan, M. & Bennett, D. L., Nov 20 2019, In : Neuron. 104, 4, p. 637-653 17 p.

Research output: Contribution to journalReview article

Open Access
Neuralgia
Clustered Regularly Interspaced Short Palindromic Repeats
Nervous System Trauma
Genetic Techniques
Pain Clinics
2018
8 Citations (Scopus)

Botulinum Toxin A for the Treatment of Photophobia and Dry Eye

Diel, R. J., Kroeger, Z. A., Levitt, R. C., Sarantopoulos, K. D., Sered, H., Martinez-Barrizonte, J. & Galor, A., Jan 1 2018, In : Ophthalmology. 125, 1, p. 139-140 2 p.

Research output: Contribution to journalArticle

Photophobia
Type A Botulinum Toxins
8 Citations (Scopus)

Epidemiology of discordance between symptoms and signs of dry eye

Ong, E. S., Felix, E., Levitt, R. C., Feuer, W. J., Sarantopoulos, K. D. & Galor, A., May 1 2018, In : British Journal of Ophthalmology. 102, 5, p. 674-679 6 p.

Research output: Contribution to journalArticle

Signs and Symptoms
Epidemiology
Pain
Eye Diseases
Forehead
7 Citations (Scopus)

Epidemiology of Persistent Dry Eye-Like Symptoms After Cataract Surgery

Iglesias, E., Sajnani, R., Levitt, R. C., Sarantopoulos, K. D. & Galor, A., Jul 1 2018, In : Cornea. 37, 7, p. 893-898 6 p.

Research output: Contribution to journalArticle

Cataract
Epidemiology
Pain
Eye Pain
Refractive Surgical Procedures
1 Citation (Scopus)

Epidemiology of Persistent Postsurgical Pain Manifesting as Dry Eye-Like Symptoms After Cataract Surgery

Sajnani, R., Raia, S., Gibbons, A., Chang, V., Karp, C., Sarantopoulos, K. D., Levitt, R. C. & Galor, A., Dec 1 2018, In : Cornea. 37, 12, p. 1535-1541 7 p.

Research output: Contribution to journalArticle

Cataract
Epidemiology
Odds Ratio
Confidence Intervals
Pain
2 Citations (Scopus)

Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice

Zhuang, G. Z., Upadhyay, U., Tong, X., Kang, Y., Erasso, D. M., Fu, E., Sarantopoulos, K. D., Martin, E. R., Wiltshire, T., Diatchenko, L., Smith, S. B., Maixner, W. & Levitt, R. C., Apr 24 2018, (Accepted/In press) In : Gene Therapy. p. 1-15 15 p.

Research output: Contribution to journalArticle

Carbonic Anhydrases
Hyperalgesia
Nerve Growth Factor
Inositol
Genetic Therapy
1 Citation (Scopus)

Neuropathic-Like Ocular Pain and Nonocular Comorbidities Correlate With Dry Eye Symptoms

Chang, V. S., Rose, T. P., Karp, C. L., Levitt, R. C., Sarantopoulos, C. & Galor, A., Nov 1 2018, In : Eye & contact lens. 44, p. S307-S313

Research output: Contribution to journalArticle

Eye Pain
Comorbidity
Odds Ratio
Chronic Pain
Anxiety
20 Citations (Scopus)

Neuropathic pain and dry eye

Galor, A., Moein, H. R., Lee, C., Rodriguez, A., Felix, E., Sarantopoulos, K. D. & Levitt, R. C., Jan 1 2018, In : Ocular Surface. 16, 1, p. 31-44 14 p.

Research output: Contribution to journalReview article

Neuralgia
Eye Pain
Signs and Symptoms
Epidemiology
Therapeutics
6 Citations (Scopus)

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Sivanesan, E., Levitt, R. C., Sarantopoulos, K. D., Patin, D. & Galor, A., Jan 1 2018, (Accepted/In press) In : Neuromodulation.

