Nagaraj Nagathihalli

Research Assistant Professor

  • 1409 Citations
20012020

Research output per year

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Research Output

2001

Effect of coriander seeds on hexachlorocyclohexane induced lipid peroxidation in rat liver

Anilakumar, K. R., Nagaraj, N. S. & Santhanam, K., 2001, In : Nutrition Research. 21, 11, p. 1455-1462 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Effect of temperature on myofibril fragmentation during post-mortem storage of muscle

Nagaraj, N. S., Anilakumar, K. R. & Santhanam, K., Jan 1 2001, In : Journal of Food Science and Technology. 38, 1, p. 52-53 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2002

Changes in the calpain-calpastatin and cathepsin (B, B+L, H and D) during postmortem storage of goat muscles

Nagaraj, N. S., Anilakumar, K. R. & Santhanam, K., Jan 1 2002, In : Journal of Food Biochemistry. 26, 1, p. 75-89 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
2004

Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways

Nagaraj, N. S., Vigneswaran, N. & Zacharias, W., Dec 21 2004, In : Molecular Cancer. 3, 38.

Research output: Contribution to journalArticle

18 Scopus citations

Protective effects of amla on oxidative stress and toxicity in rats challenged with dimethyl hydrazine

Anilakumar, K. R., Nagaraj, N. S. & Santhanam, K., Apr 1 2004, In : Nutrition Research. 24, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2005

Cathepsin B promotes both motility and invasiveness of oral carcinoma cells

Wickramasinghe, N. S., Nagaraj, N. S., Vigneswaran, N. & Zacharias, W., Apr 1 2005, In : Archives of Biochemistry and Biophysics. 436, 1, p. 187-195 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis.

Vigneswaran, N., Wu, J., Nagaraj, N., Adler-Storthz, K. & Zacharias, W., Jan 2005, In : International journal of oncology. 26, 1, p. 103-112 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines

Wickramasinghe, N. S., Banerjee, K., Nagaraj, N. S., Vigneswaran, N. & Zacharias, W., Jul 1 2005, In : Anticancer research. 25, 4, p. 2841-2850 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Postmortem changes in myofibrillar proteins of goat skeletal muscles

Nagaraj, N. S., Anilakumar, K. R. & Santhanam, K., Apr 2005, In : Journal of Food Biochemistry. 29, 2, p. 152-170 19 p.

Research output: Contribution to journalArticle

19 Scopus citations
2006

Biochemical and physicochemical changes in goat meat during postmortem aging

Nagaraj, N. S., Anilakumar, K. R. & Santhanam, K., Apr 1 2006, In : Journal of Muscle Foods. 17, 2, p. 198-213 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells

Nagaraj, N. S., Vigneswaran, N. & Zacharias, W., Mar 1 2006, In : Journal of cancer research and clinical oncology. 132, 3, p. 171-183 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells

Nagaraj, N. S., Beckers, S., Mensah, J. K., Waigel, S., Vigneswaran, N. & Zacharias, W., Aug 20 2006, In : Toxicology Letters. 165, 2, p. 182-194 13 p.

Research output: Contribution to journalArticle

122 Scopus citations
3 Scopus citations

Effects of muscle proteases, endogenous protease inhibitors and myofibril fragmentation on postmortem aging of goat meat

Nagaraj, N. S. & Santhanam, K., Jun 1 2006, In : Journal of Food Biochemistry. 30, 3, p. 269-291 23 p.

Research output: Contribution to journalArticle

4 Scopus citations

Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion

Vigneswaran, N., Wu, J., Nagaraj, N., James, R., Zeeuwen, P. & Zacharias, W., Jan 18 2006, In : Life Sciences. 78, 8, p. 898-907 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
36 Scopus citations
2007

Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells

Nagaraj, N. S. & Zacharias, W., Apr 25 2007, In : Toxicology Letters. 170, 2, p. 134-145 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Hypoxia inhibits TRAIL-induced tumor cell apoptosis: Involvement of lysosomal cathepsins

Nagaraj, N. S., Vigneswaran, N. & Zacharias, W., Jan 1 2007, In : Apoptosis. 12, 1, p. 125-139 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by emblica officinalis gaertn

