Noriyuki Kasahara

Pending Rank at Professor

  • 4055 Citations
1977 …2022
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

Filter
Article
2019
2 Citations (Scopus)

A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

Rodriguez-Blanco, J., Li, B., Long, J., Shen, C., Yang, F., Orton, D., Collins, S., Kasahara, N., Ayad, N., McCrea, H. J., Roussel, M. F., Weiss, W. A., Capobianco, A. J. & Robbins, D. J., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

Casein Kinases
Medulloblastoma
Hedgehogs
Brain
Pharmaceutical Preparations
2018
5 Citations (Scopus)

A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models

Yagiz, K., Rodriguez-Aguirre, M. E., Lopez Espinoza, F., Montellano, T. T., Mendoza, D., Mitchell, L. A., Ibanez, C. E., Kasahara, N., Gruber, H. E., Jolly, D. J. & Robbins, J. M., Mar 30 2018, In : Molecular Therapy - Oncolytics. 8, p. 14-26 13 p.

Research output: Contribution to journalArticle

Cytosine Deaminase
Flucytosine
Colorectal Neoplasms
Neoplasms
Survival
2 Citations (Scopus)

Dual-vector prodrug activator gene therapy using retroviral replicating vectors

Kubo, S., Takagi-Kimura, M., Tagawa, M. & Kasahara, N., Jan 1 2018, (Accepted/In press) In : Cancer Gene Therapy.

Research output: Contribution to journalArticle

Prodrugs
Genetic Therapy
Cytosine Deaminase
Genes
Thymidine Kinase
22 Citations (Scopus)

Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

Cloughesy, T. F., Landolfi, J., Vogelbaum, M. A., Ostertag, D., Elder, J. B., Bloomfield, S., Carter, B., Chen, C. C., Kalkanis, S. N., Kesari, S., Lai, A., Lee, I. Y., Liau, L. M., Mikkelsen, T., Nghiemphu, P., Piccioni, D., Accomando, W., Diago, O. R., Hogan, D. J., Gammon, D. & 6 others, Kasahara, N., Kheoh, T., Jolly, D. J., Gruber, H. E., Das, A. & Walbert, T., Jan 1 2018, In : Neuro-Oncology. 20, 10, p. 1383-1392 10 p.

Research output: Contribution to journalArticle

Open Access
Glioma
Isocitrate Dehydrogenase
Cytosine Deaminase
Flucytosine
Recurrence
2 Citations (Scopus)

Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors

Kubo, S., Takagi-Kimura, M. & Kasahara, N., Jan 1 2018, (Accepted/In press) In : Cancer Gene Therapy.

Research output: Contribution to journalArticle

Gibbon ape leukemia virus
Murine Leukemia Viruses
Osteosarcoma
Prodrugs
Neoplasms

Pathogens and glioma: A history of unexpected discoveries ushering in novel therapy

Shah, A. H., Jusué-Torres, I., Ivan, M. E., Komotar, R. J. & Kasahara, N., Apr 1 2018, In : Journal of Neurosurgery. 128, 4, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Glioma
Neoplasms
Enterobacter
Clostridium
Glioblastoma
2 Citations (Scopus)

Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer

Inoko, K., Hiraoka, K., Inagaki, A., Takahashi, M., Kushibiki, T., Hontani, K., Takano, H., Sato, S., Takeuchi, S., Nakamura, T., Tsuchikawa, T., Shichinohe, T., Gruber, H. E., Jolly, D. J., Kasahara, N. & Hirano, S., May 8 2018, (Accepted/In press) In : Cancer Gene Therapy. p. 1-12 12 p.

Research output: Contribution to journalArticle

Prodrugs
Pancreatic Neoplasms
Genetic Therapy
Flucytosine
Adenocarcinoma
2017
8 Citations (Scopus)

Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme

Qin, Y., Takahashi, M., Sheets, K., Soto, H., Tsui, J., Pelargos, P., Antonios, J. P., Kasahara, N., Yang, I., Prins, R. M., Braun, J., Gordon, L. K. & Wadehra, M., Jun 9 2017, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Membrane Proteins
Vascular Endothelial Growth Factor A
Immunoglobulin G
Neoplasms
10 Citations (Scopus)

Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?

