Lynn G Feun

Professor

  • 4839 Citations
1979 …2020

Research output per year

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Research Output

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A Case of Intracranial Hemorrhage Caused by Combined Dabrafenib and Trametinib Therapy for Metastatic Melanoma

Lee, L. M., Feun, L. & Tan, Y., Oct 12 2014, In : American Journal of Case Reports. 15, p. 441-443 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

A clinical trial of intravenous vinorelbine tartrate plus tamoxifen in the treatment of patients with advanced malignant melanoma

Feun, L. G., Savaraj, N., Hurley, J., Marini, A. & Lai, S., Feb 1 2000, In : Cancer. 88, 3, p. 584-588 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells

Tsai, W. B., Aiba, I., Long, Y., Lin, H. K., Feun, L., Savaraj, N. & Kuo, M. T., May 15 2012, In : Cancer Research. 72, 10, p. 2622-2633 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

Activity of pirarubicin (4′‐o‐tetrahydropyranyladriamycin) in malignant mesothelioma

Sridhar, K. S., Hussein, A. M., Feun, L. G. & Gordon Zubrod, C., Mar 15 1989, In : Cancer. 63, 6, p. 1084-1091 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Adjuvant chemotherapy with carmustine and cisplatin for patients with malignant gliomas

Yung, W. K. A., Janus, T. J., Maor, M. & Feun, L. G., Feb 1 1992, In : Journal of neuro-oncology. 12, 2, p. 131-135 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Advanced extramammary Paget's disease of the groin, penis, and scrotum

Isrow, D., Oregel, K. Z., Cortes, J., Gomez, H., Milikowski, C., Feun, L. & Silva, O. E., Jul 6 2014, In : Clinical Medicine Insights: Oncology. 8, p. 87-90 4 p.

Research output: Contribution to journalArticle

15 Scopus citations
14 Scopus citations

A phase II study of intraperitoneal cisplatin and thiotepa in residual ovarian carcinoma: A gynecologic oncology group study

Feun, L. G., Blessing, J. A., Major, F. J., DiSaia, P. J., Alvarez, R. D. & Berek, J. S., Dec 1998, In : Gynecologic oncology. 71, 3, p. 410-415 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma

Ardalan, B., Chua, L., Tian, E. M., Reddy, R., Sridhar, K., Benedetto, P., Richman, S., Legaspi, A., Waldman, S., Morrell, L., Feun, L., Savaraj, N. & Livingstone, A., Jan 1 1991, In : Journal of Clinical Oncology. 9, 4, p. 625-630 6 p.

Research output: Contribution to journalArticle

230 Scopus citations

A phase II trial of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea (PCNU, NSC 95466) in recurrent malignant brain tumors

Feun, L. G., Stewart, D. J., Leavens, M. E., Burgess, M. A., Savaraj, N., Benjamin, R. S. & Bodey, G. P., Mar 1 1983, In : Journal of neuro-oncology. 1, 1, p. 45-48 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

A phase II trial of 2,5,-diaziridinyl 3,6-bis (carboethoxy amino) 1,4-benzoquinone (AZQ, NSC 182986) in recurrent primary brain tumors

Feun, L. G., Yung, W. K. A., Leavens, M. E., Burgess, M. A., Obbens, E. A., Bedikian, A. Y., Savaraj, N., Stewart, D. J., Benjamin, R. S., Fields, W. S. & Bodey, G. P., Mar 1 1984, In : Journal of neuro-oncology. 2, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

A phase II trial of PCNU in patients with malignant melanoma and central nervous system metastases

Feldman, L. D., Feun, L. G., Benjamin, R. S., Yap, B. S., Plager, C., Papadopoulos, N., Savaraj, N., Burgess, M. A. & Bodey, G. P., Jan 1 1985, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 8, 3, p. 215-217 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
15 Scopus citations
67 Scopus citations

A phase i study of 4′‐0‐tetrahydropyranyladriamycin: Clinical pharmacology and pharmacokinetics

Sridhar, K. S., Samy, T. S. A., Agarwal, R. P., Duncan, R. C., Benedetto, P., Ganju-Krishan, A. K., Vogel, C. L., Feun, L. G., Savaraj, N. M., Richman, S. P. & Zubrod, C. G., Nov 15 1990, In : Cancer. 66, 10, p. 2082-2091 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

A phase I study of chemoembolization with cisplatin, thiotepa, and lipiodol for primary and metastatic liver cancer

Feun, L. G., Reddy, K. R., Scagnelli, T., Yrizarry, J. M., Guerra, J. J., Russell, E., Schwartz, M., Savaraj, N., Livingstone, A. S., Levi, J. U., Jeffers, L. J., Ardalan, B. & Schiff, E. R., Aug 1 1999, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 22, 4, p. 375-380 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

