Mathias G Lichtenheld

Associate Professor

  • 2737 Citations
1988 …2018
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1988 2018

  • 2737 Citations
  • 40 Article
Filter
Article
2018
1 Citation (Scopus)

Perforin-2 breaches the envelope of phagocytosed bacteria allowing antimicrobial effectors access to intracellular targets

Bai, F., McCormack, R. M., Hower, S., Plano, G. V., Lichtenheld, M. G. & Munson, G., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2710-2720 11 p.

Research output: Contribution to journalArticle

Phagocytosis
Bacteria
Peptide Hydrolases
Salmonella enterica
Phagocytes
2015
19 Citations (Scopus)

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

McCormack, R. M., de Armas, L. R., Shiratsuchi, M., Fiorentino, D. G., Olsson, M. L., Lichtenheld, M. G., Morales, A., Lyapichev, K., Gonzalez, L. E., Strbo, N., Sukumar, N., Stojadinovic, O., Plano, G. V., Munson, G., Tomic-Canic, M., Kirsner, R., Russell, D. G. & Podack, E. R., Sep 24 2015, In : eLife. 4, September2015, e06508.

Research output: Contribution to journalArticle

Phagocytes
Bacteria
perforin 2
Reactive Nitrogen Species
Salmonella
2013
56 Citations (Scopus)

HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases

Lee, J. H., Wittki, S., Bräu, T., Dreyer, F. S., Krätzel, K., Dindorf, J., Johnston, I. C. D., Gross, S., Kremmer, E., Zeidler, R., Schlötzer-Schrehardt, U., Lichtenheld, M. G., Saksela, K., Harrer, T., Schuler, G., Federico, M. & Baur, A. S., Feb 21 2013, In : Molecular Cell. 49, 4, p. 668-679 12 p.

Research output: Contribution to journalArticle

Paxillin
Peptide Hydrolases
HIV
Integrins
Human Immunodeficiency Virus nef Gene Products
4 Citations (Scopus)

Understanding the biology of ex vivo-expanded CD8 T cells for adoptive cell therapy: Role of CD62L

Díaz-Montero, C. M., Zidan, A. A., Pallin, M. F., Anagnostopoulos, V., Salem, M. L., Wieder, E., Komanduri, K. V., Montero, A. J. & Lichtenheld, M. G., Dec 1 2013, In : Immunologic Research. 57, 1-3, p. 23-33 11 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
T-Lymphocytes
Neoplasms
Lymph Nodes
Animal Structures
2011
31 Citations (Scopus)

Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells

Parmigiani, A., Pallin, M. F., Schmidtmayerova, H., Lichtenheld, M. G. & Pahwa, S. G., Feb 1 2011, In : Human Immunology. 72, 2, p. 115-123 9 p.

Research output: Contribution to journalArticle

Human Activities
Antiviral Agents
Cytokines
T-Lymphocytes
Interleukin-21 Receptors
2010
405 Citations (Scopus)

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Pipkin, M. E., Sacks, J. A., Cruz-Guilloty, F., Lichtenheld, M. G., Bevan, M. J. & Rao, A., Jan 29 2010, In : Immunity. 32, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

Interleukin-2
Interleukins
Inflammation
T-Lymphocytes
Perforin
31 Citations (Scopus)

The transcriptional control of the perforin locus

Pipkin, M. E., Rao, A. & Lichtenheld, M. G., May 1 2010, In : Immunological Reviews. 235, 1, p. 55-72 18 p.

Research output: Contribution to journalArticle

Perforin
Internal-External Control
Cytotoxic T-Lymphocytes
Natural Killer Cells
Genes
2009
246 Citations (Scopus)

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Cruz-Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y. & Rao, A., Jan 16 2009, In : Journal of Experimental Medicine. 206, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Proteins
Transcription Factors
Interferons
Granzymes
2008
34 Citations (Scopus)

HIV Nef Enhances Tat-Mediated Viral Transcription through a hnRNP-K-Nucleated Signaling Complex

Wolf, D., Witte, V., Clark, P., Blume, K., Lichtenheld, M. G. & Baur, A. S., Oct 16 2008, In : Cell Host and Microbe. 4, 4, p. 398-408 11 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
HIV
Phosphotransferases
NF-kappa B
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
48 Citations (Scopus)

IL-21 augments natural killer effector functions in chronically HIV-infected individuals

Strbo, N., De Armas, L., Liu, H., Kolber, M. A., Lichtenheld, M. G. & Pahwa, S. G., Aug 20 2008, In : AIDS. 22, 13, p. 1551-1560 10 p.

