Nagaraj Nagathihalli

Research Assistant Professor

  • 1325 Citations
20012019

Research output per year

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Research Output

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Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

Messaggio, F., Mendonsa, A. M., Castellanos, J., Nagathihalli, N., Gorden, L., Merchant, N. & Vansaun, M., Oct 17 2017, In : Oncotarget. 8, 49, p. 85378-85391 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Biochemical and physicochemical changes in goat meat during postmortem aging

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., Apr 2006, In : Journal of Muscle Foods. 17, 2, p. 198-213 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells

Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Mar 2006, In : Journal of Cancer Research and Clinical Oncology. 132, 3, p. 171-183 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Cathepsin B promotes both motility and invasiveness of oral carcinoma cells

Wickramasinghe, N. S., Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Apr 1 2005, In : Archives of Biochemistry and Biophysics. 436, 1, p. 187-195 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Changes in the calpain-calpastatin and cathepsin (B, B+L, H and D) during postmortem storage of goat muscles

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., 2002, In : Journal of Food Biochemistry. 26, 1, p. 75-89 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells

Nagathihalli, N. & Zacharias, W., Apr 25 2007, In : Toxicology Letters. 170, 2, p. 134-145 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells

Nagathihalli, N., Beckers, S., Mensah, J. K., Waigel, S., Vigneswaran, N. & Zacharias, W., Aug 20 2006, In : Toxicology Letters. 165, 2, p. 182-194 13 p.

Research output: Contribution to journalArticle

122 Scopus citations
64 Scopus citations

Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway

Nagathihalli, N., Anilakumar, K. R. & Singh, O. V., May 2010, In : Journal of Nutritional Biochemistry. 21, 5, p. 405-412 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis.

Vigneswaran, N., Wu, J., Nagathihalli, N., Adler-Storthz, K. & Zacharias, W., Jan 2005, In : International Journal of Oncology. 26, 1, p. 103-112 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effect of coriander seeds on hexachlorocyclohexane induced lipid peroxidation in rat liver

Anilakumar, K. R., Nagathihalli, N. & Santhanam, K., 2001, In : Nutrition Research. 21, 11, p. 1455-1462 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
3 Scopus citations

Effect of temperature on myofibril fragmentation during post-mortem storage of muscle

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., Jan 2001, In : Journal of Food Science and Technology. 38, 1, p. 52-53 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
3 Scopus citations

Emerging targets in pancreatic cancer: Epithelial-mesenchymal transition and cancer stem cells

Castellanos, J. A., Merchant, N. & Nagathihalli, N., Sep 12 2013, In : OncoTargets and Therapy. 6, p. 1261-1267 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
23 Scopus citations

Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines

Wickramasinghe, N. S., Banerjee, K., Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Jul 2005, In : Anticancer Research. 25, 4, p. 2841-2850 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Hypoxia inhibits TRAIL-induced tumor cell apoptosis: Involvement of lysosomal cathepsins

Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Jan 2007, In : Apoptosis. 12, 1, p. 125-139 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways

Nagathihalli, N., Vigneswaran, N. & Zacharias, W., Dec 21 2004, In : Molecular Cancer. 3, 38.

Research output: Contribution to journalArticle

18 Scopus citations

Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue

McPherson, L. A., Troccoli, C. I., Ji, D., Bowles, A. E., Gardiner, M. L., Mohsen, M. G., Nagathihalli, N. S., Nguyen, D. M., Robbins, D. J., Merchant, N. B., Kool, E. T., Rai, P. & Ford, J. M., Jan 1 2019, In : DNA Repair. 102644.

Research output: Contribution to journalArticle

Integrating genomics and proteomics-oriented biomarkers to comprehend lung cancer

Nagathihalli, N. & Singh, O. V., Mar 2009, In : Expert Opinion on Medical Diagnostics. 3, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inverse correlation of STAT3 and MEK signaling mediates resistance to Ras pathway inhibition in pancreatic cancer

Nagathihalli, N., Castellanos, J. A., Lamichhane, P., Messaggio, F., Shi, C., Dai, X., Rai, P., Chen, X., Vansaun, M. & Merchant, N., Nov 1 2018, In : Cancer Research. 78, 21, p. 6235-6246 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
34 Scopus citations

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

Walsh, A. J., Castellanos, J. A., Nagathihalli, N., Merchant, N. & Skala, M. C., Oct 22 2015, (Accepted/In press) In : Pancreas.