Cicciarelli, J. C., Lemp, N. A., Chang, Y., Koss, M., Hacke, K., Kasahara, N., Burns, K. M., Min, D. I., Naraghi, R. & Shah, T., 2017, In : Journal of Immunology Research. 2017, 1652931.

Research output: Contribution to journalArticle

Immunoglobulin G
Tissue Donors
Transplants
Kidney
Antibodies
14 Citations (Scopus)

Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity

Hiraoka, K., Inagaki, A., Kato, Y., Huang, T. T., Mitchell, L. A., Kamijima, S., Takahashi, M., Matsumoto, H., Hacke, K., Kruse, C. A., Ostertag, D., Robbins, J. M., Gruber, H. E., Jolly, D. J. & Kasahara, N., Jul 1 2017, In : Neuro-Oncology. 19, 7, p. 918-929 12 p.

Research output: Contribution to journalArticle

Genetic Therapy
Prodrugs
Immunity
Recurrence
Neoplasms
24 Citations (Scopus)

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model

Mitchell, L. A., Lopez Espinoza, F., Mendoza, D., Kato, Y., Inagaki, A., Hiraoka, K., Kasahara, N., Gruber, H. E., Jolly, D. J. & Robbins, J. M., Jul 1 2017, In : Neuro-Oncology. 19, 7, p. 930-939 10 p.

Research output: Contribution to journalArticle

Flucytosine
Prodrugs
Glioma
Immunity
T-Lymphocytes
2016
3 Citations (Scopus)

Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene

Lin, A. H., Liu, Y., Burrascano, C., Cunanan, K., Logg, C. R., Robbins, J. M., Kasahara, N., Gruber, H., Ibañez, C. & Jolly, D. J., Apr 1 2016, In : Human gene therapy methods. 27, 2, p. 59-70 12 p.

Research output: Contribution to journalArticle

Encephalomyocarditis virus
Transgenes
Gammaretrovirus
Infection
Cytosine Deaminase
5 Citations (Scopus)

Factors in the selection of surface disinfectants for use in a laboratory animal setting

Campagna, M. V., Faure-Kumar, E., Treger, J. A., Cushman, J. D., Grogan, T. R., Kasahara, N. & Lawson, G. W., Mar 1 2016, In : Journal of the American Association for Laboratory Animal Science. 55, 2, p. 175-188 14 p.

Research output: Contribution to journalArticle

disinfectants
laboratory animals
hypochlorites
peroxides
viruses
59 Citations (Scopus)

Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma

Cloughesy, T. F., Landolfi, J., Hogan, D. J., Bloomfield, S., Carter, B., Chen, C. C., Elder, J. B., Kalkanis, S. N., Kesari, S., Lai, A., Lee, I. Y., Liau, L. M., Mikkelsen, T., Nghiemphu, P. L., Piccioni, D., Walbert, T., Chu, A., Das, A., Diago, O. R., Gammon, D. & 10 others, Gruber, H. E., Hanna, M., Jolly, D. J., Kasahara, N., McCarthy, D., Mitchell, L., Ostertag, D., Robbins, J. M., Rodriguez-Aguirre, M. & Vogelbaum, M. A., Jun 1 2016, In : Science Translational Medicine. 8, 341, 341ra75.

Research output: Contribution to journalArticle

Flucytosine
Glioma
Cytosine Deaminase
Safety Management
Antimetabolites
16 Citations (Scopus)

Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells

Kozlowska, A. K., Tseng, H. C., Kaur, K., Topchyan, P., Inagaki, A., Bui, V. T., Kasahara, N., Cacalano, N. & Jewett, A., Sep 1 2016, In : Cancer Immunology, Immunotherapy. 65, 9, p. 1085-1097 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Interleukin-8
Natural Killer Cells
Interferons
Interleukin-6
2015
3 Citations (Scopus)

Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model

Kubo, S., Takagi-Kimura, M. & Kasahara, N., Aug 1 2015, In : Oncology Reports. 34, 2, p. 633-638 6 p.