Research output: Contribution to journalArticle

Perforin
Interleukin-15
HIV
Natural Killer Cells
Interferons
2007
29 Citations (Scopus)

Chromosome Transfer Activates and Delineates a Locus Control Region for Perforin

Pipkin, M. E., Ljutic, B., Cruz-Guilloty, F., Nouzova, M., Rao, A., Zúñiga-Pflücker, J. C. & Lichtenheld, M. G., Jan 1 2007, In : Immunity. 26, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

Locus Control Region
Perforin
Chromosomes
Deoxyribonuclease I
Transgenes
93 Citations (Scopus)
Interleukin-15
Perforin
T-cells
Viruses
HIV-1
90 Citations (Scopus)

Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function

Rose, S., Lichtenheld, M. G., Foote, M. R. & Adkins, R. D., Mar 1 2007, In : Journal of Immunology. 178, 5, p. 2667-2678 12 p.

Research output: Contribution to journalArticle

Conserved Sequence
Thymocytes
Interleukin-4
STAT6 Transcription Factor
T-Lymphocytes
2006
13 Citations (Scopus)
Deoxyribonuclease I
Genome
Hypersensitivity
Genes
Perforin
2005
30 Citations (Scopus)

Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341

Buzzeo, R., Enkemann, S., Nimmanapalli, R., Alsina, M., Lichtenheld, M. G., Dalton, W. S. & Beaupre, D. M., Aug 15 2005, In : Clinical Cancer Research. 11, 16, p. 6057-6064 8 p.

Research output: Contribution to journalArticle

tipifarnib
Multiple Myeloma
Cell Line
Transferases
Drug Resistance
40 Citations (Scopus)

Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells

Zhu, K., Gerbino, E., Beaupre, D. M., Mackley, P. A., Muro-Cacho, C., Beam, C., Hamilton, A. D., Lichtenheld, M. G., Kerr, W. G., Dalton, W., Alsina, M. & Sebti, S. M., Jun 15 2005, In : Blood. 105, 12, p. 4759-4766 8 p.

Research output: Contribution to journalArticle

tipifarnib
Farnesyltranstransferase
docetaxel
Paclitaxel
Multiple Myeloma
2004
47 Citations (Scopus)

R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways

Beaupre, D. M., Cepero, E., Obeng, E. A., Boise, L. H. & Lichtenheld, M. G., Feb 1 2004, In : Molecular Cancer Therapeutics. 3, 2, p. 179-186 8 p.

Research output: Contribution to journalArticle

tipifarnib
Apoptosis
Endoplasmic Reticulum Stress
Caspase 9
Mitochondrial Membranes
2003
102 Citations (Scopus)

DNA methylation and chromatin structure regulate T cell perforin gene expression

Lu, Q., Wu, A., Ray, D., Deng, C., Attwood, J., Hanash, S., Pipkin, M., Lichtenheld, M. G. & Richardson, B., May 15 2003, In : Journal of Immunology. 170, 10, p. 5124-5132 9 p.

Research output: Contribution to journalArticle

Perforin
DNA Methylation
Chromatin
T-Lymphocytes
Gene Expression
18 Citations (Scopus)

Farnesyl transferase inhibitors enhance death receptor signals and induce apoptosis in multiple myeloma cells

Beaupre, D. M., McCafferty-Grad, J., Bahlis, N. J., Boise, L. H. & Lichtenheld, M. G., Dec 1 2003, In : Leukemia and Lymphoma. 44, 12, p. 2123-2134 12 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Transferases
Multiple Myeloma
tipifarnib
Apoptosis
2002
66 Citations (Scopus)

A role for NF-κB activation in perforin expression of NK cells upon IL-2 receptor signaling

Zhou, J., Zhang, J., Lichtenheld, M. G. & Meadows, G. G., Aug 1 2002, In : Journal of Immunology. 169, 3, p. 1319-1325 7 p.

