Nevis L. Fregien

Associate Professor

  • 2402 Citations
1983 …2019

Research output per year

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Research Output

  • 2402 Citations
  • 53 Article
  • 2 Letter
  • 1 Comment/debate
  • 1 Review article
2019

Electronic cigarettes enhance replication of mycobacterium abscessus in airway epithelial cells

Korukonda, A., Zhang, C., Rodriguez, L., Guerrero, A., Campos, M. A., Holt, G., Fregien, N. L., Conner, G. E. & Mirsaeidi, M., Jun 1 2019, In : American journal of respiratory cell and molecular biology. 60, 6, p. 717-719 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

Mycobacterium abscessus—Bronchial Epithelial Cells Cross-Talk Through Type I Interferon Signaling

Zhang, C., Asif, H., Holt, G. E., Griswold, A. J., Campos, M., Bejarano, P. A., Fregien, N. L. & Mirsaeidi, M., Dec 9 2019, In : Frontiers in immunology. 10, 2888.

Research output: Contribution to journalArticle

Open Access
2017

Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways

Schmid, A., Sailland, J., Novak, L., Baumlin, N., Fregien, N. L. & Salathe, M. A., Nov 1 2017, In : FEBS Letters. 591, 21, p. 3493-3506 14 p.

Research output: Contribution to journalLetter

8 Scopus citations
2016
8 Scopus citations
5 Scopus citations

Optimal lentivirus production and cell culture conditions necessary to successfully transduce primary human bronchial epithelial cells

Baumlin-Schmid, N., Salathe, M. A. & Fregien, N. L., Jul 22 2016, In : Journal of Visualized Experiments. 2016, 113, e54176.

Research output: Contribution to journalArticle

8 Scopus citations
2014

A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice

Chen, X., Baumlin, N., Buck, J., Levin, L. R., Fregien, N. & Salathe, M., Dec 1 2014, In : American journal of respiratory cell and molecular biology. 51, 6, p. 750-760 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Submersion and hypoxia inhibit ciliated cell differentiation in a Notch-dependent manner

Gerovac, B. J., Valencia, M., Baumlin, N., Salathe, M., Conner, G. E. & Fregien, N. L., Oct 1 2014, In : American journal of respiratory cell and molecular biology. 51, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

Rapid nongenomic actions of inhaled corticosteroids on long-acting β 2-agonist transport in the airway

Horvath, G., Mendes, E. S., Schmid, N., Schmid, A., Conner, G. E., Fregien, N. L., Salathe, M. & Wanner, A., Dec 1 2011, In : Pulmonary Pharmacology and Therapeutics. 24, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation

Schmid, A., Sutto, Z., Schmid, N., Novak, L., Ivonnet, P., Horvath, G., Conner, G., Fregien, N. & Salathe, M., Sep 24 2010, In : Journal of Biological Chemistry. 285, 39, p. 29998-30007 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

Monzon Medina, M. E., Fregien, N., Schmid, N., Falcon, N. S., Campos, M., Casalino-Matsuda, S. M. & Forteza, R., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26126-26134 9 p.

Research output: Contribution to journalArticle

73 Scopus citations
2009

Molecular heterogeneity and alternative splicing of human lactoperoxidase

Fragoso, M. A., Torbati, A., Fregien, N. & Conner, G. E., Feb 1 2009, In : Archives of Biochemistry and Biophysics. 482, 1-2, p. 52-57 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli

Gattas, M. V., Forteza, R., Fragoso, M. A., Fregien, N., Salas, P., Salathe, M. & Conner, G. E., Nov 15 2009, In : Free Radical Biology and Medicine. 47, 10, p. 1450-1458 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Pannexin 1 contributes to ATP release in airway epithelia

Ransford, G. A., Fregien, N., Qiu, F., Dahl, G., Conner, G. E. & Salathe, M., Nov 26 2009, In : American journal of respiratory cell and molecular biology. 41, 5, p. 525-534 10 p.

