Nagaraj Nagathihalli

Research Asst. Professor

  • 1113 Citations
20012018
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Projects 2016 2018

Targeting cytokine mediated CREB activation in pancreatic cancer

Nagathihalli, N.

National Institutes of Health

7/5/166/30/18

Project: Research projectExploratory/Developmental Grants

Response Elements
Pancreatic Neoplasms
Cyclic AMP
Cytokines
Adenocarcinoma

Research Output 2001 2017

  • 1113 Citations
  • 38 Article
  • 2 Chapter

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

Messaggio, F., Mendonsa, A. M., Castellanos, J., Nagathihalli, N. S., Gorden, L., Merchant, N. B. & VanSaun, M. N., Oct 17 2017, In : Oncotarget. 8, 49, p. 85378-85391 14 p.

Research output: Contribution to journalArticle

Adiponectin Receptors
Adipokines
Adiponectin
Leptin
Pancreatic Neoplasms
11 Citations

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

Nagathihalli, N. S., Castellanos, J. A., Van Saun, M. N., Dai, X., Ambrose, M., Guo, Q., Xiong, Y. & Merchant, N. B., 2016, In : Oncotarget. 7, 40, p. 65982-65992 11 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
STAT3 Transcription Factor
Interleukin-6
Adenocarcinoma
Neoplasms
17 Citations

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

Walsh, A. J., Castellanos, J. A., Nagathihalli, N. S., Merchant, N. B. & Skala, M. C., Oct 22 2015, (Accepted/In press) In : Pancreas.

Research output: Contribution to journalArticle

Organoids
Optical Imaging
Pancreatic Neoplasms
Pharmaceutical Preparations
Pharmacological Biomarkers
39 Citations

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagathihalli, N. S., Castellanos, J. A., Shi, C., Beesetty, Y., Reyzer, M. L., Caprioli, R., Chen, X., Walsh, A. J., Skala, M. C., Moses, H. L. & Merchant, N. B., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1932-1943 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Tumor Microenvironment
Pancreatic Neoplasms
gemcitabine
Pharmaceutical Preparations

Altered SignaLing Pathways and Potential Therapeutic Targets in Pancreatic Cancer

Castellanos, J., NagathihalLi, N. & Merchant, N., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 2265-2273 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

gemcitabine
Neoplastic Stem Cells
Pancreatic Neoplasms
Transforming Growth Factor beta
Adenocarcinoma