Paolo Serafini

Assistant Professor

  • 5928 Citations
20002019
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Research Output 2000 2019

  • 5928 Citations
  • 37 Article
  • 4 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2019

A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer

Speransky, S., Serafini, P., Caroli, J., Bicciato, S., Lippman, M. E. & Bishopric, N. H., Jan 1 2019, In : Breast cancer research and treatment.

Research output: Contribution to journalArticle

Open Access
Nucleotide Aptamers
Adenosine Triphosphate
Cell Membrane
Neoplasms
Prostatic Neoplasms
Open Access
Clinical Trials, Phase I
Cancer Vaccines
Up-Regulation
Neoplasms
Phosphodiesterase 5 Inhibitors
2017
2 Citations (Scopus)

4PD functionalized dendrimers: A flexible tool for in vivo gene silencing of tumor-educated myeloid cells

Zilio, S., Vella, J. L., De La Fuente, A. C., Daftarian, P. M., Weed, D., Kaifer, A., Marigo, I., Leone, K., Bronte, V. & Serafini, P., May 15 2017, In : Journal of Immunology. 198, 10, p. 4166-4177 12 p.

Research output: Contribution to journalArticle

Dendrimers
Gene Silencing
Myeloid Cells
Neoplasms
MicroRNAs
2016
2 Citations (Scopus)

G-CSF and Exenatide Might Be Associated with Increased Long-Term Survival of Allogeneic Pancreatic Islet Grafts

Zoso, A., Serafini, P., Lanzoni, G., Peixoto, E., Messinger, S., Mantero, A., Padilla-Téllez, N. D., Baidal, D., Alejandro, R., Ricordi, C. & Inverardi, L. A., 2016, In : PLoS One. 11, 6, p. e0157245

Research output: Contribution to journalArticle

islets of Langerhans
Granulocyte Colony-Stimulating Factor
Islets of Langerhans
Grafts
Transplants
2015
19 Citations (Scopus)

APTANI: A computational tool to select aptamers through sequence-structure motif analysis of HT-SELEX data

Caroli, J., Taccioli, C., De La Fuente, A., Serafini, P. & Bicciato, S., Jul 22 2015, In : Bioinformatics. 32, 2, p. 161-164 4 p.

Research output: Contribution to journalArticle

Epitopes
Nucleic acids
Bioinformatics
Nucleic Acids
SELEX Aptamer Technique
58 Citations (Scopus)

Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma

Califano, J. A., Khan, Z., Noonan, K. A., Rudraraju, L., Zhang, Z., Wang, H., Goodman, S., Gourin, C. G., Ha, P. K., Fakhry, C., Saunders, J., Levine, M., Tang, M., Neuner, G., Richmon, J. D., Blanco, R., Agrawal, N., Koch, W. M., Marur, S., Weed, D. & 2 others, Serafini, P. & Borrello, I., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Immunity
Head and Neck Neoplasms
Neoplasms
Phosphodiesterase 5 Inhibitors
Type 5 Cyclic Nucleotide Phosphodiesterases
86 Citations (Scopus)

Tadalafil reduces myeloid-derived suppressor cells and regulatory t cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma

Weed, D., Vella, J. L., Reis, I., De La Fuente, A. C., Gomez-Fernandez, C., Sargi, Z. B., Nazarian, R., Califano, J., Borrello, I. & Serafini, P., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Immunity
Neoplasms
Neoplasm Antigens
T-Lymphocytes
Type 5 Cyclic Nucleotide Phosphodiesterases
2014
2 Citations (Scopus)

Gene expression profiling of human fibrocytic myeloid-derived suppressor cells (f-MDSCs)

Mazza, E. M. C., Zoso, A., Mandruzzato, S., Bronte, V., Serafini, P., Inverardi, L. A. & Bicciato, S., Jan 1 2014, In : Genomics Data. 2, p. 389-392 4 p.

