Lynn G Feun

Professor

  • 4861 Citations
1979 …2020

Research output per year

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Research Output

2020

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Kuo, M. T., Long, Y., Tsai, W. B., Li, Y. Y., Chen, H. H. W., Feun, L. G. & Savaraj, N., Feb 2020, In : Translational Oncology. 13, 2, p. 355-364 10 p.

Research output: Contribution to journalArticle

Open Access

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Durante, M. A., Rodriguez, D. A., Kurtenbach, S., Kuznetsov, J. N., Sanchez, M. I., Decatur, C. L., Snyder, H., Feun, L. G., Livingstone, A. S. & Harbour, J. W., Dec 1 2020, In : Nature communications. 11, 1, 496.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Targeting the kynurenine pathway for the treatment of cisplatin-resistant lung cancer

Nguyen, D. J. M., Theodoropoulos, G., Li, Y. Y., Wu, C., Sha, W., Feun, L. G., Lampidis, T. J., Savaraj, N. & Wangpaichitr, M., Jan 1 2020, In : Molecular Cancer Research. 18, 1, p. 105-117 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

First-in-human phase i study of fisogatinib (BLU-554) validates aberrant FGF19 signaling as a driver event in hepatocellular carcinoma

Kim, R. D., Sarker, D., Meyer, T., Yau, T., Macarulla, T., Park, J. W., Choo, S. P., Hollebecque, A., Sung, M. W., Lim, H. Y., Mazzaferro, V., Trojan, J., Zhu, A. X., Yoon, J. H., Sharma, S., Lin, Z. Z., Chan, S. L., Faivre, S., Feun, L. G., Yen, C. J. & 15 others, Dufour, J. F., Palmer, D. H., Llovet, J. M., Manoogian, M., Tugnait, M., Stransky, N., Hagel, M., Kohl, N. E., Lengauer, C., Sherwin, C. A., Schmidt-Kittler, O., Hoeflich, K. P., Shi, H., Wolf, B. B. & Kang, Y. K., Dec 2019, In : Cancer discovery. 9, 12, p. 1696-1707 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
8 Scopus citations
2018

Optical coherence tomography imaging of melanoma skin cancer

Rajabi-Estarabadi, A., Bittar, J. M., Zheng, C., Nascimento, V., Camacho, I., Feun, L. G., Nasiriavanaki, M., Kunz, M. & Nouri, K., Jan 1 2018, (Accepted/In press) In : Lasers in Medical Science.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., Mar 1 2017, In : Cancer Letters. 388, p. 54-63 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Autophagic mechanism in anti-cancer immunity: Its pros and cons for cancer therapy

Li, Y. Y., Feun, L. G., Thongkum, A., Tu, C. H., Chen, S. M., Wangpaichitr, M., Wu, C., Kuo, M. T. & Savaraj, N., Jun 19 2017, In : International journal of molecular sciences. 18, 6, 1297.

Research output: Contribution to journalReview article

11 Scopus citations

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., Dec 1 2017, In : Scientific Reports. 7, 1, 10814.

Research output: Contribution to journalArticle

2 Scopus citations

Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation

Li, Y. Y., Wu, C., Shah, S. S., Chen, S. M., Wangpaichitr, M., Kuo, M. T., Feun, L. G., Han, X., Suarez, M., Prince, J. S. & Savaraj, N., Dec 1 2017, In : Molecular Oncology. 11, 12, p. 1806-1825 20 p.

Research output: Contribution to journalArticle

2 Scopus citations

Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer

Wangpaichitr, M., Wu, C., Li, Y. Y., Nguyen, D. J. M., Kandemir, H., Shah, S., Chen, S., Feun, L. G., Prince, J. S., Kuo, M. T. & Savaraj, N., 2017, In : Oncotarget. 8, 30, p. 49275-49292 18 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tumor necrosis factor-related apoptosis-inducing ligand induces autophagic protein cleavage in melanoma cells

You, M., Nguyen, D., Feun, L. G., Kuo, M. T., Wangpaichitr, M., Wu, C. & Savaraj, N., Jan 1 2017, Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Volume 12. Elsevier, p. 473-487 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma

Li, Y. Y., Wu, C., Chen, S. M., Shah, S. S., Wangpaichitr, M., Feun, L. G., Kuo, M. T., Suarez, M., Prince, J. S. & Savaraj, N., 2016, In : Oncotarget. 7, 14, p. 17665-17680 16 p.