Anilakumar, K. R., Nagaraj, N. S. & Santhanam, K., May 1 2007, In : Indian Journal of Experimental Biology. 45, 5, p. 450-454 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2009

Evolving 'omics' technologies for diagnostics of head and neck cancer

Nagaraj, N. S., Apr 13 2009, In : Briefings in Functional Genomics and Proteomics. 8, 1, p. 49-59 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Integrating genomics and proteomics-oriented biomarkers to comprehend lung cancer

Nagaraj, N. S. & Singh, O. V., Mar 1 2009, In : Expert Opinion on Medical Diagnostics. 3, 2, p. 167-180 14 p.

Research output: Contribution to journalReview article

2 Scopus citations
2010

Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway

Nagaraj, N. S., Anilakumar, K. R. & Singh, O. V., May 1 2010, In : Journal of Nutritional Biochemistry. 21, 5, p. 405-412 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Proteomics: A strategy to understand the novel targets in protein misfolding and cancer therapy

Nagaraj, N. S., Singh, O. V. & Merchant, N. B., Aug 2010, In : Expert Review of Proteomics. 7, 4, p. 613-623 11 p.

Research output: Contribution to journalReview article

13 Scopus citations

Targeted inhibition of Src kinase signaling attenuates pancreatic tumorigenesis

Nagaraj, N. S., Smith, J. J., Revetta, F., Washington, M. K. & Merchant, N. B., Aug 2010, In : Molecular cancer therapeutics. 9, 8, p. 2322-2332 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Targeting the transforming growth factor-β signaling pathway in human cancer

Nagaraj, N. S. & Datta, P. K., Jan 1 2010, In : Expert opinion on investigational drugs. 19, 1, p. 77-91 15 p.

Research output: Contribution to journalReview article

184 Scopus citations

Using genomics to develop novel antibacterial therapeutics

Nagaraj, N. S. & Singh, O. V., Nov 1 2010, In : Critical Reviews in Microbiology. 36, 4, p. 340-348 9 p.

Research output: Contribution to journalReview article

10 Scopus citations
2011
68 Scopus citations

RAD51 as a potential biomarker and therapeutic target for pancreatic cancer

Nagathihalli, N. S. & Nagaraju, G., Dec 1 2011, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1816, 2, p. 209-218 10 p.

Research output: Contribution to journalReview article

38 Scopus citations

Translational research in gastrointestinal oncology: A focus on signaling pathways in pancreas cancer

Nagathihalli, N., Sep 1 2011, In : Gastrointestinal Cancer Research. 4, 5-6, p. 197-198 2 p.

Research output: Contribution to journalComment/debate

2012

Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer

Samanta, D., Gonzalez, A. L., Nagathihalli, N., Ye, F., Carbone, D. P. & Datta, P. K., Mar 1 2012, In : Cancer Prevention Research. 5, 3, p. 453-463 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin

Nagathihalli, N. S., Massion, P. P., Gonzalez, A. L., Lu, P. & Datta, P. K., Nov 2012, In : Molecular cancer therapeutics. 11, 11, p. 2362-2372 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

Nagathihalli, N. S. & Merchant, N. B., Jun 1 2012, In : Frontiers in Bioscience. 17, 6, p. 2059-2069 11 p.

Research output: Contribution to journalArticle

61 Scopus citations
2013

Emerging targets in pancreatic cancer: Epithelial-mesenchymal transition and cancer stem cells

Castellanos, J. A., Merchant, N. B. & Nagathihalli, N. S., Sep 12 2013, In : OncoTargets and Therapy. 6, p. 1261-1267 7 p.

