Juan Dominguez-Bendala

Research Assoc. Professor

  • 1219 Citations
20022018
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Research Output 2002 2018

  • 1219 Citations
  • 45 Article
  • 9 Chapter
  • 1 Conference contribution
2018

CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation

Hunte, R., Alonso, P., Thomas, R., Bazile, C. A., Carlos Ramos, J., van der Weyden, L., Dominguez-Bendala, J., Khan, W. & Shembade, N., Apr 1 2018, In : PLoS Pathogens. 14, 4, e1006968.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Cell Adhesion Molecules
Primary Effusion Lymphoma
Oncogenic Viruses
Kaposi's Sarcoma
1 Citations

P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics

Qadir, M. M. F., Álvarez-Cubela, S., Klein, D., Lanzoni, G., García-Santana, C., Montalvo, A., Pláceres-Uray, F., Mazza, E. M. C., Ricordi, C., Inverardi, L. A., Pastori, R. & Dominguez-Bendala, J., Feb 27 2018, In : Cell Reports. 22, 9, p. 2455-2468 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 7
Exocrine Pancreas
Bone Morphogenetic Protein Receptors
Cells
Pancreatic Ducts
2017
3 Citations

Intra-amniotic soluble endoglin impairs lung development in neonatal rats

Somashekar, S. T., Sammour, I., Huang, J., Dominguez-Bendala, J., Pastori, R., Alvarez-Cubela, S., Torres, E., Wu, S. & young, K., Oct 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 57, 4, p. 468-476 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Rats
Adenoviridae
Lung
Amniotic Fluid
2016
8 Citations

The Human Endocrine Pancreas: New Insights on Replacement and Regeneration

Dominguez-Bendala, J., Lanzoni, G., Klein, D., Álvarez-Cubela, S. & Pastori, R., Mar 1 2016, In : Trends in Endocrinology and Metabolism. 27, 3, p. 153-162 10 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Regeneration
Cell Differentiation
Islets of Langerhans Transplantation
Pluripotent Stem Cells
2015
16 Citations

BMP-7 induces adult human pancreatic exocrine-to-endocrine conversion

Klein, D., Álvarez-Cubela, S., Lanzoni, G., Vargas, N., Prabakar, K. R., Boulina, M., Ricordi, C., Inverardi, L. A., Pastori, R. & Dominguez-Bendala, J., Dec 1 2015, In : Diabetes. 64, 12, p. 4123-4134 12 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 7
Insulin
Endocrine Cells
Carbonic Anhydrase II
Exocrine Pancreas
2014
29 Citations

Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes

Orlando, G., Gianello, P., Salvatori, M., Stratta, R. J., Soker, S., Ricordi, C. & Dominguez-Bendala, J., Jan 1 2014, In : Diabetes. 63, 5, p. 1433-1444 12 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Type 1 Diabetes Mellitus
Pancreas
Technology
Bioengineering

Erratum: Cell and organ bioengineering technology as applied to gastrointestinal diseases (Gut (2013) 62 (774-86))

Orlando, G., Dominguez-Bendala, J. & Shupe, T., Feb 1 2014, In : Gut. 63, 2

Research output: Contribution to journalArticle

14 Citations

Influence of in vitro and in vivo oxygen modulation on β cell differentiation from human embryonic stem cells

Cechin, S., Álvarez-Cubela, S., Giraldo, J. A., Molano, R., Villate, S., Ricordi, C., Pileggi, A., Inverardi, L. A., Fraker, C. & Dominguez-Bendala, J., Jan 1 2014, In : Stem cells translational medicine. 3, 3, p. 277-289 13 p.

Research output: Contribution to journalArticle

Cell Differentiation
Oxygen
Stem Cells
Fluorocarbons
Partial Pressure
1 Citations

MicroRNAs in Pancreas and Islet Development

Dominguez-Bendala, J., Klein, D. & Pastori, R., Dec 23 2014, MicroRNA in Regenerative Medicine. Elsevier Inc., p. 401-418 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
Pancreas
Cell Physiological Phenomena
Cell Transplantation
Gene Expression Regulation

Pancreatic Islet Regeneration. The Developmental and Stem Cell Biology Approach.

