Mingjiang Xu

Associate Professor

  • 4437 Citations
19982023
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Research Output 1998 2019

  • 4437 Citations
  • 101 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Letter
2019
2 Citations (Scopus)

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Primary Myelofibrosis

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216), (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., Jermakowicz, A. M., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D. G., Watts, J., Vega, F. & Nimer, S. D., Jan 14 2019, In : Cancer Cell. 35, 1, 1 p.

Research output: Contribution to journalComment/debate

Hematopoiesis
Names
Neoplasms
coactivator-associated arginine methyltransferase 1

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., Dec 9 2019, In : Cancer Cell. 36, 6, p. 645-659.e8

Research output: Contribution to journalArticle

Long Noncoding RNA
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Genome
Growth

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia

Chu, Y., Chen, Y., Li, M., Shi, D., Wang, B., Lian, Y., Cheng, X., Wang, X., Xu, M., Cheng, T., Shi, J. & Yuan, W., Jul 1 2019, In : Cancer Science. 110, 7, p. 2200-2210 11 p.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Leukemia
Stem Cells
Maintenance
Transcription Factors
2018
7 Citations (Scopus)

A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

Inoue, D., Fujino, T., Sheridan, P., Zhang, Y. Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K. C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C. & 2 others, Oyama, M. & Kitamura, T., Mar 3 2018, (Accepted/In press) In : Leukemia. p. 1-11 11 p.

Research output: Contribution to journalArticle

Methylation
Transcriptional Activation
Neoplasms
Histone Code
Proteins
4 Citations (Scopus)

Cardiac Sca-1+ Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair

Zhang, L., Sultana, N., Yan, J., Yang, F., Chen, F., Chepurko, E., Yang, F-C., Du, Q., Zangi, L., Xu, M., Bu, L. & Cai, C. L., Dec 18 2018, In : Circulation. 138, 25, p. 2919-2930 12 p.

Research output: Contribution to journalArticle

Stem Cells
Endothelial Cells
Genetic Models
Cardiac Myocytes
Population
7 Citations (Scopus)

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis
2 Citations (Scopus)

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromatin
Mutation
Hematopoietic Stem Cells
Genes
1 Citation (Scopus)

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Mutation
Epigenetic Repression
Histone Deacetylase Inhibitors
Chromatin Assembly and Disassembly
9 Citations (Scopus)

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

Transcription
Acute Myeloid Leukemia
Gene expression
Chromatin
Genes

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216) (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Nov 12 2018, In : Cancer Cell. 34, 5, 1 p.

Research output: Contribution to journalComment/debate

Hematopoiesis
Names
Neoplasms
coactivator-associated arginine methyltransferase 1
28 Citations (Scopus)

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

Comb and Wattles
Stem cells
Chromatin
Mass spectrometry
Neoplasms
15 Citations (Scopus)

Idh1/2 mutations sensitize acute myeloid leukemia to parp inhibition and this is reversed by idh1/2-mutant inhibitors

Molenaar, R. J., Radivoyevitch, T., Nagata, Y., Khurshed, M., Przychodzen, B., Makishima, H., Xu, M., Bleeker, F. E., Wilmink, J. W., Carraway, H. E., Mukherjee, S., Sekeres, M. A., van Noorden, C. J. F. & Maciejewski, J. P., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1705-1715 11 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Daunorubicin
Mutation
Myeloid Cells
DNA Damage
6 Citations (Scopus)

Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates

Zhang, P., Chen, Z., Li, R., Guo, Y., Shi, H., Bai, J., Yang, H., Sheng, M., Li, Z., Li, Z., Li, J., Chen, S., Yuan, W., Cheng, T., Xu, M., Zhou, Y. & Yang, F-C., Dec 1 2018, In : Cell Discovery. 4, 1, 4.

Research output: Contribution to journalArticle

Comb and Wattles
RNA Polymerase II
Hematopoietic Stem Cells
Bone
Bone Marrow
2 Citations (Scopus)

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI insight. 3, 4

Research output: Contribution to journalArticle

Open Access
Myeloid Cells
Phosphatidylinositol 3-Kinases
Epigenomics
Ascorbic Acid
Azacitidine
4 Citations (Scopus)

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Guo, Y., Yang, H., Chen, S., Zhang, P., Li, R., Nimer, S. D., William Harbour, J., Xu, M. & Yang, F-C., Apr 2 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

Neoplasms
15 Citations (Scopus)

RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells

Guallar, D., Bi, X., Pardavila, J. A., Huang, X., Saenz, C., Shi, X., Zhou, H., Faiola, F., Ding, J., Haruehanroengra, P., Yang, F., Li, D., Sanchez-Priego, C., Saunders, A., Pan, F., Valdes, V. J., Kelley, K., Blanco, M. G., Chen, L., Wang, H. & 5 others, Sheng, J., Xu, M., Fidalgo, M., Shen, X. & Wang, J., Feb 26 2018, (Accepted/In press) In : Nature Genetics. p. 1-9 9 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Pluripotent Stem Cells
Epigenomics
Chromatin
RNA
3 Citations (Scopus)

TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2−/−-Driven Myeloid Malignancy Progression

Li, R., Zhou, Y., Cao, Z., Liu, L., Wang, J., Chen, Z., Xing, W., Chen, S., Bai, J., Yuan, W., Cheng, T., Xu, M., Yang, F-C. & Zhao, Z., Jan 1 2018, In : Stem Cell Reports. 10, 1, p. 166-179 14 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone
Neoplasms
Osteoblasts
Cell proliferation
4 Citations (Scopus)

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

Chu, Y., Zhao, Z., Sant, D. W., Zhu, G., Greenblatt, S. M., Liu, L., Wang, J., Cao, Z., Tho, J. C., Chen, S., Liu, X., Zhang, P., Maciejewski, J. P., Nimer, S. D., Wang, G., Yuan, W., Yang, F-C. & Xu, M., Jan 1 2018, (Accepted/In press) In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticle

Osteoclasts
Genomics
Macrophage
Macrophages
Translocation
2017
14 Citations (Scopus)

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in fanconi anemia

Zhou, Y., He, Y., Xing, W., Zhang, P., Shi, H., Chen, S., Shi, J., Bai, J., Rhodes, S. D., Zhang, F., Yuan, J., Yang, X., Zhu, X., Li, Y., Hanenberg, H., Xu, M., Robertson, K. A., Yuan, W., Nalepa, G., Cheng, T. & 2 others, Clapp, D. W. & Yang, F-C., 2017, In : Haematologica. 102, 6, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Mesenchymal Stromal Cells
Bone Marrow
Inborn Genetic Diseases
Hematopoietic Stem Cells
12 Citations (Scopus)

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

Chromatids
Hematopoiesis
Gene Expression
Telophase
Chromatin Immunoprecipitation
9 Citations (Scopus)

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

Autophagy
Caspase 3
Modulation
Acute Myeloid Leukemia
Leukemia
8 Citations (Scopus)

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, LL., Williams, S. L., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F-C., Jun 8 2017, In : Nature Communications. 8, 15456.

Research output: Contribution to journalArticle

stem cells
Hematopoietic Stem Cells
Stem cells
mice
deletion
11 Citations (Scopus)

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F. C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

CREB-Binding Protein
Myelodysplastic Syndromes
Hematopoietic Stem Cells
Histone Code
Neoplasms
9 Citations (Scopus)

PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia

Guo, H., Chu, Y., Wang, L., Chen, X., Chen, Y., Cheng, H., Zhang, L., Zhou, Y., Yang, F-C., Cheng, T., Xu, M., Zhang, X., Zhou, J. & Yuan, W., Jul 15 2017, In : International Journal of Cancer. 141, 2, p. 324-335 12 p.

Research output: Contribution to journalArticle

Leukemia
Stem Cells
Maintenance
Acute Myeloid Leukemia
Clustered Regularly Interspaced Short Palindromic Repeats
131 Citations (Scopus)

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., Grillo, I., Bakogianni, S., Ndiaye-Lobry, D., Martín, M. T., Guillamot, M., Banh, R. S., Xu, M., Figueroa, M., Dickins, R. A., Abdel-Wahab, O. & 4 others, Park, C. Y., Tsirigos, A., Neel, B. G. & Aifantis, I., Sep 7 2017, In : Cell. 170, 6, p. 1079-1095.e20

Research output: Contribution to journalArticle

Ascorbic Acid
Restoration
Leukemia
DNA
Dioxygenases
22 Citations (Scopus)

Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis

Li, X., Yao, B., Chen, L., Kang, Y., Li, Y., Cheng, Y., Li, L., Lin, L., Wang, Z., Wang, M., Pan, F., Dai, Q., Zhang, W., Wu, H., Shu, Q., Qin, Z., He, C., Xu, M. & Jin, P., Jun 29 2017, In : Nature Communications. 8, 15903.

Research output: Contribution to journalArticle

Adult Stem Cells
Neural Stem Cells
Neurogenesis
Stem cells
boxes
29 Citations (Scopus)

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., Nazha, A., Chen, L., Yao, B., Liu, C., Chen, S., Weeks, O., Ni, H., Phillips, B. L., Huang, S., Wang, J. & 8 others, He, C., Li, G. M., Radivoyevitch, T., Aifantis, I., MacIejewski, J. P., Yang, F-C., Jin, P. & Xu, M., Jan 1 2017, In : Nature Communications. 8, 15102.