Research output: Contribution to journalArticle

8 Scopus citations
10 Scopus citations

Pilot study of intrahepatic artery chemotherapy in combination with sorafenib in hepatocellular carcinoma

Dinh, V., Bhatia, S., Narayanan, G., Yrizarry, J., Savaraj, N., O'Brien, C. B., Martin, P. & Feun, L. G., 2016, In : Anticancer Research. 36, 7, p. 3555-3563 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Arginine deprivation in cancer therapy

Feun, L. G., Kuo, M. T. & Savaraj, N., Jan 12 2015, In : Current Opinion in Clinical Nutrition and Metabolic Care. 18, 1, p. 78-82 5 p.

Research output: Contribution to journalReview article

39 Scopus citations

Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG s9005

Ji, Y., Rankin, C., Grunberg, S., Sherrod, A. E., Ahmadi, J., Townsend, J. J., Feun, L. G., Fredericks, R. K., Russell, C. A., Kabbinavar, F. F., Stelzer, K. J., Schott, A. & Verschraegen, C., Dec 1 2015, In : Journal of Clinical Oncology. 33, 34, p. 4093-4098 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

Tsai, W. B., Long, Y., Park, J. R., Chang, J. T., Liu, H., Rodriguez-Canales, J., Savaraj, N., Feun, L. G., Davies, M. A., Wistuba, I. I. & Kuo, M. T., Jun 22 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

9 Scopus citations

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

Savaraj, N., Wu, C., Li, Y. Y., Wangpaichitr, M., You, M., Bomalaski, J., He, W., Kuo, M. T. & Feun, L. G., 2015, In : Oncotarget. 6, 8, p. 6295-6309 15 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

Chen, H. H. W., Chen, W. C., Liang, Z. D., Tsai, W. B., Long, Y., Aiba, I., Fu, S., Broaddus, R., Liu, J., Feun, L. G., Savaraj, N. & Kuo, M. T., Oct 3 2015, In : Expert Opinion on Therapeutic Targets. 19, 10, p. 1307-1317 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

A Case of Intracranial Hemorrhage Caused by Combined Dabrafenib and Trametinib Therapy for Metastatic Melanoma

Lee, L. M., Feun, L. & Tan, Y., Oct 12 2014, In : American Journal of Case Reports. 15, p. 441-443 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Advanced extramammary Paget's disease of the groin, penis, and scrotum

Isrow, D., Oregel, K. Z., Cortes, J., Gomez, H., Milikowski, C., Feun, L. & Silva, O. E., Jul 6 2014, In : Clinical Medicine Insights: Oncology. 8, p. 87-90 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Combination of Arginine deprivation with TRAIL treatment as a targeted-therapy for mesothelioma

Wangpaichitr, M., Wu, C., Bigford, G., Theodoropoulos, G., You, M., Li, Y. Y., Verona-Santos, J., Feun, L. G., Nguyen, D. M. & Savaraj, N., Dec 1 2014, In : Anticancer research. 34, 12, p. 6991-6999 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

T cell co-regulatory signals and their role in cancer therapy

Friedman, E. R., Feun, L. G., Benedetto, P. W. & Rosenblatt, J. D., Jan 1 2014, Advances in Tumor Immunology and Immunotherapy. Springer New York, p. 323-341 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

T Cell Co-regulatory Signals and Their Role in Cancer Therapy

Friedman, E. R., Feun, L. G., Benedetto, P. W. & Rosenblatt, J. D., Jan 1 2014, In : Current Cancer Research. 12, p. 323-341 19 p.