Lanzoni, G., Ricordi, C., Inverardi, L. A. & Dominguez-Bendala, J., Jun 27 2014, Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., p. 609-625 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytology
Medical problems
Stem cells
Islets of Langerhans
Cell Biology

Transient alteration of gene expression in adipose-derived stem cells using liposomal-driven protein extracts

Campillo, N., Arribas, M. I., Vicente-Salar, N., Catania, A., Ramírez-Domínguez, M., Reig, J. A., Dominguez-Bendala, J., Micol, V. & Roche, E., Jan 1 2014, In : Cellular and Molecular Bioengineering. 7, 1, p. 145-154 10 p.

Research output: Contribution to journalArticle

Stem Cells
Liposomes
Stem cells
Gene expression
Gene Expression
2013
11 Citations

A physiological pattern of oxygenation using perfluorocarbon-based culture devices maximizes pancreatic islet viability and enhances β-cell function

Fraker, C., Cechin, S., Álvarez-Cubela, S., Echeverri, F., Bernal, A., Poo, R., Ricordi, C., Inverardi, L. A. & Dominguez-Bendala, J., Sep 11 2013, In : Cell Transplantation. 22, 9, p. 1723-1733 11 p.

Research output: Contribution to journalArticle

Fluorocarbons
Oxygenation
Islets of Langerhans
Equipment and Supplies
Hyperoxia
46 Citations

Biliary tree stem cells, precursors to pancreatic committed progenitors: Evidence for possible life-long pancreatic organogenesis

Wang, Y., Lanzoni, G., Carpino, G., Cui, C. B., Dominguez-Bendala, J., Wauthier, E., Cardinale, V., Oikawa, T., Pileggi, A., Gerber, D., Furth, M. E., Alvaro, D., Gaudio, E., Inverardi, L. A. & Reid, L. M., Sep 1 2013, In : Stem Cells. 31, 9, p. 1966-1979 14 p.

Research output: Contribution to journalArticle

Organogenesis
Biliary Tract
Stem Cells
Pancreatic Ducts
Pancreas
27 Citations

Cell and organ bioengineering technology as applied to gastrointestinal diseases

Orlando, G., Dominguez-Bendala, J., Shupe, T., Bergman, C., Bitar, K. N., Booth, C., Carbone, M., Koch, K. L., Lerut, J. P., Neuberger, J. M., Petersen, B., Ricordi, C., Atala, A., Stratta, R. J. & Soker, S., May 1 2013, In : Gut. 62, 5, p. 774-786 13 p.

Research output: Contribution to journalArticle

Bioengineering
Gastrointestinal Diseases
Bioreactors
Technology
Regenerative Medicine
50 Citations

Concise review: Clinical programs of stem cell therapies for liver and pancreas

Lanzoni, G., Oikawa, T., Wang, Y., Cui, C. B., Carpino, G., Cardinale, V., Gerber, D., Gabriel, M., Dominguez-Bendala, J., Furth, M. E., Gaudio, E., Alvaro, D., Inverardi, L. A. & Reid, L. M., Oct 1 2013, In : Stem Cells. 31, 10, p. 2047-2060 14 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Pancreas
Stem Cells
Liver
Hematopoietic Stem Cells
1 Citations

Islet Cell Therapy and Pancreatic Stem Cells

Dominguez-Bendala, J., Pileggi, A. & Ricordi, C., Aug 27 2013, Handbook of Stem Cells. Elsevier Inc., Vol. 2. p. 835-853 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations

MicroRNA-7 control of b-cell replication

Dominguez-Bendala, J., Klein, D. & Pastori, R., Mar 1 2013, In : Diabetes. 62, 3, p. 694-695 2 p.