Research output: Contribution to journalArticle

Angiostatins
Genetic Therapy
Endostatins
Lentivirus
Endothelial Cells
10 Citations (Scopus)

Differential targeting of stem cells and differentiated glioblastomas by NK cells

Tseng, H. C., Inagaki, A., Bui, V. T., Cacalano, N., Kasahara, N., Man, Y. G. & Jewett, A., 2015, In : Journal of Cancer. 6, 9, p. 866-876 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Glioblastoma
Natural Killer Cells
Stem Cells
Brain Neoplasms
1 Citation (Scopus)

Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene

Iwabuchi, M., Narita, M., Uchiyama, T., Iwaya, S., Oiwa, E., Nishizawa, Y., Hashimoto, S., Bonehill, A., Kasahara, N., Takizawa, J. & Takahashi, M., Aug 1 2015, In : Molecular Medicine Reports. 12, 2, p. 2443-2450 8 p.

Research output: Contribution to journalArticle

T-cells
Cytotoxic T-Lymphocytes
Dendritic Cells
Genes
Antigens
28 Citations (Scopus)

Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model

Huang, T. T., Parab, S., Burnett, R., Diago, O., Ostertag, D., Hofman, F. M., Espinoza, F. L., Martin, B., Ibañez, C. E., Kasahara, N., Gruber, H. E., Pertschuk, D., Jolly, D. J. & Robbins, J. M., Feb 1 2015, In : Human Gene Therapy. 26, 2, p. 82-93 12 p.

Research output: Contribution to journalArticle

Flucytosine
Glioma
Intravenous Administration
Cytosine Deaminase
Neoplasms
3 Citations (Scopus)

Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives

Awe, J. P., Gschweng, E. H., Vega-Crespo, C., Voutila, J., Williamson, M. H., Truong, B., Kohn, D. B., Kasahara, N. & Byrne, J. A., Jan 1 2015, In : Stem cells translational medicine. 4, 2, p. 136-145 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Antigen-Presenting Cells
Coculture Techniques
Genes

Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes

Erickson, K. L., Hickey, M. J., Kato, Y., Malone, C. C., Owens, G. C., Prins, R. M., Liau, L. M., Kasahara, N. & Kruse, C. A., Feb 11 2015, In : Journal of visualized experiments : JoVE. 96

Research output: Contribution to journalArticle

T-cells
Tumors
Assays
Extracellular Matrix Proteins
Cells
16 Citations (Scopus)

Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance

Yang, O. O., Ali, A., Kasahara, N., Faure-Kumar, E., Bae, J. Y., Picker, L. J. & Park, H., 2015, In : Journal of Virology. 89, 2, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

conserved sequences
Conserved Sequence
Human immunodeficiency virus 1
HIV-1
Vaccines
2014
17 Citations (Scopus)

Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma

Qin, Y., Fu, M., Takahashi, M., Iwanami, A., Kuga, D., Rao, R. G., Sudhakar, D., Huang, T., Kiyohara, M., Torres, K., Dillard, C., Inagaki, A., Kasahara, N., Goodglick, L., Braun, J., Mischel, P. S., Gordon, L. K. & Wadehra, M., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 13974-13985 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Membrane Proteins
Tumors
Proteins
src-Family Kinases
6 Citations (Scopus)

Exploiting human CD34+ stem cell-conditioned medium for tissue repair

Mintz, P. J., Huang, K. W., Reebye, V., Nteliopoulos, G., Lai, H. S., Sætrom, P., Kasahara, N., Jensen, S., Pai, M., Gordon, M. Y. A., Marley, S. B., Behan, R., Spalding, D. R., Haoudi, A., Emara, M. M., Nicholls, J., Rossi, J. J. & Habib, N. A., Jan 2014, In : Molecular Therapy. 22, 1, p. 149-159 11 p.

Research output: Contribution to journalArticle

Conditioned Culture Medium
Stem Cells
Liver
Stem Cell Factor
Essential Genes

Maintaining therapeutic activity in the operating room: Compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids

Burnett, R., Ibañez, C. E., Pettersson, P. L., Chen, C. I., Parab, S., Huang, T., Robbins, J., Bankiewicz, K., Aghi, M., Logg, C., Kasahara, N., Pertschuk, D., Gruber, H. E. & Jolly, D. J., Jan 8 2014, In : Molecular Therapy - Methods and Clinical Development. 1, 14024.

