Ramiro E Verdun

Associate Professor

  • 1870 Citations
1998 …2024
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Research Output 1998 2019

  • 1870 Citations
  • 30 Article
2019

Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling

Jiang, X., Lu, X., Zhang, Y., Lacaria, L., Schuchardt, B. J., Mikles, D. C., Magistri, M., García-Ramírez, I., Sanchez-Garcia, I., Farooq, A., Verdun, R. E., Abdulreda, M. H., Moy, V. T. & Lossos, I. S., Aug 13 2019, In : Blood Advances. 3, 15, p. 2286-2297 12 p.

Research output: Contribution to journalArticle

Open Access
GRB2 Adaptor Protein
B-Lymphocytes
Germinal Center
Binding Sites
Phosphopeptides
1 Citation (Scopus)

LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL

Parvin, S., Ramirez-Labrada, A., Aumann, S., Lu, X. Q., Weich, N., Santiago, G., Cortizas, E. M., Sharabi, E., Zhang, Y., Sanchez-Garcia, I., Gentles, A. J., Roberts, E., Bilbao-Cortes, D., Vega, F., Chapman, J. R., Verdun, R. E. & Lossos, I. S., Sep 16 2019, In : Cancer Cell. 36, 3, p. 237-249.e6

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Lymphoma, Large B-Cell, Diffuse
T-Cell Lymphoma
Homologous Recombination
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL

Guo, F., Luo, Y., Jiang, X., Lu, X. Q., Roberti, D., Lossos, C., Kunkalla, K., Magistri, M., Rui, L., Verdun, R., Vega, F., Moy, V. T. & Lossos, I. S., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Germinal Center
Lymphoma
B-Lymphocytes
Phosphorylation
Immunoreceptor Tyrosine-Based Inhibition Motif
2018
4 Citations (Scopus)

A licensing step links AID to transcription elongation for mutagenesis in B cells

Methot, S. P., Litzler, L. C., Subramani, P. G., Eranki, A. K., Fifield, H., Patenaude, A. M., Gilmore, J. C., Santiago, G. E., Bagci, H., Côté, J. F., Larijani, M., Verdun, R. E. & Di Noia, J. M., Dec 1 2018, In : Nature Communications. 9, 1, 1248.

Research output: Contribution to journalArticle

mutagenesis
licensing
Mutagenesis
Transcription
Licensure
19 Citations (Scopus)

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

Hamard, P. J., Santiago, G. E., Liu, F., Karl, D. L., Martinez, C., Man, N., Mookhtiar, A. K., Duffort, S., Greenblatt, S., Verdun, R. E. & Nimer, S. D., Sep 4 2018, In : Cell Reports. 24, 10, p. 2643-2657 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Alternative Splicing
DNA Repair
Histones
Repair
2017
8 Citations (Scopus)

Epstein-Barr virus-positive follicular lymphoma

Mackrides, N., Campuzano-Zuluaga, G., Maque-Acosta, Y., Moul, A., Hijazi, N., Ikpatt, O., Levy, R., Verdun, R. E., Kunkalla, K., Natkunam, Y., Lossos, I., Vega, F. & Chapman-Fredricks, J., Apr 1 2017, In : Modern Pathology. 30, 4, p. 519-529 11 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Human Herpesvirus 4
Disease Progression
Hydroxychloroquine
Epstein-Barr Virus Infections
2016
8 Citations (Scopus)

Active IKKb promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

Agarwal, N. K., Kim, C. H., Kunkalla, K., Konno, H., Tjendra, Y., Kwon, D., Blonska, M., Kozloski, G. A., Moy, V. T., Verdun, R. E., Barber, G. N., Lossos, I. & Vega, F., Feb 4 2016, In : Blood. 127, 5, p. 605-615 11 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Crosstalk
Oncogenes
Tumor Necrosis Factor-alpha
Chemical activation
10 Citations (Scopus)

Class-switch recombination in the absence of the igh 39 regulatory region

Kim, A., Han, L., Santiago, G. E., Verdun, R. E. & Yu, K., Oct 1 2016, In : Journal of Immunology. 197, 7, p. 2930-2935 6 p.

Research output: Contribution to journalArticle

Nucleic Acid Regulatory Sequences
Genetic Recombination
Deoxyribonuclease I
Allergy and Immunology
Immunoglobulin A
3 Citations (Scopus)

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Asai, T., Hatlen, M. A., Lossos, C., Ndiaye-Lobry, D., Deblasio, A., Murata, K., Fleisher, M., Cortizas, E. M., Verdun, R. E., Petrini, J. & Nimer, S. D., Mar 10 2016, In : Scientific Reports. 6, 22760.

