Mathias G Lichtenheld

Associate Professor

  • 2792 Citations
1988 …2018

Research output per year

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Research Output

  • 2792 Citations
  • 38 Article
  • 2 Review article
2018

Perforin-2 breaches the envelope of phagocytosed bacteria allowing antimicrobial effectors access to intracellular targets

Bai, F., McCormack, R. M., Hower, S., Plano, G. V., Lichtenheld, M. G. & Munson, G., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2710-2720 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

McCormack, R. M., de Armas, L. R., Shiratsuchi, M., Fiorentino, D. G., Olsson, M. L., Lichtenheld, M. G., Morales, A., Lyapichev, K., Gonzalez, L. E., Strbo, N., Sukumar, N., Stojadinovic, O., Plano, G. V., Munson, G. P., Tomic-Canic, M., Kirsner, R. S., Russell, D. G. & Podack, E. R., Sep 24 2015, In : eLife. 4, September2015, e06508.

Research output: Contribution to journalArticle

21 Scopus citations
2013

HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases

Lee, J. H., Wittki, S., Bräu, T., Dreyer, F. S., Krätzel, K., Dindorf, J., Johnston, I. C. D., Gross, S., Kremmer, E., Zeidler, R., Schlötzer-Schrehardt, U., Lichtenheld, M., Saksela, K., Harrer, T., Schuler, G., Federico, M. & Baur, A. S., Feb 21 2013, In : Molecular Cell. 49, 4, p. 668-679 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Understanding the biology of ex vivo-expanded CD8 T cells for adoptive cell therapy: Role of CD62L

Díaz-Montero, C. M., Zidan, A. A., Pallin, M. F., Anagnostopoulos, V., Salem, M. L., Wieder, E., Komanduri, K., Montero, A. J. & Lichtenheld, M. G., Dec 1 2013, In : Immunologic Research. 57, 1-3, p. 23-33 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells

Parmigiani, A., Pallin, M. F., Schmidtmayerova, H., Lichtenheld, M. G. & Pahwa, S., Feb 1 2011, In : Human Immunology. 72, 2, p. 115-123 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2010

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Pipkin, M. E., Sacks, J. A., Cruz-Guilloty, F., Lichtenheld, M. G., Bevan, M. J. & Rao, A., Jan 29 2010, In : Immunity. 32, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

426 Scopus citations

The transcriptional control of the perforin locus

Pipkin, M. E., Rao, A. & Lichtenheld, M. G., May 1 2010, In : Immunological reviews. 235, 1, p. 55-72 18 p.

Research output: Contribution to journalReview article

32 Scopus citations
2009

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Cruz-Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y. & Rao, A., Jan 16 2009, In : Journal of Experimental Medicine. 206, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

257 Scopus citations
2008

HIV Nef Enhances Tat-Mediated Viral Transcription through a hnRNP-K-Nucleated Signaling Complex

Wolf, D., Witte, V., Clark, P., Blume, K., Lichtenheld, M. G. & Baur, A. S., Oct 16 2008, In : Cell Host and Microbe. 4, 4, p. 398-408 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

IL-21 augments natural killer effector functions in chronically HIV-infected individuals

Strbo, N., De Armas, L., Liu, H., Kolber, M. A., Lichtenheld, M. & Pahwa, S., Aug 20 2008, In : AIDS. 22, 13, p. 1551-1560 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2007

Chromosome Transfer Activates and Delineates a Locus Control Region for Perforin

Pipkin, M. E., Ljutic, B., Cruz-Guilloty, F., Nouzova, M., Rao, A., Zúñiga-Pflücker, J. C. & Lichtenheld, M. G., Jan 1 2007, In : Immunity. 26, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
95 Scopus citations

Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function

Rose, S., Lichtenheld, M., Foote, M. R. & Adkins, B., Mar 1 2007, In : Journal of Immunology. 178, 5, p. 2667-2678 12 p.

Research output: Contribution to journalArticle

Open Access
94 Scopus citations
2006
13 Scopus citations
2005

Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341

Buzzeo, R., Enkemann, S., Nimmanapalli, R., Alsina, M., Lichtenheld, M. G., Dalton, W. S. & Beaupre, D. M., Aug 15 2005, In : Clinical Cancer Research. 11, 16, p. 6057-6064 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells

Zhu, K., Gerbino, E., Beaupre, D. M., Mackley, P. A., Muro-Cacho, C., Beam, C., Hamilton, A. D., Lichtenheld, M. G., Kerr, W. G., Dalton, W., Alsina, M. & Sebti, S. M., Jun 15 2005, In : Blood. 105, 12, p. 4759-4766 8 p.

