Mingjiang Xu

Associate Professor

  • 4542 Citations
19982023

Research output per year

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Research Output

  • 4542 Citations
  • 101 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Letter
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Article

Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms

Wang, J., Ishii, T., Zhang, W., Sozer, S., Dai, Y., Mascarenhas, J., Najfeld, V., Zhao, Z. J., Hoffman, R., Wisch, N. & Xu, M., Sep 2009, In : Leukemia. 23, 9, p. 1577-1586 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Involvement of various hematopoietic-cell lineages by the JAK2 V617F mutation in polycythemia vera

Ishii, T., Bruno, E., Hoffman, R. & Xu, M., Nov 1 2006, In : Blood. 108, 9, p. 3128-3134 7 p.

Research output: Contribution to journalArticle

102 Scopus citations

Is bone marrow fibrosis the real problem?

Hoffman, R. & Xu, M., May 1 2006, In : Blood. 107, 9, p. 3421-3422 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice

Zhang, P., Xing, C., Rhodes, S. D., He, Y., Deng, K., Li, Z., He, F., Zhu, C., Nguyen, L., Zhou, Y., Chen, S., Mohammad, K. S., Guise, T. A., Abdel-Wahab, O., Xu, M., Wang, Q. F. & Yang, F-C., Jan 26 2016, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

12 Scopus citations

Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates

Zhang, P., Chen, Z., Li, R., Guo, Y., Shi, H., Bai, J., Yang, H., Sheng, M., Li, Z., Li, Z., Li, J., Chen, S., Yuan, W., Cheng, T., Xu, M., Zhou, Y. & Yang, F-C., Dec 1 2018, In : Cell Discovery. 4, 1, 4.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

Wang, J., Li, Z., He, Y., Pan, F., Chen, S., Rhodes, S., Nguyen, L., Yuan, J., Jiang, L., Yang, X., Weeks, O., Liu, Z., Zhou, J., Ni, H., Cai, C. L., Xu, M. & Yang, F-C., Jan 23 2014, In : Blood. 123, 4, p. 541-553 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, LL., Williams, S. L., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F-C., Jun 8 2017, In : Nature Communications. 8, 15456.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI insight. 3, 4

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F. C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular cloning and characterization of SPAP1, an inhibitory receptor

Xu, M., Zhao, R. & Zhao, Z. J., 2001, In : Biochemical and Biophysical Research Communications. 280, 3, p. 768-775 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, Christian, K. M., Shi, P. Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G. L. & Jin, P., Oct 14 2016, In : Nucleic Acids Research. 44, 18, p. 8610-8620 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

Costa, Y., Ding, J., Theunissen, T. W., Faiola, F., Hore, T. A., Shliaha, P. V., Fidalgo, M., Saunders, A., Lawrence, M., Dietmann, S., Das, S., Levasseur, D. N., Li, Z., Xu, M., Reik, W., Silva, J. C. R. & Wang, J., Mar 21 2013, In : Nature. 495, 7441, p. 370-374 5 p.

Research output: Contribution to journalArticle

249 Scopus citations

Nf1 haploinsufficiency alters myeloid lineage commitment and function, leading to deranged skeletal homeostasis

Rhodes, S. D., Yang, H., Dong, R., Menon, K., He, Y., Li, Z., Chen, S., Staser, K. W., Jiang, L., Wu, X., Yang, X., Peng, X., Mohammad, K. S., Guise, T. A., Xu, M. & Yang, F-C., Oct 1 2015, In : Journal of Bone and Mineral Research. 30, 10, p. 1840-1851 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia

Guo, H., Chu, Y., Wang, L., Chen, X., Chen, Y., Cheng, H., Zhang, L., Zhou, Y., Yang, F-C., Cheng, T., Xu, M., Zhang, X., Zhou, J. & Yuan, W., Jul 15 2017, In : International Journal of Cancer. 141, 2, p. 324-335 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia

Hu, T., Li, C., Zhang, Y., Wang, L., Peng, L., Cheng, H., Wang, W., Chu, Y., Xu, M., Cheng, T. & Yuan, W., Apr 17 2015, In : Biochemical and Biophysical Research Communications. 459, 4, p. 692-698 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis

Ciurea, S. O., Merchant, D., Mahmud, N., Ishii, T., Zhao, Y., Hu, W., Bruno, E., Barosi, G., Xu, M. & Hoffman, R., Aug 1 2007, In : Blood. 110, 3, p. 986-993 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders

Ishii, T., Wang, J., Zhang, W., Mascarenhas, J., Hoffman, R., Dai, Y., Wisch, N. & Xu, M., 2009, In : Blood. 113, 23, p. 5942-5950 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells

Xu, M., Sui, X., Zhao, R., Dai, C., Krantz, S. B. & Zhao, Z. J., Dec 15 2003, In : Blood. 102, 13, p. 4354-4360 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Purified hybrid cells from dendritic cell and tumor cell fusions are superior activators of antitumor immunity

Xu, M., Zhao, R., Sui, X., Xu, F. & Zhao, Z. J., 2001, In : Cancer Immunology, Immunotherapy. 50, 9, p. 456-462 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38-cells expressing Flk2/Flt3

Ebihara, Y., Wada, M., Ueda, T., Xu, M., Manabe, A., Tanaka, R., Ito, M., Mugishima, H., Asano, S., Nakahata, T. & Tsuji, K., 2002, In : British Journal of Haematology. 119, 2, p. 525-534 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Recurrence of clonal hematopoiesis after discontinuing pegylated recombinant interferon-α 2a in a patient with polycythemia vera [11]

Ishii, T., Xu, M., Zhao, Y., Hu, W. Y., Ciurea, S., Bruno, E. & Hoffman, R., Feb 2007, In : Leukemia. 21, 2, p. 373-374 2 p.

