Mingjiang Xu

Associate Professor

  • 4491 Citations
19982023
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Research Output 1998 2019

  • 4491 Citations
  • 101 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Letter
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Article
6 Citations (Scopus)
Mesenchymal Stromal Cells
Bone Marrow
Density Gradient Centrifugation
Chondrocytes
Centrifugation
103 Citations (Scopus)

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

Liao, H. J., Kume, T., McKay, C., Xu, M., Ihle, J. N. & Carpenter, G., Mar 15 2002, In : Journal of Biological Chemistry. 277, 11, p. 9335-9341 7 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Embryonic Structures
CD31 Antigens
Vascular Endothelial Growth Factor Receptor-2
Macrophages
39 Citations (Scopus)

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1low mouse model of the disease

Migliaccio, A. R., Martelli, F., Verrucci, M., Migliaccio, G., Vannucchi, A. M., Ni, H., Xu, M., Jiang, Y., Nakamoto, B., Papayannopoulou, T. & Hoffman, R., Feb 2008, In : Experimental Hematology. 36, 2, p. 158-171 14 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Primary Myelofibrosis
Bone Marrow
Stem Cells
Plasma Cells
5 Citations (Scopus)

A multidisciplinary investigation of a polycythemia vera cancer cluster of unknown origin

Seaman, V., Dearwent, S. M., Gable, D., Lewis, B., Metcalf, S., Orloff, K., Tierney, B., Zhu, J., Logue, J., Marchetto, D., Ostroff, S., Hoffman, R., Xu, M., Carey, D., Erlich, P., Gerhard, G., Roda, P., Iannuzzo, J., Lewis, R., Mellow, J. & 10 others, Mulvihill, L., Myles, Z., Wu, M., Frank, A., Gross-Davis, C. A., Klotz, J., Lynch, A., Weissfeld, J., Weinberg, R. & Cole, H., Mar 2010, In : International Journal of Environmental Research and Public Health. 7, 3, p. 1139-1153 15 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Public Health
Neoplasms
Resource Allocation
Health Resources
14 Citations (Scopus)

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in fanconi anemia

Zhou, Y., He, Y., Xing, W., Zhang, P., Shi, H., Chen, S., Shi, J., Bai, J., Rhodes, S. D., Zhang, F., Yuan, J., Yang, X., Zhu, X., Li, Y., Hanenberg, H., Xu, M., Robertson, K. A., Yuan, W., Nalepa, G., Cheng, T. & 2 others, Clapp, D. W. & Yang, F-C., 2017, In : Haematologica. 102, 6, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Mesenchymal Stromal Cells
Bone Marrow
Inborn Genetic Diseases
Hematopoietic Stem Cells
8 Citations (Scopus)

Analysis of signals and functions of the chimeric human granulocyte- macrophage colony-stimulating factor receptor in BA/F3 cells and transgenic mice

Watanabe, S., Aoki, Y., Nishijima, I., Xu, M. & Arai, K. I., Apr 1 2000, In : Journal of Immunology. 164, 7, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Bone Marrow Cells
Transgenic Mice
Interleukin-3
Interleukin-5
9 Citations (Scopus)

A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

Inoue, D., Fujino, T., Sheridan, P., Zhang, Y. Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K. C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C. & 2 others, Oyama, M. & Kitamura, T., Mar 3 2018, (Accepted/In press) In : Leukemia. p. 1-11 11 p.

Research output: Contribution to journalArticle

Methylation
Transcriptional Activation
Neoplasms
Histone Code
Proteins
3 Citations (Scopus)

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Primary Myelofibrosis
13 Citations (Scopus)

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

Chromatids
Hematopoiesis
Gene Expression
Telophase
Chromatin Immunoprecipitation
18 Citations (Scopus)

ASXL1 plays an important role in erythropoiesis

Shi, H., Yamamoto, S., Sheng, M., Bai, J., Zhang, P., Chen, R., Chen, S., Shi, L., Abdel-Wahab, O., Xu, M., Zhou, Y. & Yang, F-C., Jun 29 2016, In : Scientific Reports. 6, 28789.

Research output: Contribution to journalArticle

Erythropoiesis
Myelodysplastic Syndromes
Erythroblasts
Leukemia, Myelomonocytic, Chronic
Erythrocytes
27 Citations (Scopus)

Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice

Ishii, T., Zhao, Y., Sozer, S., Shi, J., Zhang, W., Hoffman, R. & Xu, M., Nov 2007, In : Experimental Hematology. 35, 11, p. 1633-1640 8 p.

Research output: Contribution to journalArticle

Polycythemia Vera
SCID Mice
Primary Myelofibrosis
Blood Cells
Transplants
5 Citations (Scopus)

Cardiac Sca-1+ Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair

Zhang, L., Sultana, N., Yan, J., Yang, F., Chen, F., Chepurko, E., Yang, F-C., Du, Q., Zangi, L., Xu, M., Bu, L. & Cai, C. L., Dec 18 2018, In : Circulation. 138, 25, p. 2919-2930 12 p.