Research output: Contribution to journalArticle

Eye Pain
Photophobia
Chronic Pain
Electric Stimulation
Transcutaneous Electric Nerve Stimulation
4 Citations (Scopus)

Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

Diel, R. J., Hwang, J., Kroeger, Z. A., Levitt, R. C., Sarantopoulos, K. D., Sered, H., Felix, E., Martinez-Barrizonte, J. & Galor, A., Jan 1 2018, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Photophobia
Type A Botulinum Toxins
Migraine Disorders
Tears
Injections
10 Citations (Scopus)

The Association of Dry Eye Symptom Severity and Comorbid Insomnia in US Veterans

Galor, A., Seiden, B. E., Park, J. J., Feuer, W. J., McClellan, A. L., Felix, E. R., Levitt, R. C., Sarantopoulos, C. D. & Wallace, D. M., Sep 1 2018, In : Eye & contact lens. 44, p. S118-S124

Research output: Contribution to journalArticle

Sleep Initiation and Maintenance Disorders
Veterans
Eye Pain
Odds Ratio
Confidence Intervals
2 Citations (Scopus)

Traumatic brain injury, dry eye and comorbid pain diagnoses in US veterans

Lee, C. J., Felix, E., Levitt, R. C., Eddy, C., Vanner, E. A., Feuer, W. J., Sarantopoulos, K. D. & Galor, A., May 1 2018, In : British Journal of Ophthalmology. 102, 5, p. 667-673 7 p.

Research output: Contribution to journalArticle

Eye Pain
Veterans
Headache Disorders
Chronic Pain
Traumatic Brain Injury
2017
5 Citations (Scopus)

Bulbar conjunctival microvascular responses in dry eye

Chen, W., Batawi, H. I. M., Alava, J. R., Galor, A., Yuan, J., Sarantopoulos, K. D., McClellan, A. L., Feuer, W. J., Levitt, R. C. & Wang, J., Apr 1 2017, In : Ocular Surface. 15, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Blood Flow Velocity
Eye Pain
Hyperalgesia
Perfusion
Air
5 Citations (Scopus)

Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice

Levitt, R. C., Zhuang, G. Y., Kang, Y., Erasso, D. M., Upadhyay, U., Ozdemir, M., Fu, E., Sarantopoulos, K. D., Smith, S. B., Maixner, W., Diatchenko, L., Martin, E. R. & Wiltshire, T., May 25 2017, (Accepted/In press) In : Mammalian Genome. p. 1-9 9 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Morphine
Analgesics
Calcium
Inositol
16 Citations (Scopus)
Eye Pain
Central Nervous System Sensitization
Anesthesia
Pain
Forehead
4 Citations (Scopus)

Evidence that dry eye is a comorbid pain condition in a U.S. veteran population

Lee, C. J., Levitt, R. C., Felix, E. R., Sarantopoulos, C. D. & Galor, A., Nov 1 2017, In : Pain Reports. 2, 6, e629.

Research output: Contribution to journalArticle

Veterans
Eye Pain
Odds Ratio
Confidence Intervals
Pain
8 Citations (Scopus)

Evidence that dry eye represents a chronic overlapping pain condition

Levitt, A. E., Galor, A., Chowdhury, A. R., Felix, E., Sarantopoulos, K. D., Zhuang, G. Y., Patin, D., Maixner, W., Smith, S. B., Martin, E. R. & Levitt, R. C., Sep 1 2017, In : Molecular Pain. 13

Research output: Contribution to journalReview article

Chronic Pain
Eye Pain
Neuralgia
Pain
Dry Eye Syndromes
3 Citations (Scopus)

Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice

Fu, E., Erasso, D. M., Zhuang, G. Z., Upadhyay, U., Ozdemir, M., Wiltshire, T., Sarantopoulos, K. D., Smith, S. B., Maixner, W., Martin, E. R. & Levitt, R. C., Jan 1 2017, In : NeuroReport. 28, 18, p. 1215-1220 6 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Morphine
Hot Temperature
Virion
Analgesia
12 Citations (Scopus)

Longitudinal examination of frequency of and risk factors for severe dry eye symptoms in us veterans

Ong, E. S., Alghamdi, Y. A., Levitt, R. C., McClellan, A. L., Lewis, G., Sarantopoulos, K. D., Felix, E. & Galor, A., Feb 1 2017, In : JAMA Ophthalmology. 135, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

Veterans
Eye Pain
Dry Eye Syndromes
Odds Ratio
Sleep Apnea Syndromes
4 Citations (Scopus)
Eye Pain
Pain
Forearm
2016
16 Citations (Scopus)

Assessment of somatosensory function in patients with idiopathic dry eye symptoms

Galor, A., Levitt, R. C., McManus, K. T., Kalangara, J. P., Seiden, B. E., Park, J. J., Covington, D. B., Sarantopoulos, K. D. & Felix, E., Nov 1 2016, In : JAMA Ophthalmology. 134, 11, p. 1290-1298 9 p.

