Nevis L. Fregien

Associate Professor

  • 2340 Citations
1983 …2019
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Research Output 1983 2019

  • 2340 Citations
  • 54 Article
  • 2 Letter
2019

Electronic cigarettes enhance replication of mycobacterium abscessus in airway epithelial cells

Korukonda, A., Zhang, C., Rodriguez, L., Guerrero, A., Campos, M. A., Holt, G., Fregien, N. L., Conner, G. E. & Mirsaeidi, M., Jun 1 2019, In : American journal of respiratory cell and molecular biology. 60, 6, p. 717-719 3 p.

Research output: Contribution to journalLetter

Mycobacterium
Tobacco Products
Epithelial Cells
Electronic Cigarettes
2017
4 Citations (Scopus)

Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways

Schmid, A., Sailland, J., Novak, L., Baumlin, N., Fregien, N. L. & Salathe, M. A., Nov 1 2017, In : FEBS Letters. 591, 21, p. 3493-3506 14 p.

Research output: Contribution to journalLetter

Catenins
Epithelial Cells
Modulation
Cell Count
Glycogen Synthase Kinase 3
2016
6 Citations (Scopus)
smoke
Epidermal Growth Factor Receptor
Smoke
Protein-Tyrosine Kinases
tyrosine
4 Citations (Scopus)
Janus Kinases
Interleukin-13
Transcription
Transducers
Cell Differentiation
6 Citations (Scopus)

Optimal lentivirus production and cell culture conditions necessary to successfully transduce primary human bronchial epithelial cells

Baumlin-Schmid, N., Salathe, M. A. & Fregien, N. L., Jul 22 2016, In : Journal of Visualized Experiments. 2016, 113, e54176.

Research output: Contribution to journalArticle

Lentivirus
Cell culture
Cell Culture Techniques
Epithelial Cells
Transgenes
2014
14 Citations (Scopus)

A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice

Chen, X., Baumlin, N., Buck, J., Levin, L. R., Fregien, N. L. & Salathe, M. A., Jan 1 2014, In : American Journal of Respiratory Cell and Molecular Biology. 51, 6, p. 750-760 11 p.

Research output: Contribution to journalArticle

Axoneme
Adenylyl Cyclases
Knockout Mice
Cilia
Epithelial Cells
19 Citations (Scopus)

Submersion and hypoxia inhibit ciliated cell differentiation in a Notch-dependent manner

Gerovac, B. J., Valencia, M., Baumlin, N., Salathe, M. A., Conner, G. E. & Fregien, N. L., Jan 1 2014, In : American Journal of Respiratory Cell and Molecular Biology. 51, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

Immersion
Cell Differentiation
Cells
Amyloid Precursor Protein Secretases
Gene expression
2011
15 Citations (Scopus)

Rapid nongenomic actions of inhaled corticosteroids on long-acting β 2-agonist transport in the airway

Horvath, G., Mendes, E., Schmid, N., Schmid, A., Conner, G. E., Fregien, N. L., Salathe, M. A. & Wanner, A., Dec 1 2011, In : Pulmonary Pharmacology and Therapeutics. 24, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

Adrenal Cortex Hormones
Smooth Muscle Myocytes
Muscle
Cells
Bronchodilator Agents
2010
33 Citations (Scopus)

Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation

Schmid, A., Sutto, Z., Schmid, N., Novak, L., Ivonnet, P., Horvath, G., Conner, G. E., Fregien, N. L. & Salathe, M. A., Sep 24 2010, In : Journal of Biological Chemistry. 285, 39, p. 29998-30007 10 p.

Research output: Contribution to journalArticle

Bicarbonates
Adenylyl Cyclases
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Acidification
66 Citations (Scopus)

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

Monzon, M. E., Fregien, N. L., Schmid, N., Falcon, N. S., Campos, M. A., Casalino-Matsuda, S. M. & Forteza, R. M., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26126-26134 9 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Hyaluronic Acid
Reactive Oxygen Species
Glycosylphosphatidylinositols
Epithelial Cells
2009
13 Citations (Scopus)

Molecular heterogeneity and alternative splicing of human lactoperoxidase

Fragoso, M. A., Torbati, A., Fregien, N. L. & Conner, G. E., Feb 1 2009, In : Archives of Biochemistry and Biophysics. 482, 1-2, p. 52-57 6 p.

Research output: Contribution to journalArticle

Lactoperoxidase
Alternative Splicing
Exons
Glycosylation
Messenger RNA
58 Citations (Scopus)

Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli

Gattas, M. V., Forteza, R., Fragoso, M. A., Fregien, N. L., Salas, P. J., Salathe, M. A. & Conner, G. E., Nov 15 2009, In : Free Radical Biology and Medicine. 47, 10, p. 1450-1458 9 p.

Research output: Contribution to journalArticle

Lactoperoxidase
Messenger RNA
Flagellin
Pseudomonas aeruginosa
Small Interfering RNA
142 Citations (Scopus)

Pannexin 1 contributes to ATP release in airway epithelia

Ransford, G. A., Fregien, N. L., Qiu, F., Dahl, G., Conner, G. E. & Salathe, M. A., Nov 26 2009, In : American Journal of Respiratory Cell and Molecular Biology. 41, 5, p. 525-534 10 p.

Research output: Contribution to journalArticle

Epithelium
Adenosine Triphosphate
Epithelial Cells
Osmotic Pressure
Liquids
2008
51 Citations (Scopus)

Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells

Wald, F. A., Oriolo, A. S., Mashukova, A., Fregien, N. L., Langshaw, A. & Salas, P. J., Mar 1 2008, In : Journal of Cell Science. 121, 5, p. 644-654 11 p.

Research output: Contribution to journalArticle

Epithelial Cells
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Sf9 Cells
ezrin
29 Citations (Scopus)

Epigenetic regulation of HYAL-1 hyaluronidase expression: Identification of HYAL-1 promoter

Lokeshwar, V. B., Gomez, P., Kramer, M., Knapp, J., McCornack, M. A., Lopez, L. E., Fregien, N. L., Dhir, N., Scherer, S., Klumpp, D. J., Manoharan, M., Soloway, M. S. & Lokeshwar, B. L., Oct 24 2008, In : Journal of Biological Chemistry. 283, 43, p. 29215-29227 13 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Epigenomics
Transcription Initiation Site
Tissue
Methylation
2007
15 Citations (Scopus)

Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia

Nlend, M. C., Schmid, A., Sutto, Z., Ransford, G. A., Conner, G. E., Fregien, N. L. & Salathe, M. A., Jul 10 2007, In : FEBS Letters. 581, 17, p. 3241-3246 6 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Protein Isoforms
Epithelium
Epithelial Cells
Calcium
7 Citations (Scopus)

Control of core 2 β1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells

Falkenberg, V. R. & Fregien, N. L., Dec 1 2007, In : Glycoconjugate Journal. 24, 9, p. 511-519 9 p.

Research output: Contribution to journalArticle

Lymphocytes
Transcription
Epithelial Cells
Mucins
Binding Sites
72 Citations (Scopus)

Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP

Schmid, A., Sutto, Z., Nlend, M. C., Horvath, G., Schmid, N., Buck, J., Levin, L. R., Conner, G. E., Fregien, N. L. & Salathe, M. A., Jul 1 2007, In : Journal of General Physiology. 130, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

Cilia
Adenylyl Cyclases
Fluorescent Antibody Technique
Western Blotting
Axoneme
2006
52 Citations (Scopus)

Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells

Schmid, A., Bai, G., Schmid, N., Zaccolo, M., Ostrowski, L. E., Conner, G. E., Fregien, N. L. & Salathe, M. A., Oct 15 2006, In : Journal of Cell Science. 119, 20, p. 4176-4186 11 p.

