Nagaraj Nagathihalli

Research Assistant Professor

  • 1321 Citations
20012019
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Research Output 2001 2019

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11 Citations (Scopus)

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

Messaggio, F., Mendonsa, A. M., Castellanos, J., Nagathihalli, N., Gorden, L., Merchant, N. & Vansaun, M., Oct 17 2017, In : Oncotarget. 8, 49, p. 85378-85391 14 p.

Research output: Contribution to journalArticle

Adiponectin Receptors
Leptin
Pancreatic Neoplasms
Adiponectin
Growth
12 Citations (Scopus)

Biochemical and physicochemical changes in goat meat during postmortem aging

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., Apr 2006, In : Journal of Muscle Foods. 17, 2, p. 198-213 16 p.

Research output: Contribution to journalArticle

meat aging
goat meat
Goats
longissimus muscle
Meat
46 Citations (Scopus)

Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells

Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Mar 2006, In : Journal of Cancer Research and Clinical Oncology. 132, 3, p. 171-183 13 p.

Research output: Contribution to journalArticle

Cathepsin B
Mouth Neoplasms
Apoptosis
Squamous Cell Carcinoma
Catalytic RNA
27 Citations (Scopus)

Cathepsin B promotes both motility and invasiveness of oral carcinoma cells

Wickramasinghe, N. S., Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Apr 1 2005, In : Archives of Biochemistry and Biophysics. 436, 1, p. 187-195 9 p.

Research output: Contribution to journalArticle

Cathepsin B
Catalytic RNA
Cells
Carcinoma
Squamous Cell Carcinoma
13 Citations (Scopus)

Changes in the calpain-calpastatin and cathepsin (B, B+L, H and D) during postmortem storage of goat muscles

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., 2002, In : Journal of Food Biochemistry. 26, 1, p. 75-89 15 p.

Research output: Contribution to journalArticle

calpastatin
cathepsin B
Cathepsin B
calpain
Calpain
25 Citations (Scopus)

Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells

Nagathihalli, N. & Zacharias, W., Apr 25 2007, In : Toxicology Letters. 170, 2, p. 134-145 12 p.

Research output: Contribution to journalArticle

Cathepsins
Smoke
Tobacco Products
Cathepsin L
Cathepsin B
122 Citations (Scopus)

Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells

Nagathihalli, N., Beckers, S., Mensah, J. K., Waigel, S., Vigneswaran, N. & Zacharias, W., Aug 20 2006, In : Toxicology Letters. 165, 2, p. 182-194 13 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Smoke
Tobacco Products
Cytochrome P-450 Enzyme System
Cells
64 Citations (Scopus)
gemcitabine
src-Family Kinases
Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Growth
41 Citations (Scopus)

Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway

Nagathihalli, N., Anilakumar, K. R. & Singh, O. V., May 2010, In : Journal of Nutritional Biochemistry. 21, 5, p. 405-412 8 p.

Research output: Contribution to journalArticle

Caspases
Cells
Apoptosis
Caspase 3
Neoplasms
27 Citations (Scopus)

Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis.

Vigneswaran, N., Wu, J., Nagathihalli, N., Adler-Storthz, K. & Zacharias, W., Jan 2005, In : International Journal of Oncology. 26, 1, p. 103-112 10 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Apoptosis
Cathepsin B
Cystatins
Cell Line
35 Citations (Scopus)

Effect of coriander seeds on hexachlorocyclohexane induced lipid peroxidation in rat liver

Anilakumar, K. R., Nagathihalli, N. & Santhanam, K., 2001, In : Nutrition Research. 21, 11, p. 1455-1462 8 p.

Research output: Contribution to journalArticle

Coriandrum
Lindane
Lipid Peroxidation
Seeds
Powders
3 Citations (Scopus)
cathepsin B
Cathepsin B
calpain
Calpain
Goats
2 Citations (Scopus)

Effect of temperature on myofibril fragmentation during post-mortem storage of muscle

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., Jan 2001, In : Journal of Food Science and Technology. 38, 1, p. 52-53 2 p.

Research output: Contribution to journalArticle

Myofibrils
myofibrils
Goats
Chickens
Sheep
3 Citations (Scopus)
meat aging
goat meat
calpain
Calpain
Myofibrils
59 Citations (Scopus)

Emerging targets in pancreatic cancer: Epithelial-mesenchymal transition and cancer stem cells

Castellanos, J. A., Merchant, N. & Nagathihalli, N., Sep 12 2013, In : OncoTargets and Therapy. 6, p. 1261-1267 7 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Mesenchymal Stromal Cells
Pancreatic Neoplasms
Neoplasms
23 Citations (Scopus)
Head and Neck Neoplasms
Tumors
Technology
Neoplasms
Cell growth
18 Citations (Scopus)

Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines

Wickramasinghe, N. S., Banerjee, K., Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Jul 2005, In : Anticancer Research. 25, 4, p. 2841-2850 10 p.