Research output: Contribution to journalArticle

35 Scopus citations

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

Nagathihalli, N., Castellanos, J. A., Van Saun, M. N., Dai, X., Ambrose, M., Guo, Q., Xiong, Y. & Merchant, N., 2016, In : Oncotarget. 7, 40, p. 65982-65992 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Postmortem changes in myofibrillar proteins of goat skeletal muscles

Nagathihalli, N., Anilakumar, K. R. & Santhanam, K., Apr 2005, In : Journal of Food Biochemistry. 29, 2, p. 152-170 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Protective effects of amla on oxidative stress and toxicity in rats challenged with dimethyl hydrazine

Anilakumar, K. R., Nagathihalli, N. & Santhanam, K., Apr 2004, In : Nutrition Research. 24, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Proteomics: A strategy to understand the novel targets in protein misfolding and cancer therapy

Nagathihalli, N., Singh, O. V. & Merchant, N., Aug 2010, In : Expert Review of Proteomics. 7, 4, p. 613-623 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

RAD51 as a potential biomarker and therapeutic target for pancreatic cancer

Nagathihalli, N. & Nagaraju, G., Dec 2011, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1816, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by emblica officinalis gaertn

Anilakumar, K. R., Nagathihalli, N. & Santhanam, K., May 2007, In : Indian Journal of Experimental Biology. 45, 5, p. 450-454 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagathihalli, N., Castellanos, J. A., Shi, C., Beesetty, Y., Reyzer, M. L., Caprioli, R., Chen, X., Walsh, A. J., Skala, M. C., Moses, H. L. & Merchant, N., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1932-1943 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion

Vigneswaran, N., Wu, J., Nagathihalli, N., James, R., Zeeuwen, P. & Zacharias, W., Jan 18 2006, In : Life Sciences. 78, 8, p. 898-907 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer

Samanta, D., Gonzalez, A. L., Nagathihalli, N., Ye, F., Carbone, D. P. & Datta, P. K., Mar 2012, In : Cancer Prevention Research. 5, 3, p. 453-463 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin

Nagathihalli, N., Massion, P. P., Gonzalez, A. L., Lu, P. & Datta, P. K., Nov 2012, In : Molecular Cancer Therapeutics. 11, 11, p. 2362-2372 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Src kinase inhibition restores E-cadherin expression in Dasatinib-sensitive pancreatic cancer cells

Dosch, A. R., Dai, X., Gaidarski, A. A., Shi, C., Castellanos, J. A., Vansaun, M., Merchant, N. & Nagathihalli, N., Feb 1 2019, In : Oncotarget. 10, 10, p. 1056-1069 14 p.

Research output: Contribution to journalArticle

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

Nagathihalli, N. & Merchant, N., Jun 1 2012, In : Frontiers in Bioscience. 17, 6, p. 2059-2069 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Targeted inhibition of Src kinase signaling attenuates pancreatic tumorigenesis

Nagathihalli, N., Smith, J. J., Revetta, F., Washington, M. K. & Merchant, N., Aug 2010, In : Molecular Cancer Therapeutics. 9, 8, p. 2322-2332 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Targeting the transforming growth factor-β signaling pathway in human cancer

Nagathihalli, N. & Datta, P. K., Jan 2010, In : Expert Opinion on Investigational Drugs. 19, 1, p. 77-91 15 p.

Research output: Contribution to journalArticle

172 Scopus citations

Tobacco carcinogen–induced production of GM-CSF activates CREB to promote pancreatic cancer

Srinivasan, S., Totiger, T., Shi, C., Castellanos, J., Lamichhane, P., Dosch, A. R., Messaggio, F., Kashikar, N., Honnenahally, K., Ban, Y., Merchant, N., Vansaun, M. & Nagathihalli, N., Nov 1 2018, In : Cancer Research. 78, 21, p. 6146-6158 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
35 Scopus citations

Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Totiger, T. M., Srinivasan, S., Jala, V. R., Lamichhane, P., Dosch, A. R., Gaidarski, A. A., Joshi, C., Rangappa, S., Castellanos, J., Vemula, P. K., Chen, X., Kwon, D., Kashikar, N., Vansaun, M., Merchant, N. & Nagathihalli, N., Feb 1 2019, In : Molecular cancer therapeutics. 18, 2, p. 301-311 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Using genomics to develop novel antibacterial therapeutics

Nagathihalli, N. & Singh, O. V., Nov 2010, In : Critical Reviews in Microbiology. 36, 4, p. 340-348 9 p.

Research output: Contribution to journalArticle

10 Scopus citations