Research output: Contribution to journalArticle

stem cells
mutations
Hematopoietic Stem Cells
Stem cells
Hematologic Neoplasms
13 Citations (Scopus)

Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia

Chen, Y., Pan, Y., Guo, Y., Zhao, W., Ho, W. T., Wang, J., Xu, M., Yang, F-C. & Zhao, Z. J., Jun 1 2017, In : Stem Cell Investigation. 4, 6, 48.

Research output: Contribution to journalReview article

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Therapeutics
Neoplasms
Poisons
2016
18 Citations (Scopus)

ASXL1 plays an important role in erythropoiesis

Shi, H., Yamamoto, S., Sheng, M., Bai, J., Zhang, P., Chen, R., Chen, S., Shi, L., Abdel-Wahab, O., Xu, M., Zhou, Y. & Yang, F-C., Jun 29 2016, In : Scientific Reports. 6, 28789.

Research output: Contribution to journalArticle

Erythropoiesis
Myelodysplastic Syndromes
Erythroblasts
Leukemia, Myelomonocytic, Chronic
Erythrocytes
9 Citations (Scopus)

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice

Zhang, P., Xing, C., Rhodes, S. D., He, Y., Deng, K., Li, Z., He, F., Zhu, C., Nguyen, L., Zhou, Y., Chen, S., Mohammad, K. S., Guise, T. A., Abdel-Wahab, O., Xu, M., Wang, Q. F. & Yang, F-C., Jan 26 2016, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone
Genes
Osteoblasts
Defects
77 Citations (Scopus)

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, Christian, K. M., Shi, P. Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G. L. & Jin, P., Oct 14 2016, In : Nucleic Acids Research. 44, 18, p. 8610-8620 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Transcriptome
Apoptosis
Microcephaly
Viral Genes

Research advances in the mutation of TET2 gene in myeloid maligancies

Li, R., Xu, M., Yang, F-C. & Zhou, Y., Oct 30 2016, In : Acta Academiae Medicinae Sinicae. 38, 5, p. 583-588 6 p.

Research output: Contribution to journalReview article

5-Methylcytosine
Mutation
Tumor Suppressor Genes
Oncogenes
Research
7 Citations (Scopus)

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9- initiated murine acute myeloid leukemia

Gao, Y., Gao, J., Li, M., Zheng, Y., Wang, Y., Zhang, H., Wang, W., Chu, Y., Wang, X., Xu, M., Cheng, T., Ju, Z. & Yuan, W., 2016, In : Journal of Hematology and Oncology. 9, 1, 36.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Sirolimus
Neoplasms
Myeloid Cells
Phosphatidylinositol 3-Kinase
11 Citations (Scopus)

The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells

Zhao, Z., Chen, S., Zhu, X., Pan, F., Li, R., Zhou, Y., Yuan, W., Ni, H., Yang, F-C. & Xu, M., Aug 1 2016, In : Leukemia. 30, 8, p. 1784-1788 5 p.

Research output: Contribution to journalLetter

Hematopoietic Stem Cells
Neoplasms
2015
46 Citations (Scopus)

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., Chen, S., Yuan, W., Qin, Z., Ni, H., Nimer, S. D., Yang, F-C., Jaenisch, R., Jin, P. & Xu, M., Nov 24 2015, In : Cell Reports. 13, 8, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Dioxygenases
Hematologic Neoplasms
Neoplasms
2 Citations (Scopus)

Hyperactive RAS/PI3-K/MAPK signaling cascade in migration and adhesion of Nf1 haploinsufficient mesenchymal stem/progenitor cells

Zhou, Y., He, Y., Sharma, R., Xing, W., Estwick, S. A., Wu, X., Rhodes, S. D., Xu, M. & Yang, F-C., 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12345-12359 15 p., A031.

Research output: Contribution to journalArticle

MAP Kinase Kinase 3
1-Phosphatidylinositol 4-Kinase
stem cells
Phosphatidylinositols
Mitogen-Activated Protein Kinases
2 Citations (Scopus)

Nf1 haploinsufficiency alters myeloid lineage commitment and function, leading to deranged skeletal homeostasis

Rhodes, S. D., Yang, H., Dong, R., Menon, K., He, Y., Li, Z., Chen, S., Staser, K. W., Jiang, L., Wu, X., Yang, X., Peng, X., Mohammad, K. S., Guise, T. A., Xu, M. & Yang, F-C., Oct 1 2015, In : Journal of Bone and Mineral Research. 30, 10, p. 1840-1851 12 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Neurofibromatosis 1
Osteoclasts
Homeostasis
Osteogenesis
7 Citations (Scopus)

Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia

Hu, T., Li, C., Zhang, Y., Wang, L., Peng, L., Cheng, H., Wang, W., Chu, Y., Xu, M., Cheng, T. & Yuan, W., Apr 17 2015, In : Biochemical and Biophysical Research Communications. 459, 4, p. 692-698 7 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Stem cells
Acute Myeloid Leukemia
Leukemia
134 Citations (Scopus)

Resident c-kit + cells in the heart are not cardiac stem cells

Sultana, N., Zhang, L., Yan, J., Chen, J., Cai, W., Razzaque, S., Jeong, D., Sheng, W., Bu, L., Xu, M., Huang, G. Y., Hajjar, R. J., Zhou, B., Moon, A. & Cai, C. L., Oct 30 2015, In : Nature Communications. 6, 8701.