Research output: Contribution to journalArticle

T-cells
Gene Expression Profiling
Gene expression
Blood
Transplantation (surgical)
47 Citations (Scopus)

Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion

Zoso, A., Mazza, E. M. C., Bicciato, S., Mandruzzato, S., Bronte, V., Serafini, P. & Inverardi, L. A., Jan 1 2014, In : European Journal of Immunology. 44, 11, p. 3307-3319 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
T-Lymphocytes
Therapeutic Uses
Granulocyte Colony-Stimulating Factor
Myeloid Cells
2013
26 Citations (Scopus)

A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis

Daftarian, P. M., Stone, G., Kovalski, L., Kumar, M., Vosoughi, A., Urbieta, M., Blackwelder, P., Dikici, E., Serafini, P., Duffort, S., Boodoo, R., Rodríguez-Cortés, A., Lemmon, V., Deo, S. K., Alberola, J., Perez Quinones, V. L., Daunert, S. & Ager, A. L., Dec 1 2013, In : Journal of Infectious Diseases. 208, 11, p. 1914-1922 9 p.

Research output: Contribution to journalArticle

Cutaneous Leishmaniasis
Dendrimers
Adaptive Immunity
Parasites
Antigen-Presenting Cells
11 Citations (Scopus)

FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma

Weed, D., Walker, G., De La Fuente, A. C., Nazarian, R., Vella, J. L., Gomez-Fernandez, C. & Serafini, P., Aug 20 2013, In : PLoS One. 8, 8, e71908.

Research output: Contribution to journalArticle

squamous cell carcinoma
Tumors
Squamous Cell Carcinoma
mouth
T-cells
65 Citations (Scopus)

Myeloid derived suppressor cells in physiological and pathological conditions: The good, the bad, and the ugly

Serafini, P., Dec 1 2013, In : Immunologic Research. 57, 1-3, p. 172-184 13 p.

Research output: Contribution to journalArticle

Tumor Escape
Population
Neoplasms
Clinical Trials
Myeloid-Derived Suppressor Cells
22 Citations (Scopus)

The immune system and head and neck squamous cell carcinoma: From carcinogenesis to new therapeutic opportunities

Freiser, M. E., Serafini, P. & Weed, D., Dec 1 2013, In : Immunologic Research. 57, 1-3, p. 52-69 18 p.

Research output: Contribution to journalArticle

Immune System
Carcinogenesis
Neoplasms
Immunologic Factors
Therapeutics
2012
102 Citations (Scopus)

Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression

Roth, F., De La Fuente, A. C., Vella, J. L., Zoso, A., Inverardi, L. A. & Serafini, P., Mar 15 2012, In : Cancer Research. 72, 6, p. 1373-1383 11 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Macrophages
Cell Survival
Interleukin-4 Receptors
2011
44 Citations (Scopus)

In vivo induction of myeloid suppressor cells and CD4 +foxp3 + T regulatory cells prolongs skin allograft survival in mice

Adeegbe, D., Serafini, P., Bronte, V., Zoso, A., Ricordi, C. & Inverardi, L. A., Aug 22 2011, In : Cell Transplantation. 20, 6, p. 941-954 14 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Myeloid Cells
Allografts
Skin
Grafts
56 Citations (Scopus)

Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells

Daftarian, P., Kaifer, A., Li, W., Blomberg, B. B., Frasca, D., Roth, F., Chowdhury, R., Berg, E. A., Fishman, J. B., Al Sayegh, H. A., Blackwelder, P., Inverardi, L. A., Perez Quinones, V. L., Lemmon, V. & Serafini, P., Dec 15 2011, In : Cancer Research. 71, 24, p. 7452-7462 11 p.

Research output: Contribution to journalArticle

DNA Vaccines
Antigen-Presenting Cells
Dendrimers
Peptides
DNA
2010
24 Citations (Scopus)

Editorial: PGE2-producing MDSC: A role in tumor progression?

Serafini, P., Nov 1 2010, In : Journal of Leukocyte Biology. 88, 5, p. 827-829 3 p.