Research output: Contribution to journalArticle

TOR Serine-Threonine Kinases
Insulin-Secreting Cells
MicroRNAs
Signal Transduction
Cell Proliferation
59 Citations

MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets

Klein, D., Misawa, R., Bravo-Egana, V., Vargas, N., Rosero, S., Piroso, J., Ichii, H., Umland, O., Zhijie, J., Tsinoremas, N., Ricordi, C., Inverardi, L. A., Dominguez-Bendala, J. & Pastori, R., Jan 29 2013, In : PLoS One. 8, 1, e55064.

Research output: Contribution to journalArticle

islets of Langerhans
MicroRNAs
Islets of Langerhans
microRNA
Cells
1 Citations

MSCs for diabetes

Inverardi, L. A., Lanzoni, G., Dominguez-Bendala, J. & Ricordi, C., Jan 1 2013, Mesenchymal Stromal Cells: Biology and Clinical Applications. Springer New York, p. 571-597 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Medical problems
Stem cells
Mesenchymal Stromal Cells
Type 1 Diabetes Mellitus
Mesoderm

Pancreatic reprogramming

Dominguez-Bendala, J., Jan 1 2013, Regenerative Medicine and Cell Therapy. Humana Press Inc., p. 155-168 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem cells
Liver
Hormones
Insulin
Tissue
4 Citations

Stem cell populations giving rise to liver, biliary tree, and pancreas

Furth, M. E., Wang, Y., Cardinale, V., Carpino, G., Lanzoni, G., Cui, C. B., Wauthier, E., Gerber, D., Oikawa, T., Dominguez-Bendala, J., Inverardi, L. A., Alvaro, D., Gaudio, E. & Reid, L. M., Jan 1 2013, Stem Cells Handbook: Second Edition. Springer New York, p. 283-310 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012
38 Citations

Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds

Nieto, M., Hevia, P., Garcia, E., Klein, D., Alvarez-Cubela, S., Bravo-Egana, V., Rosero, S., Molano, R., Vargas, N., Ricordi, C., Pileggi, A., Diez, J., Dominguez-Bendala, J. & Pastori, R., Nov 5 2012, In : Cell Transplantation. 21, 8, p. 1761-1774 14 p.

Research output: Contribution to journalArticle

Insulin
In Situ Hybridization
Pancreas
Morpholinos
Endocrine Cells
48 Citations

Concise review: Mesenchymal stem cells for diabetes

Dominguez-Bendala, J., Lanzoni, G., Inverardi, L. A. & Ricordi, C., Dec 1 2012, In : Stem cells translational medicine. 1, 1, p. 59-63 5 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Type 1 Diabetes Mellitus
Germ Layers
Islets of Langerhans Transplantation
Regenerative Medicine
8 Citations
Medical problems
Cell- and Tissue-Based Therapy
Tissue
Stem cells
Islets of Langerhans
38 Citations

Generation of Glucose-Responsive, Insulin-Producing Cells from Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells

Prabakar, K. R., Dominguez-Bendala, J., Molano, R., Pileggi, A., Villate, S., Ricordi, C. & Inverardi, L. A., Sep 3 2012, In : Cell Transplantation. 21, 6, p. 1321-1339 19 p.

Research output: Contribution to journalArticle

Insulin
Stem cells
Mesenchymal Stromal Cells
Fetal Blood
Glucose
4 Citations

Intracardial embryonic delivery of developmental modifiers in utero

Dominguez-Bendala, J., Álvarez-Cubela, S., Nieto, M., Vargas, N., Espino-Grosso, P., Sacher, V. Y., Pileggi, A., García, E., Ricordi, C., Inverardi, L. A. & Pastori, R., Sep 1 2012, In : Cold Spring Harbor Protocols. 7, 9, p. 962-968 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Modulators
Embryonic Structures
Morpholinos
Direct injection
11 Citations

