Mingjiang Xu

Associate Professor

  • 4542 Citations
19982023

Research output per year

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Research Output

  • 4542 Citations
  • 101 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Letter
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Article
6 Scopus citations

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

Liao, H. J., Kume, T., McKay, C., Xu, M., Ihle, J. N. & Carpenter, G., Mar 15 2002, In : Journal of Biological Chemistry. 277, 11, p. 9335-9341 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1low mouse model of the disease

Migliaccio, A. R., Martelli, F., Verrucci, M., Migliaccio, G., Vannucchi, A. M., Ni, H., Xu, M., Jiang, Y., Nakamoto, B., Papayannopoulou, T. & Hoffman, R., Feb 2008, In : Experimental Hematology. 36, 2, p. 158-171 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

A multidisciplinary investigation of a polycythemia vera cancer cluster of unknown origin

Seaman, V., Dearwent, S. M., Gable, D., Lewis, B., Metcalf, S., Orloff, K., Tierney, B., Zhu, J., Logue, J., Marchetto, D., Ostroff, S., Hoffman, R., Xu, M., Carey, D., Erlich, P., Gerhard, G., Roda, P., Iannuzzo, J., Lewis, R., Mellow, J. & 10 others, Mulvihill, L., Myles, Z., Wu, M., Frank, A., Gross-Davis, C. A., Klotz, J., Lynch, A., Weissfeld, J., Weinberg, R. & Cole, H., Mar 2010, In : International Journal of Environmental Research and Public Health. 7, 3, p. 1139-1153 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in fanconi anemia

Zhou, Y., He, Y., Xing, W., Zhang, P., Shi, H., Chen, S., Shi, J., Bai, J., Rhodes, S. D., Zhang, F., Yuan, J., Yang, X., Zhu, X., Li, Y., Hanenberg, H., Xu, M., Robertson, K. A., Yuan, W., Nalepa, G., Cheng, T. & 2 others, Clapp, D. W. & Yang, F-C., 2017, In : Haematologica. 102, 6, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Analysis of signals and functions of the chimeric human granulocyte- macrophage colony-stimulating factor receptor in BA/F3 cells and transgenic mice

Watanabe, S., Aoki, Y., Nishijima, I., Xu, M. & Arai, K. I., Apr 1 2000, In : Journal of Immunology. 164, 7, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

Inoue, D., Fujino, T., Sheridan, P., Zhang, Y. Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K. C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C. & 2 others, Oyama, M. & Kitamura, T., Mar 3 2018, (Accepted/In press) In : Leukemia. p. 1-11 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

4 Scopus citations

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

14 Scopus citations

ASXL1 plays an important role in erythropoiesis

Shi, H., Yamamoto, S., Sheng, M., Bai, J., Zhang, P., Chen, R., Chen, S., Shi, L., Abdel-Wahab, O., Xu, M., Zhou, Y. & Yang, F-C., Jun 29 2016, In : Scientific Reports. 6, 28789.

Research output: Contribution to journalArticle

19 Scopus citations

Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice

Ishii, T., Zhao, Y., Sozer, S., Shi, J., Zhang, W., Hoffman, R. & Xu, M., Nov 2007, In : Experimental Hematology. 35, 11, p. 1633-1640 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cardiac Sca-1+ Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair

Zhang, L., Sultana, N., Yan, J., Yang, F., Chen, F., Chepurko, E., Yang, F-C., Du, Q., Zangi, L., Xu, M., Bu, L. & Cai, C. L., Dec 18 2018, In : Circulation. 138, 25, p. 2919-2930 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

7 Scopus citations

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages

Matsuoka, S., Ebihara, Y., Xu, M., Ishii, T., Sugiyama, D., Yoshino, H., Ueda, T., Manabe, A., Tanaka, R., Ikeda, Y., Nakahata, T. & Tsuji, K., Jan 15 2001, In : Blood. 97, 2, p. 419-425 7 p.

Research output: Contribution to journalArticle

97 Scopus citations

c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

He, Y., Rhodes, S. D., Chen, S., Wu, X., Yuan, J., Yang, X., Jiang, L., Li, X., Takahashi, N., Xu, M., Mohammad, K. S., Guise, T. A. & Yang, F-C., Nov 7 2012, In : PLoS One. 7, 11, e46900.