A Phase I study of chemoembolization with cisplatin and lipiodol for primary and metastatic liver cancer

Feun, L. G., Reddy, K. R., Yrizarry, J. M., Savaraj, N., Guerra, J. J., Purser, R. K., Waldman, S., Levi, J. U., Moffatt, F., Morrell, L., Livingstone, A. S., Ardalan, B. & Benedetto, P., Jan 1 1994, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 17, 5, p. 405-410 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

A Phase I Study of Intracarotid Artery Infusion of Cis-Diamminedichloroplatinum(II) in Patients with Recurrent Malignant Intracerebral Tumors

Stewart, D. J., Benjamin, R. S., Feun, L., Mavligit, G., Wallace, S., Handel, S., Leavens, M. & Young, S. E., May 1 1982, In : Cancer Research. 42, 5, p. 2059-2062 4 p.

Research output: Contribution to journalArticle

89 Scopus citations

A Pilot Clinical and Pharmacokinetic Study of Intracarotid Cisplatin and Bleomycin

Feun, L. G., Savaraj, N., Lee, Y. Y., Landy, H., Martinez-Prieto, J., Charnsangavej, C., Post, J. D., Lee, K. F., Wallace, S., Bowen, B., Kochan, J. P. & Yung, W. K. A., Jan 1 1991, In : Selective Cancer Therapeutics. 7, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa

Savaraj, N., Feun, L. G., Blyden, G., Yrizarry, J. M., Hsiang, J. T. G., Curtas, J., Waldman, S., Post, J. D., Benedetto, P., Landy, H. & Guerra, J. J., Jan 1 1993, In : Cancer Biotherapy. 8, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

A pilot study of cis-diamminedichloroplatinum and radiation therapy in patients with high grade astrocytomas

Feun, L. G., Stewart, D. J., Maor, M., Leavens, M., Savaraj, N., Burgess, M. A., Yung, W. K. A. & Benjamin, R. S., Jun 1 1983, In : Journal of neuro-oncology. 1, 2, p. 109-113 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

Prados, M. D., Schold, S. C., Fine, H. A., Jaeckle, K., Hochberg, F., Mechtler, L., Fetell, M. R., Phuphanich, S., Feun, L., Janus, T. J., Ford, K. & Graney, W., Apr 1 2003, In : Neuro-Oncology. 5, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

127 Scopus citations

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

Long, Y., Tsai, W. B., Wangpaichitr, M., Tsukamoto, T., Savaraj, N., Feun, L. G. & Kuo, M. T., Nov 2013, In : Molecular cancer therapeutics. 12, 11, p. 2581-2590 10 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Arginine deprivation, autophagy, apoptosis (aaa) for the treatment of melanoma

Savaraj, N., You, M., Wu, C., Wangpaichitr, M., Kuo, M. T. & Feun, L. G., Jun 18 2010, In : Current Molecular Medicine. 10, 4, p. 405-412 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., Mar 1 2017, In : Cancer Letters. 388, p. 54-63 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Autoantibodies against retinal bipolar cells in cutaneous melanoma- associated retinopathy

Milam, A. H., Saari, J. C., Jacobson, S. G., Lubinski, W. P., Feun, L. G. & Alexander, K. R., Jan 1 1993, In : Investigative Ophthalmology and Visual Science. 34, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

190 Scopus citations

BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma

Li, Y. Y., Wu, C., Chen, S. M., Shah, S. S., Wangpaichitr, M., Feun, L. G., Kuo, M. T., Suarez, M., Prince, J. & Savaraj, N., 2016, In : Oncotarget. 7, 14, p. 17665-17680 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Carcinoid tumor presenting as central nervous system symptoms. Case report and review of th literature

Hussein, A. M., Feun, L. G., Savaraj, N., East, D. & Hussein, D. T., Jan 1 1990, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 13, 3, p. 251-255 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Carcinomatous meningitis from transitional cell carcinoma of the bladder: Case report

Hussein, A. M., Savaraj, N., Feun, L. G., Ganjei-Azar, P. & Donnelly, E., Sep 1 1989, In : Journal of neuro-oncology. 7, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Central nervous system (CNS) penetration of homoharringtonine (HHT)

Savaraj, N., Feun, L. G., Lu, K., Leavens, M., Moser, R., Fields, W. S. & Loo, T. L., Mar 1 1987, In : Journal of neuro-oncology. 5, 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Chemotherapy for metastatic merkel cell carcinoma. Review of the M. D. Anderson hospital's experience

Feun, L. G., Savaraj, N., Legha, S. S., Silva, E. G., Benjamin, R. S. & Burgess, M. A., Aug 15 1988, In : Cancer. 62, 4, p. 683-685 3 p.

Research output: Contribution to journalArticle

109 Scopus citations

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., Dec 1 2017, In : Scientific Reports. 7, 1, 10814.

Research output: Contribution to journalArticle

2 Scopus citations
10 Scopus citations

Cisplatin in medulloblastoma with extracranial metastasis: A case report

Feun, L. G., Savaraj, N. & Ozarda, A. T., Jan 1 1984, In : Cancer Treatment Reports. 68, 10, p. 1307-1309 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical and pharmacological study of intrahepatic artery infusion of Thiotepa

Feun, L. G., Blyden, G., Yrizarry, J., Dorvil, M., Waldman, S., Benedetto, P., Donnelly, E., Curtas, J., George, M. & Savaraj, N., Jan 1 1993, In : Cancer Biotherapy. 8, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Clinical pharmacolinetics of 9, 10-anthracenedicarboxaldehyde-bis [(4,5-dihydro-1 H-imidazol-2-yl)hydrazone]dihydrochloride

Lu, K., Savaraj, N., Yap, B. S., Feun, L. G., Umsawasdi, T. & Loo, T. L., Mar 1 1986, In : Cancer Chemotherapy And Pharmacology. 16, 2, p. 156-159 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Clinical pharmacology of 2,5′-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ)

Lu, K., Savaraj, N., Yap, B. S., Bedikian, A. Y., Feun, L., Benjamin, R. S. & Loo, T. L., May 1983, In : European Journal of Cancer and Clinical Oncology. 19, 5, p. 603-606 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Clinical pharmacology of 4-demethoxydaunorubicin (DMDR)

Lu, K., Savaraj, N., Kavanagh, J., Feun, L. G., Burgess, M., Bodey, G. P. & Loo, T. L., Jun 1 1986, In : Cancer Chemotherapy And Pharmacology. 17, 2, p. 143-148 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Clinical pharmacology of homoharringtonine

Savaraj, N., Lu, K., Dimery, I., Feun, L. G., Burgess, M., Keating, M. & Loo, T. L., Dec 1 1986, In : Cancer Treatment Reports. 70, 12, p. 1403-1407 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Clinical pharmacology of intracarotid etoposide

Savaraj, N., Feun, L. G., Lu, K., Wallace, S., Fields, W. S. & Loo, T. L., Apr 1 1986, In : Cancer Chemotherapy And Pharmacology. 16, 3, p. 292-294 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors

Feun, L. G., Marini, A., Landy, H., Markoe, A., Heros, D., Robles, C., Herrera, C. & Savaraj, N., Apr 1 2007, In : Journal of neuro-oncology. 82, 2, p. 177-181 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Kuo, M. T., Long, Y., Tsai, W. B., Li, Y. Y., Chen, H. H. W., Feun, L. G. & Savaraj, N., Feb 2020, In : Translational Oncology. 13, 2, p. 355-364 10 p.

Research output: Contribution to journalArticle

Open Access

Combination of Arginine deprivation with TRAIL treatment as a targeted-therapy for mesothelioma

Wangpaichitr, M., Wu, C., Bigford, G., Theodoropoulos, G., You, M., Li, Y. Y., Verona-Santos, J., Feun, L. G., Nguyen, D. M. & Savaraj, N., Dec 1 2014, In : Anticancer research. 34, 12, p. 6991-6999 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Comparison of CNS penetration, tissue distribution, and pharmacology of VP 16-213 by intracarotid and intravenous administration in dogs

Savaraj, N., Lu, K., Feun, L. G., Burgess, M. A. & Loo, T. L., Jan 1 1987, In : Cancer Investigation. 5, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer

Savaraj, N., Xu, R., Landy, H., Lai, S., Sternau, L., Solomon, J., Wu, C. J., Lampidis, T. & Feun, L. G., Jul 1 1997, In : Oncology Reports. 4, 4, p. 857-861 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Correlation of a unique 220-kDa protein with vitamin D sensitivity in glioma cells

Zou, J., Landy, H., Feun, L., Xu, R., Lampidis, T., Wu, C. J., Furst, A. J. & Savaraj, N., Nov 1 2000, In : Biochemical Pharmacology. 60, 9, p. 1361-1365 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
11 Scopus citations

Cytogenetic studies on the in vitro genotoxicity of 4-nitroquinoline-1- oxide on human lymphocytes

Hsu, T. C., Savaraji, N., Trizna, Z., Feun, L., Furlong, C., Schantz, S. P. & Shirley, L., Jan 1 1993, In : International journal of oncology. 3, 5, p. 823-826 4 p.

Research output: Contribution to journalArticle

11 Scopus citations