Mark E Sharkey

Research Assistant Professor

  • 2245 Citations
19962020

Research output per year

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Research Output

  • 2245 Citations
  • 25 Article
  • 2 Review article
  • 1 Chapter
2020

A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption

Andrade, V. M., Mavian, C., Babic, D., Cordeiro, T., Sharkey, M., Barrios, L., Brander, C., Martinez-Picado, J., Dalmau, J., Llano, A., Li, J. Z., Jacobson, J., Lavine, C. L., Seaman, M. S., Salemi, M. & Stevenson, M., May 5 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 18, p. 9981-9990 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

HIV-1 escape from small-molecule antagonism of Vif

Sharkey, M., Sharova, N., Mohammed, I., Huff, S. E., Kummetha, I. R., Singh, G., Rana, T. M. & Stevenson, M., Jan 1 2019, In : mBio. 10, 1, e00144-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Occupational Exposure to the Ugandan Research Strain (MR766) of Zika Virus

Lichtenberger, P. N., Ricciardi, M. J., Solorzano, D., Raccamarich, P., Leda, A., Sharkey, M., Watkins, D. I., El Sahly, H., Rouphael, N., Mulligan, M. J., Doblecki-Lewis, S., Stevenson, M. & Alcaide, M. L., Oct 1 2019, In : Open Forum Infectious Diseases. 6, 10, ofz420.

Research output: Contribution to journalArticle

Open Access

Post-traumatic Stress Disorder, Cocaine Use, and HIV Persistence

Oni, O., Glynn, T. R., Antoni, M. H., Jemison, D., Rodriguez, A., Sharkey, M., Salinas, J., Stevenson, M. & Carrico, A. W., Oct 1 2019, In : International journal of behavioral medicine. 26, 5, p. 542-550 9 p.

Research output: Contribution to journalArticle

Psychosocial Correlates of Monocyte Activation and HIV Persistence in Methamphetamine Users

Grosgebauer, K., Salinas, J., Sharkey, M., Roach, M., Pallikkuth, S., Dilworth, S. E., Pahwa, S., Koru-Sengul, T., Stevenson, M. & Carrico, A. W., Mar 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL

Ricciardi, M. J., Magnani, D. M., Grifoni, A., Kwon, Y. C., Gutman, M. J., Grubaugh, N. D., Gangavarapu, K., Sharkey, M., Silveira, C. G. T., Bailey, V. K., Pedreño-Lopez, N., Gonzalez-Nieto, L., Maxwell, H. S., Domingues, A., Martins, M. A., Pham, J., Weiskopf, D., Altman, J., Kallas, E. G., Andersen, K. G. & 6 others, Stevenson, M., Lichtenberger, P., Choe, H., Whitehead, S. S., Sette, A. & Watkins, D. I., Dec 21 2017, In : PLoS neglected tropical diseases. 11, 12, e0006000.

Research output: Contribution to journalArticle

19 Scopus citations
2016
67 Scopus citations
2015

HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles

Côrtes, F. H., Passaes, C. P. B., Bello, G., Teixeira, S. L. M., Vorsatz, C., Babic, D., Sharkey, M., Grinsztejn, B., Veloso, V., Stevenson, M. & Morgado, M. G., Apr 1 2015, In : Journal of Acquired Immune Deficiency Syndromes. 68, 4, p. 377-385 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Restriction of retroviral infection of macrophages

Sharkey, M., Sep 3 2013, Intrinsic Immunity. Cullen, B. (ed.). p. 105-122 18 p. (Current Topics in Microbiology and Immunology; vol. 371).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Restriction of retroviral infection of macrophages.

Sharkey, M., Aug 26 2013, In : Current Topics in Microbiology and Immunology. 371, p. 105-122 18 p.

Research output: Contribution to journalArticle

Tracking episomal HIV DNA: Implications for viral persistence and eradication of HIV

Sharkey, M., Mar 1 2013, In : Current Opinion in HIV and AIDS. 8, 2, p. 93-99 7 p.

Research output: Contribution to journalReview article

7 Scopus citations
2011

Episomal viral cDNAS identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure

Sharkey, M., Babic, D. Z., Greenough, T., Gulick, R., Kuritzkes, D. R. & Stevenson, M., Feb 2011, In : PLoS pathogens. 7, 2, e1001303.

Research output: Contribution to journalArticle

60 Scopus citations
2010

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

J Buzón, M., Massanella, M., Llibre, J. M., Esteve, A., Dahl, V., Puertas, M. C., Gatell, J. M., Domingo, P., Paredes, R., Sharkey, M., Palmer, S., Stevenson, M., Clotet, B., Blanco, J. & Martinez-Picado, J., Apr 1 2010, In : Nature medicine. 16, 4, p. 460-465 6 p.

Research output: Contribution to journalArticle

411 Scopus citations
2008

Mutation detection using ENDO1: Application to disease diagnostics in humans and TILLING and Eco-TILLING in plants

Triques, K., Piednoir, E., Dalmais, M., Schmidt, J., Le Signor, C., Sharkey, M., Caboche, M., Sturbois, B. & Bendahmane, A., Apr 23 2008, In : BMC Molecular Biology. 9, 42.

