Mingjiang Xu

Associate Professor

  • 3879 Citations
19982018
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Polycythemia Vera Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
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Stem cells Chemical Compounds
Hematopoiesis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Mutation Medicine & Life Sciences
Bone Chemical Compounds

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Projects 2012 2018

No-nonsense approach to treat myeloid malignancies with ASXL1 nonsense mutations

Xu, M. & Yang, F.

National Institutes of Health

4/3/143/31/16

Project: Research projectExploratory/Developmental Grants

Comb and Wattles
Nonsense Codon
Neoplasms
Myeloid Cells
Hematopoietic Stem Cells

Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignancies

Xu, M. & Yang, F.

National Institutes of Health

1/1/1412/31/18

Project: Research projectResearch Project

Hematopoiesis
Haploinsufficiency
Neoplasms
Myelopoiesis
Hematopoietic Stem Cells
Hematopoiesis
Myelopoiesis
Neoplasms
Phenotype
Tumor Suppressor Genes

Research Output 1998 2018

  • 3879 Citations
  • 97 Article
  • 2 Review article
  • 1 Comment/debate
  • 1 Letter
4 Citations

A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

Inoue, D., Fujino, T., Sheridan, P., Zhang, Y. Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K. C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C. & 2 othersOyama, M. & Kitamura, T., Mar 3 2018, (Accepted/In press) In : Leukemia. p. 1-11 11 p.

Research output: Contribution to journalArticle

Methylation
Transcriptional Activation
Neoplasms
Histone Code
Proteins

Cardiac Sca-1+ Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair

Zhang, L., Sultana, N., Yan, J., Yang, F., Chen, F., Chepurko, E., Yang, F-C., Du, Q., Zangi, L., Xu, M., Bu, L. & Cai, C. L., Dec 18 2018, In : Circulation. 138, 25, p. 2919-2930 12 p.

Research output: Contribution to journalArticle

Stem Cells
Endothelial Cells
Genetic Models
Cardiac Myocytes
Population
1 Citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 othersYang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromatin
Mutation
Hematopoietic Stem Cells
Genes
1 Citations

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Mutation
Epigenetic Repression
Histone Deacetylase Inhibitors
Chromatin Assembly and Disassembly