Research output: Contribution to journalArticle

Cathepsin B
Cystatin B
Carcinoma
Cystatin C
Cell Line
32 Citations (Scopus)

Hypoxia inhibits TRAIL-induced tumor cell apoptosis: Involvement of lysosomal cathepsins

Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Jan 2007, In : Apoptosis. 12, 1, p. 125-139 15 p.

Research output: Contribution to journalArticle

Cathepsins
Tumors
Cells
Apoptosis
Cathepsin B
18 Citations (Scopus)

Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways

Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Dec 21 2004, In : Molecular Cancer. 3, 38.

Research output: Contribution to journalArticle

Mouth Neoplasms
Cells
Apoptosis
Carcinoma
Chemotherapy

Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue

McPherson, L. A., Troccoli, C. I., Ji, D., Bowles, A. E., Gardiner, M. L., Mohsen, M. G., Nagathihalli, N. S., Nguyen, D. M., Robbins, D. J., Merchant, N. B., Kool, E. T., Rai, P. & Ford, J. M., Jan 1 2019, In : DNA Repair. 102644.

Research output: Contribution to journalArticle

Colonic Neoplasms
Guanine
Adenosine Triphosphate
Tissue
Lung
2 Citations (Scopus)

Integrating genomics and proteomics-oriented biomarkers to comprehend lung cancer

Nagathihalli, N. & Singh, O. V., Mar 2009, In : Expert Opinion on Medical Diagnostics. 3, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle

Biomarkers
Genomics
Proteomics
Lung Neoplasms
Monitoring
7 Citations (Scopus)

Inverse correlation of STAT3 and MEK signaling mediates resistance to Ras pathway inhibition in pancreatic cancer

Nagathihalli, N., Castellanos, J. A., Lamichhane, P., Messaggio, F., Shi, C., Dai, X., Rai, P., Chen, X., Vansaun, M. & Merchant, N., Nov 1 2018, In : Cancer Research. 78, 21, p. 6235-6246 12 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Pancreatic Neoplasms
Adenocarcinoma
Heterografts
Neoplasms
33 Citations (Scopus)
Gastrointestinal Neoplasms
Deoxycholic Acid
Bile Acids and Salts
Colorectal Neoplasms
Ligands
35 Citations (Scopus)

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

Walsh, A. J., Castellanos, J. A., Nagathihalli, N., Merchant, N. & Skala, M. C., Oct 22 2015, (Accepted/In press) In : Pancreas.

Research output: Contribution to journalArticle

Organoids
Optical Imaging
Pancreatic Neoplasms
Pharmaceutical Preparations
Pharmacological Biomarkers
23 Citations (Scopus)

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

Nagathihalli, N., Castellanos, J. A., Van Saun, M. N., Dai, X., Ambrose, M., Guo, Q., Xiong, Y. & Merchant, N., 2016, In : Oncotarget. 7, 40, p. 65982-65992 11 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
STAT3 Transcription Factor
Interleukin-6
Adenocarcinoma
Neoplasms
19 Citations (Scopus)

Postmortem changes in myofibrillar proteins of goat skeletal muscles

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., Apr 2005, In : Journal of Food Biochemistry. 29, 2, p. 152-170 19 p.

Research output: Contribution to journalArticle

Postmortem Changes
postmortem changes
myofibrillar proteins
Goats
Muscle
17 Citations (Scopus)

Protective effects of amla on oxidative stress and toxicity in rats challenged with dimethyl hydrazine

Anilakumar, K. R., Nagathihalli, N. & Santhanam, K., Apr 2004, In : Nutrition Research. 24, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

hydrazine
Phyllanthus emblica
Oxidative Stress
Liver
Malondialdehyde
12 Citations (Scopus)

Proteomics: A strategy to understand the novel targets in protein misfolding and cancer therapy

Nagathihalli, N., Singh, O. V. & Merchant, N., Aug 2010, In : Expert Review of Proteomics. 7, 4, p. 613-623 11 p.

Research output: Contribution to journalArticle

Proteomics
Neoplasms
Proteins
Tumor Suppressor Proteins
Oncogenes
36 Citations (Scopus)

RAD51 as a potential biomarker and therapeutic target for pancreatic cancer

Nagathihalli, N. & Nagaraju, G., Dec 2011, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1816, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Resistance
Biomarkers
Neoplasms
Rad51 Recombinase
23 Citations (Scopus)

Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by emblica officinalis gaertn

Anilakumar, K. R., Nagathihalli, N. & Santhanam, K., May 2007, In : Indian Journal of Experimental Biology. 45, 5, p. 450-454 5 p.

