Ralf Landgraf

Associate Professor

  • 1310 Citations
1989 …2024
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Research Output 1989 2019

  • 1310 Citations
  • 47 Article
  • 2 Chapter
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Article
2019

Impeding the single-strand annealing pathway of DNA double-strand break repair by withaferin A-mediated FANCA degradation

Liu, W., Wang, G., Palovcak, A., Li, Y., Hao, S., Liu, Z. J., Landgraf, R., Yuan, F. & Zhang, Y., May 1 2019, In : DNA Repair. 77, p. 10-17 8 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Repair
Annealing
Degradation
Fanconi Anemia Complementation Group A Protein
2018
2 Citations (Scopus)

Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2)

Garri, C., Howell, S., Tiemann, K., Tiffany, A., Jalali-Yazdi, F., Alba, M. M., Katz, J. E., Takahashi, T. T., Landgraf, R., Gross, M. E., Roberts, R. W. & Kani, K., Jun 1 2018, In : Oncotarget. 9, 44, p. 27363-27379 17 p.

Research output: Contribution to journalArticle

Peptides
Neoplasms
Enzyme-Linked Immunosorbent Assay
Cell Line
Messenger RNA

Smoothened stabilizes and protects TRAF6 from degradation: A novel non-canonical role of smoothened with implications in lymphoma biology

Qu, C., Kunkalla, K., Vaghefi, A., Frederiksen, J. K., Liu, Y., Chapman-Fredricks, J., Blonska, M., Bernal-Mizrachi, L., Alderuccio, J. P., Lossos, I., Landgraf, R. & Vega, F., Nov 1 2018, In : Cancer Letters. 436, p. 149-158 10 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Lymphoma
Lymphoma, Large B-Cell, Diffuse
Doxorubicin
Ubiquitin-Specific Proteases
2017
4 Citations (Scopus)
Fluorescent Dyes
Phosphotransferases
Imaging techniques
Dynamic response
Quenching
2016
3 Citations (Scopus)

ERBB2 overexpression establishes ERBB3-dependent hypersensitivity of breast cancer cells to withaferin A

Liu, W., Barnette, A. R., Andreansky, S. & Landgraf, R., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2750-2757 8 p.

Research output: Contribution to journalArticle

Hypersensitivity
Breast Neoplasms
Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Lactones
4 Citations (Scopus)

Fluorescent kinase probes enabling identification and dynamic imaging of HER2(+) Cells

Lee, H., Liu, W., Brown, A. S., Landgraf, R. & Wilson, J. N., Jan 1 2016, In : Analytical Chemistry. 88, 23, p. 11310-11313 4 p.

Research output: Contribution to journalArticle

Phosphotransferases
Imaging techniques
Chemical activation
Phosphotyrosine
Chemotherapy
31 Citations (Scopus)

Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37

Keramisanou, D., Aboalroub, A., Zhang, Z., Liu, W., Marshall, D., Diviney, A., Larsen, R. W., Landgraf, R. & Gelis, I., Apr 21 2016, In : Molecular Cell. 62, 2, p. 260-271 12 p.

Research output: Contribution to journalArticle

Protein Transport
Protein Kinases
Phosphotransferases
Quality Control
Hot Temperature
9 Citations (Scopus)

Regulation of receptor for advanced glycation end products (rage) ectodomain shedding and its role in cell function

Braley, A., Kwak, T., Jules, J., Harja, E., Landgraf, R. & Hudson, B., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12057-12073 17 p.

Research output: Contribution to journalArticle

Cell Movement
Proteolysis
Ligands
Amyloid Precursor Protein Secretases
Advanced Glycosylation End Product-Specific Receptor
14 Citations (Scopus)

The small molecule IMR-1 inhibits the notch transcriptional activation complex to suppress tumorigenesis

Astudillo, L., Da Silva, T. G., Wang, Z., Han, X., Jin, K., VanWye, J., Zhu, X., Weaver, K., Oashi, T., Lopes, P. E. M., Orton, D., Neitzel, L. R., Lee, E., Landgraf, R., Robbins, D. J., MacKerell, A. D. & Capobianco, A. J., Jun 15 2016, In : Cancer Research. 76, 12, p. 3593-3603 11 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Carcinogenesis
Computer-Aided Design
Neoplasms
Neoplastic Stem Cells
2015
12 Citations (Scopus)

Binding-induced, turn-on fluorescence of the EGFR/ERBB kinase inhibitor, lapatinib

Wilson, J. N., Liu, W., Brown, A. S. & Landgraf, R., May 7 2015, In : Organic and Biomolecular Chemistry. 13, 17, p. 5006-5011 6 p.