Research output: Contribution to journalArticle

Cyclic AMP
Epithelial Cells
Fluorescence Resonance Energy Transfer
Phosphotransferases
Phosphoprotein Phosphatases
2005
26 Citations (Scopus)

Forskolin increases neuregulin receptors in human Schwann cells without increasing receptor mRNA

Fregien, N. L., White, L. A., Bunge, M. B. & Wood, P., Jan 1 2005, In : GLIA. 49, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

Neuregulins
Schwann Cells
Colforsin
Neuregulin-1
Messenger RNA
2003
9 Citations (Scopus)

Influenza a virus infection of human Schwann cells in vitro

Levine, J., Buchman, C. A. & Fregien, N. L., Feb 27 2003, In : Acta Oto-Laryngologica. 123, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

Schwann Cells
Influenza A virus
Virus Diseases
Orthomyxoviridae
Human Influenza
11 Citations (Scopus)

Multiple transcription initiation and alternative splicing in the 5′ untranslated region of the core 2 β1-6 N-acetylglucosaminyltransferase I gene

Falkenberg, V. R., Alvarez, K., Roman, C. & Fregien, N. L., Jun 1 2003, In : Glycobiology. 13, 6, p. 411-418 8 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Alternative Splicing
Transcription
Exons
Genes
2002
5 Citations (Scopus)

Sequences of the mouse N-acetylglucosaminyltransferase V (Mgat5) mRNA and an mRNA expressed by an Mgat5-deficient cell line

Alverez, K., Haswell, C., St. Clair, M., Perng, G. S., Shorebah, M., Pierce, M. & Fregien, N. L., Jul 1 2002, In : Glycobiology. 12, 7, p. 389-394 6 p.

Research output: Contribution to journalArticle

alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
Cells
Cell Line
Messenger RNA
Genes
2000
10 Citations (Scopus)

Influenza A virus infection of human middle ear cells in vitro

Buchman, C. A. & Fregien, N. L., Jan 1 2000, In : Laryngoscope. 110, 10 I, p. 1739-1744 6 p.

Research output: Contribution to journalArticle

Influenza A virus
Middle Ear
Virus Diseases
Reverse Transcriptase Polymerase Chain Reaction
Keratin-18
1999
154 Citations (Scopus)

An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling

Carraway, K. L., Rossi, E. A., Komatsu, M., Price-Schiavi, S. A., Huang, D., Guy, P. M., Carvajal, M. E., Fregien, N. L., Carothers Carraway, C. A. & Carraway, K. L., Feb 26 1999, In : Journal of Biological Chemistry. 274, 9, p. 5263-5266 4 p.

Research output: Contribution to journalArticle

Neuregulins
Receptor Protein-Tyrosine Kinases
Modulators
Rats
Tumors
1998
54 Citations (Scopus)

Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: Implications for uterine receptivity

McNeer, R., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Jul 1 1998, In : Journal of Cellular Physiology. 176, 1, p. 110-119 10 p.

Research output: Contribution to journalArticle

Sialomucins
Steroid hormones
Uterus
Rats
Steroids
49 Citations (Scopus)

Post-transcriptional regulation of a milk membrane protein, the sialomucin complex (ascites sialoglycoprotein (ASGP)-1/ASGP-2, Rat Muc4), by transforming growth factor β

Price-Schiavi, S. A., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 35228-35237 10 p.

Research output: Contribution to journalArticle

Mucin-4
Sialomucins
Milk Proteins
Transforming Growth Factors
Rats
45 Citations (Scopus)

Sialomucin complex in the rat respiratory tract: A model for its role in epithelial protection

McNeer, R., Huang, D., Fregien, N. L. & Carraway, K. L., Mar 1 1998, In : Biochemical Journal. 330, 2, p. 737-744 8 p.

Research output: Contribution to journalArticle

Sialomucins
Respiratory System
Rats
Epithelium
Epithelial Cells
82 Citations (Scopus)

The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide products

Chen, L., Zhang, W., Fregien, N. L. & Pierce, M., Oct 22 1998, In : Oncogene. 17, 16, p. 2087-2093 7 p.