Research output: Contribution to journalArticle

Hemostatics
Operating Rooms
Contrast Media
Cerebrospinal Fluid
Cytosine Deaminase
4 Citations (Scopus)

MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response

Lin, A. H., Timberlake, N., Logg, C. R., Liu, Y., Kamijima, S., Diago, O., Wong, K., Gammon, D. K., Ostertag, D., Hacke, K., Yang, E. C., Gruber, H., Kasahara, N. & Jolly, D. J., Aug 1 2014, In : Human Gene Therapy. 25, 8, p. 759-771 13 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
MicroRNAs
Antiviral Agents
Spleen
Bone Marrow
8 Citations (Scopus)

Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis

Matsumoto, H., Haga, K., Ohno, I., Hiraoka, K., Kimura, T., Hermann, K., Kasahara, N., Anton, P. & McGowan, I., Apr 8 2014, In : BMC Gastroenterology. 14, 1, 68.

Research output: Contribution to journalArticle

Lentivirus
Dextran Sulfate
Colitis
Genetic Therapy
Interleukin-10
60 Citations (Scopus)

Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo

Reebye, V., Sætrom, P., Mintz, P. J., Huang, K. W., Swiderski, P., Peng, L., Liu, C., Liu, X., Lindkær-Jensen, S., Zacharoulis, D., Kostomitsopoulos, N., Kasahara, N., Nicholls, J. P., Jiao, L. R., Pai, M., Spalding, D. R., Mizandari, M., Chikovani, T., Emara, M. M., Haoudi, A. & 3 others, Tomalia, D. A., Rossi, J. J. & Habib, N. A., Jan 1 2014, In : Hepatology. 59, 1, p. 216-227 12 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Oligonucleotides
Carcinogenesis
RNA
Liver
16 Citations (Scopus)

P16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells

Veena, M. S., Wilken, R., Zheng, J. Y., Gholkar, A., Venkatesan, N., Vira, D., Ahmed, S., Basak, S. K., Dalgard, C. L., Ravichandran, S., Batra, R. K., Kasahara, N., Elashoff, D., Fishbein, M. C., Whitelegge, J. P., Torres, J. Z., Wang, M. B. & Srivatsan, E. S., Dec 12 2014, In : Journal of Biological Chemistry. 289, 50, p. 34921-34937 17 p.

Research output: Contribution to journalArticle

Cell Aging
Ubiquitination
Papillomaviridae
Cisplatin
Tumors
11 Citations (Scopus)

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector

Takahashi, M., Valdes, G., Hiraoka, K., Inagaki, A., Kamijima, S., Micewicz, E., Gruber, H. E., Robbins, J. M., Jolly, D. J., McBride, W. H., Iwamoto, K. S. & Kasahara, N., Oct 25 2014, In : Cancer Gene Therapy. 21, 10, p. 405-410 6 p.

Research output: Contribution to journalArticle

Prodrugs
Flucytosine
Glioma
Fluorouracil
Genetic Therapy
2013
8 Citations (Scopus)

A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34+ cells

Reebye, V., Sætrom, P., Mintz, P. J., Rossi, J. J., Kasahara, N., Nteliopoulos, G., Nicholls, J., Haoudi, A., Gordon, M. & Habib, N. A., 2013, In : Molecular Therapy - Nucleic Acids. 2, e97.

Research output: Contribution to journalArticle

Islets of Langerhans
Oligonucleotides
RNA
Insulin
Sulfonylurea Receptors
4 Citations (Scopus)

Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain

Hickey, M. J., Malone, C. C., Erickson, K. L., Lin, A., Soto, H., Ha, E. T., Kamijima, S., Inagaki, A., Takahashi, M., Kato, Y., Kasahara, N., Mueller, B. M. & Kruse, C. A., Aug 1 2013, In : Clinical Cancer Research. 19, 15, p. 4137-4148 12 p.

Research output: Contribution to journalArticle

Prodrugs
Genetic Therapy
Breast Neoplasms
Cytosine Deaminase
Brain
1 Citation (Scopus)

Combining cellular and gene therapy approaches for treatment of intracranial tumors

Hickey, M. J., Kasahara, N., Mueller, B. M. & Kruse, C. A., 2013, In : OncoImmunology. 2, 10, e25989.