Research output: Contribution to journalArticle

CD4-Positive T-Lymphocytes
Myeloid Leukemia
Antigen-Presenting Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Dinoprostone
2008
432 Citations (Scopus)

Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells

Serafini, P., Mgebroff, S., Noonan, K. & Borrello, I., Jul 1 2008, In : Cancer Research. 68, 13, p. 5439-5449 11 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Regulatory T-Lymphocytes
Antigens
Neoplasms
Type 5 Cyclic Nucleotide Phosphodiesterases
455 Citations (Scopus)

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

Marigo, I., Dolcetti, L., Serafini, P., Zanovello, P. & Bronte, V., Apr 1 2008, In : Immunological Reviews. 222, 1, p. 162-179 18 p.

Research output: Contribution to journalArticle

Immune Tolerance
Neoplasms
Myeloid-Derived Suppressor Cells
Immunotherapy
Dendritic Cells
2006
574 Citations (Scopus)

Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression

Serafini, P., Borrello, I. & Bronte, V., Feb 1 2006, In : Seminars in Cancer Biology. 16, 1, p. 53-65 13 p.

Research output: Contribution to journalArticle

Myeloid Cells
Phenotype
Neoplasms
Hematopoiesis
T-Lymphocytes
461 Citations (Scopus)

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., Dolcetti, L., Bronte, V. & Borrello, I., Nov 1 2006, In : Journal of Experimental Medicine. 203, 12, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Immunity
Phosphodiesterase 5 Inhibitors
Neoplasms
T-Lymphocytes
597 Citations (Scopus)

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

Gallina, G., Dolcetti, L., Serafini, P., De Santo, C., Marigo, I., Colombo, M. P., Basso, G., Brombacher, F., Borrello, I., Zanovello, P., Bicciato, S. & Bronte, V., Oct 2 2006, In : Journal of Clinical Investigation. 116, 10, p. 2777-2790 14 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Monocytes
T-Lymphocytes
Neoplasms
Interleukin-4 Receptors
2005
89 Citations (Scopus)

Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors

Noonan, K., Matsui, W., Serafini, P., Carbley, R., Tan, G., Khalili, J., Bonyhadi, M., Levitsky, H., Whartenby, K. & Borrello, I., Mar 1 2005, In : Cancer Research. 65, 5, p. 2026-2034 9 p.

Research output: Contribution to journalArticle

Plasma Cells
Bone Marrow
Lymphocytes
Adoptive Immunotherapy
Neoplasms

Educated T-cells mount stronger anti-tumor response in myeloma

Matsui, W., Serafini, P., Carbley, R., Tan, G., Levitsky, H., Whartenby, K., Khalili, J. & Bonyhadi, M., Apr 1 2005, In : Cancer Biology and Therapy. 4, 4

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
213 Citations (Scopus)

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

De Santo, C., Serafini, P., Marigo, I., Dolcetti, L., Bolla, M., Del Soldato, P., Melani, C., Guiducci, C., Colombo, M. P., Iezzi, M., Musiani, P., Zanovello, P. & Bronte, V., Mar 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 11, p. 4185-4190 6 p.

Research output: Contribution to journalArticle

Vaccination
Aspirin
Neoplasms
Nitric Oxide
Myeloid Cells
2004
278 Citations (Scopus)

Derangement of immune responses by myeloid suppressor cells

Serafini, P., De Santo, C., Marigo, I., Cingarlini, S., Dolcetti, L., Gallina, G., Zanovello, P. & Bronte, V., Feb 1 2004, In : Cancer Immunology, Immunotherapy. 53, 2, p. 64-72 9 p.

Research output: Contribution to journalArticle

Myeloid Cells
Neoplasms
T-Lymphocytes
Hematopoiesis
Phenotype
371 Citations (Scopus)

High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells

Serafini, P., Carbley, R., Noonan, K. A., Tan, G., Bronte, V. & Borrello, I., Sep 1 2004, In : Cancer Research. 64, 17, p. 6337-6343 7 p.