Research output: Contribution to journalArticle

16 Scopus citations

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Guo, Y., Yang, H., Chen, S., Zhang, P., Li, R., Nimer, S. D., William Harbour, J., Xu, M. & Yang, F-C., Apr 2 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Resident c-kit + cells in the heart are not cardiac stem cells

Sultana, N., Zhang, L., Yan, J., Chen, J., Cai, W., Razzaque, S., Jeong, D., Sheng, W., Bu, L., Xu, M., Huang, G. Y., Hajjar, R. J., Zhou, B., Moon, A. & Cai, C. L., Oct 30 2015, In : Nature Communications. 6, 8701.

Research output: Contribution to journalArticle

142 Scopus citations

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., Grillo, I., Bakogianni, S., Ndiaye-Lobry, D., Martín, M. T., Guillamot, M., Banh, R. S., Xu, M., Figueroa, M., Dickins, R. A., Abdel-Wahab, O. & 4 others, Park, C. Y., Tsirigos, A., Neel, B. G. & Aifantis, I., Sep 7 2017, In : Cell. 170, 6, p. 1079-1095.e20

Research output: Contribution to journalArticle

143 Scopus citations

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9- initiated murine acute myeloid leukemia

Gao, Y., Gao, J., Li, M., Zheng, Y., Wang, Y., Zhang, H., Wang, W., Chu, Y., Wang, X., Xu, M., Cheng, T., Ju, Z. & Yuan, W., 2016, In : Journal of Hematology and Oncology. 9, 1, 36.

Research output: Contribution to journalArticle

8 Scopus citations

Rictor/mammalian target of rapamycin 2 regulates the development of notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3

Hua, C., Guo, H., Bu, J., Zhou, M., Cheng, H., He, F., Wang, J., Wang, X., Zhang, Y., Wang, Q., Zhou, J., Cheng, T., Xu, M. & Yuan, W., Dec 1 2014, In : Experimental Hematology. 42, 12, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells

Guallar, D., Bi, X., Pardavila, J. A., Huang, X., Saenz, C., Shi, X., Zhou, H., Faiola, F., Ding, J., Haruehanroengra, P., Yang, F., Li, D., Sanchez-Priego, C., Saunders, A., Pan, F., Valdes, V. J., Kelley, K., Blanco, M. G., Chen, L., Wang, H. & 5 others, Sheng, J., Xu, M., Fidalgo, M., Shen, X. & Wang, J., Feb 26 2018, (Accepted/In press) In : Nature Genetics. p. 1-9 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Sensitive detection of MPLW515L/K mutations by amplification refractory mutation system (ARMS)-PCR

Zhuge, J., Zhang, W., Xu, M., Hoffman, R. & Zhang, W., Jan 4 2010, In : Clinica Chimica Acta. 411, 1-2, p. 122-123 2 p.

Research output: Contribution to journalArticle

10 Scopus citations

Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells

Wang, X., Zhang, W., Tripodi, J., Lu, M., Xu, M., Najfeld, V., Li, Y. & Hoffman, R., Dec 23 2010, In : Blood. 116, 26, p. 5972-5982 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia

Chu, Y., Chen, Y., Li, M., Shi, D., Wang, B., Lian, Y., Cheng, X., Wang, X., Xu, M., Cheng, T., Shi, J. & Yuan, W., Jul 1 2019, In : Cancer Science. 110, 7, p. 2200-2210 11 p.

Research output: Contribution to journalArticle

Open Access

SPAP2, an Ig family receptor containing both ITIMs and ITAMs

Xu, M., Zhao, R., Cao, H. & Zhao, Z. J., 2002, In : Biochemical and Biophysical Research Communications. 293, 3, p. 1037-1046 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines

Xu, M., Tsuji, K., Ueda, T., Mukouyama, Y. S., Hara, T., Yang, F-C., Ebihara, Y., Matsuoka, S., Manabe, A., Kikuchi, A., Ito, M., Miyajima, A. & Nakahata, T., Sep 15 1998, In : Blood. 92, 6, p. 2032-2040 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation

Ishii, T., Zhao, Y., Shi, J., Sozer, S., Hoffman, R. & Xu, M., Dec 2007, In : Leukemia. 21, 12, p. 2433-2441 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis

Li, X., Yao, B., Chen, L., Kang, Y., Li, Y., Cheng, Y., Li, L., Lin, L., Wang, Z., Wang, M., Pan, F., Dai, Q., Zhang, W., Wu, H., Shu, Q., Qin, Z., He, C., Xu, M. & Jin, P., Jun 29 2017, In : Nature Communications. 8, 15903.