Research output: Contribution to journalArticle

Phyllanthus emblica
Lindane
Oxidative stress
Cytotoxicity
Liver
69 Citations (Scopus)

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagathihalli, N., Castellanos, J. A., Shi, C., Beesetty, Y., Reyzer, M. L., Caprioli, R., Chen, X., Walsh, A. J., Skala, M. C., Moses, H. L. & Merchant, N., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1932-1943 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Tumor Microenvironment
Pancreatic Neoplasms
gemcitabine
Pharmaceutical Preparations
24 Citations (Scopus)

Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion

Vigneswaran, N., Wu, J., Nagathihalli, N., James, R., Zeeuwen, P. & Zacharias, W., Jan 18 2006, In : Life Sciences. 78, 8, p. 898-907 10 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Cystatin M
Cysteine Proteases
Mouth Neoplasms
Cell proliferation
20 Citations (Scopus)

Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer

Samanta, D., Gonzalez, A. L., Nagathihalli, N., Ye, F., Carbone, D. P. & Datta, P. K., Mar 2012, In : Cancer Prevention Research. 5, 3, p. 453-463 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Smoke
Tobacco Products
Lung Neoplasms
Down-Regulation
61 Citations (Scopus)

Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin

Nagathihalli, N., Massion, P. P., Gonzalez, A. L., Lu, P. & Datta, P. K., Nov 2012, In : Molecular Cancer Therapeutics. 11, 11, p. 2362-2372 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Epithelial-Mesenchymal Transition
Cadherins
Non-Small Cell Lung Carcinoma
Down-Regulation

Src kinase inhibition restores E-cadherin expression in Dasatinib-sensitive pancreatic cancer cells

Dosch, A. R., Dai, X., Gaidarski, A. A., Shi, C., Castellanos, J. A., Vansaun, M., Merchant, N. & Nagathihalli, N., Feb 1 2019, In : Oncotarget. 10, 10, p. 1056-1069 14 p.

Research output: Contribution to journalArticle

src-Family Kinases
Cadherins
Pancreatic Neoplasms
Adenocarcinoma
Gastropoda
56 Citations (Scopus)

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

Nagathihalli, N. & Merchant, N., Jun 1 2012, In : Frontiers in Bioscience. 17, 6, p. 2059-2069 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Cadherins
Pancreatic Neoplasms
Tumors
Signal transduction
76 Citations (Scopus)

Targeted inhibition of Src kinase signaling attenuates pancreatic tumorigenesis

Nagathihalli, N., Smith, J. J., Revetta, F., Washington, M. K. & Merchant, N., Aug 2010, In : Molecular Cancer Therapeutics. 9, 8, p. 2322-2332 11 p.

Research output: Contribution to journalArticle

src-Family Kinases
Carcinogenesis
Pancreatic Neoplasms
STAT3 Transcription Factor
Adenocarcinoma
171 Citations (Scopus)

Targeting the transforming growth factor-β signaling pathway in human cancer

Nagathihalli, N. & Datta, P. K., Jan 2010, In : Expert Opinion on Investigational Drugs. 19, 1, p. 77-91 15 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Neoplasms
Critical Pathways
Carcinogens
Therapeutics
5 Citations (Scopus)

Tobacco carcinogen–induced production of GM-CSF activates CREB to promote pancreatic cancer

Srinivasan, S., Totiger, T., Shi, C., Castellanos, J., Lamichhane, P., Dosch, A. R., Messaggio, F., Kashikar, N., Honnenahally, K., Ban, Y., Merchant, N., Vansaun, M. & Nagathihalli, N., Nov 1 2018, In : Cancer Research. 78, 21, p. 6146-6158 13 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Granulocyte-Macrophage Colony-Stimulating Factor
Pancreatic Neoplasms
Tobacco
Adenocarcinoma
34 Citations (Scopus)
Environmental Biodegradation
Bioremediation
Proteomics
Microarrays
Proteins
Translational Medical Research
Pancreatic Neoplasms
7 Citations (Scopus)

Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Totiger, T. M., Srinivasan, S., Jala, V. R., Lamichhane, P., Dosch, A. R., Gaidarski, A. A., Joshi, C., Rangappa, S., Castellanos, J., Vemula, P. K., Chen, X., Kwon, D., Kashikar, N., Vansaun, M., Merchant, N. & Nagathihalli, N., Feb 1 2019, In : Molecular cancer therapeutics. 18, 2, p. 301-311 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Phosphatidylinositol 3-Kinases
Adenocarcinoma
70-kDa Ribosomal Protein S6 Kinases
gemcitabine
10 Citations (Scopus)

Using genomics to develop novel antibacterial therapeutics

Nagathihalli, N. & Singh, O. V., Nov 2010, In : Critical Reviews in Microbiology. 36, 4, p. 340-348 9 p.

Research output: Contribution to journalArticle

Bacterial Genomes
Genomics
Microbial Genome
Bacterial DNA
Anti-Infective Agents