Richard S Jope

Professor

  • 18342 Citations
1974 …2021
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Glycogen Synthase Kinase 3 Medicine & Life Sciences
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Projects 1984 2021

Toll-Like Receptor 2
Toll-Like Receptor 4
Depression
Antidepressive Agents
Therapeutics

Adaptive immune system function in depression

Jope, R. S.

National Institutes of Health

1/6/1212/31/17

Project: Research projectResearch Project

Immune System
Depression
Glycogen Synthase Kinase 3
T-Lymphocytes
Th17 Cells

GSK3beta: Signaling and apoptosis

Jope, R. S.

National Institutes of Health

9/15/038/31/09

Project: Research projectResearch Project

Glycogen Synthase Kinases
Apoptosis
Neuronal Plasticity
Thapsigargin
Alzheimer Disease

NEURONAL SIGNALING--OXIDANTS AND ALZHEIMERS DISEASE

Jope, R. S.

National Institutes of Health

7/1/996/30/09

Project: Research projectResearch Project

Oxidants
Alzheimer Disease
Oxidative Stress
Glycogen Synthase Kinases
Muscarinic Receptors

LITHIUM POTENTIATED STATUS EPILEPTICUS

Jope, R. S.

National Institutes of Health

12/1/8811/30/91

Project: Research projectResearch Project

lithium
seizures
calcium
testing
synaptosomes

Research Output 1974 2018

2 Citations

Distinct characteristics of hippocampal pathogenic TH17 cells in a mouse model of depression

Beurel, E., Lowell, J. A. & Jope, R. S., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Th17 Cells
Depression
Learned Helplessness
Hippocampus
T-Lymphocytes
5 Citations

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

Cheng, Y., Desse, S., Martinez, A., Worthen, R. J., Jope, R. S. & Beurel, E., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Learned Helplessness
Blood-Brain Barrier
Tumor Necrosis Factor-alpha
Glycogen Synthase Kinase 3
Tight Junction Proteins
6 Citations

Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome

Pardo, M., Beurel, E. & Jope, R. S., Feb 1 2017, In : European Journal of Neuroscience. 45, 4, p. 490-498 9 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Cotinine
Glycogen Synthase Kinases
Cognition
Serine

Glycogen Synthase Kinase-3: Abnormalities and Therapeutic Potential in Fragile X Syndrome

Jope, R. S., May 26 2017, Fragile X Syndrome: From Genetics to Targeted Treatment. Elsevier, p. 261-275 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycogen Synthase Kinase 3
Fragile X Syndrome
Lithium
Knockout Mice
Therapeutics
15 Citations

Stressed and Inflamed, Can GSK3 Be Blamed?

Jope, R. S., Cheng, Y., Lowell, J. A., Worthen, R. J., Sitbon, Y. H. & Beurel, E., Mar 1 2017, In : Trends in Biochemical Sciences. 42, 3, p. 180-192 13 p.

Research output: Contribution to journalReview article

Glycogen Synthase Kinase 3
Inflammation
Psychological Stress
Learning
Long-Term Potentiation