Research output: Contribution to journalArticle

Prodrugs
Genetic Therapy
Cytotoxic T-Lymphocytes
Heterografts
Neoplasms
4 Citations (Scopus)

Contextual effect of repression of bone morphogenetic protein activity in prostate cancer

Pham, L. K., Liang, M., Adisetiyo, H. A., Liao, C. P., Cohen, M. B., Tahara, S. M., Frenkel, B., Kasahara, N. & Roy-Burman, P., Dec 2013, In : Endocrine-Related Cancer. 20, 6, p. 861-874 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Prostatic Neoplasms
Neoplasms
Growth
Transplants
17 Citations (Scopus)

Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model

Yin, D., Zhai, Y., Gruber, H. E., Ibanez, C. E., Robbins, J. M., Kells, A. P., Kasahara, N., Forsayeth, J., Jolly, D. J. & Bankiewicz, K. S., Jun 2013, In : Cancer Gene Therapy. 20, 6, p. 336-341 6 p.

Research output: Contribution to journalArticle

Cytosine Deaminase
Convection
Brain Neoplasms
Flucytosine
Rodentia
18 Citations (Scopus)

Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma

Takagi-Kimura, M., Yamano, T., Tamamoto, A., Okamura, N., Okamura, H., Hashimoto-Tamaoki, T., Tagawa, M., Kasahara, N. & Kubo, S., Nov 2013, In : Cancer Science. 104, 11, p. 1433-1439 7 p.

Research output: Contribution to journalArticle

Human Adenoviruses
Adenoviridae
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Virus Receptors
Enterovirus

Erratum: Design and selection of toca 511 for clinical use: Modified retroviral replicating vector with improved stability and gene expression (Molecular Therapy (2012) 20 (1689-1698) DOI:10.1038/mt.2012.83)

Perez, O. D., Logg, C. R., Hiraoka, K., Diago, O., Burnett, R., Inagaki, A., Jolson, D., Amundson, K., Buckley, T., Lohse, D., Lin, A., Burrascano, C., Ibanez, C., Kasahara, N., Gruber, H. E. & Jolly, D. J., Feb 2013, In : Molecular Therapy. 21, 2, p. 494 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Thioguanine
Hypoxanthine Phosphoribosyltransferase
Small Interfering RNA
Bone Marrow
Hematopoietic Stem Cells
7 Citations (Scopus)

Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus

Kubo, S., Takagi-Kimura, M., Logg, C. R. & Kasahara, N., Dec 2013, In : Cancer Gene Therapy. 20, 12, p. 671-677 7 p.

Research output: Contribution to journalArticle

Gibbon ape leukemia virus
Murine Leukemia Viruses
Mesothelioma
Prodrugs
Neoplasms
9 Citations (Scopus)

Immunoglobulin G subclass analysis of HLA donor specific antibodies in heart and renal transplant recipients.

Cicciarelli, J. C., Kasahara, N., Lemp, N. A., Adamson, R., Dembitsky, W., Browne, B. & Steinberg, S., 2013, In : Clinical transplants. p. 413-422 10 p.

Research output: Contribution to journalArticle

HLA Antigens
Immunoglobulin G
Kidney
Antibodies
Fc Receptors
12 Citations (Scopus)

Innovative evolution of cancer gene and cellular therapies

Lam, P., Khan, G., Stripecke, R., Hui, K. M., Kasahara, N., Peng, K. W. & Guinn, B. A., Mar 2013, In : Cancer Gene Therapy. 20, 3, p. 141-149 9 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Genetic Therapy
Biotechnology
Clinical Trials
Pharmaceutical Preparations

Reduction of HLA class I expression by ribonucleic acid interference mitigates allogenicity of human primary and Immortalized cells.

Lemp, N. A., Haga, K., Hacke, K., Treger, J. A., Bogan, B. T., Faure-Kumar, E., Logg, C. R., Kruse, C. A., Cicciarelli, J. C. & Kasahara, N., 2013, In : Clinical transplants. p. 93-101 9 p.

