Karoline Briegel

Research Associate Professor

  • 712 Citations
1991 …2020
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Research Output 1991 2019

  • 712 Citations
  • 24 Article
18 Citations (Scopus)
Limb Buds
Intrinsically Disordered Proteins
Embryonic Development
Plasticity
Conformations
15 Citations (Scopus)

cis and trans regulation of tissue-specific transcription

Engel, J. D., Beug, H., LaVail, J. H., Zenke, M. W., Mayo, K., Leonard, M. W., Foley, K. P., Yang, Z., Kornhauser, J. M., Ko, L. J., Lim, K. C., George, K. M. & Briegel, K., Dec 1 1992, In : Journal of Cell Science. 103, SUPPL. 16, p. 21-31 11 p.

Research output: Contribution to journalArticle

Globins
GATA Transcription Factors
Genes
Trans-Activators
Chickens
36 Citations (Scopus)

Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh

Briegel, K., Baldwin, H. S., Epstein, J. A. & Joyner, A. L., Jul 1 2005, In : Development. 132, 14, p. 3305-3316 12 p.

Research output: Contribution to journalArticle

Limb Buds
Trisomy
Transgenic Mice
Heart Diseases
Transcription Factors
57 Citations (Scopus)

Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER

Boehmelt, G., Madruga, J., Dörfler, P., Briegel, K., Schwarz, H., Enrietto, P. J. & Zenke, M., Feb 16 1995, In : Cell. 80, 2, p. 341-352 12 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Dendritic Cells
Fusion reactions
Estrogen Antagonists
Oncogene Proteins
2 Citations (Scopus)

Dendritic cells conditionally transformed by v-relER oncogene express lymphoid marker genes

Madruga, J., Briegel, K., Diebold, S., Boehmelt, G., Vogel, F. & Zenke, M., Dec 7 2000, In : Immunobiology. 202, 4, p. 394-407 14 p.

Research output: Contribution to journalArticle

Oncogenes
Dendritic Cells
Genes
Transcription Factor 3
Natural Killer T-Cells
163 Citations (Scopus)

Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner

Briegel, K., Lim, K. C., Plank, C., Beug, H., Engel, J. D. & Zenke, M., Jun 1 1993, In : Genes and Development. 7, 6, p. 1097-1109 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
GATA Transcription Factors
Hormones
Erythroblasts
Erythroid Precursor Cells
25 Citations (Scopus)

Embryonic transcription factors in human breast cancer

Briegel, K., Mar 1 2006, In : IUBMB Life. 58, 3, p. 123-132 10 p.

Research output: Contribution to journalArticle

Tumors
Transcription Factors
Breast Neoplasms
Cells
Cell growth

Erratum: Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh (Development vol. 132 (3305-3316))

Briegel, K., Baldwin, H. S., Epstein, J. A. & Joyner, A. L., Sep 1 2005, In : Development. 132, 17

Research output: Contribution to journalArticle

Trisomy
Transgenic Mice
Heart Diseases
Transcription Factors
Trisomy 2p Chromosome 2
7 Citations (Scopus)

Generation of mice with a conditional Lbh null allele

Lindley, L. E. & Briegel, K., Jul 1 2013, In : Genesis. 51, 7, p. 491-497 7 p.

Research output: Contribution to journalArticle

Limb Buds
Alleles
Embryonic Development
Exons
Human Mammary Glands
32 Citations (Scopus)

Hedgehog-producing cancer cells respond to and require autocrine hedgehog activity

Singh, S., Wang, Z., Fei, D. L., Black, K. E., Goetz, J. A., Tokhunts, R., Giambelli, C., Rodriguez-Blanco, J., Long, J., Lee, E., Briegel, K., Bejarano, P. A., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., Jul 1 2011, In : Cancer Research. 71, 13, p. 4454-4463 10 p.

Research output: Contribution to journalArticle

Neoplasms
Autocrine Communication
Stromal Cells
Growth
Antineoplastic Agents
28 Citations (Scopus)

Hedgehog signaling regulates bladder cancer growth and tumorigenicity

Fei, D. L., Sanchez-Mejias, A., Wang, Z., Flaveny, C., Long, J., Singh, S., Rodriguez-Blanco, J., Tokhunts, R., Giambelli, C., Briegel, K., Schulz, W. A., Gandolfi, A. J., Karagas, M., Zimmers, T. A., Jorda, M., Bejarano, P., Capobianco, A. J. & Robbins, D. J., Sep 1 2012, In : Cancer Research. 72, 17, p. 4449-4458 10 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Growth
Carcinoma
Cell Line
Tumor Suppressor Genes
10 Citations (Scopus)

Identification and analysis of Escherichia coli ribonuclease E dominant-negative mutants

Briegel, K., Baker, A. & Jain, C., Jan 1 2006, In : Genetics. 172, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Escherichia coli
Proteins
Phenotype
Mutant Proteins
ribonuclease E
48 Citations (Scopus)

Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development

Briegel, K. & Joyner, A. L., May 15 2001, In : Developmental Biology. 233, 2, p. 291-304 14 p.