Research output: Contribution to journalArticle

2013

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

Long, Y., Tsai, W. B., Wangpaichitr, M., Tsukamoto, T., Savaraj, N., Feun, L. G. & Kuo, M. T., Nov 2013, In : Molecular cancer therapeutics. 12, 11, p. 2581-2590 10 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

You, M., Savaraj, N., Kuo, M. T., Wangpaichitr, M., Varona-Santos, J., Wu, C., Nguyen, D. M. & Feun, L., Feb 1 2013, In : Molecular and Cellular Biochemistry. 374, 1-2, p. 181-190 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells

Tsai, W. B., Aiba, I., Long, Y., Lin, H. K., Feun, L., Savaraj, N. & Kuo, M. T., May 15 2012, In : Cancer Research. 72, 10, p. 2622-2633 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Arginine deprivation therapy for malignant melanoma

Yoon, J. K., Frankel, A. E., Feun, L. G., Ekmekcioglu, S. & Kim, K. B., Dec 21 2012, In : Clinical Pharmacology: Advances and Applications. 5, 1, p. 11-19 9 p.

Research output: Contribution to journalReview article

21 Scopus citations

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase

Feun, L. G., Marini, A., Walker, G., Elgart, G., Moffat, F., Rodgers, S. E., Wu, C. J., You, M., Wangpaichitr, M., Kuo, M. T., Sisson, W., Jungbluth, A. A., Bomalaski, J. & Savaraj, N., Apr 24 2012, In : British Journal of Cancer. 106, 9, p. 1481-1485 5 p.

Research output: Contribution to journalArticle

63 Scopus citations

The relationship of thioredoxin-1 and cisplatin resistance: Its impact on ROS and oxidative metabolism in lung cancer cells

Wangpaichitr, M., Sullivan, E. J., Theodoropoulos, G., Wu, C., You, M., Feun, L. G., Lampidis, T. J., Kuo, M. T. & Savaraj, N., Mar 2012, In : Molecular cancer therapeutics. 11, 3, p. 604-615 12 p.

Research output: Contribution to journalArticle

44 Scopus citations
2011

Preoperative evaluation for patients with choroidal/ciliary body melanomas: What is necessary?

Wykoff, C. C., Murray, T. G., Markoe, A. M., Feun, L. G., Schefler, A. C. & Gayer, S., Jun 1 2011, In : American journal of ophthalmology. 151, 6, p. 921-924 4 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Targeting argininosuccinate synthetase in cancer therapy

Savaraj, N., You, M., Wu, C., Kuo, M. T., Dinh, V., Wangpaichitr, M. & Feun, L. G., May 1 2011, Cell Signaling & Molecular Targets in Cancer. Springer New York, p. 37-51 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2010

Arginine Deiminase and Cancer Therapy

Feun, L., Tien Kuo, M., You, M., Wu, C. J., Wangpaichitr, M. & Savaraj, N., Aug 18 2010, Emerging Cancer Therapy: Microbial Approaches and Biotechnological Tools. John Wiley and Sons, p. 199-217 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Arginine deprivation, autophagy, apoptosis (aaa) for the treatment of melanoma

Savaraj, N., You, M., Wu, C., Wangpaichitr, M., Kuo, M. T. & Feun, L. G., Jun 18 2010, In : Current Molecular Medicine. 10, 4, p. 405-412 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Liver Transplantation for Hepatocellular Carcinoma in the Model for End-Stage Liver Disease Era

Levi, D. M., Tzakis, A. G., Martin, P., Nishida, S., Island, E., Moon, J., Selvaggi, G., Tekin, A., Madrazo, B. L., Narayanan, G., Garcia, M. T., Feun, L. G., Tryphonopoulos, P., Skartsis, N. & Livingstone, A. S., May 1 2010, In : Journal of the American College of Surgeons. 210, 5, p. 727-734 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma

Wu, J., Henderson, C., Feun, L., Van Veldhuizen, P., Gold, P., Zheng, H., Ryan, T., Blaszkowsky, L. S., Chen, H., Costa, M., Rosenzweig, B., Nierodzik, M., Hochster, H., Muggia, F., Abbadessa, G., Lewis, J. & Zhu, A. X., Oct 1 2010, In : Investigational New Drugs. 28, 5, p. 670-676 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.