Research output: Contribution to journalArticle

inhibitors
Phosphotransferases
Fluorescence
fluorescence
photoelectric emission
5 Citations (Scopus)

HGAL localization to cell membrane regulates B-cell receptor signaling

Lu, X., Sicard, R., Jiang, X., Stockus, J. N., McNamara, G., Abdulreda, M. H., Moy, V. T., Landgraf, R. & Lossos, I., Jan 22 2015, In : Blood. 125, 4, p. 649-657 9 p.

Research output: Contribution to journalArticle

Germinal Center
Cell membranes
Lymphoma
B-Lymphocytes
Cells
14 Citations (Scopus)

Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains

Liu, W. & Landgraf, R., Feb 24 2015, In : Biochemistry. 54, 7, p. 1493-1504 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Serine
Protein Kinases
Phosphotransferases
Casein Kinase II
2014
18 Citations (Scopus)

Emission tuning of fluorescent kinase inhibitors: Conjugation length and substituent effects

Dhuguru, J., Liu, W., Gonzalez, W. G., Babinchak, W. M., Miksovska, J., Landgraf, R. & Wilson, J. N., Jun 6 2014, In : Journal of Organic Chemistry. 79, 11, p. 4940-4947 8 p.

Research output: Contribution to journalArticle

Phosphotransferases
Tuning
Quinazolines
Fluorophores
Phosphorylation
2013
21 Citations (Scopus)

Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging

Macdonald-Obermann, J. L., Adak, S., Landgraf, R., Piwnica-Worms, D. & Pike, L. J., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30773-30784 12 p.

Research output: Contribution to journalArticle

Luciferases
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Dynamic analysis
Imaging techniques
5 Citations (Scopus)

The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale

Patel, N., Barrientos, A. & Landgraf, R., Dec 6 2013, In : Journal of Biological Chemistry. 288, 49, p. 35253-35265 13 p.

Research output: Contribution to journalArticle

Mitochondria
Growth Factor Receptors
Deregulation
Intercellular Signaling Peptides and Proteins
25 Citations (Scopus)

Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation, and is associated with loss of phosphorylated STAT5

Ward, T. M., Iorns, E., Liu, X., Hoe, N., Kim, P., Singh, S., Dean, S., Jegg, A. M., Gallas, M., Rodriguez, C., Lippman, M. E., Landgraf, R. & Pegram, M. D., May 9 2013, In : Oncogene. 32, 19, p. 2463-2474 12 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Heterografts
Cell Movement
Protein Isoforms
Breast
2012
5 Citations (Scopus)

A fluorescent reporter of ATP binding-competent receptor kinases

Sicard, R., Dhuguru, J., Liu, W., Patel, N., Landgraf, R. & Wilson, J. N., Sep 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 17, p. 5532-5535 4 p.

Research output: Contribution to journalArticle

Phosphotransferases
Adenosine Triphosphate
Population
Chemical activation
Tyrosine
51 Citations (Scopus)
Phosphorylation
Ligands
Nucleotide Aptamers
Proxy
Carcinogenesis
31 Citations (Scopus)

PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells

Jegg, A. M., Ward, T. M., Iorns, E., Hoe, N., Zhou, J., Liu, X., Singh, S., Landgraf, R. & Pegram, M. D., Dec 1 2012, In : Breast Cancer Research and Treatment. 136, 3, p. 683-692 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Phenotype
S 6
mechanistic target of rapamycin complex 1
6 Citations (Scopus)
Nucleic Acids
Biological Phenomena
Technology
Antibodies
Proteins
2010
2 Citations (Scopus)

ERBB3: Multifunctional enabler or primary actor in pancreatic cancer?

Landgraf, R., Sep 15 2010, In : Cancer Biology and Therapy. 10, 6, p. 564-566 3 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Xenograft Model Antitumor Assays
ErbB-3 Receptor
Quinazolines
Protein Kinase Inhibitors
16 Citations (Scopus)

Geldanamycin selectively targets the nascent form of ERBB3 for degradation

Gerbin, C. S. & Landgraf, R., Sep 1 2010, In : Cell Stress and Chaperones. 15, 5, p. 529-544 16 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Phosphotransferases
Degradation
Epidermal Growth Factor Receptor
Dimerization
2008
25 Citations (Scopus)

Higher-order association states of cellular ERBB3 probed with photo-cross-linkable aptamers

Park, E., Baron, R. & Landgraf, R., Nov 18 2008, In : Biochemistry. 47, 46, p. 11992-12005 14 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Cross-Linking Reagents
Uracil
Nucleic Acids
Cells
2007
42 Citations (Scopus)
Receptor Protein-Tyrosine Kinases
Neoplasms
Therapeutics
2006
99 Citations (Scopus)

Signaling through ERBB receptors: Multiple layers of diversity and control

Warren, C. M. & Landgraf, R., Jul 1 2006, In : Cellular Signalling. 18, 7, p. 923-933 11 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Phosphotransferases
Phosphorylation
Membranes
19 Citations (Scopus)

The N-terminal domains of neuregulin 1 confer signal attenuation

Warren, C. M., Kani, K. & Landgraf, R., Sep 15 2006, In : Journal of Biological Chemistry. 281, 37, p. 27306-27316 11 p.