Research output: Contribution to journalArticle

Stem Cells
Endothelial Cells
Genetic Models
Cardiac Myocytes
Population
7 Citations (Scopus)

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis
9 Citations (Scopus)

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

Autophagy
Caspase 3
Modulation
Acute Myeloid Leukemia
Leukemia
97 Citations (Scopus)

CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages

Matsuoka, S., Ebihara, Y., Xu, M., Ishii, T., Sugiyama, D., Yoshino, H., Ueda, T., Manabe, A., Tanaka, R., Ikeda, Y., Nakahata, T. & Tsuji, K., Jan 15 2001, In : Blood. 97, 2, p. 419-425 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Bone Marrow
Assays
Bone
14 Citations (Scopus)

c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

He, Y., Rhodes, S. D., Chen, S., Wu, X., Yuan, J., Yang, X., Jiang, L., Li, X., Takahashi, N., Xu, M., Mohammad, K. S., Guise, T. A. & Yang, F-C., Nov 7 2012, In : PLoS One. 7, 11, e46900.

Research output: Contribution to journalArticle

osteoclasts
Neurofibromatosis 1
Osteoclasts
macrophage colony-stimulating factor
Macrophage Colony-Stimulating Factor
4 Citations (Scopus)

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromatin
Mutation
Hematopoietic Stem Cells
Genes
6 Citations (Scopus)

Circulating angiogenic monocyte progenitor cells are reduced in JAK2V617F high allele burden myeloproliferative disorders

Sozer, S., Wang, X., Zhang, W., Fiel, M. I., Ishii, T., Wang, J., Wisch, N., Xu, M. & Hoffman, R., Nov 2008, In : Blood Cells, Molecules, and Diseases. 41, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Monocytes
Stem Cells
Alleles
Endothelial Cells
13 Citations (Scopus)

Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms*

Wang, X., LeBlanc, A., Gruenstein, S., Xu, M., Mascarenhas, J., Panzera, B., Wisch, N., Parker, C., Goldberg, J. D., Prchal, J., Hoffman, R. & Najfeld, V., Oct 2009, In : Experimental Hematology. 37, 10, p. 1194-1200 7 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Essential Thrombocythemia
Neoplasms
Polycythemia Vera
Primary Myelofibrosis
254 Citations (Scopus)

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Dawlaty, M. M., Breiling, A., Le, T., Raddatz, G., Barrasa, M. I., Cheng, A. W., Gao, Q., Powell, B. E., Li, Z., Xu, M., Faull, K. F., Lyko, F. & Jaenisch, R., Feb 11 2013, In : Developmental Cell. 24, 3, p. 310-323 14 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Epigenomics
Stem cells
Enzymes
Embryonic Structures
47 Citations (Scopus)

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., Chen, S., Yuan, W., Qin, Z., Ni, H., Nimer, S. D., Yang, F-C., Jaenisch, R., Jin, P. & Xu, M., Nov 24 2015, In : Cell Reports. 13, 8, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Dioxygenases
Hematologic Neoplasms
Neoplasms
1 Citation (Scopus)

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Mutation
Epigenetic Repression
Histone Deacetylase Inhibitors
Chromatin Assembly and Disassembly
89 Citations (Scopus)

Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases

Xu, M., Bruno, E., Chao, J., Huang, S., Finazzi, G., Fruchtman, S. M., Popat, U., Prchal, J. T., Barosi, G. & Hoffman, R., Jun 1 2005, In : Blood. 105, 11, p. 4508-4515 8 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Matrix Metalloproteinase 9
Leukocyte Elastase
Vascular Cell Adhesion Molecule-1
Blood
24 Citations (Scopus)

Correction of the abnormal trafficking of primary myelofibrosis CD34 + cells by treatment with chromatin-modifying agents

Xiaoli, W., Wei, Z., Takefumi, I., Sozer, S., Jiapeng, W., Xu, M. & Hoffman, R., Oct 1 2009, In : Cancer Research. 69, 19, p. 7612-7618 7 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Chromatin
SCID Mice
decitabine
Spleen
10 Citations (Scopus)

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

Transcription
Acute Myeloid Leukemia
Gene expression
Chromatin
Genes
343 Citations (Scopus)

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C. L., Wang, J., Zhang, W., Petersen, B. E., Yang, F-C. & Xu, M., Oct 27 2011, In : Blood. 118, 17, p. 4509-4518 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
5-Methylcytosine
Neoplasms
Tumors
23 Citations (Scopus)

Differential effects of human granulocyte colony-stimulating factor (hG- CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice

Yang, F-C., Tsuji, K., Oda, A., Ebihara, Y., Xu, M., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., Watanabe, S., Ikeda, Y. & Nakahata, T., Aug 1 1999, In : Blood. 94, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Thrombopoietin
Granulocyte Colony-Stimulating Factor
Platelets
Transgenic Mice
49 Citations (Scopus)

Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis

Shi, J., Zhao, Y., Ishii, T., Hu, W., Sozer, S., Zhang, W., Bruno, E., Lindgren, V., Xu, M. & Hoffman, R., Jul 1 2007, In : Cancer Research. 67, 13, p. 6417-6424 8 p.