Kuo, M. T., Savaraj, N. & Feun, L. G., Aug 2010, In : Oncotarget. 1, 4, p. 246-251 6 p.

Research output: Contribution to journalReview article

Open Access
59 Scopus citations

The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines

You, M., Savaraj, N., Wangpaichitr, M., Wu, C., Kuo, M. T., Varona-Santos, J., Nguyen, D. M. & Feun, L., Apr 9 2010, In : Biochemical and biophysical research communications. 394, 3, p. 760-766 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Topoisomerase I inhibitors in the treatment of primary CNS malignancies: An update on recent trends

Sasine, J. P., Savaraj, N. & Feun, L. G., Jan 1 2010, In : Mini-Reviews in Medicinal Chemistry. 10, 9, p. 683-696 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2009

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1α/Sp4

Tsai, W. B., Aiba, I., Lee, S. Y., Feun, L., Savaraj, N. & Kuo, M. T., Dec 2009, In : Molecular cancer therapeutics. 8, 12, p. 3223-3233 11 p.

Research output: Contribution to journalArticle

77 Scopus citations
2008

Arginine deprivation as a targeted therapy for cancer

Feun, L., You, M., Wu, C. J., Kuo, M. T., Wangpaichitr, M., Spector, S. & Savaraj, N., Apr 1 2008, In : Current pharmaceutical design. 14, 11, p. 1049-1057 9 p.

Research output: Contribution to journalReview article

138 Scopus citations

Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins

Wangpaichitr, M., Wu, C., You, M., Kuo, M. T., Feun, L., Lampidis, T. & Savaraj, N., Sep 4 2008, In : European Journal of Pharmacology. 591, 1-3, p. 124-127 4 p.

Research output: Contribution to journalArticle

59 Scopus citations

Topoisomerase I inhibitors for the treatment of brain tumors

Feun, L. & Savaraj, N., Aug 28 2008, In : Expert review of anticancer therapy. 8, 5, p. 707-716 10 p.

Research output: Contribution to journalReview article

18 Scopus citations
2007

Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors

Feun, L. G., Marini, A., Landy, H., Markoe, A., Heros, D., Robles, C., Herrera, C. & Savaraj, N., Apr 1 2007, In : Journal of neuro-oncology. 82, 2, p. 177-181 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Merkel Cell Carcinomas

Dinh, V. T., Feun, L., Elgart, G. & Savaraj, N., Jun 1 2007, In : Hematology/Oncology Clinics of North America. 21, 3, p. 527-544 18 p.

Research output: Contribution to journalReview article

29 Scopus citations

Phase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicin

Gish, R. G., Porta, C., Lazar, L., Ruff, P., Feld, R., Croitoru, A., Feun, L., Jeziorski, K., Leighton, J., Gallo, J. & Kennealey, G. T., Jul 20 2007, In : Journal of Clinical Oncology. 25, 21, p. 3068-3075 8 p.

Research output: Contribution to journalArticle

185 Scopus citations
2006

Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation

Wei, Y., Lin-Lee, Y. C., Yang, X., Dai, W., Zhao, S., Rassool, F. V., Elgart, G. W., Feun, L., Savaraj, N. & Kuo, M. T., May 10 2006, In : Gene. 372, 1-2, p. 44-52 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pegylated arginine deiminase: A novel anticancer enzyme agent

Feun, L. & Savaraj, N., Jul 1 2006, In : Expert opinion on investigational drugs. 15, 7, p. 815-822 8 p.

Research output: Contribution to journalReview article

77 Scopus citations
2005