Mingjiang Xu

Associate Professor

  • 4746 Citations
19982020

Research output per year

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Research Output

  • 4746 Citations
  • 96 Article
  • 5 Letter
  • 4 Review article
  • 3 Comment/debate
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Article
2010

Interferon-α targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway

Lu, M., Zhang, W., Li, Y., Berenzon, D., Wang, X., Wang, J., Mascarenhas, J., Xu, M. & Hoffman, R., Jun 1 2010, In : Experimental Hematology. 38, 6, p. 472-480 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells

Wang, X., Zhang, W., Tripodi, J., Lu, M., Xu, M., Najfeld, V., Li, Y. & Hoffman, R., Dec 23 2010, In : Blood. 116, 26, p. 5972-5982 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms

Cho, S. Y., Xu, M., Roboz, J., Lu, M., Mascarenhas, J. & Hoffman, R., Apr 15 2010, In : Cancer Research. 70, 8, p. 3402-3410 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells

Lu, M., Wang, J., Li, Y., Berenzon, D., Wang, X., Mascarenhas, J., Xu, M. & Hoffman, R., Nov 18 2010, In : Blood. 116, 20, p. 4284-4287 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms*

Wang, X., LeBlanc, A., Gruenstein, S., Xu, M., Mascarenhas, J., Panzera, B., Wisch, N., Parker, C., Goldberg, J. D., Prchal, J., Hoffman, R. & Najfeld, V., Oct 1 2009, In : Experimental Hematology. 37, 10, p. 1194-1200 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Correction of the abnormal trafficking of primary myelofibrosis CD34 + cells by treatment with chromatin-modifying agents

Xiaoli, W., Wei, Z., Takefumi, I., Sozer, S., Jiapeng, W., Mingjiang, X. & Hoffman, R., Oct 1 2009, In : Cancer Research. 69, 19, p. 7612-7618 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human CD34+ cells are capable of generating normal and JAK2V617F positive endothelial like cells in vivo

Sozer, S., Ishii, T., Fiel, M. I., Wang, J., Wang, X., Zhang, W., Godbold, J., Xu, M. & Hoffman, R., Nov 1 2009, In : Blood Cells, Molecules, and Diseases. 43, 3, p. 304-312 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms

Wang, J., Ishii, T., Zhang, W., Sozer, S., Dai, Y., Mascarenhas, J., Najfeld, V., Zhao, Z. J., Hoffman, R., Wisch, N. & Xu, M., Sep 2009, In : Leukemia. 23, 9, p. 1577-1586 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders

Ishii, T., Wang, J., Zhang, W., Mascarenhas, J., Hoffman, R., Dai, Y., Wisch, N. & Xu, M., Nov 17 2009, In : Blood. 113, 23, p. 5942-5950 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome

Sozer, S., Fiel, M. I., Schiano, T., Xu, M., Mascarenhas, J. & Hoffman, R., 2009, In : Blood. 113, 21, p. 5246-5249 4 p.

Research output: Contribution to journalArticle

96 Scopus citations

Use of molecular testing to identify a cluster of patients with polycythemia vera in eastern Pennsylvania

Seaman, V., Jumaan, A., Yanni, E., Lewis, B., Neyer, J., Roda, P., Xu, M. & Hoffman, R., Feb 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 2, p. 534-540 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1low mouse model of the disease

Migliaccio, A. R., Martelli, F., Verrucci, M., Migliaccio, G., Vannucchi, A. M., Ni, H., Xu, M., Jiang, Y., Nakamoto, B., Papayannopoulou, T. & Hoffman, R., Feb 1 2008, In : Experimental Hematology. 36, 2, p. 158-171 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Circulating angiogenic monocyte progenitor cells are reduced in JAK2V617F high allele burden myeloproliferative disorders

Sozer, S., Wang, X., Zhang, W., Fiel, M. I., Ishii, T., Wang, J., Wisch, N., Xu, M. & Hoffman, R., Nov 1 2008, In : Blood Cells, Molecules, and Diseases. 41, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transgenic expression of JAK2 V617F causes myeloproliferative disorders in mice

Xing, S., Ho, W. T., Zhao, W., Ma, J., Wang, S., Xu, E., Li, Q., Fu, X., Xu, M. & Zhao, Z. J., May 15 2008, In : Blood. 111, 10, p. 5109-5117 9 p.