Research output: Contribution to journalArticle

148 Scopus citations
2008

Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells

Wald, F. A., Oriolo, A. S., Mashukova, A., Fregien, N. L., Langshaw, A. H. & Salas, P. J. I., Mar 1 2008, In : Journal of Cell Science. 121, 5, p. 644-654 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Epigenetic regulation of HYAL-1 hyaluronidase expression: Identification of HYAL-1 promoter

Lokeshwar, V. B., Gomez, P., Kramer, M., Knapp, J., McCornack, M. A., Lopez, L. E., Fregien, N., Dhir, N., Scherer, S., Klumpp, D. J., Manoharan, M., Soloway, M. S. & Lokeshwar, B. L., Oct 24 2008, In : Journal of Biological Chemistry. 283, 43, p. 29215-29227 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2007

Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia

Nlend, M. C., Schmid, A., Sutto, Z., Ransford, G. A., Conner, G. E., Fregien, N. & Salathe, M., Jul 10 2007, In : FEBS letters. 581, 17, p. 3241-3246 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Control of core 2 β1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells

Falkenberg, V. R. & Fregien, N., Dec 1 2007, In : Glycoconjugate Journal. 24, 9, p. 511-519 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP

Schmid, A., Sutto, Z., Nlend, M. C., Horvath, G., Schmid, N., Buck, J., Levin, L. R., Conner, G. E., Fregien, N. & Salathe, M., Jul 2007, In : Journal of General Physiology. 130, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

75 Scopus citations
2006

Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells

Schmid, A., Bai, G., Schmid, N., Zaccolo, M., Ostrowski, L. E., Conner, G. E., Fregien, N. & Salathe, M., Oct 15 2006, In : Journal of Cell Science. 119, 20, p. 4176-4186 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2005

Forskolin increases neuregulin receptors in human Schwann cells without increasing receptor mRNA

Fregien, N. L., White, L. A., Bunge, M. B. & Wood, P. M., Jan 1 2005, In : Glia. 49, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
2003

Influenza a virus infection of human Schwann cells in vitro

Levine, J., Buchman, C. A. & Fregien, N., Jan 1 2003, In : Acta Oto-Laryngologica. 123, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Multiple transcription initiation and alternative splicing in the 5� untranslated region of the core 2 β1-6 N-acetylglucosaminyltransferase I gene

Falkenberg, V. R., Alvarez, K., Roman, C. & Fregien, N., Jun 1 2003, In : Glycobiology. 13, 6, p. 411-418 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2002

Sequences of the mouse N-acetylglucosaminyltransferase V (Mgat5) mRNA and an mRNA expressed by an Mgat5-deficient cell line

Alverez, K., Haswell, C., St. Clair, M., Perng, G. S., Shorebah, M., Pierce, M. & Fregien, N., Jul 2002, In : Glycobiology. 12, 7, p. 389-394 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2000

Influenza A virus infection of human middle ear cells in vitro

Buchman, C. A. & Fregien, N., Jan 1 2000, In : Laryngoscope. 110, 10, p. 1739-1744 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
1999

An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling

Carraway, K. L., Rossi, E. A., Komatsu, M., Price-Schiavi, S. A., Huang, D., Guy, P. M., Carvajal, M. E., Fregien, N., Carothers Carraway, C. A. & Carraway, K. L., Feb 26 1999, In : Journal of Biological Chemistry. 274, 9, p. 5263-5266 4 p.

Research output: Contribution to journalArticle

155 Scopus citations
1998

Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: Implications for uterine receptivity

McNeer, R. R., Carothers Carraway, C. A., Fregien And, N. L. & Carraway, K. L., Jul 1 1998, In : Journal of Cellular Physiology. 176, 1, p. 110-119 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Post-transcriptional regulation of a milk membrane protein, the sialomucin complex (ascites sialoglycoprotein (ASGP)-1/ASGP-2, Rat Muc4), by transforming growth factor β

Price-Schiavi, S. A., Carothers Carraway, C. A., Fregien, N. & Carraway, K. L., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 35228-35237 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Sialomucin complex in the rat respiratory tract: A model for its role in epithelial protection

McNeer, R. R., Huang, D., Fregien, N. L. & Carraway, K. L., Mar 1 1998, In : Biochemical Journal. 330, 2, p. 737-744 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide products

Chen, L., Zhang, W., Fregien, N. & Pierce, M., Oct 22 1998, In : Oncogene. 17, 16, p. 2087-2093 7 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
1997

Characterization and steroid hormone control of sialomucin complex in rat uterus: Implications for uterine receptivity

McNeer, R. R., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333, 1 p.

Research output: Contribution to journalArticle

61 Scopus citations

Regulation of sialomucin complex expression in normal rat mammary epithelial cells

Price-Schiavi, S. A., Fregien, N. L., Carraway, C. A. C. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333, 1 p.

Research output: Contribution to journalArticle

Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex

Komatsu, M., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 26 1997, In : Journal of Biological Chemistry. 272, 52, p. 33245-33254 10 p.

Research output: Contribution to journalArticle

142 Scopus citations

Sialomucin complex: A new respiratory mucin with potential growth factor activity is expressed as soluble and transmembrane forms in rat airways

McNeer, R. R., Huang, D., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333, 1 p.