Research output: Contribution to journalArticle

39 Scopus citations

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction

Sharova, N., Wu, Y., Zhu, X., Stranska, R., Kaushik, R., Sharkey, M. & Stevenson, M., May 2008, In : PLoS pathogens. 4, 5, e1000057.

Research output: Contribution to journalArticle

140 Scopus citations

Small-molecule inhibition of HIV-1 Vif

Nathans, R., Cao, H., Sharova, N., Ali, A., Sharkey, M., Stranska, R., Stevenson, M. & Rana, T. M., Oct 1 2008, In : Nature Biotechnology. 26, 10, p. 1187-1192 6 p.

Research output: Contribution to journalArticle

147 Scopus citations
2005

In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA

Sharkey, M., Triques, K., Kuritzkes, D. R. & Stevenson, M., Apr 2005, In : Journal of virology. 79, 8, p. 5203-5210 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Macrophages archive HIV-1 virions for dissemination in trans

Sharova, N., Swingler, C., Sharkey, M. & Stevenson, M., Jul 6 2005, In : EMBO Journal. 24, 13, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

143 Scopus citations
2003

HIV-1 replication increases HIV-specific CD4+ T cell frequencies but limits proliferative capacity in chronically infected children

Scott, Z. A., Beaumier, C. M., Sharkey, M., Stevenson, M. & Luzuriaga, K., Jun 1 2003, In : Journal of Immunology. 170, 11, p. 5786-5792 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2002

Evidence for a cytopathogenicity determinant in HIV-1 Vpr

Somasundaran, M., Sharkey, M., Brichacek, B., Luzuriaga, K., Emerman, M., Sullivan, J. L. & Stevenson, M., Jul 9 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 14, p. 9503-9508 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1

Keppler, O. T., Welte, F. J., Ngo, T. A., Chin, P. S., Patton, K. S., Tsou, C. L., Abbey, N. W., Sharkey, M. E., Grant, R. M., You, Y., Scarborough, J. D., Ellmeier, W., Littman, D. R., Stevenson, M., Charo, I. F., Herndier, B. G., Speck, R. F. & Goldsmith, M. A., Mar 18 2002, In : Journal of Experimental Medicine. 195, 6, p. 719-736 18 p.

Research output: Contribution to journalArticle

82 Scopus citations
2001

Two long terminal repeat circles and persistent HIV-1 replication

Sharkey, M. E. & Stevenson, M., Jan 1 2001, In : Current Opinion in Infectious Diseases. 14, 1, p. 5-11 7 p.

Research output: Contribution to journalReview article

17 Scopus citations
2000

Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: Control of viral replication and absence of persistent HIV-1- specific immune responses

Luzuriaga, K., McManus, M., Catalina, M., Mayack, S., Sharkey, M., Stevenson, M., Sullivan, J. L., Gay, H., Vink, P., Pahwa, S., Bakshi, S., Borkowsky, W., Cunningham, C., Pelton, S., Spector, S., Mofenson, L. & Smith, B., Aug 2000, In : Journal of virology. 74, 15, p. 6984-6991 8 p.

Research output: Contribution to journalArticle

164 Scopus citations

Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

Sharkey, M. E., Teo, I., Greenough, T., Sharova, N., Luzuriaga, K., Sullivan, J. L., Bucy, R. P., Kostrikis, L. G., Haase, A., Veryard, C., Davaro, R. E., Cheeseman, S. H., Daly, J. S., Bova, C., Ellison, R. T., Mady, B., Lai, K. K., Moyle, G., Nelson, M., Gazzard, B. & 2 others, Shaunak, S. & Stevenson, M., Jan 2000, In : Nature medicine. 6, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

360 Scopus citations
1998

Differential association of uracil DNA glycosylase with SIV(SM) Vpr and Vpx proteins

Sleigh, R., Sharkey, M., Newman, M. A., Hahn, B. & Stevenson, M., Jun 5 1998, In : Virology. 245, 2, p. 338-343 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Vpx is required for dissemination and pathogenesis of SIV(SM) PBj: Evidence of macrophage-dependent viral amplification

Hirsch, V. M., Sharkey, M. E., Brown, C. R., Brichacek, B., Goedstein, S., Wakefield, J., Byrum, R., Elkins, W. R., Hahn, B. H., Lifson, J. D. & Stevenson, M., Dec 1 1998, In : Nature medicine. 4, 12, p. 1401-1408 8 p.

Research output: Contribution to journalArticle

150 Scopus citations
1997

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1

Briggs, S. D., Sharkey, M., Stevenson, M. & Smithgall, T. E., Jul 18 1997, In : Journal of Biological Chemistry. 272, 29, p. 17899-17902 4 p.

Research output: Contribution to journalArticle

170 Scopus citations
1996

Matrix metalloproteinase expression during mouse peri-implantation development

Sharkey, M. E., Adler, R. R., Nieder, G. L. & Brenner, C. A., Aug 1996, In : American Journal of Reproductive Immunology. 36, 2, p. 72-80 9 p.

Research output: Contribution to journalArticle

26 Scopus citations