Research output: Contribution to journalArticle

Plasma Cell Neoplasms
Plasma Cells
Multiple Myeloma
Exome
Oncogenes
4 Citations (Scopus)

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

Matthews, J. M., Bhatt, S., Patricelli, M. P., Nomanbhoy, T. K., Jiang, X., Natkunam, Y., Gentles, A. J., Martinez, E., Zhu, D., Chapman-Fredricks, J., Cortizas, E., Shyam, R., Chinichian, S., Advani, R., Tan, L., Zhang, J., Choi, H. G., Tibshirani, R., Buhrlage, S. J., Gratzinger, D. & 3 others, Verdun, R. E., Gray, N. S. & Lossos, I., Jul 14 2016, In : Blood. 128, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Cells
Tumors
Phosphotransferases
Bearings (structural)
20 Citations (Scopus)

The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related

Rice, M. A., Ishteiwy, R. A., Magani, F., Udayakumar, T., Reiner, T., Yates, T. J., Miller, P., Perez-Stable, C., Rai, P., Verdun, R. E., Dykxhoorn, D. M. & Burnstein, K. L., Feb 22 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

MicroRNAs
Prostatic Neoplasms
Neoplasm Metastasis
Seminal Vesicles
Heterografts
12 Citations (Scopus)

UNG protects B cells from AID-induced telomere loss

Cortizas, E. M., Zahn, A., Safavi, S., Reed, J. A., Vega, F., Di Noia, J. M. & Verdun, R. E., Oct 17 2016, In : The Journal of experimental medicine. 213, 11, p. 2459-2472 14 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Telomere
B-Lymphocytes
Cell Proliferation
DNA Mismatch Repair
2015
6 Citations (Scopus)

Cyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region

He, M., Cortizas, E. M., Verdun, R. E. & Severinson, E., May 1 2015, In : Journal of Immunology. 194, 9, p. 4231-4239 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Cyclin-Dependent Kinases
G1 Phase
B-Lymphocytes
Cell Proliferation
2014
33 Citations (Scopus)

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

Zahn, A., Eranki, A. K., Patenaude, A. M., Methot, S. P., Fifield, H., Cortizas, E. M., Foster, P., Imai, K., Durandy, A., Larijani, M., Verdun, R. E. & Di Noia, J. M., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11

Research output: Contribution to journalArticle

DNA Breaks
Genetic Recombination
Exons
DNA Repair
DNA Damage
2 Citations (Scopus)

A novel mouse model for the hyper-IgM syndrome: A spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation

Dahlberg, C. I. M., He, M., Visnes, T., Torres, M. L., Cortizas, E. M., Verdun, R. E., Westerberg, L. S., Severinson, E. & Ström, L., Jan 1 2014, In : Journal of Immunology. 193, 9, p. 4732-4738 7 p.

Research output: Contribution to journalArticle

Hyper-IgM Immunodeficiency Syndrome
Immunoglobulin Class Switching
Mutation
Immunoglobulin G
Immunoglobulin M
2013
30 Citations (Scopus)

Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination

Cortizas, E. M., Zahn, A., Hajjar, M. E., Patenaude, A. M., Di Noia, J. M. & Verdun, R. E., Dec 1 2013, In : Journal of Immunology. 191, 11, p. 5751-5763 13 p.

Research output: Contribution to journalArticle

Genetic Recombination
Deamination
Chromatids
Double-Stranded DNA Breaks
Single-Stranded DNA
2012
10 Citations (Scopus)

Severe heat shock induces nucleolar accumulation of mRNAs in Trypanosoma cruzi

Názer, E., Verdun, R. E. & Sánchez, D. O., Aug 27 2012, In : PLoS One. 7, 8, e43715.

Research output: Contribution to journalArticle

Trypanosoma cruzi
cell nucleolus
heat stress
Shock
messenger RNA
2011
16 Citations (Scopus)

Nucleolar localization of RNA binding proteins induced by Actinomycin D and heat shock in Trypanosoma cruzi

Názer, E., Verdun, R. E. & Sánchez, D. O., May 27 2011, In : PLoS One. 6, 5, e19920.

Research output: Contribution to journalArticle

RNA-binding proteins
actinomycin D
RNA-Binding Proteins
Trypanosoma cruzi
cell nucleolus
2008
70 Citations (Scopus)

C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins

Raices, M., Verdun, R. E., Compton, S. A., Haggblom, C. I., Griffith, J. D., Dillin, A. & Karlseder, J., Mar 7 2008, In : Cell. 132, 5, p. 745-757 13 p.

Research output: Contribution to journalArticle

Telomere
Chromosomes
Telomere-Binding Proteins
Nucleotides
DNA-Binding Proteins
2007
347 Citations (Scopus)

Replication and protection of telomeres

Verdun, R. E. & Karlseder, J., Jun 21 2007, In : Nature. 447, 7147, p. 924-931 8 p.

