Rong G Zhai

Assoc. Professor

  • 2626 Citations
19972019
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Nicotinamide-Nucleotide Adenylyltransferase Medicine & Life Sciences
Drosophila Medicine & Life Sciences
Synapses Medicine & Life Sciences
Synaptic Vesicles Medicine & Life Sciences
Nicotinamide Mononucleotide Medicine & Life Sciences
Proteins Medicine & Life Sciences
Diptera Medicine & Life Sciences
Tauopathies Medicine & Life Sciences

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Projects 2008 2018

Enhance Neuroprotection through post-transcriptional regulations

Zhai, R. G.

National Institutes of Health

9/25/179/29/18

Project: Research projectHigh Priority, Short Term Project Award

Neurons
Drosophila
Protein Isoforms
Alternative Splicing
Mammals

Functional Interaction of GBAS and SLC41A2 in Drosophila models for UDP_755

Zhai, R. G.

National Institutes of Health

5/6/164/30/18

Project: Research projectExploratory/Developmental Grants

Uridine Diphosphate
Drosophila
4-Nitrophenylphosphatase
Craniosynostoses
Microcephaly

Mechanisms of Neuronal Maintenance and Protection.

Zhai, R. G.

National Institutes of Health

12/1/0812/31/16

Project: Research projectResearch Project, High Priority, Short Term Project Award

Maintenance
Neurons
Drosophila
Housekeeping
Proteins

Research Output 1997 2019

  • 2626 Citations
  • 40 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

Ni, J., Guo, M., Cao, Y., Lei, L., Liu, K., Wang, B., Lu, F., Zhai, R. G., Gao, X., Yan, C., Wang, H. & Bi, Y., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 122-131 10 p.

Research output: Contribution to journalArticle

Fusidic Acid
Hydroxyl Radical
Tumors
Apoptosis
Derivatives

Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents

Wang, X., Ren, Q. W., Liu, X. X., Yang, Y. T., Wang, B. H., Zhai, R. G., Qi, J. G., Tian, J. W., Wang, H. B. & Bi, Y., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 364-377 14 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Drug Resistance
Paclitaxel
Pharmaceutical Preparations
G2 Phase

Erratum: Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome (Nature communications (2017) 8 1 (1257))

Li, C., Brazill, J. M., Liu, S., Bello, C., Zhu, Y., Morimoto, M., Cascio, L., Pauly, R., Diaz-Perez, Z., Malicdan, M. C. V., Wang, H., Boccuto, L., Schwartz, C. E., Gahl, W. A., Boerkoel, C. F. & Zhai, R. G., Jan 18 2018, In : Nature communications. 9, 1, 1 p.

Research output: Contribution to journalComment/debate

Spermine Synthase
Sagittaria
Oxidative stress
Manuscripts
Oxidative Stress
3 Citations

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

Yang, Y., Guan, D., Lei, L., Lu, J., Liu, J. Q., Yang, G., Yan, C., Zhai, R. G., Tian, J., Bi, Y., Fu, F. & Wang, H., Feb 15 2018, In : Toxicology and Applied Pharmacology. 341, p. 98-105 8 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
P-Glycoprotein
Paclitaxel
Derivatives
Rhodamine 123

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Brazill, J. M., Cruz, B., Zhu, Y. & Zhai, R. G., Jun 1 2018, In : DMM Disease Models and Mechanisms. 11, 6, dmm.032938.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
Peripheral Nervous System Diseases
Paclitaxel
Drosophila
Drug Therapy