Research output: Contribution to journalArticle

Eye Pain
Post-Traumatic Stress Disorders
Forearm
Eye Diseases
Neuralgia
13 Citations (Scopus)

Burning Eye Syndrome: Do Neuropathic Pain Mechanisms Underlie Chronic Dry Eye?

Kalangara, J. P., Galor, A., Levitt, R. C., Felix, E., Alegret, R. & Sarantopoulos, K. D., Apr 1 2016, In : Pain medicine (Malden, Mass.). 17, 4, p. 746-755 10 p.

Research output: Contribution to journalReview article

Neuralgia
Eye Pain
Chronic Pain
Somatoform Disorders
Neuronal Plasticity
21 Citations (Scopus)

Characteristics of Ocular Pain Complaints in Patients With Idiopathic Dry Eye Symptoms

Kalangara, J. P., Galor, A., Levitt, R. C., Covington, D. B., McManus, K. T., Sarantopoulos, K. D. & Felix, E., Feb 29 2016, (Accepted/In press) In : Eye and Contact Lens.

Research output: Contribution to journalArticle

Eye Pain
Neuralgia
Chronic Pain
Veterans
30 Citations (Scopus)

Corneal mechanical thresholds negatively associate with dry eye and ocular pain symptoms

Spierer, O., Felix, E., McClellan, A. L., Parel, J-M. A., Gonzalez, A., Feuer, W. J., Sarantopoulos, K. D., Levitt, R. C., Ehrmann, K. & Galor, A., Feb 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 617-625 9 p.

Research output: Contribution to journalArticle

Eye Pain
Pain Threshold
Cornea
Linear Models
Neuralgia
24 Citations (Scopus)

Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients

Lanza, N. L., McClellan, A. L., Batawi, H., Felix, E., Sarantopoulos, K. D., Levitt, R. C. & Galor, A., Apr 1 2016, In : Ocular Surface. 14, 2, p. 216-223 8 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Matrix Metalloproteinase 9
Signs and Symptoms
9 Citations (Scopus)

HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a

Kanda, H., Kanao, M., Liu, S., Yi, H., Iida, T., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jan 11 2016, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Neuralgia
HIV
Human Herpesvirus 1
Superoxides
14 Citations (Scopus)
Mitochondrial Dynamics
Mitochondrial Proteins
Hyperalgesia
Superoxides
Oligodeoxyribonucleotides
23 Citations (Scopus)
Eye Pain
Neuralgia
Chronic Pain
Psychiatry
Mental Health
3 Citations (Scopus)

What can photophobia tell us about dry eye?

Galor, A., Levitt, R. C., Felix, E. & Sarantopoulos, K. D., Aug 25 2016, In : Expert Review of Ophthalmology. 11, 5, p. 321-324 4 p.

Research output: Contribution to journalEditorial

Photophobia
Neuralgia
29 Citations (Scopus)

ω-3 tear film lipids correlate with clinical measures of dry eye

Walter, S. D., Gronert, K., McClellan, A. L., Levitt, R. C., Sarantopoulos, K. D. & Galor, A., May 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2472-2478 7 p.

Research output: Contribution to journalArticle

Tears
Lipids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Staining and Labeling
2015
13 Citations (Scopus)

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway

Zhuang, G. Z., Keeler, B., Grant, J., Bianchi, L., Fu, E., Zhang, Y. P., Erasso, D. M., Cui, J. G., Wiltshire, T., Li, Q., Hao, S., Sarantopoulos, K. D., Candiotti, K. A., Wishnek, S. M., Smith, S. B., Maixner, W., Diatchenko, L., Martin, E. R. & Levitt, R. C., Mar 3 2015, In : PLoS One. 10, 3, e0118273.

Research output: Contribution to journalArticle

Carbonic Anhydrases
carbonate dehydratase
Inositol
pain
Calcium
45 Citations (Scopus)
Laser In Situ Keratomileusis
Somatoform Disorders
Pain
Epidemiology
Eye Pain
41 Citations (Scopus)

Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters

Galor, A., Felix, E., Feuer, W. J., Shalabi, N., Martin, E. R., Margolis, T. P., Sarantopoulos, K. D. & Levitt, R. C., Aug 1 2015, In : British Journal of Ophthalmology. 99, 8, p. 1126-1129 4 p.