Research output: Contribution to journalArticle

24 Scopus citations

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

Huang, H., Jiang, X., Li, Z., Li, Y., Song, C. X., He, C., Sun, M., Chen, P., Gurbuxani, S., Wang, J., Hong, G. M., Elkahloun, A. G., Arnovitz, S., Wang, J., Szulwach, K., Lin, L., Street, C., Wunderlich, M., Dawlaty, M., Neilly, M. B. & 9 others, Jaenisch, R., Yang, F-C., Mulloy, J. C., Jin, P., Liu, P. P., Rowley, J. D., Xu, M., He, C. & Chen, J., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 11994-11999 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2−/−-Driven Myeloid Malignancy Progression

Li, R., Zhou, Y., Cao, Z., Liu, L., Wang, J., Chen, Z., Xing, W., Chen, S., Bai, J., Yuan, W., Cheng, T., Xu, M., Yang, F-C. & Zhao, Z., Jan 1 2018, In : Stem Cell Reports. 10, 1, p. 166-179 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., Nazha, A., Chen, L., Yao, B., Liu, C., Chen, S., Weeks, O., Ni, H., Phillips, B. L., Huang, S., Wang, J. & 8 others, He, C., Li, G. M., Radivoyevitch, T., Aifantis, I., MacIejewski, J. P., Yang, F-C., Jin, P. & Xu, M., Jan 1 2017, In : Nature Communications. 8, 15102.

Research output: Contribution to journalArticle

31 Scopus citations

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

Chu, Y., Zhao, Z., Sant, D. W., Zhu, G., Greenblatt, S. M., Liu, L., Wang, J., Cao, Z., Tho, J. C., Chen, S., Liu, X., Zhang, P., Maciejewski, J. P., Nimer, S. D., Wang, G., Yuan, W., Yang, F-C. & Xu, M., Jan 1 2018, (Accepted/In press) In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticle

5 Scopus citations

The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis

Xu, M., Bruno, E., Chao, J., Ni, H., Lindgren, V., Nunez, R., Mahmud, N., Finazzi, G., Fruchtman, S. M., Popat, U., Liu, E., Prchal, J. T., Rondelli, D., Barosi, G. & Hoffman, R., Feb 15 2005, In : Blood. 105, 4, p. 1699-1705 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms

Cho, S. Y., Xu, M., Roboz, J., Lu, M., Mascarenhas, J. & Hoffman, R., Apr 15 2010, In : Cancer Research. 70, 8, p. 3402-3410 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia

Rosti, V., Massa, M., Vannucchi, A. M., Bergamaschi, G., Campanelli, R., Pecci, A., Viarengo, G., Meli, V., Marchetti, M., Guglielmelli, P., Bruno, E., Xu, M., Hoffman, R. & Barosi, G., May 2007, In : Blood Cells, Molecules, and Diseases. 38, 3, p. 280-286 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome

Sozer, S., Fiel, M. I., Schiano, T., Xu, M., Mascarenhas, J. & Hoffman, R., 2009, In : Blood. 113, 21, p. 5246-5249 4 p.

Research output: Contribution to journalArticle

89 Scopus citations

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

Shinagawa, T., Dong, H. D., Xu, M., Maekawa, T. & Ishii, S., May 15 2000, In : EMBO Journal. 19, 10, p. 2280-2291 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

The TET2 interactors and their links to hematological malignancies

Pan, F., Weeks, O., Yang, F-C. & Xu, M., Jun 1 2015, In : IUBMB Life. 67, 6, p. 438-445 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transgenic expression of JAK2 V617F causes myeloproliferative disorders in mice

Xing, S., Ho, W. T., Zhao, W., Ma, J., Wang, S., Xu, E., Li, Q., Fu, X., Xu, M. & Zhao, Z. J., May 15 2008, In : Blood. 111, 10, p. 5109-5117 9 p.

Research output: Contribution to journalArticle

141 Scopus citations

Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells

Lu, M., Wang, J., Li, Y., Berenzon, D., Wang, X., Mascarenhas, J., Xu, M. & Hoffman, R., Nov 18 2010, In : Blood. 116, 20, p. 4284-4287 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Tyrosine phosphatases SHP-1 and SHP-2 are associated with distinct tyrosine-phosphorylated proteins

Xu, F., Xu, M., Zhao, R., Guerrah, A., Zeng, F. & Zhao, Z. J., 2002, In : Experimental Cell Research. 272, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Tyrosine phosphorylation of myelin P0 and its implication in signal transduction

Xu, M., Zhao, R., Sui, X., Xu, F. & Zhao, Z. J., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 820-825 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Use of molecular testing to identify a cluster of patients with polycythemia vera in eastern Pennsylvania

Seaman, V., Jumaan, A., Yanni, E., Lewis, B., Neyer, J., Roda, P., Xu, M. & Hoffman, R., Feb 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 2, p. 534-540 7 p.

Research output: Contribution to journalArticle

9 Scopus citations