Research output: Contribution to journalArticle

Myeloid Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Vaccines
Cancer Vaccines
Nitric Oxide Synthase Type II
19 Citations (Scopus)

Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor α usage by melanoma-specific CD8+ T lymphocytes

De Palma, R., Marigo, I., Del Galdo, F., De Santo, C., Serafini, P., Cingarlini, S., Tüting, T., Lenz, J., Basso, G., Milan, G., Zanovello, P. & Bronte, V., Nov 1 2004, In : Cancer Research. 64, 21, p. 8068-8076 9 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Synthetic Vaccines
T-Cell Antigen Receptor
Melanoma
T-Lymphocytes
2003
19 Citations (Scopus)

Effective Genetic Vaccination with a Widely Shared Endogenous Retroviral Tumor Antigen Requires CD40 Stimulation during Tumor Rejection Phase

Bronte, V., Cingarlini, S., Apolloni, E., Serafini, P., Marigo, I., De Santo, C., Macino, B., Marin, O. & Zanovello, P., Dec 15 2003, In : Journal of Immunology. 171, 12, p. 6396-6405 10 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Vaccination
T-Lymphocytes
Endogenous Retroviruses
Neoplasms
327 Citations (Scopus)

IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice

Bronte, V., Serafini, P., De Santo, C., Marigo, I., Tosello, V., Mazzoni, A., Segal, D. M., Staib, C., Lowel, M., Sutter, G., Colombo, M. P. & Zanovello, P., Jan 1 2003, In : Journal of Immunology. 170, 1, p. 270-278 9 p.

Research output: Contribution to journalArticle

Arginase
Myeloid Cells
Interleukin-4
T-Lymphocytes
Neoplasms
351 Citations (Scopus)

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M. & Zanovello, P., Jun 1 2003, In : Trends in Immunology. 24, 6, p. 301-305 5 p.

Research output: Contribution to journalArticle

Myeloid Cells
Arginine
T-Lymphocytes
Arginase
Enzymes

L-arginine metabolism in myeloid cells controls T-lymphocyte functions.

Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M. & Zanovello, P., Jun 1 2003, In : Trends in Immunology. 24, 6, p. 302-306 5 p.

Research output: Contribution to journalArticle

Myeloid Cells
Arginine
T-Lymphocytes
Arginase
Enzymes
2002
424 Citations (Scopus)

Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism

Mazzoni, A., Bronte, V., Visintin, A., Spitzer, J. H., Apolloni, E., Serafini, P., Zanovello, P. & Segal, D. M., Jan 15 2002, In : Journal of Immunology. 168, 2, p. 689-695 7 p.

Research output: Contribution to journalArticle

Myeloid Cells
T-Lymphocytes
Cell Line
Interleukin-2
Janus Kinase 3
2001
188 Citations (Scopus)

Tumor-induced immune dysfunctions caused by myeloid suppressor cells

Bronte, V., Serafini, P., Apolloni, E. & Zanovello, P., Dec 12 2001, In : Journal of Immunotherapy. 24, 6, p. 431-446 16 p.

Research output: Contribution to journalArticle

Myeloid Cells
Neoplasms
Immune System
Antigens
Immunotherapy

Vaccini antitumorali a DNA

Translated title of the contribution: Antitumors DNA vaccinesMilan, G., Apolloni, E., Bronte, V., Dalla Santa, S., Macino, B., Mandruzzato, S., Rosato, A., Quintieri, L., Serafini, P., Zoso, A. & Zanovello, P., Dec 1 2001, In : EOS Rivista di Immunologia ed Immunofarmacologia. 21, 3-4, p. 86-93 8 p.

Research output: Contribution to journalArticle

DNA Vaccines
Neoplasms
Plasmids
Immunodominant Epitopes
Differentiation Antigens
2000
409 Citations (Scopus)

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+ T cells

Bronte, V., Apolloni, E., Cabrelle, A., Ronca, R., Serafini, P., Zamboni, P., Restifo, N. P. & Zanovello, P., Dec 1 2000, In : Blood. 96, 12, p. 3838-3846 9 p.

Research output: Contribution to journalArticle

T-cells
Macrophages
T-Lymphocytes
Granulocyte-Macrophage Colony-Stimulating Factor
Cytokines
121 Citations (Scopus)

Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes

Apolloni, E., Bronte, V., Mazzoni, A., Serafini, P., Cabrelle, A., Segal, D. M., Young, H. A. & Zanovello, P., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 6723-6730 8 p.

Research output: Contribution to journalArticle

Myeloid Cells
Apoptosis
T-Lymphocytes
Antigens
Cell Line