Research output: Contribution to journalArticle

HLA Antigens
RNA
Hematopoietic Stem Cells
Alleles
Lymphokine-Activated Killer Cells
32 Citations (Scopus)

Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model

Huang, T. T., Hlavaty, J., Ostertag, D., Espinoza, F. L., Martin, B., Petznek, H., Rodriguez-Aguirre, M., Ibañez, C. E., Kasahara, N., Gunzburg, W., Gruber, H. E., Pertschuk, D., Jolly, D. J. & Robbins, J. M., Oct 2013, In : Cancer Gene Therapy. 20, 10, p. 544-551 8 p.

Research output: Contribution to journalArticle

temozolomide
Flucytosine
Glioblastoma
Glioma
Genes
2012
73 Citations (Scopus)

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector

Ostertag, D., Amundson, K. K., Espinoza, F. L., Martin, B., Buckley, T., Da Silva, A. P. G., Lin, A. H., Valenta, D. T., Perez, O. D., Ibañez, C. E., Chen, C. I., Pettersson, P. L., Burnett, R., Daublebsky, V., Hlavaty, J., Gunzburg, W., Kasahara, N., Gruber, H. E., Jolly, D. J. & Robbins, J. M., Feb 2012, In : Neuro-Oncology. 14, 2, p. 145-159 15 p.

Research output: Contribution to journalArticle

Flucytosine
Brain Neoplasms
Fluorouracil
Prodrugs
Survival
9 Citations (Scopus)

Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow

Hacke, K., Szakmary, A., Cuddihy, A. R., Rozengurt, N., Lemp, N. A., Aubrecht, J., Lawson, G. W., Rao, N. P., Crooks, G. M., Schiestl, R. H. & Kasahara, N., Jan 2012, In : Experimental Hematology. 40, 1

Research output: Contribution to journalArticle

Thioguanine
Hypoxanthine Phosphoribosyltransferase
Hematopoiesis
Bone Marrow
Transplantation Conditioning
16 Citations (Scopus)

Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function

Lemp, N. A., Hiraoka, K., Kasahara, N. & Logg, C. R., Aug 2012, In : Nucleic Acids Research. 40, 15, p. 7280-7290 11 p.

Research output: Contribution to journalArticle

Genetic Complementation Test
RNA Splice Sites
Replication Origin
Plasmids
RNA
63 Citations (Scopus)

Design and selection of toca 511 for clinical use: Modified retroviral replicating vector with improved stability and gene expression

Perez, O. D., Logg, C. R., Hiraoka, K., Diago, O., Burnett, R., Inagaki, A., Jolson, D., Amundson, K., Buckley, T., Lohse, D., Lin, A., Burrascano, C., Ibanez, C., Kasahara, N., Gruber, H. E. & Jolly, D. J., Sep 2012, In : Molecular Therapy. 20, 9, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

Cytosine Deaminase
Flucytosine
Gene Expression
Heterografts
Oncolytic Viruses
4 Citations (Scopus)

Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene

Yamahira, A., Narita, M., Ishii, K., Jayathilake, R. M. C., Iwabuchi, M., Satoh, N., Uchiyama, T., Taniguchi, T., Hashimoto, S., Kasahara, N., Faure, E., Bogan, B., Takizawa, J., Sone, H. & Takahashi, M., Dec 2012, In : Leukemia Research. 36, 12, p. 1541-1546 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Antigens
Cell Line
Genes
Adoptive Immunotherapy
20 Citations (Scopus)

Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells

Voutila, J., Sætrom, P., Mintz, P., Sun, G., Alluin, J., Rossi, J. J., Habib, N. A. & Kasahara, N., 2012, In : Molecular Therapy - Nucleic Acids. 1, e35.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Transcriptome
RNA
Transgenes
Gene Expression
80 Citations (Scopus)

High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting

Cronin, M., Akin, A. R., Collins, S. A., Meganck, J., Kim, J. B., Baban, C. K., Joyce, S. A., van Dam, G. M., Zhang, N., van Sinderen, D., O'Sullivan, G. C., Kasahara, N., Gahan, C. G., Francis, K. P. & Tangney, M., Jan 25 2012, In : PLoS One. 7, 1, e30940.

Research output: Contribution to journalArticle

Tumors
image analysis
Bacteria
Imaging techniques
neoplasms