Research output: Contribution to journalArticle

143 Scopus citations
2007

Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice

Ishii, T., Zhao, Y., Sozer, S., Shi, J., Zhang, W., Hoffman, R. & Xu, M., Nov 1 2007, In : Experimental Hematology. 35, 11, p. 1633-1640 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis

Shi, J., Zhao, Y., Ishii, T., Hu, W., Sozer, S., Zhang, W., Bruno, E., Lindgren, V., Xu, M. & Hoffman, R., Jul 1 2007, In : Cancer Research. 67, 13, p. 6417-6424 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth

Li, Z., Xu, M., Xing, S., Ho, W. T., Ishii, T., Li, Q., Fu, X. & Zhao, Z. J., Jan 9 2007, In : Journal of Biological Chemistry. 282, 6, p. 3428-3432 5 p.

Research output: Contribution to journalArticle

91 Scopus citations

Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis

Ciurea, S. O., Merchant, D., Mahmud, N., Ishii, T., Zhao, Y., Hu, W., Bruno, E., Barosi, G., Xu, M. & Hoffman, R., Aug 1 2007, In : Blood. 110, 3, p. 986-993 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation

Ishii, T., Zhao, Y., Shi, J., Sozer, S., Hoffman, R. & Xu, M., Dec 2007, In : Leukemia. 21, 12, p. 2433-2441 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia

Rosti, V., Massa, M., Vannucchi, A. M., Bergamaschi, G., Campanelli, R., Pecci, A., Viarengo, G., Meli, V., Marchetti, M., Guglielmelli, P., Bruno, E., Xu, M., Hoffman, R. & Barosi, G., May 1 2007, In : Blood Cells, Molecules, and Diseases. 38, 3, p. 280-286 7 p.

Research output: Contribution to journalArticle

49 Scopus citations
2006

Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents

Araki, H., Mahmud, N., Milhem, M., Nunez, R., Xu, M., Beam, C. A. & Hoffman, R., Feb 2006, In : Experimental Hematology. 34, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Involvement of various hematopoietic-cell lineages by the JAK2 V617F mutation in polycythemia vera

Ishii, T., Bruno, E., Hoffman, R. & Xu, M., Nov 1 2006, In : Blood. 108, 9, p. 3128-3134 7 p.

Research output: Contribution to journalArticle

103 Scopus citations
2005

Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases

Xu, M., Bruno, E., Chao, J., Huang, S., Finazzi, G., Fruchtman, S. M., Popat, U., Prchal, J. T., Barosi, G. & Hoffman, R., Jun 1 2005, In : Blood. 105, 11, p. 4508-4515 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis

Xu, M., Bruno, E., Chao, J., Ni, H., Lindgren, V., Nunez, R., Mahmud, N., Finazzi, G., Fruchtman, S. M., Popat, U., Liu, E., Prchal, J. T., Rondelli, D., Barosi, G. & Hoffman, R., Feb 15 2005, In : Blood. 105, 4, p. 1699-1705 7 p.

Research output: Contribution to journalArticle

53 Scopus citations
2003

PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells

Xu, M. J., Sui, X., Zhao, R., Dai, C., Krantz, S. B. & Zhao, Z. J., Dec 15 2003, In : Blood. 102, 13, p. 4354-4360 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
2002

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

Liao, H. J., Kume, T., McKay, C., Xu, M. J., Ihle, J. N. & Carpenter, G., Mar 15 2002, In : Journal of Biological Chemistry. 277, 11, p. 9335-9341 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38-cells expressing Flk2/Flt3

Ebihara, Y., Wada, M., Ueda, T., Xu, M. J., Manabe, A., Tanaka, R., Ito, M., Mugishima, H., Asano, S., Nakahata, T. & Tsuji, K., Dec 2 2002, In : British Journal of Haematology. 119, 2, p. 525-534 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

SPAP2, an Ig family receptor containing both ITIMs and ITAMs

Xu, M. J., Zhao, R., Cao, H. & Zhao, Z. J., Jan 1 2002, In : Biochemical and biophysical research communications. 293, 3, p. 1037-1046 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Tyrosine phosphatases SHP-1 and SHP-2 are associated with distinct tyrosine-phosphorylated proteins

Xu, F., Xu, M. J., Zhao, R., Guerrah, A., Zeng, F. & Zhao, Z. J., 2002, In : Experimental Cell Research. 272, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2001

CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages

Matsuoka, S., Ebihara, Y., Xu, M. J., Ishii, T., Sugiyama, D., Yoshino, H., Ueda, T., Manabe, A., Tanaka, R., Ikeda, Y., Nakahata, T. & Tsuji, K., Jan 15 2001, In : Blood. 97, 2, p. 419-425 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac

Xu, M. J., Matsuoka, S., Yang, F. C., Ebihara, Y., Manabe, A., Tanaka, R., Eguchi, M., Asano, S., Nakahata, T. & Tsuji, K., Apr 1 2001, In : Blood. 97, 7, p. 2016-2022 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells

Matsuoka, S., Tsuji, K., Hisakawa, H., Xu, M. J., Ebihara, Y., Ishii, T., Sugiyama, D., Manabe, A., Tanaka, R., Ikeda, Y., Asano, S. & Nakahata, T., Jul 1 2001, In : Blood. 98, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors

Hisakawa, H., Sugiyama, D., Nishijima, I., Xu, M. J., Wu, H., Nakao, K., Watanabe, S., Katsuki, M., Asano, S., Aral, K. I., Nakahata, T. & Tsuji, K., Dec 15 2001, In : Blood. 98, 13, p. 3618-3625 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular cloning and characterization of SPAP1, an inhibitory receptor

Xu, M. J., Zhao, R. & Zhao, Z. J., Jan 26 2001, In : Biochemical and biophysical research communications. 280, 3, p. 768-775 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Purified hybrid cells from dendritic cell and tumor cell fusions are superior activators of antitumor immunity

Xu, M. J., Zhao, R., Sui, X., Xu, F. & Zhao, Z. J., Jan 1 2001, In : Cancer Immunology, Immunotherapy. 50, 9, p. 456-462 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
2000

Analysis of signals and functions of the chimeric human granulocyte- macrophage colony-stimulating factor receptor in BA/F3 cells and transgenic mice

Watanabe, S., Aoki, Y., Nishijima, I., Xu, M. J. & Arai, K. I., Apr 1 2000, In : Journal of Immunology. 164, 7, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34+ cells

Ebihara, Y., Xu, M. J., Manabe, A., Kikuchi, A., Tanaka, R., Kato, S., Nakahata, T. & Tsuji, K., Jan 1 2000, In : British Journal of Haematology. 109, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein

Tanaka, Y., Naruse, I., Hongo, T., Xu, M. J., Nakahata, T., Maekawa, T. & Ishii, S., Jul 1 2000, In : Mechanisms of Development. 95, 1-2, p. 133-145 13 p.

Research output: Contribution to journalArticle

120 Scopus citations
41 Scopus citations

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

Shinagawa, T., Dong, H. D., Xu, M., Maekawa, T. & Ishii, S., May 15 2000, In : EMBO Journal. 19, 10, p. 2280-2291 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

Tyrosine phosphorylation of myelin P0 and its implication in signal transduction

Xu, M. J., Zhao, R., Sui, X., Xu, F. & Zhao, Z. J., Jan 27 2000, In : Biochemical and biophysical research communications. 267, 3, p. 820-825 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
1999

Differential effects of human granulocyte colony-stimulating factor (hG- CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice

Yang, F. C., Tsuji, K., Oda, A., Ebihara, Y., Xu, M. J., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., Watanabe, S., Ikeda, Y. & Nakahata, T., Aug 1 1999, In : Blood. 94, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis

Kinoshita, T., Sekiguchi, T., Xu, M. J., Ito, Y., Kamiya, A., Tsuji, K. I., Nakahata, T. & Miyajima, A., Jun 22 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 13, p. 7265-7270 6 p.

Research output: Contribution to journalArticle

145 Scopus citations
1998

Human granulocyte colony-stimulating factor (G-CSF) stimulates the in vitro and in vivo development but not commitment of primitive multipotential progenitors from transgenic mice expressing the human G-CSF receptor

Yang, F. C., Watanabe, S., Tsuji, K., Xu, M. J., Kaneko, A., Ebihara, Y. & Nakahata, T., Dec 15 1998, In : Blood. 92, 12, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region

Mukouyama, Y. S., Hara, T., Xu, M. J., Tamura, K., Donovan, P. J., Kim, H. J., Kogo, H., Tsuji, K., Nakahata, T. & Miyajima, A., Jan 1998, In : Immunity. 8, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines

Xu, M. J., Tsuji, K., Ueda, T., Mukouyama, Y. S., Hara, T., Yang, F. C., Ebihara, Y., Matsuoka, S., Manabe, A., Kikuchi, A., Ito, M., Miyajima, A. & Nakahata, T., Sep 15 1998, In : Blood. 92, 6, p. 2032-2040 9 p.

Research output: Contribution to journalArticle

132 Scopus citations