Research output: Contribution to journalArticle

Perforin
Interleukin-2 Receptors
Natural Killer Cells
Transcription Factors
Up-Regulation
2001
71 Citations (Scopus)

Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

Malek, T., Yu, A., Scibelli, P., Lichtenheld, M. G. & Codias, E. K., Feb 1 2001, In : Journal of Immunology. 166, 3, p. 1675-1683 9 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptors
Cytokines
T-Lymphocytes
Antigens
Interleukin-2
1999
87 Citations (Scopus)

Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

Zhang, J., Scordi, I., Smyth, M. J. & Lichtenheld, M. G., Nov 1 1999, In : Journal of Experimental Medicine. 190, 9, p. 1297-1307 11 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Perforin
Interleukin-2 Receptors
Transcriptional Activation
Interleukins
1998
6 Citations (Scopus)

Potent inhibition of CTLA-4 expression by an anti-CTLA-4 ribozyme

Cepero, E., Hnatyszyn, H. J., Kraus, G. & Lichtenheld, M. G., Jun 29 1998, In : Biochemical and Biophysical Research Communications. 247, 3, p. 838-843 6 p.

Research output: Contribution to journalArticle

Gene transfer
Catalytic RNA
T-cells
T-Lymphocytes
Tumors
1997
23 Citations (Scopus)

Non-Killer Cell-Specific Transcription Factors Silence the Perforin Promoter

Zhang, Y. & Lichtenheld, M. G., Feb 15 1997, In : Journal of Immunology. 158, 4, p. 1734-1741 8 p.

Research output: Contribution to journalArticle

Perforin
Transcription Factors
Lymphocytes
Proteins
Reporter Genes
1995
24 Citations (Scopus)

Transgenic control of perform gene expression: Functional evidence for two separate control regions

Lichtenheld, M. G., Podack, E. R. & Levy, R. B., Dec 1 1995, In : Journal of Immunology. 154, 5, p. 2153-2163 11 p.

Research output: Contribution to journalArticle

Perforin
T-Lymphocytes
Gene Expression
Natural Killer Cells
Genetic Promoter Regions
1992
51 Citations (Scopus)

Perforin expression in human peripheral blood mononuclear cells: Definition of an IL-2-independent pathway of perforin induction in CD8+ T cells

Lu, P., Garcia-Sanz, J. A., Lichtenheld, M. G. & Podack, E. R., Jun 1 1992, In : Journal of Immunology. 148, 11, p. 3354-3360 7 p.

Research output: Contribution to journalArticle

Perforin
Interleukin-2
Blood Cells
Granzymes
T-Lymphocytes
24 Citations (Scopus)
Perforin
Gene Silencing
Genetic Promoter Regions
Transcriptional Activation
Chloramphenicol O-Acetyltransferase
1991
272 Citations (Scopus)

A central role of perforin in cytolysis?

Podack, E. R., Hengartner, H. & Lichtenheld, M. G., Dec 1 1991, In : Annual Review of Immunology. 9, 1, p. 129-157 29 p.

Research output: Contribution to journalArticle

Perforin
Granzymes
Secretory Vesicles
Graft Rejection
Virus Diseases
33 Citations (Scopus)

Perforin and granzyme B as markoers for acute rejection in heart transplantation

Clement, M. V., Haddad, P., Soulie, A., Benvenuti, C., Lichtenheld, M. G., Podack, E. R., Sigaux, N. & Sasportes, M., Jan 1 1991, In : International Immunology. 3, 11, p. 1175-1181 7 p.

Research output: Contribution to journalArticle

Heart Transplantation
Biopsy
Rejection
Acute
Grafts
1990
1 Citation (Scopus)

Chapter 14 Perforin and the Mechanism of Lymphocyte-Mediated Cytolysis

Podack, E. R. & Lichtenheld, M. G., Dec 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 161-175 15 p.