Research output: Contribution to journalArticle

Tears
Post-Traumatic Stress Disorders
Pain
Eye Diseases
Depression
40 Citations (Scopus)

Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain

Galor, A., Zlotcavitch, L., Walter, S. D., Felix, E., Feuer, W. J., Martin, E. R., Margolis, T. P., Sarantopoulos, K. D. & Levitt, R. C., May 1 2015, In : British Journal of Ophthalmology. 99, 5, p. 665-668 4 p.

Research output: Contribution to journalArticle

Neuralgia
Eye Pain
Veterans
Hypersensitivity
Cohort Studies
12 Citations (Scopus)

Gene transfer of glutamic acid decarboxylase 67 by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 combined with ddC in rats

Kanao, M., Kanda, H., Huang, W., Liu, S., Yi, H., Candiotti, K. A., Lubarsky, D., Levitt, R. C. & Hao, S., Jun 25 2015, In : Anesthesia and Analgesia. 120, 6, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Neuralgia
Simplexvirus
HIV
Genes
17 Citations (Scopus)

Human Tear Serotonin Levels Correlate with Symptoms and Signs of Dry Eye

Chhadva, P., Lee, T., Sarantopoulos, K. D., Hackam, A. S., McClellan, A. L., Felix, E., Levitt, R. C. & Galor, A., Aug 1 2015, In : Ophthalmology. 122, 8, p. 1675-1680 6 p.

Research output: Contribution to journalArticle

Tears
Signs and Symptoms
Serotonin
Eye Diseases
Photophobia
29 Citations (Scopus)

Incomplete response to artificial tears is associated with features of neuropathic ocular pain

Galor, A., Batawi, H., Felix, E., Margolis, T. P., Sarantopoulos, K. D., Martin, E. R. & Levitt, R. C., Sep 16 2015, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Eye Pain
Neuralgia
Pain
Tears
Meibomian Glands
70 Citations (Scopus)

Neuropathic ocular pain: An important yet underevaluated feature of dry eye

Galor, A., Levitt, R. C., Felix, E., Martin, E. R. & Sarantopoulos, K. D., Mar 15 2015, In : Eye (Basingstoke). 29, 3, p. 301-312 12 p.

Research output: Contribution to journalArticle

Eye Pain
Neuralgia
Hyperalgesia
Chronic Pain
Central Nervous System Sensitization
34 Citations (Scopus)

Neuropathic Ocular Pain due to Dry Eye Is Associated With Multiple Comorbid Chronic Pain Syndromes

Galor, A., Covington, D., Levitt, A. E., McManus, K. T., Seiden, B., Felix, E., Kalangara, J., Feuer, W. J., Patin, D., Martin, E. R., Sarantopoulos, K. D. & Levitt, R. C., Aug 10 2015, (Accepted/In press) In : Journal of Pain.

Research output: Contribution to journalArticle

Eye Pain
Neuralgia
Chronic Pain
Veterans Hospitals
Pain
2 Citations (Scopus)

Understanding the true burden of dry eye disease

Galor, A., Levitt, R. C., Felix, E. & Sarantopoulos, K. D., Sep 3 2015, In : Expert Review of Ophthalmology. 10, 5, p. 403-405 3 p.

Research output: Contribution to journalArticle

Eye Diseases
Deficiency Diseases
Paresthesia
Signs and Symptoms
Morbidity
2014
2 Citations (Scopus)

Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression

Erasso, D., Tender, G., Levitt, R. C. & Cui, J. G., Jan 1 2014, In : Experimental Neurology. 261, p. 646-653 8 p.

Research output: Contribution to journalArticle

Agrin
Aminobutyrates
Neuralgia
Neurons
Pain
16 Citations (Scopus)

HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity

Huang, W., Zheng, W., Liu, S., Zeng, W., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Mar 1 2014, In : Gene Therapy. 21, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

Neuralgia
Simplexvirus
Tumor Necrosis Factor-alpha
HIV
Spinal Ganglia
22 Citations (Scopus)

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jul 30 2014, In : Molecular Pain. 10, 1, 49.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Neuralgia
Simplexvirus
Interleukin-10
HIV
14 Citations (Scopus)

Interleukin 10 mediated by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 in rats

Zheng, W., Huang, W., Liu, S., Levitt, R. C., Candiotti, K. A., Lubarsky, D. & Hao, S., Jan 1 2014, In : Anesthesia and Analgesia. 119, 3, p. 693-701 9 p.

Research output: Contribution to journalArticle

Neuralgia
Simplexvirus
Interleukin-10
HIV
Spinal Ganglia