Present and future cell therapies for pancreatic beta cell replenishment

Dominguez-Bendala, J. & Ricordi, C., Dec 1 2012, In : World Journal of Gastroenterology. 18, 47, p. 6876-6884 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Insulin-Secreting Cells
Cell- and Tissue-Based Therapy
Multipotent Stem Cells
Stem Cell Research
17 Citations
Insulin-Secreting Cells
Medical problems
Stem cells
Islets of Langerhans
Regeneration
2011
1 Citations

Islet Cell Therapy and Pancreatic Stem Cells

Dominguez-Bendala, J., Pileggi, A. & Ricordi, C., Dec 1 2011, Principles of Regenerative Medicine. Elsevier Inc., p. 403-426 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell- and Tissue-Based Therapy
Stem cells
Islets of Langerhans
Stem Cells
Islets of Langerhans Transplantation
169 Citations

Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets

Cardinale, V., Wang, Y., Carpino, G., Cui, C. B., Gatto, M., Rossi, M., Bartolomeo Berloco, P., Cantafora, A., Wauthier, E., Furth, M. E., Inverardi, L. A., Dominguez-Bendala, J., Ricordi, C., Gerber, D., Gaudio, E., Alvaro, D. & Reid, L. M., Dec 1 2011, In : Hepatology. 54, 6, p. 2159-2172 14 p.

Research output: Contribution to journalArticle

Multipotent Stem Cells
Biliary Tract
Islets of Langerhans
Hepatocytes
Cystic Fibrosis Transmembrane Conductance Regulator
15 Citations

Stem cell-derived islet cells for transplantation

Dominguez-Bendala, J., Inverardi, L. A. & Ricordi, C., Feb 1 2011, In : Current Opinion in Organ Transplantation. 16, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Cell Transplantation
Islets of Langerhans
Adult Stem Cells
Stem Cells
10 Citations

TAT-mediated transduction of MafA protein in Utero results in enhanced pancreatic insulin expression and changes in islet morphology

Vargas, N., Álvarez-Cubela, S., Giraldo, J. A., Nieto, M., Fort, N. M., Cechin, S., García, E., Espino-Grosso, P., Fraker, C., Ricordi, C., Inverardi, L. A., Pastori, R. & Dominguez-Bendala, J., Aug 10 2011, In : PLoS One. 6, 8, e22364.

Research output: Contribution to journalArticle

insulin
Insulin
Proteins
proteins
acinar cells
2010

Diabetes and stem cells

Dominguez-Bendala, J. & Ricordi, C., Dec 1 2010, Stem Cell and Regenerative Medicine. Bentham Science Publishers Ltd., p. 120-139 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Transdifferentiation
Art Therapy
Islets of Langerhans Transplantation
Adult Stem Cells
Aptitude
Periodontal Ligament
Adult Stem Cells
Regenerative Medicine
Ligaments
Stem cells
37 Citations

MicroRNA signature of the human developing pancreas

Rosero, S., Bravo-Egana, V., Jiang, Z., Khuri, S., Tsinoremas, N., Klein, D., Sabates, E., Correa-Medina, M., Ricordi, C., Dominguez-Bendala, J., Diez, J. & Pastori, R., Sep 22 2010, In : BMC Genomics. 11, 1, 509.

Research output: Contribution to journalArticle

MicroRNAs
Pancreas
Messenger RNA
Genome
Gene Expression
2009
1 Citations

A novel cell culture platform for in-vitro enhancement of oxygen delivery leads to improved physiological function of isolated islets of langerhans

Fraker, C., Stabler, C. L., Asfura-Gattas, K. & Dominguez-Bendala, J., Nov 6 2009, IFMBE Proceedings. Vol. 24. p. 163-164 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell culture
Oxygen
Polydimethylsiloxane
Polystyrenes
Plating
Molecular Medicine
Cell- and Tissue-Based Therapy
Stem Cells
22 Citations

Oxygen: A master regulator of pancreatic development?

Fraker, C., Ricordi, C., Inverardi, L. A. & Dominguez-Bendala, J., Sep 24 2009, In : Biology of the Cell. 101, 8, p. 431-440 10 p.