Research output: Contribution to journalArticle

1989
95 Citations (Scopus)

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9

Lowrey, D. M., Aebischer, T., Olsen, K., Lichtenheld, M. G., Rupp, F., Hengartner, H. & Podack, E. R., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 1, p. 247-251 5 p.

Research output: Contribution to journalArticle

Complement C9
Perforin
Organism Cloning
Complementary DNA
T-Lymphocytes
79 Citations (Scopus)

Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis

Hameed, A., Olsen, K. J., Lee, M. K., Lichtenheld, M. G. & Podack, E. R., Jan 1 1989, In : Journal of Experimental Medicine. 169, 3, p. 765-777 13 p.

Research output: Contribution to journalArticle

DNA
Monensin
Perforin
Egtazic Acid
Chloroquine
36 Citations (Scopus)

Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes

Nagler-Anderson, C., Lichtenheld, M. G., Eisen, H. N. & Podack, E. R., Dec 21 1989, In : Journal of Immunology. 143, 11, p. 3440-3443 4 p.

Research output: Contribution to journalArticle

Perforin
Cytotoxic T-Lymphocytes
Exudates and Transudates
Messenger RNA
Cell Line
26 Citations (Scopus)

Structure and function of perforin.

Podack, E. R., Olsen, K. J., Lowrey, D. M. & Lichtenheld, M. G., Jan 1 1989, In : Current Topics in Microbiology and Immunology. 140, p. 11-17 7 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
Cytoplasmic Granules
Perforin
Structure-Activity Relationship
Membrane Proteins
63 Citations (Scopus)

Structure of the human perforin gene. A simple gene organization with interesting potential regulatory sequences

Lichtenheld, M. G. & Podack, E. R., Dec 1 1989, In : Journal of Immunology. 143, 12, p. 4267-4274 8 p.

Research output: Contribution to journalArticle

Perforin
5' Flanking Region
Exons
5' Untranslated Regions
Response Elements
1988
89 Citations (Scopus)

Characterization of three serine esterases isolated from human IL-2 activated killer cells

Hameed, A., Lowrey, D. M., Lichtenheld, M. G. & Podack, E. R., Jan 1 1988, In : Journal of Immunology. 141, 9, p. 3142-3147 6 p.

Research output: Contribution to journalArticle

Granzymes
Interleukin-2
Esterases
Isoflurophate
Cytoplasmic Granules
16 Citations (Scopus)

Function of granule perforin and esterases in T cell-mediated reactions. Components required for delivery of molecules to target cells

Podack, E. R., Lowrey, D. M., Lichtenheld, M. G. & Hameed, A., Dec 1 1988, In : Annals of the New York Academy of Sciences. 532, p. 292-302 11 p.

Research output: Contribution to journalArticle

Perforin
T-cells
Esterases
T-Lymphocytes
Molecules
33 Citations (Scopus)

Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells

Lowrey, D. M., Hameed, A., Lichtenheld, M. G. & Podack, E. R., Jan 1 1988, In : Cancer Research. 48, 16, p. 4681-4688 8 p.

Research output: Contribution to journalArticle

Lymphokines
Interleukin-2
Lymphokine-Activated Killer Cells
Perforin
Carbamazepine
38 Citations (Scopus)

Structure, function and expression of murine and human perforin 1 (P1).

Podack, E. R., Lowrey, D. M., Lichtenheld, M. G., Olsen, K. J., Aebischer, T., Binder, D., Rupp, F. & Hengartner, H., Mar 1 1988, In : Immunological Reviews. 103, p. 203-211 9 p.

Research output: Contribution to journalArticle

Complement C9
Gene Expression Regulation
Molecular Cloning
Cytotoxic T-Lymphocytes
Membrane Proteins
267 Citations (Scopus)

Structure and function of human perforin

Lichtenheld, M. G., Olsen, K. J., Lu, P., Lowrey, D. M., Hameed, A., Hengartner, H. & Podack, E. R., Jan 1 1988, In : Nature. 335, 6189, p. 448-451 4 p.

Research output: Contribution to journalArticle

Perforin
Complement C9
Natural Killer Cells
T-Lymphocytes
Proteins