Research output: Contribution to journalArticle

Neuregulin-1
Epidermal Growth Factor
Neuregulins
Degradation
Epidermal Growth Factor Receptor
2005
44 Citations (Scopus)

Oligomers of ERBB3 have two distinct interfaces that differ in their sensitivity to disruption by heregulin

Kani, K., Warren, C. M., Kaddis, C. S., Loo, J. A. & Landgraf, R., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 8238-8247 10 p.

Research output: Contribution to journalArticle

Neuregulin-1
Oligomers
Ligands
Conformations
Oligomerization
17 Citations (Scopus)

The extracellular domains of ErbB3 retain high ligand binding affinity at endosome pH and in the locked conformation

Kani, K., Park, E. & Landgraf, R., Dec 6 2005, In : Biochemistry. 44, 48, p. 15842-15857 16 p.

Research output: Contribution to journalArticle

Endosomes
Conformations
Ligands
Dimerization
Crystal structure
2003
137 Citations (Scopus)
Neuregulin-1
Epidermal Growth Factor Receptor
Binding Sites
Receptor Protein-Tyrosine Kinases
SELEX Aptamer Technique
2001
77 Citations (Scopus)

Artificial nucleases

Chen, C. H. B., Milne, L., Landgraf, R., Perrin, D. M. & Sigman, D. S., Dec 1 2001, In : ChemBioChem. 2, 10, p. 735-740 6 p.

Research output: Contribution to journalArticle

Oligonucleotides
DNA
DNA-Binding Proteins
Nucleic Acids
Hydrogen Peroxide
33 Citations (Scopus)

Identification of a Heregulin Binding Site in HER3 Extracellular Domain

Singer, E., Landgraf, R., Horan, T., Slamon, D. & Eisenberg, D., Nov 23 2001, In : Journal of Biological Chemistry. 276, 47, p. 44266-44274 9 p.

Research output: Contribution to journalArticle

Neuregulin-1
Binding Sites
Somatomedin Receptors
Somatomedins
Proteolysis
197 Citations (Scopus)

Three-dimensional cluster analysis identifies interfaces and functional residue clusters in proteins

Landgraf, R., Xenarios, I. & Eisenberg, D., Apr 13 2001, In : Journal of Molecular Biology. 307, 5, p. 1487-1502 16 p.

Research output: Contribution to journalArticle

Cluster Analysis
Proteins
Fructose-Bisphosphate Aldolase
Sequence Alignment
Sequence Homology
2000
40 Citations (Scopus)

Heregulin reverses the oligomerization of HER3

Landgraf, R. & Eisenberg, D., Jul 25 2000, In : Biochemistry. 39, 29, p. 8503-8511 9 p.

Research output: Contribution to journalArticle

Neuregulin-1
Oligomerization
Association reactions
Surface Plasmon Resonance
Surface plasmon resonance
20 Citations (Scopus)

Human ERK1 induces filamentous growth and cell wall remodeling pathways in Saccharomyces cerevisiae

Atienza, J. M., Suh, M., Xenarios, I., Landgraf, R. & Colicelli, J., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20638-20646 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase Kinases
Yeast
Cell Wall
Saccharomyces cerevisiae
1999
69 Citations (Scopus)

Analysis of heregulin symmetry by weighted evolutionary tracing

Landgraf, R., Fischer, D. & Eisenberg, D., Dec 13 1999, In : Protein Engineering. 12, 11, p. 943-951 9 p.

Research output: Contribution to journalArticle

Neuregulin-1
Epidermal Growth Factor
Growth Differentiation Factors
Amino acids
Trace analysis
1998
21 Citations (Scopus)

Cytotoxicity and specificity of directed toxins composed of diphtheria toxin and the EGF-like domain of heregulin β1

Landgraf, R., Pegram, M., Slamon, D. J. & Eisenberg, D., Mar 3 1998, In : Biochemistry. 37, 9, p. 3220-3222 3 p.