Research output: Contribution to journalArticle

Oxygen
Cell Differentiation
Endocrine Cells
beta Catenin
Respiration
77 Citations

Plasticity of stem cells derived from adult periodontal ligament

Huang, C-Y., Pelaez, D., Dominguez-Bendala, J., Garcia-Godoy, F. & Cheung, H. S., Nov 1 2009, In : Regenerative Medicine. 4, 6, p. 809-821 13 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Adult Stem Cells
Ligaments
Stem cells
Plasticity
11 Citations

The immune boundaries for stem cell based therapies: Problems and prospective solutions

Hmadcha, A., Dominguez-Bendala, J., Wakeman, J., Arredouani, M. & Soria, B., Aug 1 2009, In : Journal of Cellular and Molecular Medicine. 13, 8 A, p. 1464-1475 12 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem Cells
Medicine
Safety
2008
37 Citations

Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity

Martin-Pagola, A., Sisino, G., Allende, G., Dominguez-Bendala, J., Gianani, R., Reijonen, H., Nepom, G. T., Ricordi, C., Ruiz, P., Sageshima, J., Ciancio, G., Burke, G. W. & Pugliese, A., Oct 1 2008, In : Diabetologia. 51, 10, p. 1803-1813 11 p.

Research output: Contribution to journalArticle

Autoimmunity
Type 1 Diabetes Mellitus
Pancreas
Insulin
Recurrence

Islet Cell Therapy and Pancreatic Stem Cells

Dominguez-Bendala, J., Pileggi, A. & Ricordi, C., Dec 1 2008, Principles of Regenerative Medicine. Elsevier Inc., p. 398-417 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

97 Citations
Oxytocin
NADP
Superoxides
Blood Vessels
Interleukin-6
89 Citations

Quantitative differential expression analysis reveals miR-7 as major islet microRNA

Bravo-Egana, V., Rosero, S., Molano, R., Pileggi, A., Ricordi, C., Dominguez-Bendala, J. & Pastori, R., Feb 22 2008, In : Biochemical and Biophysical Research Communications. 366, 4, p. 922-926 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Gene expression
Gene Expression
Microarrays
Islets of Langerhans
2007
39 Citations

Enhanced oxygenation promotes β-cell differentiation in vitro

Fraker, C., Álvarez, S., Papadopoulos, P., Giraldo, J., Gu, W., Ricordi, C., Inverardi, L. A. & Dominguez-Bendala, J., Dec 1 2007, In : Stem Cells. 25, 12, p. 3155-3164 10 p.

Research output: Contribution to journalArticle

Cell Differentiation
Stem Cells
Fluorocarbons
Adult Stem Cells
Differentiation Antigens
2006
15 Citations

Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs, results in higher gene targeting efficiency

Dominguez-Bendala, J., Masutani, M. & McWhir, J., Apr 1 2006, In : Cell Biology International. 30, 4, p. 389-393 5 p.

Research output: Contribution to journalArticle

Gene Targeting
Homologous Recombination
Down-Regulation
DNA
Embryonic Stem Cells
10 Citations
Stem cells
Stem Cells
Proteins
Pancreas
Technology
24 Citations

Sodium butyrate activates genes of early pancreatic development in embryonic stem cells

Goicoa, S., Álvarez, S., Ricordi, C., Inverardi, L. A. & Dominguez-Bendala, J., Nov 17 2006, In : Cloning and Stem Cells. 8, 3, p. 140-149 10 p.

Research output: Contribution to journalArticle

Butyric Acid
Butyrates
Embryonic Stem Cells
Stem Cells
Islets of Langerhans
2005
7 Citations

Stem cell plasticity and tissue replacement

Dominguez-Bendala, J. & Ricordi, C., Nov 14 2005, In : Cell Transplantation. 14, 7, p. 423-425 3 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Stem cells
Plasticity
Regeneration
Animals