Research output: Contribution to journalArticle

40 Scopus citations
2004

R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways

Beaupre, D. M., Cepero, E., Obeng, E. A., Boise, L. H. & Lichtenheld, M. G., Feb 1 2004, In : Molecular cancer therapeutics. 3, 2, p. 179-186 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2003

DNA methylation and chromatin structure regulate T cell perforin gene expression

Lu, Q., Wu, A., Ray, D., Deng, C., Attwood, J., Hanash, S., Pipkin, M., Lichtenheld, M. & Richardson, B., May 15 2003, In : Journal of Immunology. 170, 10, p. 5124-5132 9 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Farnesyl transferase inhibitors enhance death receptor signals and induce apoptosis in multiple myeloma cells

Beaupre, D. M., McCafferty-Grad, J., Bahlis, N. J., Boise, L. H. & Lichtenheld, M. G., Dec 1 2003, In : Leukemia and Lymphoma. 44, 12, p. 2123-2134 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2002

A role for NF-κB activation in perforin expression of NK cells upon IL-2 receptor signaling

Zhou, J., Zhang, J., Lichtenheld, M. G. & Meadows, G. G., Aug 1 2002, In : Journal of Immunology. 169, 3, p. 1319-1325 7 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations
2001

Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

Malek, T. R., Yu, A., Scibelli, P., Lichtenheld, M. G. & Codias, E. K., Feb 1 2001, In : Journal of Immunology. 166, 3, p. 1675-1683 9 p.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations
1999

Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

Zhang, J., Scordi, I., Smyth, M. J. & Lichtenheld, M. G., Nov 1 1999, In : Journal of Experimental Medicine. 190, 9, p. 1297-1307 11 p.

Research output: Contribution to journalArticle

87 Scopus citations
1998

Potent inhibition of CTLA-4 expression by an anti-CTLA-4 ribozyme

Cepero, E., Hnatyszyn, H. J., Kraus, G. & Lichtenheld, M. G., Jun 29 1998, In : Biochemical and biophysical research communications. 247, 3, p. 838-843 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
1997

Non-Killer Cell-Specific Transcription Factors Silence the Perforin Promoter

Zhang, Y. & Lichtenheld, M. G., Feb 15 1997, In : Journal of Immunology. 158, 4, p. 1734-1741 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
1995

Transgenic control of perforin gene expression: Functional evidence for two separate control regions

Lichtenheld, M. G., Podack, E. R. & Levy, R. B., Jan 1 1995, In : Journal of Immunology. 154, 5, p. 2153-2163 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
1992

Perforin expression in human peripheral blood mononuclear cells: Definition of an IL-2-independent pathway of perforin induction in CD8+ T cells

Lu, P., Garcia-Sanz, J. A., Lichtenheld, M. G. & Podack, E. R., Jan 1 1992, In : Journal of Immunology. 148, 11, p. 3354-3360 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
24 Scopus citations
1991

A central role of perforin in cytolysis?

Podack, E. R., Hengartner, H. & Lichtenheld, M. G., Jan 1 1991, In : Annual Review of Immunology. 9, 1, p. 129-157 29 p.

Research output: Contribution to journalArticle

273 Scopus citations

Perforin and granzyme B as markers for acute rejection in heart transplantation

Clément, M. V., Haddad, P., Soulié, A., Benvenuti, C., Lichtenheld, M. G., Podack, E. R., Sigaux, N. & Sasportes, M., Nov 1 1991, In : International Immunology. 3, 11, p. 1175-1181 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
1990

Chapter 14 Perforin and the Mechanism of Lymphocyte-Mediated Cytolysis

Podack, E. R. & Lichtenheld, M. G., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 161-175 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
1989

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9

Lowrey, D. M., Aebischer, T., Olsen, K., Lichtenheld, M., Rupp, F., Hengartner, H. & Podack, E. R., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 1, p. 247-251 5 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations

Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis

Hameed, A., Olsen, K. J., Lee, M. K., Lichtenheld, M. G. & Podack, E. R., 1989, In : Journal of Experimental Medicine. 169, 3, p. 765-777 13 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes

Nagler-Anderson, C., Lichtenheld, M., Eisen, H. N. & Podack, E. R., Dec 21 1989, In : Journal of Immunology. 143, 11, p. 3440-3443 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

Structure and function of perforin.

Podack, E. R., Olsen, K. J., Lowrey, D. M. & Lichtenheld, M., Jan 1 1989, In : Current topics in microbiology and immunology. 140, p. 11-17 7 p.

Research output: Contribution to journalReview article

26 Scopus citations

Structure of the human perforin gene. A simple gene organization with interesting potential regulatory sequences

Lichtenheld, M. G. & Podack, E. R., Dec 1 1989, In : Journal of Immunology. 143, 12, p. 4267-4274 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
1988

Characterization of three serine esterases isolated from human IL-2 activated killer cells

Hameed, A., Lowrey, D. M., Lichtenheld, M. & Podack, E. R., Jan 1 1988, In : Journal of Immunology. 141, 9, p. 3142-3147 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Function of Granule Perform and Esterases in T Cell‐Mediated Reactions: Components Required for Delivery of Molecules to Target Cells

PODACK, ECKHARD. R., LOWREY, DAVID. M., LICHTENHELD, MATHIAS. & HAMEED, ARIF., Aug 1988, In : Annals of the New York Academy of Sciences. 532, 1, p. 292-302 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells

Lowrey, D. M., Hameed, A., Lichtenheld, M. & Podack, E. R., Jan 1 1988, In : Cancer Research. 48, 16, p. 4681-4688 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure, Function and Expression of Murine and Human Perforin 1 (P1)

Podack, E. R., Lowrey, D. M., Lichtenheld, M., Olsen, K. J., Aebischer, T., Binder, D., Rupp, F. & Hengartner, H., Jun 1988, In : Immunological reviews. 103, 1, p. 203-211 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Structure and function of human perforin

Lichtenheld, M. G., Olsen, K. J., Lu, P., Lowrey, D. M., Hameed, A., Hengartner, H. & Podack, E. R., Jan 1 1988, In : Nature. 335, 6189, p. 448-451 4 p.

Research output: Contribution to journalArticle

270 Scopus citations