Nagi Ayad

Associate Professor

  • 1548 Citations
19952019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1995 2019

2019
1 Citation (Scopus)

A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

Rodriguez-Blanco, J., Li, B., Long, J., Shen, C., Yang, F., Orton, D., Collins, S., Kasahara, N., Ayad, N., McCrea, H. J., Roussel, M. F., Weiss, W. A., Capobianco, A. J. & Robbins, D. J., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

Casein Kinases
Medulloblastoma
Hedgehogs
Brain
Pharmaceutical Preparations
1 Citation (Scopus)

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1114 Paediatrics and Reproductive Medicine

Winterbottom, E. F., Moroishi, Y., Halchenko, Y., Armstrong, D. A., Beach, P. J., Nguyen, Q. P., Capobianco, A. J., Ayad, N., Marsit, C. J., Li, Z., Karagas, M. R. & Robbins, D. J., Feb 28 2019, In : Environmental Health: A Global Access Science Source. 18, 1, 18.

Research output: Contribution to journalArticle

Open Access
Reproductive Medicine
Biological Science Disciplines
Medical Genetics
Arsenic
Epigenomics

Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

Penas, C., Maloof, M. E., Stathias, V., Long, J., Tan, S. K., Mier, J., Fang, Y., Valdes, C., Rodriguez-Blanco, J., Chiang, C. M., Robbins, D. J., Liebl, D. J., Lee, J., Hatten, M. E., Clarke, J. & Ayad, N., Dec 1 2019, In : Nature communications. 10, 1, 3028.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Time series
Cell Cycle
Stem Cells
Cells
2018
6 Citations (Scopus)

Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury

Rudman, M. D., Choi, J. S., Lee, H. E., Tan, S. K., Ayad, N. & Lee, J., Nov 1 2018, In : Experimental Neurology. 309, p. 181-192 12 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Inflammation
Epigenomics
Spinal Cord
Cytokines
4 Citations (Scopus)

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., William Harbour, J., Volmar, C. H., Lyons, N. J., Wahlestedt, C. R., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schuerer, S. C. & Ayad, N., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

Glioblastoma
drugs
signatures
Gene expression
Genes
11 Citations (Scopus)

Drug repositioning in glioblastoma: A pathway perspective

Tan, S. K., Jermakowicz, A., Mookhtiar, A. K., Nemeroff, C., Schuerer, S. C. & Ayad, N., Mar 16 2018, In : Frontiers in Pharmacology. 9, MAR, 218.

Research output: Contribution to journalReview article

Drug Repositioning
Glioblastoma
Cell Death
Therapeutics
Drug Delivery Systems
3 Citations (Scopus)

Immunotherapy and epigenetic pathway modulation in glioblastoma multiforme

Chin, C., Lunking, E. S., De La Fuente, M. I. & Ayad, N., Jan 1 2018, In : Frontiers in Oncology. 8, NOV, 521.

Research output: Contribution to journalReview article

Open Access
Glioblastoma
Epigenomics
Immunotherapy
Neoplasms
Immune System
32 Citations (Scopus)

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

Tan, S. K., Pastori, C., Penas, C., Komotar, R. J., Ivan, M. E., Wahlestedt, C. R. & Ayad, N., Mar 20 2018, In : Molecular Cancer. 17, 1, 74.

Research output: Contribution to journalLetter

Long Noncoding RNA
Glioblastoma
Biomarkers
Serum
Exosomes
3 Citations (Scopus)

Sustainable data and metadata management at the BD2K-LINCS Data coordination and integration center

Stathias, V., Koleti, A., Vidovic, D., Cooper, D. J., Jagodnik, K. M., Terryn, R., Forlin, M., Chung, C., Torre, D., Ayad, N., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schuerer, S. C., Jun 19 2018, In : Scientific data. 5, 180117.

Research output: Contribution to journalArticle

Metadata
Information management
Data Management
Assays
management
2017

A cell based screening approach for identifying protein degradation regulators

Simanski, S., Maloof, M. E., Sato, T. K., Cavett, V., Caldwell Busby, J. & Ayad, N., May 19 2017, In : Cell Cycle. 16, 10, p. 940-946 7 p.

Research output: Contribution to journalArticle

Cyclin B1
Luciferases
Proteolysis
Proteins
Cell Cycle
5 Citations (Scopus)

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. & Schuerer, S. C., Jan 1 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
Screening
Ligands
Proteins
Molecular dynamics
Computer simulation
4 Citations (Scopus)

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

Rodriguez-Blanco, J., Pednekar, L., Penas, C., Li, B., Martin, V., Long, J., Lee, E., Weiss, W. A., Rodriguez, C., Nadji, M., Nguyen, D., Ayad, N., Rai, P., Capobianco, A. J. & Robbins, D. J., Nov 9 2017, In : Oncogene. 36, 45, p. 6306-6314 9 p.

Research output: Contribution to journalArticle

HhAntag691
Medulloblastoma
Neoplasms
Basal Cell Carcinoma
Recurrence
2016

Casein kinase signaling in axon regeneration

Ayad, N., Lee, J. & Lemmon, V., Feb 1 2016, In : Neural Regeneration Research. 11, 2, p. 210-211 2 p.

Research output: Contribution to journalArticle

Casein Kinases
Axons
Regeneration
2015
14 Citations (Scopus)

Casein kinase 1δ is an APC/C<sup>Cdh1</sup> substrate that regulates cerebellar granule cell neurogenesis

Penas, C., Govek, E. E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M. E., Rahaim, R. J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J. L., Long, J., Li, B., Robbins, D. J., Malumbres, M., Roussel, M. F., Roush, W. R., Hatten, M. E. & Ayad, N., 2015, In : Cell Reports. 11, 2, p. 249-260 12 p.

Research output: Contribution to journalArticle

Casein Kinase I
Neurogenesis
Substrates
Stem Cells
Cell Cycle

Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. iii

Research output: Contribution to journalArticle

5 Citations (Scopus)

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

DNA sequences
Cell proliferation
Drug Combinations
Glioblastoma
Epigenomics
2 Citations (Scopus)

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Penas, C., Mishra, J. K., Wood, S. D., Schuerer, S. C., Roush, W. R. & Ayad, N., Feb 1 2015, In : Cell Cycle. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

Cell Cycle
Cell Proliferation
Interphase
S Phase
Mitosis
27 Citations (Scopus)

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Allen, B. K., Mehta, S., Ember, S. W. J., Schonbrunn, E., Ayad, N. & Schuerer, S. C., Nov 24 2015, In : Scientific Reports. 5, 16924.

Research output: Contribution to journalArticle

Phosphotransferases
Neoplasms
Drug Design
Epigenomics
Therapeutics
1 Citation (Scopus)

Screening of cell cycle fusion proteins to identify kinase signaling networks

Trojanowsky, M., Vidovic, D., Simanski, S., Penas, C., Schuerer, S. C. & Ayad, N., Apr 15 2015, In : Cell Cycle. 14, 8, p. 1274-1281 8 p.

Research output: Contribution to journalArticle

Cell Cycle Proteins
Cell Fusion
Phosphotransferases
Luciferases
Ubiquitin

The APC/C and CK1 in the developing brain

Penas, C., Hatten, M. E. & Ayad, N., 2015, In : Oncotarget. 6, 19, p. 16792-16793 2 p.

Research output: Contribution to journalArticle

Casein Kinase Idelta
Anaphase-Promoting Complex-Cyclosome
Organogenesis
Neurogenesis
Signal Transduction
87 Citations (Scopus)

The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Pastori, C., Kapranov, P., Penas, C., Peschansky, V., Volmar, C. H., Sarkaria, J. N., Bregy, A., Komotar, R. J., Laurent, G. S., Ayad, N., Wahlestedt, C. R. & Roberts, T. C., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8326-8331 6 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Antisense RNA
Glioblastoma
Proteins
Epigenomics

The Epigenetics of Medulloblastoma

Penas, C., Stathias, V., Allen, B. K. & Ayad, N., Jul 22 2015, Epigenetic Cancer Therapy. Elsevier Inc., p. 317-337 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Medulloblastoma
Epigenomics
MicroRNAs
Tumors
Enzymes
2014
67 Citations (Scopus)

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. R. & Ayad, N., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Proliferation
temozolomide
Cell Cycle
Protein Domains
14 Citations (Scopus)

Casein kinase 1-dependent wee1 protein degradation

Penas, L., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schuerer, S. C., Hodder, P., Steen, J., Roush, W. R. & Ayad, N., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 18893-18903 11 p.

Research output: Contribution to journalArticle

Casein Kinase I
Protein Kinases
Proteolysis
Cell Cycle
Phosphotransferases
6 Citations (Scopus)

Identifying glioblastoma gene networks based on hypergeometric test analysis

Stathias, V., Pastori, C., Griffin, T. Z., Komotar, R. J., Clarke, J., Zhang, M. & Ayad, N., Dec 31 2014, In : PLoS One. 9, 12, e115842.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Glioblastoma
Genes
neoplasms
Tumors
54 Citations (Scopus)

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers

Long, J., Li, B., Rodriguez-Blanco, J., Pastori, C., Volmar, C. H., Wahlestedt, C. R., Capobianco, A. J., Bai, F., Pei, X-H., Ayad, N. & Robbins, D. J., Dec 19 2014, In : Journal of Biological Chemistry. 289, 51, p. 35494-35502 9 p., A32.

Research output: Contribution to journalArticle

Hedgehog Proteins
Hedgehogs
Medulloblastoma
Growth
Epigenomics
9 Citations (Scopus)

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs

Plotkin, A., Volmar, C. H., Wahlestedt, C. R., Ayad, N. & El-Ashry, D., Sep 1 2014, In : Breast Cancer Research and Treatment. 147, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle

Histones
Breast Neoplasms
Estrogens
Cell Line
Messenger RNA
2013
32 Citations (Scopus)

Epigenetic pathways and glioblastoma treatment

Clarke, J., Penas, C., Pastori, C., Komotar, R. J., Bregy, A., Shah, A. H., Wahlestedt, C. R. & Ayad, N., Aug 7 2013, In : Epigenetics. 8, 8, p. 785-795 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Epigenomics
Therapeutics
Neoplasms
temozolomide
2012
26 Citations (Scopus)

The APC/C ubiquitin ligase: From cell biology to tumorigenesis

Penas, C., Ramachandran, V. & Ayad, N., Dec 1 2012, In : Frontiers in Oncology. 1, JAN, 00060.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Ligases
Ubiquitin
Cell Biology
Carcinogenesis
2010
13 Citations (Scopus)

Activation domain-dependent degradation of somatic wee1 kinase

Owens, L., Simanski, S., Squire, C., Smith, A., Cartzendafner, J., Cavett, V., Busby, J. C., Sato, T. & Ayad, N., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6761-6769 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Chemical activation
Degradation
Cell Cycle
Cells
12 Citations (Scopus)

An ultra-high throughput cell-based screen for wee1 degradation inhibitors

Madoux, F., Simanski, S., Chase, P., Mishra, J. K., Roush, W. R., Ayad, N. & Hodder, P., Sep 1 2010, In : Journal of Biomolecular Screening. 15, 8, p. 907-917 11 p.

Research output: Contribution to journalArticle

Corrosion inhibitors
Luciferases
Assays
Throughput
Ubiquitin
2009
29 Citations (Scopus)

The anaphase promoting complex induces substrate degradation during neuronal differentiation

Harmey, D., Smith, A., Simanski, S., Moussa, C. Z. & Ayad, N., Feb 13 2009, In : Journal of Biological Chemistry. 284, 7, p. 4317-4323 7 p.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
PC12 Cells
Nerve Growth Factor
Degradation
Substrates
2007
27 Citations (Scopus)

Redundant ubiquitin ligase activities regulate wee1 degradation and mitotic entry

Smith, A., Simanski, S., Fallahi, M. & Ayad, N., Nov 15 2007, In : Cell Cycle. 6, 22, p. 2795-2799 5 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Cyclin B
Mitosis
Degradation
2005
10 Citations (Scopus)

CDKs give Cdc6 a license to drive into S phase

Ayad, N., Sep 23 2005, In : Cell. 122, 6, p. 825-827 3 p.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Licensure
DNA Replication
S Phase
Phosphorylation
Anaphase-Promoting Complex-Cyclosome
Chromatids
Vertebrates
15 Citations (Scopus)

Identification of ubiquitin ligase substrates by in vitro expression cloning

Ayad, N., Rankin, S., Ooi, D., Rape, M. & Kirschner, M. W., Dec 19 2005, In : Methods in Enzymology. 399, p. 404-414 11 p., 28.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Cloning
Ligases
Ubiquitin
Organism Cloning
141 Citations (Scopus)

Sororin, a substrate of the anaphase- promoting complex, is required for sister chromatid cohesion in vertebrates

Rankin, S., Ayad, N. & Kirschner, M. W., Apr 15 2005, In : Molecular Cell. 18, 2, p. 185-200 16 p.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Chromatids
Vertebrates
Proteins
Mitosis
2004
332 Citations (Scopus)

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Wei, W., Ayad, N., Wan, Y., Zhang, G. J., Kirschner, M. W. & Kaelin, W. G., Mar 11 2004, In : Nature. 428, 6979, p. 194-198 5 p.

Research output: Contribution to journalArticle

SKP Cullin F-Box Protein Ligases
Anaphase-Promoting Complex-Cyclosome
G1 Phase
Cell Cycle
Ubiquitin
259 Citations (Scopus)

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

Song, M. S., Song, S. J., Ayad, N., Chang, J. S., Lee, J. H., Hong, H. K., Lee, H., Choi, N., Kim, J., Kim, H., Kim, J. W., Choi, E. J., Kirschner, M. W. & Lim, D. S., Feb 1 2004, In : Nature Cell Biology. 6, 2, p. 129-137 9 p.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Mitosis
Cyclins
Centrosome
Neoplasms
2003
113 Citations (Scopus)

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC

Ayad, N., Rankin, S., Murakami, M., Jebanathirajah, J., Gygi, S. & Kirschner, M. W., Apr 4 2003, In : Cell. 113, 1, p. 101-113 13 p.

Research output: Contribution to journalArticle

Cyclin B
Mitosis
Chemical activation
Anaphase-Promoting Complex-Cyclosome
Proteolysis
1997
48 Citations (Scopus)

Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes

Ayad, N., Hull, M. & Mellman, I., Aug 1 1997, In : EMBO Journal. 16, 15, p. 4497-4507 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Endosomes
Membranes
Guanine Nucleotide Dissociation Inhibitors
Cytosol
1995
15 Citations (Scopus)

Isolation of a preadipocyte cell line from rat bone marrow and differentiation to adipocytes

Marko, O., Cascieri, M. A., Ayad, N., Strader, C. D. & Candelore, M. R., Oct 1 1995, In : Endocrinology. 136, 10, p. 4582-4588 7 p.

Research output: Contribution to journalArticle

Adipocytes
Bone Marrow
Cell Line
Adrenergic Agonists
Brown Adipose Tissue
120 Citations (Scopus)

Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones

Moyle, W. R., Campbell, R. K., Rao, S. N. V., Ayad, N., Bernard, M. P., Han, Y. & Wang, Y., Jan 1 1995, In : Journal of Biological Chemistry. 270, 34, p. 20020-20031 12 p.

Research output: Contribution to journalArticle

LH Receptors
Signal transduction
Signal Transduction
Glycoproteins
Hormones