Research output: Contribution to journalArticle

Sialomucin complex is secreted by proteolytic cleavage of membrane precursor

Komatsu, M., Rossi, E. A., McNeer, R. R., Carraway, C. A. C., Fregien, N. L. & Carraway, K. L., Dec 1 1997, In : Protein Engineering. 10, 3333, 1 p.

Research output: Contribution to journalArticle

Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene

Buckhaults, P., Chen, L., Fregien, N. & Pierce, M., Aug 1 1997, In : Journal of Biological Chemistry. 272, 31, p. 19575-19581 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

Transmembrane glycoprotein ASGP

Carraway, K., Carothers, C. C. A. & Fregien, N. L., Jan 1 1997, In : Biotechnology Advances. 15, 3-4, 1 p.

Research output: Contribution to journalArticle

1996

Sialomucin complex, a heterodimeric glycoprotein complex: Expression as a soluble, secretable form in lactating mammary gland and colon

Rossi, E. A., McNeer, R. R., Price-Schiavi, S. A., Van den Brande, J. M. H., Komatsu, M., Thompson, J. F., Carothers Carraway, C. A., Fregien, N. L. & Carraway, K. L., Dec 1 1996, In : Journal of Biological Chemistry. 271, 52, p. 33476-33485 10 p.

Research output: Contribution to journalArticle

103 Scopus citations
1995

GlcNAc-transferase V and core 2 GlcNAc-transferase expression in the developing mouse embryo

Granovsky, M., Fode, C., Warren, C. E., Campbell, R. M., Marth, J. D., Pierce, M., Fregien, N. & Dennis, J. W., Dec 1995, In : Glycobiology. 5, 8, p. 797-806 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mucin Structure and Function: Insights from Molecular Biology

Carraway, K. L. & Fregien, N. L., Jan 1 1995, In : Trends in Glycoscience and Glycotechnology. 7, 33, p. 31-44 14 p.

Research output: Contribution to journalArticle

30 Scopus citations
1994

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function

Lokeshwar, V. B., Fregien, N. & Bourguignon, L. Y. W., Aug 1994, In : Journal of Cell Biology. 126, 4, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

189 Scopus citations

Expression of N-acetylglucosaminyltransferase V mRNA in mammalian tissues and cell lines

Perng, G. S., Shoreibah, M., Margitich, I., Pierce, M. & Fregien, N., Dec 1 1994, In : Glycobiology. 4, 6, p. 867-871 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Modification of glycoproteins by N-acetylglucosaminyltransferase V is greatly influenced by accessibility of the enzyme to oligosaccharide acceptors

Do, K. Y., Fregien, N., Pierce, M. & Cummings, R. D., Sep 23 1994, In : Journal of Biological Chemistry. 269, 38, p. 23456-23464 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Molecular cloning and sequencing of a 58-kDa membrane- and microfilament- associated protein from ascites tumor cell microvilli with sequence similarities to retroviral Gag proteins

Juang, S. H., Huang, J., Li, Y., Salas, P. J. I., Fregien, N., Carraway, C. A. C. & Carraway, K. L., Jan 1 1994, In : Journal of Biological Chemistry. 269, 21, p. 15067-15075 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
65 Scopus citations

Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185(neu)

Wu, K., Salas, P. J. I., Yee, L., Fregien, N. & Carraway, K. L., Jan 1 1994, In : Oncogene. 9, 11, p. 3139-3147 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
1993

Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation

Fernandez-Valle, C., Fregien, N., Wood, P. M. & Bunge, M. B., Jan 1 1993, In : Development. 119, 3, p. 867-880 14 p.

Research output: Contribution to journalArticle

58 Scopus citations

Isolation, characterization, and expression of a cDNA encoding N- acetylglucosaminyltransferase V

Shoreibah, M., Perng, G. S., Adler, B., Weinstein, J., Basu, R., Cupples, R., Wen, D., Browne, J. K., Buckhaults, P., Fregien, N. & Pierce, M., Jan 1 1993, In : Journal of Biological Chemistry. 268, 21, p. 15381-15385 5 p.

Research output: Contribution to journalArticle

111 Scopus citations
1992

Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex: A new member of the epidermal growth factor superfamily

Sheng, Z., Wu, K., Carraway, K. K. & Fregien, N., Jan 1 1992, In : Journal of Biological Chemistry. 267, 23, p. 16341-16346 6 p.

Research output: Contribution to journalArticle

106 Scopus citations