Research output: Contribution to journalArticle

alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
Oligosaccharides
Oncogenes
Glycoproteins
Proto-Oncogene Proteins c-ets
1997

Characterization and steroid hormone control of sialomucin complex in rat uterus: Implications for uterine receptivity

McNeer, R., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333

Research output: Contribution to journalArticle

Sialomucins
Steroid hormones
Rats
61 Citations (Scopus)
alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
N-Acetylglucosaminyltransferases
Glycosyltransferases
Growth Factor Receptors
Cell adhesion

Regulation of sialomucin complex expression in normal rat mammary epithelial cells

Price-Schiavi, S. A., Fregien, N. L., Carraway, C. A. C. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333

Research output: Contribution to journalArticle

Sialomucins
Rats
Epithelial Cells
141 Citations (Scopus)

Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex

Komatsu, M., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 26 1997, In : Journal of Biological Chemistry. 272, 52, p. 33245-33254 10 p.

Research output: Contribution to journalArticle

Sialomucins
Cell Communication
Mucin-4
Mucins
Cell adhesion

Sialomucin complex: A new respiratory mucin with potential growth factor activity is expressed as soluble and transmembrane forms in rat airways

McNeer, R., Huang, D., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333

Research output: Contribution to journalArticle

Sialomucins
Mucins
Intercellular Signaling Peptides and Proteins

Sialomucin complex is secreted by proteolytic cleavage of membrane precursor

Komatsu, M., Rossi, E. A., McNeer, R., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333

Research output: Contribution to journalArticle

Sialomucins
Membranes
108 Citations (Scopus)

Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene

Buckhaults, P., Chen, L., Fregien, N. L. & Pierce, M., Aug 1 1997, In : Journal of Biological Chemistry. 272, 31, p. 19575-19581 7 p.

Research output: Contribution to journalArticle

alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
src Genes
src-Family Kinases
Messenger RNA
Transfection

Transmembrane glycoprotein ASGP

Carraway, K., Carothers, C. C. A. & Fregien, N. L., Jan 1 1997, In : Biotechnology Advances. 15, 3-4

Research output: Contribution to journalArticle

Glycoproteins
DNA
Recombinant DNA
Patents and inventions
Mucin-4
1996
103 Citations (Scopus)

Sialomucin complex, a heterodimeric glycoprotein complex: Expression as a soluble, secretable form in lactating mammary gland and colon

Rossi, E. A., McNeer, R., Price-Schiavi, S. A., Van den Brande, J. M. H., Komatsu, M., Thompson, J. F., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 1 1996, In : Journal of Biological Chemistry. 271, 52, p. 33476-33485 10 p.

Research output: Contribution to journalArticle

Mucin-4
Sialomucins
Human Mammary Glands
Glycoproteins
Colon
1995
36 Citations (Scopus)

GlcNAc-transferase V and core 2 GlcNAc-transferase expression in the developing mouse embryo

Granovsky, M., Fode, C., Warren, C. E., Campbell, R. M., Marth, J. D., Pierce, M., Fregien, N. L. & Dennis, J. W., Dec 1 1995, In : Glycobiology. 5, 8, p. 797-806 10 p.

Research output: Contribution to journalArticle

alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
Embryonic Structures
Uridine Diphosphate
Epithelium
Biosynthesis
30 Citations (Scopus)

Mucin Structure and Function: Insights from Molecular Biology

Carraway, K. L. & Fregien, N. L., Jan 1 1995, In : Trends in Glycoscience and Glycotechnology. 7, 33, p. 31-44 14 p.

Research output: Contribution to journalArticle

Molecular biology
Mucins
Molecular Biology
Tissue
Cysteine
1994
185 Citations (Scopus)

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function

Lokeshwar, V. B., Fregien, N. L. & Bourguignon, L. Y. W., Aug 1 1994, In : Journal of Cell Biology. 126, 4, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

Ankyrins
Hyaluronic Acid
Proteins
COS Cells
Cell Adhesion Molecules
29 Citations (Scopus)

Expression of n-acetylglucosaminyltransferase V mRNA in mammalian tissues and cell lines

Perug, G. S., Shoreibah, M., Margitich, I., Pierce, M. & Fregien, N. L., Dec 1 1994, In : Glycobiology. 4, 6, p. 867-871 5 p.

Research output: Contribution to journalArticle

Messenger RNA
Cells
Tissue
Cell Line
Line
33 Citations (Scopus)

Modification of glycoproteins by N-acetylglucosaminyltransferase V is greatly influenced by accessibility of the enzyme to oligosaccharide acceptors

Do, K. Y., Fregien, N. L., Pierce, M. & Cummings, R. D., Sep 23 1994, In : Journal of Biological Chemistry. 269, 38, p. 23456-23464 9 p.

Research output: Contribution to journalArticle

alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
Oligosaccharides
Glycoproteins
Enzymes
Fetuins
13 Citations (Scopus)

Molecular Cloning and Sequencing of a 58-kDa Membrane- and Microfilament-associated Protein from Ascites Tumor Cell Microvilli with Sequence Similarities to Retroviral Gag Proteins

Juang, S. H., Huang, J., Li, Y., Salas, P. J., Fregien, N. L., Carothers Carraway, C. A. & Carraway, K. L., May 27 1994, In : Journal of Biological Chemistry. 269, 21, p. 15067-15075 9 p.

Research output: Contribution to journalArticle

gag Gene Products
Microfilament Proteins
Cloning
Molecular Cloning
Microvilli
64 Citations (Scopus)
Mucin-4
Cloning
Membrane Glycoproteins
Molecular Cloning
Mucins
19 Citations (Scopus)

Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185neu

Wu, K., Salas, P. J., Yee, L., Fregien, N. L. & Carraway, K. L., Nov 1 1994, In : Oncogene. 9, 11, p. 3139-3147 9 p.

Research output: Contribution to journalArticle

Membrane Glycoproteins
Ascites
Neoplasms
Brain
Sialomucins
1993
57 Citations (Scopus)

Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation

Fernandez-Valle, C., Fregien, N. L., Wood, P. & Bunge, M. B., Nov 1 1993, In : Development. 119, 3, p. 867-880 14 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Schwann Cells
Basement Membrane
Axons
Genes
110 Citations (Scopus)

Isolation, characterization, and expression of a cDNA encoding n-acetylglucosaminyltransferase V

Shoreibah, M., Perng, G. S., Adler, B., Weinstein, J., Basu, R., Cupples, R., Wen, D., Browne, J. K., Buckhaults, P., Fregien, N. L. & Pierce, M., Jul 25 1993, In : Journal of Biological Chemistry. 268, 21, p. 15381-15385 5 p.

Research output: Contribution to journalArticle

alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
Complementary DNA
Rats
Clone Cells
COS Cells
1992
106 Citations (Scopus)

Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex: A new member of the epidermal growth factor superfamily

Sheng, Z., Wu, K., Carraway, K. L. & Fregien, N. L., Aug 15 1992, In : Journal of Biological Chemistry. 267, 23, p. 16341-16346 6 p.

Research output: Contribution to journalArticle

Mucin-4
Sialomucins
Cloning
Molecular Cloning
Epidermal Growth Factor
70 Citations (Scopus)

Tumor sialomucin complexes as tumor antigens and modulators of cellular interactions and proliferation

Carraway, K. L., Fregien, N. L., Carraway, K. L. & Carraway, C. A. C., Jan 1 1992, In : Journal of Cell Science. 103, 2, p. 299-307 9 p.

Research output: Contribution to journalArticle

Experimental Neoplasms
Molecular Sequence Data
Sialomucins
Neoplasm Antigens
Mucins