Research output: Contribution to journalArticle

14 Scopus citations

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Circulating angiogenic monocyte progenitor cells are reduced in JAK2V617F high allele burden myeloproliferative disorders

Sozer, S., Wang, X., Zhang, W., Fiel, M. I., Ishii, T., Wang, J., Wisch, N., Xu, M. & Hoffman, R., Nov 2008, In : Blood Cells, Molecules, and Diseases. 41, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms*

Wang, X., LeBlanc, A., Gruenstein, S., Xu, M., Mascarenhas, J., Panzera, B., Wisch, N., Parker, C., Goldberg, J. D., Prchal, J., Hoffman, R. & Najfeld, V., Oct 2009, In : Experimental Hematology. 37, 10, p. 1194-1200 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Dawlaty, M. M., Breiling, A., Le, T., Raddatz, G., Barrasa, M. I., Cheng, A. W., Gao, Q., Powell, B. E., Li, Z., Xu, M., Faull, K. F., Lyko, F. & Jaenisch, R., Feb 11 2013, In : Developmental Cell. 24, 3, p. 310-323 14 p.

Research output: Contribution to journalArticle

257 Scopus citations

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., Chen, S., Yuan, W., Qin, Z., Ni, H., Nimer, S. D., Yang, F-C., Jaenisch, R., Jin, P. & Xu, M., Nov 24 2015, In : Cell Reports. 13, 8, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases

Xu, M., Bruno, E., Chao, J., Huang, S., Finazzi, G., Fruchtman, S. M., Popat, U., Prchal, J. T., Barosi, G. & Hoffman, R., Jun 1 2005, In : Blood. 105, 11, p. 4508-4515 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Correction of the abnormal trafficking of primary myelofibrosis CD34 + cells by treatment with chromatin-modifying agents

Xiaoli, W., Wei, Z., Takefumi, I., Sozer, S., Jiapeng, W., Xu, M. & Hoffman, R., Oct 1 2009, In : Cancer Research. 69, 19, p. 7612-7618 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C. L., Wang, J., Zhang, W., Petersen, B. E., Yang, F-C. & Xu, M., Oct 27 2011, In : Blood. 118, 17, p. 4509-4518 10 p.

Research output: Contribution to journalArticle

345 Scopus citations

Differential effects of human granulocyte colony-stimulating factor (hG- CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice

Yang, F-C., Tsuji, K., Oda, A., Ebihara, Y., Xu, M., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., Watanabe, S., Ikeda, Y. & Nakahata, T., Aug 1 1999, In : Blood. 94, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis

Shi, J., Zhao, Y., Ishii, T., Hu, W., Sozer, S., Zhang, W., Bruno, E., Lindgren, V., Xu, M. & Hoffman, R., Jul 1 2007, In : Cancer Research. 67, 13, p. 6417-6424 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth

Li, Z., Xu, M., Xing, S., Ho, W. T., Ishii, T., Li, Q., Fu, X. & Zhao, Z. J., Jan 9 2007, In : Journal of Biological Chemistry. 282, 6, p. 3428-3432 5 p.

Research output: Contribution to journalArticle

90 Scopus citations

Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac

Xu, M., Matsuoka, S., Yang, F-C., Ebihara, Y., Manabe, A., Tanaka, R., Eguchi, M., Asano, S., Nakahata, T. & Tsuji, K., Apr 1 2001, In : Blood. 97, 7, p. 2016-2022 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34+ cells

Ebihara, Y., Xu, M., Manabe, A., Kikuchi, A., Tanaka, R., Kato, S., Nakahata, T. & Tsuji, K., 2000, In : British Journal of Haematology. 109, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents

Araki, H., Mahmud, N., Milhem, M., Nunez, R., Xu, M., Beam, C. A. & Hoffman, R., Feb 2006, In : Experimental Hematology. 34, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein

Tanaka, Y., Naruse, I., Hongo, T., Xu, M., Nakahata, T., Maekawa, T. & Ishii, S., Jul 1 2000, In : Mechanisms of Development. 95, 1-2, p. 133-145 13 p.