Research output: Contribution to journalReview article

60 Scopus citations
2014

Altered SignaLing Pathways and Potential Therapeutic Targets in Pancreatic Cancer

Castellanos, J., Nagathihalli, N. & Merchant, N., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 2265-2273 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Scopus citations

Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair

Nagathihalli, N. & Brown, E. T., Mar 1 2014, DNA Repair of Cancer Stem Cells. Springer Netherlands, p. 141-155 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagathihalli, N. S., Castellanos, J. A., Shi, C., Beesetty, Y., Reyzer, M. L., Caprioli, R., Chen, X., Walsh, A. J., Skala, M. C., Moses, H. L. & Merchant, N. B., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1932-1943.e9

Research output: Contribution to journalArticle

76 Scopus citations
2016

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

Walsh, A. J., Castellanos, J. A., Nagathihalli, N. S., Merchant, N. B. & Skala, M. C., Jul 1 2016, In : Pancreas. 45, 6, p. 863-869 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

Nagathihalli, N. S., Castellanos, J. A., Van Saun, M. N., Dai, X., Ambrose, M., Guo, Q., Xiong, Y. & Merchant, N. B., 2016, In : Oncotarget. 7, 40, p. 65982-65992 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2017

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

Messaggio, F., Mendonsa, A. M., Castellanos, J., Nagathihalli, N. S., Gorden, L., Merchant, N. B. & VanSaun, M. N., Oct 17 2017, In : Oncotarget. 8, 49, p. 85378-85391 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
2018

Inverse correlation of STAT3 and MEK signaling mediates resistance to Ras pathway inhibition in pancreatic cancer

Nagathihalli, N. S., Castellanos, J. A., Lamichhane, P., Messaggio, F., Shi, C., Dai, X., Rai, P., Chen, X., VanSaun, M. N. & Merchant, N. B., Nov 1 2018, In : Cancer Research. 78, 21, p. 6235-6246 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tobacco carcinogen–induced production of GM-CSF activates CREB to promote pancreatic cancer

Srinivasan, S., Totiger, T., Shi, C., Castellanos, J., Lamichhane, P., Dosch, A. R., Messaggio, F., Kashikar, N., Honnenahally, K., Ban, Y., Merchant, N. B., VanSaun, M. & Nagathihalli, N. S., Nov 1 2018, In : Cancer Research. 78, 21, p. 6146-6158 13 p.

Research output: Contribution to journalArticle

12 Scopus citations
2019

Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue

McPherson, L. A., Troccoli, C. I., Ji, D., Bowles, A. E., Gardiner, M. L., Mohsen, M. G., Nagathihalli, N. S., Nguyen, D. M., Robbins, D. J., Merchant, N. B., Kool, E. T., Rai, P. & Ford, J. M., Nov 2019, In : DNA Repair. 83, 102644.

Research output: Contribution to journalArticle

2 Scopus citations

New mechanistic insights into modifiable risk factors that promote pancreatic cancer

Srinivasan, S., Dosch, A. R. & Nagathihalli, N. S., Mar 29 2019, In : Oncotarget. 10, 25, p. 2417-2418 2 p.

Research output: Contribution to journalEditorial

Open Access

Src kinase inhibition restores E-cadherin expression in Dasatinib-sensitive pancreatic cancer cells

Dosch, A. R., Dai, X., Gaidarski, A. A., Shi, C., Castellanos, J. A., VanSaun, M. N., Merchant, N. B. & Nagathihalli, N. S., Feb 1 2019, In : Oncotarget. 10, 10, p. 1056-1069 14 p.

Research output: Contribution to journalArticle

Open Access

Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer

Totiger, T. M., Srinivasan, S., Jala, V. R., Lamichhane, P., Dosch, A. R., Gaidarski, A. A., Joshi, C., Rangappa, S., Castellanos, J., Vemula, P. K., Chen, X., Kwon, D., Kashikar, N., VanSaun, M., Merchant, N. B. & Nagathihalli, N. S., Feb 2019, In : Molecular cancer therapeutics. 18, 2, p. 301-311 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2020

Combined Src/EGFR inhibition targets STAT3 signaling and induces stromal remodeling to improve survival in pancreatic cancer

Dosch, A. R., Dai, X., Reyzer, M. L., Mehra, S., Srinivasan, S., Willobee, B. A., Kwon, D., Kashikar, N., Caprioli, R., Merchant, N. B. & Nagathihalli, N. S., Apr 1 2020, In : Molecular Cancer Research. 18, 4, p. 623-631 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations