Karen Young

Associate Professor of Clinical

  • 322 Citations
20022019
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Research Output 2002 2019

  • 322 Citations
  • 24 Article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Caspase-1 Inhibition Attenuates Hyperoxia-induced Lung and Brain Injury in Neonatal Mice

Dapaah-Siakwan, F., Zambrano, R., Luo, S., Duncan, M. R., Kerr, N., Donda, K., De Rivero Vaccari, J. P., Keane, R. W., Dalton Dietrich, W., Benny, M., Young, K. & Wu, S., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 3, p. 341-354 14 p.

Research output: Contribution to journalArticle

Caspase 1
Hyperoxia
Lung Injury
Inflammasomes
Brain Injuries

Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia

Guerra, K., Bryan, C., Dapaah-Siakwan, F., Sammour, I., Drummond, S., Zambrano, R., Chen, P., Huang, J., Sharma, M., Shrager, S., Benny, M., Wu, S. & Young, K. C., Nov 12 2019, In : Respiratory research. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Bronchopulmonary Dysplasia
Rodentia
Hyperoxia
Plasmids
Lung
2018
3 Citations (Scopus)

Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth

Donda, K., Zambrano, R., Moon, Y., Percival, J., Vaidya, R., Dapaah-Siakwan, F., Luo, S., Duncan, M. R., Bao, Y., Wang, L., Qin, L., Benny, M., Young, K. & Wu, S., Jul 1 2018, In : PLoS One. 13, 7, e0199927.

Research output: Contribution to journalArticle

hyperoxia
Hyperoxia
Bone Development
Lung Injury
Pulmonary Hypertension
2 Citations (Scopus)

TNFα-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia

Bryan, C., Sammour, I., Guerra, K., Sharma, M., Dapaah-Siakwan, F., Huang, J., Zambrano, R., Benny, M., Wu, S. & Young, K., Jan 1 2018, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
Adenoviridae
Pneumonia
Theoretical Models
Hyperoxia
2017
10 Citations (Scopus)

Inhibition of Rac1 Signaling Downregulates Inflammasome Activation and Attenuates Lung Injury in Neonatal Rats Exposed to Hyperoxia

Hummler, J. K., Dapaah-Siakwan, F., Vaidya, R., Zambrano, R., Luo, S., Chen, S., Kerr, N., de Rivero Vaccari, J. P. P., Keane, R., Dalton Dietrich, W., Bancalari, E., Young, K. & Wu, S., Mar 1 2017, In : Neonatology. 111, 3, p. 280-288 9 p.

Research output: Contribution to journalArticle

Inflammasomes
Hyperoxia
Lung Injury
Bronchopulmonary Dysplasia
Down-Regulation
6 Citations (Scopus)

Intra-amniotic soluble endoglin impairs lung development in neonatal rats

Somashekar, S. T., Sammour, I., Huang, J., Dominguez-Bendala, J., Pastori, R., Alvarez-Cubela, S., Torres, E., Wu, S. & Young, K., Oct 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 57, 4, p. 468-476 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Rats
Adenoviridae
Lung
Amniotic Fluid
5 Citations (Scopus)

Recombinant CCN1 prevents hyperoxia-induced lung injury in neonatal rats

Vaidya, R., Zambrano, R., Hummler, J. K., Luo, S., Duncan, M. R., Young, K., Lau, L. F. & Wu, S., Nov 1 2017, In : Pediatric Research. 82, 5, p. 863-871 9 p.

Research output: Contribution to journalArticle

Hyperoxia
Lung Injury
Right Ventricular Hypertrophy
CCN Intercellular Signaling Proteins
Blood Vessels
12 Citations (Scopus)

Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

Reiter, J., Drummond, S., Sammour, I., Huang, J., Florea, V., Dornas, P., Hare, J., Rodrigues, C. D. & Young, K., Jul 12 2017, In : Respiratory Research. 18, 1, 137.

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
Mesenchymal Stromal Cells
Rodentia
Lung
Hyperoxia
2016
7 Citations (Scopus)

Antagonism of stem cell factor/c-kit signaling attenuates neonatal chronic hypoxia-induced pulmonary vascular remodeling

Young, K., Torres, E., Hehre, D., Wu, S., Suguihara, C. & Hare, J., Apr 1 2016, In : Pediatric Research. 79, 4, p. 637-646 10 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Lung
Right Ventricular Hypertrophy
Pulmonary Hypertension
Ventricular Pressure
26 Citations (Scopus)

The effect of gender on mesenchymal stem cell (MSC) efficacy in neonatal hyperoxia-induced lung injury

Sammour, I., Somashekar, S., Huang, J., Batlahally, S., Breton, M., Valasaki, K., Khan, A., Wu, S. & Young, K., Oct 1 2016, In : PLoS One. 11, 10, e0164269.

Research output: Contribution to journalArticle

hyperoxia
Hyperoxia
Lung Injury
Stem cells
Mesenchymal Stromal Cells
2015
10 Citations (Scopus)

Bone marrow-derived c-kit+ cells attenuate neonatal hyperoxia-induced lung injury

Ramachandran, S., Suguihara, C., Drummond, S., Chatzistergos, K., Klim, J., Torres, E., Huang, J., Hehre, D., Rodrigues, C. D., McNiece, I. K., Hare, J. & Young, K., Jan 1 2015, In : Cell Transplantation. 24, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

Hyperoxia
Lung Injury
Bone
Bone Marrow
Lung
11 Citations (Scopus)

CXCR4 blockade attenuates hyperoxia-induced lung injury in neonatal rats

Drummond, S., Ramachandran, S., Torres, E., Huang, J., Hehre, D., Suguihara, C. & Young, K., Jun 9 2015, In : Neonatology. 107, 4, p. 304-311 8 p.

Research output: Contribution to journalArticle

Hyperoxia
Lung Injury
Bronchopulmonary Dysplasia
Pneumonia
Lung
2013
60 Citations (Scopus)

Long-term reparative effects of mesenchymal stem cell therapy following neonatal hyperoxia-induced lung injury

Sutsko, R. P., Young, K., Ribeiro, A., Torres, E., Rodriguez, M., Hehre, D., Devia, C., McNiece, I. & Suguihara, C., Jan 1 2013, In : Pediatric Research. 73, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Hyperoxia
Lung Injury
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
Conditioned Culture Medium
13 Citations (Scopus)

Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced lung injury

Miranda, L. F., Rodrigues, C. D., Ramachandran, S., Torres, E., Huang, J., Klim, J., Hehre, D., McNiece, I., Hare, J., Suguihara, C. Y. & Young, K., Dec 1 2013, In : Pediatric Research. 74, 6, p. 682-688 7 p.

Research output: Contribution to journalArticle

Hyperoxia
Stem Cell Factor
Lung Injury
Lung
Right Ventricular Hypertrophy
2012
18 Citations (Scopus)

Antagonism of CXCR7 attenuates chronic hypoxia-induced pulmonary hypertension

Sartina, E., Suguihara, C., Ramchandran, S., Nwajei, P., Rodriguez, M., Torres, E., Hehre, D., Devia, C., Walters, M. J., Penfold, M. E. T. & Young, K., Jun 1 2012, In : Pediatric Research. 71, 6, p. 682-688 7 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Lung
Blood Vessels
Placebos
Cell Proliferation
2010
25 Citations (Scopus)

Toll-like receptor 4deficient mice are resistant to chronic hypoxia-induced pulmonary hypertension

Young, K., Hussein, S. M. A., Dadiz, R., Demello, D., Devia, C., Hehre, D. & Suguihara, C., Mar 15 2010, In : Experimental Lung Research. 36, 2, p. 111-119 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Toll-Like Receptors
Pulmonary Hypertension
Lung
Blood Vessels
2009
67 Citations (Scopus)

Inhibition of the SDF-1/CXCR4 axis attenuates neonatal hypoxia-induced pulmonary hypertension

Young, K., Torres, E., Hatzistergos, K. E., Hehre, D., Suguihara, C. & Hare, J., Jun 5 2009, In : Circulation Research. 104, 11, p. 1293-1301 9 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Chemokine CXCL12
Pulmonary Hypertension
Lung
Right Ventricular Hypertrophy
2008

Newborn Girl with Massive Hepatomegaly, Anemia, and Thrombocytopenia

Thompson, S. M., Dadiz, R., Young, K., Teomete, U., Toledano, S. & Rodriguez, M., Jan 1 2008, In : Journal of Pediatrics. 152, 1, p. 129-132 4 p.

Research output: Contribution to journalArticle

Hepatomegaly
Liver Neoplasms
Neuroblastoma
Thrombocytopenia
Anemia
4 Citations (Scopus)
Stem Cells
Pediatrics
Heart Diseases
Adult Stem Cells
Embryonic Stem Cells
2005
4 Citations (Scopus)

Effects of a nebulized NONOate, DPTA/NO, on group B Streptococcus-induced pulmonary hypertension in newborn piglets

Dabrowska, K., Hehre, D., Young, K., Navarette, C., Ladino, J. F., Bancalari, E. & Suguihara, C., Mar 1 2005, In : Pediatric Research. 57, 3, p. 378-383 6 p.

Research output: Contribution to journalArticle

Streptococcus agalactiae
Pulmonary Hypertension
Vascular Resistance
Nitric Oxide
Methemoglobin
19 Citations (Scopus)

The association between early tracheal colonization and bronchopulmonary dysplasia

Young, K., Delmoral, T., Claure, N. R., Vanbuskirk, S. & Bancalari, E., Jun 1 2005, In : Journal of Perinatology. 25, 6, p. 403-407 5 p.

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
Chorioamnionitis
Newborn Infant
Confounding Factors (Epidemiology)
Neonatal Intensive Care Units
2004
10 Citations (Scopus)

The effect of a nebulized NO donor, DPTA/NO, on acute hypoxic pulmonary hypertension in newborn piglets

Young, K., Ladino, J., Navarrete, C., Dabrowska, K., Hehre, D., Bancalari, E. & Suguihara, C., Apr 16 2004, In : Biology of the Neonate. 85, 3, p. 195-202 8 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Vascular Resistance
Methemoglobin
Placebos
Cardiac Output
2003
7 Citations (Scopus)

The role of endothelin converting enzyme inhibition during group B Streptococcus-induced pulmonary hypertension in newborn piglets

Navarrete, C., Devia, C., Lessa, A. C., Hehre, D., Young, K., Martinez, O. V., Bancalari, E. & Suguihara, C., Sep 1 2003, In : Pediatric Research. 54, 3, p. 387-392 6 p.

Research output: Contribution to journalArticle

Streptococcus agalactiae
Pulmonary Hypertension
Vascular Resistance
Enzyme Inhibitors
Endothelin-1
2002
3 Citations (Scopus)

Reye's syndrome in a 17-year-old male: Is this disease really disappearing?

Da Silveira, E. B. V., Young, K., Rodriguez, M. & Ameen, N., Sep 1 2002, In : Digestive Diseases and Sciences. 47, 9, p. 1959-1961 3 p.

Research output: Contribution to journalArticle

Reye Syndrome
Electron Microscopy
Biopsy
Liver