Research output: Contribution to journalArticle

Neuregulin-1
Diphtheria Toxin
Cytotoxicity
Epidermal Growth Factor
Fusion reactions
12 Citations (Scopus)

Scission of DNA at a preselected sequence using a single-strand-specific chemical nuclease

Chen, C. H. B., Landgraf, R., Walts, A. D., Chan, L., Schlonk, P. M., Terwilliger, T. C. & Sigman, D. S., Jan 1 1998, In : Chemistry and Biology. 5, 5, p. 283-292 10 p.

Research output: Contribution to journalArticle

DNA
Genes
Plasmids
Deoxyribose
Proteins
1996
8 Citations (Scopus)

Engineering of DNA binding proteins into site-specific cutters: Reactivity of Trp repressor-1,10-phenanthroline chimeras

Landgraf, R., Pan, C., Sutton, C., Pearson, L. & Sigman, D. S., Jul 1 1996, In : Protein Engineering. 9, 7, p. 603-610 8 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
DNA
Proteins
Tryptophan
Molecular modeling
2 Citations (Scopus)

Kinetics of spontaneous displacement of RNA from heteroduplexes by DNA

Landgraf, R., Ramamurthi, K. S. & Sigman, D. S., Sep 4 1996, In : Nucleic Acids Research. 24, 16, p. 3246-3252 7 p.

Research output: Contribution to journalArticle

Nucleic Acid Heteroduplexes
RNA
Magnesium
DNA
Base Composition
58 Citations (Scopus)

Nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives.

Sigman, D. S., Landgraf, R., Perrin, D. M. & Pearson, L., Oct 11 1996, In : Metal Ions in Biological Systems. 33, p. 485-513 29 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Intercalating Agents
Nucleic Acid Conformation
Molecular Models
Phenanthrolines
1995
5 Citations (Scopus)

Double stranded scission of DNA directed through sequence-specific R-loop formation

Landgraf, R., Chen -h., C. B. & Sigman, D. S., Jan 1 1995, In : Nucleic Acids Research. 23, 17, p. 3524-3530 7 p.

Research output: Contribution to journalArticle

DNA
Plasmids
RNA
Glyoxal
Micrococcal Nuclease
9 Citations (Scopus)

Drosophila engrailed-1,10-phenanthroline chimeras as probes of homeodomain-DNA complexes

Pan, C. Q., Landgraf, R. & Sigman, D. S., Jan 1 1995, In : Protein Science. 4, 11, p. 2279-2288 10 p.

Research output: Contribution to journalArticle

DNA Probes
Drosophila
Homeodomain Proteins
DNA
DNA Cleavage
10 Citations (Scopus)

R-loop stability as a function of RNA structure and size

Landgraf, R., Chen -h., C. B. & Sigman, D. S., Jan 1 1995, In : Nucleic Acids Research. 23, 17, p. 3516-3523 8 p.

Research output: Contribution to journalArticle

RNA
Uridine
DNA
Allylamine
Backbone
1994
22 Citations (Scopus)

DNA-binding proteins as site-specific nucleases

Pan, C. Q., Landgraf, R. & Sigman, D. S., May 1 1994, In : Molecular Microbiology. 12, 3, p. 335-342 8 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Site-Directed Mutagenesis
Cysteine
Carrier Proteins
Magnetic Resonance Spectroscopy
6 Citations (Scopus)

Oligonucleotide-directed nucleic acid scission by micrococcal nuclease

Landgraf, R., Dec 1 1994, In : Biochemistry®. 33, 35, p. 10607-10615 9 p.

Research output: Contribution to journalArticle

Micrococcal Nuclease
Oligonucleotides
Nucleic Acids
Cibacron Blue F 3GA
Fusion reactions
57 Citations (Scopus)

Structure of the Escherichia coli Fis-DNA complex probed by protein conjugated with 1,10-phenanthroline copper(I) complex

Pan, C. Q., Feng, J. A., Finkel, S. E., Landgraf, R., Sigman, D. & Johnson, R. C., Mar 1 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 5, p. 1721-1725 5 p.

Research output: Contribution to journalArticle

Factor For Inversion Stimulation Protein
Escherichia coli
DNA
Proteins
copper-1,10-phenanthroline
1989
3 Citations (Scopus)

Double mixing technique for linked enzyme assays

Landgraf, R. & Betts, G. F., Feb 1 1989, In : Analytical Biochemistry. 176, 2, p. 444-448 5 p.

Research output: Contribution to journalArticle

Enzyme Assays
Assays
Enzymes
Phosphoglycerate Kinase
Glyceraldehyde-3-Phosphate Dehydrogenases