Research output: Contribution to journalArticle

120 Scopus citations

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

34 Scopus citations

Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells

Matsuoka, S., Tsuji, K., Hisakawa, H., Xu, M., Ebihara, Y., Ishii, T., Sugiyama, D., Manabe, A., Tanaka, R., Ikeda, Y., Asano, S. & Nakahata, T., Jul 1 2001, In : Blood. 98, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Haematopoietic cell lineage distribution of MPLW515L/K mutations in patients with idiopathic myelofibrosis [4]

Hu, W. Y., Zhao, Y., Ishii, T., Sozer, S., Shi, J., Zhang, W., Bruno, E., Hoffman, R. & Xu, M., May 2007, In : British Journal of Haematology. 137, 4, p. 378-379 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis

Kinoshita, T., Sekiguchi, T., Xu, M., Ito, Y., Kamiya, A., Tsuji, K. I., Nakahata, T. & Miyajima, A., Jun 22 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 13, p. 7265-7270 6 p.

Research output: Contribution to journalArticle

142 Scopus citations

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., Dec 9 2019, In : Cancer Cell. 36, 6, p. 645-659.e8

Research output: Contribution to journalArticle

Human CD34+ cells are capable of generating normal and JAK2V617F positive endothelial like cells in vivo

Sozer, S., Ishii, T., Fiel, M. I., Wang, J., Wang, X., Zhang, W., Godbold, J., Xu, M. & Hoffman, R., Nov 2009, In : Blood Cells, Molecules, and Diseases. 43, 3, p. 304-312 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Human granulocyte colony-stimulating factor (G-CSF) stimulates the in vitro and in vivo development but not commitment of primitive multipotential progenitors from transgenic mice expressing the human G-CSF receptor

Yang, F-C., Watanabe, S., Tsuji, K., Xu, M., Kaneko, A., Ebihara, Y. & Nakahata, T., Dec 15 1998, In : Blood. 92, 12, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors

Hisakawa, H., Sugiyama, D., Nishijima, I., Xu, M., Wu, H., Nakao, K., Watanabe, S., Katsuki, M., Asano, S., Aral, K. I., Nakahata, T. & Tsuji, K., Dec 15 2001, In : Blood. 98, 13, p. 3618-3625 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hydroxylation of 5-methylcytosine by Tet2 maintains the active state of the mammalian Hoxa cluster

Bocker, M. T., Tuorto, F., Raddatz, G., Musch, T., Yang, F-C., Xu, M., Lyko, F. & Breiling, A., 2012, In : Nature Communications. 3, 818.

Research output: Contribution to journalArticle

55 Scopus citations

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurobromin-decient mice

Sharma, R., Wu, X., Rhodes, S. D., Chen, S., He, Y., Yuan, J., Li, J., Yang, X., Li, X., Jiang, L., Kim, E. T., Stevenson, D. A., Viskochil, D., Xu, M. & Yang, F-C., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4818-4828 11 p., ddt333.

Research output: Contribution to journalArticle

26 Scopus citations

Hyperactive RAS/PI3-K/MAPK signaling cascade in migration and adhesion of Nf1 haploinsufficient mesenchymal stem/progenitor cells

Zhou, Y., He, Y., Sharma, R., Xing, W., Estwick, S. A., Wu, X., Rhodes, S. D., Xu, M. & Yang, F-C., 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12345-12359 15 p., A031.

Research output: Contribution to journalArticle

2 Scopus citations

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Rhodes, S. D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K. W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K. S., Xu, M., Guise, T. A. & Yang, F-C., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

27 Scopus citations
41 Scopus citations

Idh1/2 mutations sensitize acute myeloid leukemia to parp inhibition and this is reversed by idh1/2-mutant inhibitors

Molenaar, R. J., Radivoyevitch, T., Nagata, Y., Khurshed, M., Przychodzen, B., Makishima, H., Xu, M., Bleeker, F. E., Wilmink, J. W., Carraway, H. E., Mukherjee, S., Sekeres, M. A., van Noorden, C. J. F. & Maciejewski, J. P., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1705-1715 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Interferon-α targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway

Lu, M., Zhang, W., Li, Y., Berenzon, D., Wang, X., Wang, J., Mascarenhas, J., Xu, M. & Hoffman, R., Jun 2010, In : Experimental Hematology. 38, 6, p. 472-480 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region

Mukouyama, Y. S., Hara, T., Xu, M., Tamura, K., Donovan, P. J., Kim, H. J., Kogo, H., Tsuji, K., Nakahata, T. & Miyajima, A., Jan 1998, In : Immunity. 8, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

118 Scopus citations