Research output: Contribution to journalArticle

decitabine
Primary Myelofibrosis
trichostatin A
Chromatin
Therapeutics
89 Citations (Scopus)

Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth

Li, Z., Xu, M., Xing, S., Ho, W. T., Ishii, T., Li, Q., Fu, X. & Zhao, Z. J., Jan 9 2007, In : Journal of Biological Chemistry. 282, 6, p. 3428-3432 5 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Cell growth
Essential Thrombocythemia
Growth
Cells
74 Citations (Scopus)

Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac

Xu, M., Matsuoka, S., Yang, F-C., Ebihara, Y., Manabe, A., Tanaka, R., Eguchi, M., Asano, S., Nakahata, T. & Tsuji, K., Apr 1 2001, In : Blood. 97, 7, p. 2016-2022 7 p.

Research output: Contribution to journalArticle

Yolk Sac
Megakaryocytes
Platelets
Thrombopoietin
Stem Cell Factor
21 Citations (Scopus)

Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34+ cells

Ebihara, Y., Xu, M., Manabe, A., Kikuchi, A., Tanaka, R., Kato, S., Nakahata, T. & Tsuji, K., 2000, In : British Journal of Haematology. 109, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Gastrin-Secreting Cells
Granulocyte Colony-Stimulating Factor
Bone Marrow Cells
Myelopoiesis
76 Citations (Scopus)

Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents

Araki, H., Mahmud, N., Milhem, M., Nunez, R., Xu, M., Beam, C. A. & Hoffman, R., Feb 2006, In : Experimental Hematology. 34, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

decitabine
Fetal Blood
Chromatin
trichostatin A
Blood Cells
119 Citations (Scopus)

Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein

Tanaka, Y., Naruse, I., Hongo, T., Xu, M., Nakahata, T., Maekawa, T. & Ishii, S., Jul 1 2000, In : Mechanisms of Development. 95, 1-2, p. 133-145 13 p.

Research output: Contribution to journalArticle

Rubinstein-Taybi Syndrome
CREB-Binding Protein
Intracranial Hemorrhages
Embryonic Structures
Neural Tube
31 Citations (Scopus)

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

Comb and Wattles
Stem cells
Chromatin
Mass spectrometry
Neoplasms
133 Citations (Scopus)

Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells

Matsuoka, S., Tsuji, K., Hisakawa, H., Xu, M., Ebihara, Y., Ishii, T., Sugiyama, D., Manabe, A., Tanaka, R., Ikeda, Y., Asano, S. & Nakahata, T., Jul 1 2001, In : Blood. 98, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Mesonephros
Yolk Sac
Gonads
Stromal Cells
Hematopoietic Stem Cells
8 Citations (Scopus)

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Chemotaxis
Mast Cells
Cell Differentiation
Microphthalmia-Associated Transcription Factor
11 Citations (Scopus)

Haematopoietic cell lineage distribution of MPLW515L/K mutations in patients with idiopathic myelofibrosis [4]

Hu, W. Y., Zhao, Y., Ishii, T., Sozer, S., Shi, J., Zhang, W., Bruno, E., Hoffman, R. & Xu, M., May 2007, In : British Journal of Haematology. 137, 4, p. 378-379 2 p.

Research output: Contribution to journalArticle

Thrombopoietin
Pluripotent Stem Cells
Primary Myelofibrosis
Cell Lineage
DNA Sequence Analysis
142 Citations (Scopus)

Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis

Kinoshita, T., Sekiguchi, T., Xu, M., Ito, Y., Kamiya, A., Tsuji, K. I., Nakahata, T. & Miyajima, A., Jun 22 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 13, p. 7265-7270 6 p.

Research output: Contribution to journalArticle

Oncostatin M
Hematopoiesis
Liver
Glucocorticoids
Hepatocytes

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., Dec 9 2019, In : Cancer Cell. 36, 6, p. 645-659.e8

Research output: Contribution to journalArticle

Long Noncoding RNA
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Genome
Growth
16 Citations (Scopus)

Human CD34+ cells are capable of generating normal and JAK2V617F positive endothelial like cells in vivo

Sozer, S., Ishii, T., Fiel, M. I., Wang, J., Wang, X., Zhang, W., Godbold, J., Xu, M. & Hoffman, R., Nov 2009, In : Blood Cells, Molecules, and Diseases. 43, 3, p. 304-312 9 p.

Research output: Contribution to journalArticle

Endothelial Cells
Monocytes
Stem Cells
Philadelphia Chromosome
Neoplasms
37 Citations (Scopus)

Human granulocyte colony-stimulating factor (G-CSF) stimulates the in vitro and in vivo development but not commitment of primitive multipotential progenitors from transgenic mice expressing the human G-CSF receptor

Yang, F-C., Watanabe, S., Tsuji, K., Xu, M., Kaneko, A., Ebihara, Y. & Nakahata, T., Dec 15 1998, In : Blood. 92, 12, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Granulocyte Colony-Stimulating Factor
Transgenic Mice
Bone
Interleukin-3
9 Citations (Scopus)

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors

Hisakawa, H., Sugiyama, D., Nishijima, I., Xu, M., Wu, H., Nakao, K., Watanabe, S., Katsuki, M., Asano, S., Aral, K. I., Nakahata, T. & Tsuji, K., Dec 15 2001, In : Blood. 98, 13, p. 3618-3625 8 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Erythropoietin Receptors
Erythropoiesis
Granulocyte-Macrophage Colony-Stimulating Factor
Colony-Stimulating Factor Receptors
54 Citations (Scopus)

Hydroxylation of 5-methylcytosine by Tet2 maintains the active state of the mammalian Hoxa cluster

Bocker, M. T., Tuorto, F., Raddatz, G., Musch, T., Yang, F-C., Xu, M., Lyko, F. & Breiling, A., 2012, In : Nature Communications. 3, 818.

Research output: Contribution to journalArticle

5-Methylcytosine
Hydroxylation
genes
Genes
maintenance
26 Citations (Scopus)

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurobromin-decient mice

Sharma, R., Wu, X., Rhodes, S. D., Chen, S., He, Y., Yuan, J., Li, J., Yang, X., Li, X., Jiang, L., Kim, E. T., Stevenson, D. A., Viskochil, D., Xu, M. & Yang, F-C., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4818-4828 11 p., ddt333.

Research output: Contribution to journalArticle

Tibial Fractures
Mitogen-Activated Protein Kinases
Osteoblasts
Pseudarthrosis
Mitogen-Activated Protein Kinase Kinases
2 Citations (Scopus)

Hyperactive RAS/PI3-K/MAPK signaling cascade in migration and adhesion of Nf1 haploinsufficient mesenchymal stem/progenitor cells

Zhou, Y., He, Y., Sharma, R., Xing, W., Estwick, S. A., Wu, X., Rhodes, S. D., Xu, M. & Yang, F-C., 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12345-12359 15 p., A031.

Research output: Contribution to journalArticle

MAP Kinase Kinase 3
1-Phosphatidylinositol 4-Kinase
stem cells
Phosphatidylinositols
Mitogen-Activated Protein Kinases
25 Citations (Scopus)

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Rhodes, S. D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K. W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K. S., Xu, M., Guise, T. A. & Yang, F-C., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Transforming Growth Factors
Transforming Growth Factor beta
Osteoblasts
Pseudarthrosis
41 Citations (Scopus)
Non-Receptor Type 6 Protein Tyrosine Phosphatase
Anchors
Tyrosine
Leukocytes
Phosphorylation
15 Citations (Scopus)

Idh1/2 mutations sensitize acute myeloid leukemia to parp inhibition and this is reversed by idh1/2-mutant inhibitors

Molenaar, R. J., Radivoyevitch, T., Nagata, Y., Khurshed, M., Przychodzen, B., Makishima, H., Xu, M., Bleeker, F. E., Wilmink, J. W., Carraway, H. E., Mukherjee, S., Sekeres, M. A., van Noorden, C. J. F. & Maciejewski, J. P., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1705-1715 11 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Daunorubicin
Mutation
Myeloid Cells
DNA Damage
48 Citations (Scopus)

Interferon-α targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway

Lu, M., Zhang, W., Li, Y., Berenzon, D., Wang, X., Wang, J., Mascarenhas, J., Xu, M. & Hoffman, R., Jun 2010, In : Experimental Hematology. 38, 6, p. 472-480 9 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Polycythemia Vera
Interferons
Apoptosis
118 Citations (Scopus)

In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region

Mukouyama, Y. S., Hara, T., Xu, M., Tamura, K., Donovan, P. J., Kim, H. J., Kogo, H., Tsuji, K., Nakahata, T. & Miyajima, A., Jan 1998, In : Immunity. 8, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

Mesonephros
Oncostatin M
Gonads
Aorta
Hematopoietic Stem Cells