Research output: Contribution to journalArticle

kits
stem cells
Stem cells
Stem Cells
Endothelial cells
9 Citations (Scopus)

The TET2 interactors and their links to hematological malignancies

Pan, F., Weeks, O., Yang, F-C. & Xu, M., Jun 1 2015, In : IUBMB Life. 67, 6, p. 438-445 8 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Protein Transport
DNA
5-Methylcytosine
Dioxygenases
2014
76 Citations (Scopus)

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

Wang, J., Li, Z., He, Y., Pan, F., Chen, S., Rhodes, S., Nguyen, L., Yuan, J., Jiang, L., Yang, X., Weeks, O., Liu, Z., Zhou, J., Ni, H., Cai, C. L., Xu, M. & Yang, F-C., Jan 23 2014, In : Blood. 123, 4, p. 541-553 13 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Apoptosis
Stem cells
Tumors
Neoplasms
6 Citations (Scopus)

Rictor/mammalian target of rapamycin 2 regulates the development of notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3

Hua, C., Guo, H., Bu, J., Zhou, M., Cheng, H., He, F., Wang, J., Wang, X., Zhang, Y., Wang, Q., Zhou, J., Cheng, T., Xu, M. & Yuan, W., Dec 1 2014, In : Experimental Hematology. 42, 12, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Sirolimus
Leukemia
Ribosomal Protein S6 Kinases
T-Cell Leukemia
Comb and Wattles
Mutation
Neoplasms
Repression (Psychology)
Leukemia, Myelomonocytic, Chronic
6 Citations (Scopus)

Whole exome sequencing reveals concomitant mutations of multiple FA genes in individual Fanconi anemia patients

Chang, L., Yuan, W., Zeng, H., Zhou, Q., Wei, W., Zhou, J., Li, M., Wang, X., Xu, M., Yang, F-C., Yang, Y., Cheng, T. & Zhu, X., May 15 2014, In : BMC Medical Genomics. 7, 1, 24.

Research output: Contribution to journalArticle

Exome
Fanconi Anemia
Mutation
Genes
Stanozolol
2013
6 Citations (Scopus)
Mesenchymal Stromal Cells
Bone Marrow
Density Gradient Centrifugation
Chondrocytes
Centrifugation
250 Citations (Scopus)

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Dawlaty, M. M., Breiling, A., Le, T., Raddatz, G., Barrasa, M. I., Cheng, A. W., Gao, Q., Powell, B. E., Li, Z., Xu, M., Faull, K. F., Lyko, F. & Jaenisch, R., Feb 11 2013, In : Developmental Cell. 24, 3, p. 310-323 14 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Epigenomics
Stem cells
Enzymes
Embryonic Structures
25 Citations (Scopus)

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurobromin-decient mice

Sharma, R., Wu, X., Rhodes, S. D., Chen, S., He, Y., Yuan, J., Li, J., Yang, X., Li, X., Jiang, L., Kim, E. T., Stevenson, D. A., Viskochil, D., Xu, M. & Yang, F-C., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4818-4828 11 p., ddt333.

Research output: Contribution to journalArticle

Tibial Fractures
Mitogen-Activated Protein Kinases
Osteoblasts
Pseudarthrosis
Mitogen-Activated Protein Kinase Kinases
25 Citations (Scopus)

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Rhodes, S. D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K. W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K. S., Xu, M., Guise, T. A. & Yang, F-C., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Transforming Growth Factors
Transforming Growth Factor beta
Osteoblasts
Pseudarthrosis
247 Citations (Scopus)

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

Costa, Y., Ding, J., Theunissen, T. W., Faiola, F., Hore, T. A., Shliaha, P. V., Fidalgo, M., Saunders, A., Lawrence, M., Dietmann, S., Das, S., Levasseur, D. N., Li, Z., Xu, M., Reik, W., Silva, J. C. R. & Wang, J., Mar 21 2013, In : Nature. 495, 7441, p. 370-374 5 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
5-Methylcytosine
Homeodomain Proteins
Proteins
Embryonic Stem Cells