Research output: Contribution to journalArticle

Limb Buds
Nuclear Proteins
Extremities
Ectoderm
Activator Appliances
1 Citation (Scopus)

Loss of Limb-Bud-and-Heart (LBH) attenuates mammary hyperplasia and tumor development in MMTV-Wnt1 transgenic mice

Ashad-Bishop, K., Garikapati, K., Lindley, L. E., Jorda, M. & Briegel, K., Jan 8 2019, In : Biochemical and Biophysical Research Communications. 508, 2, p. 536-542 7 p.

Research output: Contribution to journalArticle

Mouse mammary tumor virus
Limb Buds
Viruses
Transgenic Mice
Hyperplasia
47 Citations (Scopus)
Epithelial-Mesenchymal Transition
Transforming Growth Factor beta
Breast
Epithelial Cells
Cadherins
10 Citations (Scopus)

Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene

Heikenwälder, M. F., Koritschoner, N. P., Pajer, P., Chaboissier, M. C., Kurz, S. M., Briegel, K., Bartunek, P. & Zenke, M., Jul 25 2001, In : Gene. 273, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

Molecular Cloning
Proteins
Chickens
Complementary DNA
Thyroid Hormone Receptors
45 Citations (Scopus)

One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter

Briegel, K., Hentsch, B., Pfeuffer, I. & Serfling, E., Nov 11 1991, In : Nucleic Acids Research. 19, 21, p. 5929-5936 8 p.

Research output: Contribution to journalArticle

Interleukin
T-cells
NF-kappa B
Promoter
Base Pairing
2 Citations (Scopus)

P27 transcriptionally coregulates cJun to drive programs of tumor progression

Yoon, H., Kim, M., Jang, K., Shin, M., Besser, A., Xiao, X., Zhao, D., Wander, S. A., Briegel, K., Morey, LL., Minn, A. & Slingerland, J. M., Apr 2 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7005-7014 10 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Cyclin-Dependent Kinase Inhibitor p27
Breast Neoplasms
Neoplasm Metastasis
Chromatin Assembly and Disassembly
10 Citations (Scopus)

Periodic Estrogen Receptor-Beta Activation: A Novel Approach to Prevent Ischemic Brain Damage

Cue, L., Diaz, F., Briegel, K., Patel, H. H. & Raval, A., Jun 7 2014, In : Neurochemical Research. 40, 10, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Brain Ischemia
Brain
Estrogens
Chemical activation
41 Citations (Scopus)

Regulation and function of transcription factor GATA-1 during red blood cell differentiation

Briegel, K., Bartunek, P., Stengl, G., Lim, K. C., Beug, H., Engel, J. D. & Zenke, M., Dec 1 1996, In : Development. 122, 12, p. 3839-3850 12 p.

Research output: Contribution to journalArticle

GATA Transcription Factors
Erythroid Precursor Cells
Cell Differentiation
Erythrocytes
Genes
7 Citations (Scopus)

Regulation of the cell cycle and inflammatory arthritis by the transcription cofactor LBH gene

Matsuda, S., Hammaker, D., Topolewski, K., Briegel, K., Boyle, D. L., Dowdy, S., Wang, W. & Firestein, G. S., Oct 1 2017, In : Journal of Immunology. 199, 7, p. 2316-2322 7 p.

Research output: Contribution to journalArticle

Limb Buds
Arthritis
Cell Cycle
Rheumatoid Arthritis
Genes
48 Citations (Scopus)

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers

Rieger, M. E., Sims, A. H., Coats, E. R., Clarke, R. B. & Briegel, K., Sep 1 2010, In : Molecular and Cellular Biology. 30, 17, p. 4267-4279 13 p.

Research output: Contribution to journalArticle

Limb Buds
Wnt Signaling Pathway
Breast Neoplasms
Catenins
TCF Transcription Factors
39 Citations (Scopus)

The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells

Wang, B., Lindley, L. E., Fernandez-Vega, V., Rieger, M. E., Sims, A. H. & Briegel, K., Jul 23 2012, In : PLoS One. 7, 7, e41355.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
breasts
Tumors
Breast
epithelial cells
21 Citations (Scopus)

The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage

Lindley, L. E., Curtis, K. M., Sanchez-Mejias, A., Rieger, M. E., Robbins, D. J. & Briegel, K., 2015, In : Development (Cambridge). 142, 5, p. 893-904 12 p.

Research output: Contribution to journalArticle

Breast
Stem Cells
Maintenance
Human Mammary Glands
Transcription Factors