Research output: Contribution to journalArticle

Telomere
DNA Repair
DNA Damage
Chromosomes
DNA Replication
2006
246 Citations (Scopus)

The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres

Verdun, R. E. & Karlseder, J., Nov 17 2006, In : Cell. 127, 4, p. 709-720 12 p.

Research output: Contribution to journalArticle

Homologous Recombination
Telomere
DNA Damage
Machinery
DNA
2005
215 Citations (Scopus)

Functional human telomeres are recognized as DNA damage in G2 of the cell cycle

Verdun, R. E., Crabbe, L., Haggblom, C. & Karlseder, J., Nov 23 2005, In : Molecular Cell. 20, 4, p. 551-561 11 p.

Research output: Contribution to journalArticle

Telomere
DNA Damage
Cell Cycle
DNA Breaks
G2 Phase
2004
441 Citations (Scopus)

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity

Crabbe, L., Verdun, R. E., Haggblom, C. I. & Karlseder, J., Dec 10 2004, In : Science. 306, 5703, p. 1951-1953 3 p.

Research output: Contribution to journalArticle

Telomere
Genomic Instability
RecQ Helicases
Werner Syndrome
Telomere Shortening
2003
202 Citations (Scopus)

p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage

Espinosa, J. M., Verdun, R. E. & Emerson, B. M., Oct 1 2003, In : Molecular Cell. 12, 4, p. 1015-1027 13 p.

Research output: Contribution to journalArticle

RNA Polymerase II
DNA Damage
Transcription Factor TFIIB
Tumor Suppressor Protein p53
p53 Genes
2001
33 Citations (Scopus)

Gene discovery through genomic sequencing of brucella abortus

Sánchez, D. O., Zandomeni, R. O., Cravero, S., Verdun, R. E., Pierrou, E., Faccio, P., Diaz, G., Lanzavecchia, S., Agüero, F., Frasch, A. C. C., Andersson, S. G. E., Rossetti, O. L., Grau, O. & Ugalde, R. A., Feb 12 2001, In : Infection and Immunity. 69, 2, p. 865-868 4 p.

Research output: Contribution to journalArticle

Brucella abortus
Genetic Association Studies
Brucella
Genes
Databases
2000
44 Citations (Scopus)

A random sequencing approach for the analysis of the Trypanosoma cruzi genome: General structure, large gene and repetitive DNA families, and gene discovery

Agüero, F., Verdun, R. E., Frasch, A. C. C. & Sánchez, D. O., Dec 1 2000, In : Genome Research. 10, 12, p. 1996-2005 10 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Genetic Association Studies
Parasites
Genome
Haploidy
1999
17 Citations (Scopus)

GB virus C/hepatitis G virus groups and subgroups: Classification by a restriction fragment length polymorphism method based on phylogenetic analysis of the 5' untranslated region

Quarleri, J. F., Mathet, V. L., Feld, M., Ferrario, D., Della Latta, M. P., Verdun, R. E., Sánchez, D. O. & Oubiña, J. R., Apr 29 1999, In : Journal of Clinical Microbiology. 37, 5, p. 1340-1347 8 p.

Research output: Contribution to journalArticle

GB virus C
5' Untranslated Regions
Restriction Fragment Length Polymorphisms
Nucleic Acid Databases
Sequence Analysis
14 Citations (Scopus)

Genetic diversity of GBV-C/HGV strains among HIV infected-IVDU and blood donors from Buenos Aires, Argentina

Oubiña, J. R., Mathet, V., Feld, M., Della Latta, M. P., Ferrario, D., Verdun, R. E., Libonatti, O., Fernández, J., Carballal, G., Sánchez, D. O. & Quarleri, J. F., Dec 15 1999, In : Virus Research. 65, 2, p. 121-129 9 p.

Research output: Contribution to journalArticle

GB virus C
Argentina
Drug Users
Blood Donors
HIV

Organizacion de la red para el estudio del genoma de Trypanosoma cruzi

Translated title of the contribution: Organization of the parasite genome programme networkFrasch, A. C. C., Verdun, R. E. & Sanchez, D. O., Dec 1 1999, In : Medicina. 59, SUPPL. 2, p. 4-6 3 p.

Research output: Contribution to journalArticle

Parasites
Organizations
Genome
Research Personnel
Schistosoma
1998
55 Citations (Scopus)

Gene discovery through expressed sequence tag sequencing in Trypanosoma cruzi

Verdun, R. E., Di Paolo, N., Urmenyi, T. P., Rondinelli, E., Frasch, A. C. C. & Sanchez, D. O., Dec 1 1998, In : Infection and Immunity. 66, 11, p. 5393-5398 6 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Expressed Sequence Tags
Genetic Association Studies
Clone Cells
Databases