Joshua Hare

Professor of Medicine; Director, Interdisciplinary Stem Cell Institute

  • 30502 Citations
1974 …2021

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Research Output

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Article
2020

The Effect of Transendocardial Stem Cell Injection on Erectile Function in Men With Cardiomyopathy: Results From the TRIDENT, POSEIDON, and TAC-HFT Trials

Ory, J., Saltzman, R. G., Blachman-Braun, R., Dadoun, S., DiFede, D. L., Premer, C., Hurwitz, B., Hare, J. M. & Ramasamy, R., Jan 1 2020, (Accepted/In press) In : Journal of Sexual Medicine.

Research output: Contribution to journalArticle

2019

Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists

Schally, A. V., Zhang, X., Cai, R., Hare, J. M., Granata, R. & Bartoli, M., Jul 1 2019, In : Endocrinology. 160, 7, p. 1600-1612 13 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Age induced nitroso-redox imbalance leads to subclinical hypogonadism in Male mice

Lee, J. A., Kuchakulla, M., Arora, H., Kulandavelu, S., Gonzalez, E., Masterson, T. A., Hare, J. M., Kaiser, U. B. & Ramasamy, R., Jan 1 2019, In : Frontiers in Endocrinology. 10, MAR, 190.

Research output: Contribution to journalArticle

Open Access

A meta-analysis of arrhythmia endpoints in randomized controlled trials of transendocardial stem cell injections for chronic ischemic heart disease

Fernandes, G. C., Fernandes, A. D. F., Rivera, M., Khan, A., Schulman, I. H., Lambrakos, L. K., Myerburg, R. J., Goldberger, J. J., Hare, J. M. & Mitrani, R. D., Nov 1 2019, In : Journal of Cardiovascular Electrophysiology. 30, 11, p. 2492-2500 9 p.

Research output: Contribution to journalArticle

Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia

Kurtenbach, S., Goss, G. M., Goncalves, S., Choi, R., Hare, J. M., Chaudhari, N. & Goldstein, B. J., Jun 11 2019, In : Stem Cell Reports. 12, 6, p. 1354-1365 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Clinical and neurophysiological changes after targeted intrathecal injections of bone marrow stem cells in a C3 tetraplegic subject

Santamaría, A. J., Benavides, F. D., Difede, D. L., Khan, A., Pujol, M. V., Dietrich, W. D., Marttos, A., Green, B. A., Hare, J. M. & Guest, J. D., Feb 1 2019, In : Journal of Neurotrauma. 36, 3, p. 500-516 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Embryonic Stem Cell-Derived mmu-miR-291a-3p Inhibits Cellular Senescence in Human Dermal Fibroblasts Through the TGF-β Receptor 2 Pathway

Bae, Y. U., Son, Y., Kim, C. H., Kim, K. S., Hyun, S. H., Woo, H. G., Jee, B. A., Choi, J. H., Sung, H. K., Choi, H. C., Park, S. Y., Bae, J. H., Doh, K. O., Kim, J. R., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy

Rieger, A. C., Myerburg, R. J., Florea, V., Tompkins, B. A., Natsumeda, M., Premer, C., Khan, A., Schulman, I. H., Vidro-Casiano, M., DiFede, D. L., Heldman, A. W., Mitrani, R. & Hare, J. M., Oct 2019, In : EBioMedicine. 48, p. 377-385 9 p.

Research output: Contribution to journalArticle

Open Access

Intravascular Stem Cell Bioreactor for Prevention of Adverse Remodeling After Myocardial Infarction

Johnston, P. V., Hwang, C. W., Bogdan, V., Mills, K. J., Eggan, E. R., Leszczynska, A., Wu, K. C., Herzka, D. A., Brinker, J. A., Schulman, S. P., Banerjee, M., Florea, V., Natsumeda, M., Tompkins, B., Balkan, W. E., Hare, J., Tomaselli, G. F., Weiss, R. G. & Gerstenblith, G., Aug 6 2019, In : Journal of the American Heart Association. 8, 15, p. e012351

Research output: Contribution to journalArticle

Open Access

Intravenous Stem Cell Therapy for High-Grade Aneurysmal Subarachnoid Hemorrhage: Case Report and Literature Review

Brunet, M. C., Chen, S. H., Khandelwal, P., Hare, J., Starke, R. M., Peterson, E. C. & Yavagal, D. R., Aug 1 2019, In : World neurosurgery. 128, p. 573-575 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
7 Scopus citations

Mesenchymal stem cell secretion of SDF-1α modulates endothelial function in dilated cardiomyopathy

Premer, C., Wanschel, A., Porras, V., Balkan, W., Legendre-Hyldig, T., Saltzman, R. G., Dong, C., Schulman, I. H. & Hare, J. M., Sep 1 2019, In : Frontiers in Physiology. 10, SEP, 1182.

Research output: Contribution to journalArticle

Open Access

Mesenchymal Stem Cells for Periodontal Tissue Regeneration in Elderly Patients

Ledesma-Martínez, E., Mendoza-Núñez, V. M., Santiago-Osorio, E., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1351-1358 8 p.

Research output: Contribution to journalArticle

Open Access

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D. I., Hahn, V. S., Kass, D. A., Hatzistergos, K. E., Hare, J. M., Webster, K. A. & Shehadeh, L. A., Jun 4 2019, In : Journal of the American College of Cardiology. 73, 21, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Progenitor/Stem Cell Delivery by Suprarenal Aorta Route in Acute Kidney Injury

Rangel, É. B., Gomes, S. A., Kanashiro-Takeuchi, R. & Hare, J. M., Nov 1 2019, In : Cell Transplantation. 28, 11, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access

Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial

Parkinson Study Group SURE-PD Investigators, Oct 1 2019, In : Neurology. 93, 14, p. e1328-e1338

Research output: Contribution to journalArticle

1 Scopus citations

Soluble Factors Released from Activated T Lymphocytes Regulate C2C12 Myoblast Proliferation and Cellular Signaling, but Effects Are Blunted in the Elderly

Al-Dabbagh, S., McPhee, J. S., Piasecki, M., Stewart, C. E., Al-Shanti, N., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1375-1385 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
4 Scopus citations

Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair

Hatzistergos, K. E., Williams, A. R., Dykxhoorn, D., Bellio, M. A., Yu, W. & Hare, J. M., Apr 12 2019, In : Circulation research. 124, 8, p. 1184-1197 14 p.

Research output: Contribution to journalArticle

2018

Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth

Arora, H., Panara, K., Kuchakulla, M., Kulandavelu, S., Burnstein, K. L., Schally, A. V., Hare, J. & Ramasamy, R., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11298-11303 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cigarette smoke initiates oxidative stress-induced cellular phenotypic modulation leading to cerebral aneurysm pathogenesis

Starke, R. M., Thompson, J. W., Ali, M. S., Pascale, C. L., Lege, A. M., Ding, D., Chalouhi, N., Hasan, D. M., Jabbour, P., Owens, G. K., Toborek, M. J., Hare, J. & Dumont, A. S., Jan 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 3, p. 610-621 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
27 Scopus citations

Comparison of mesenchymal stem cell efficacy in ischemic versus nonischemic dilated cardiomyopathy

Tompkins, B. A., Rieger, A. C., Florea, V., Banerjee, M. N., Natsumeda, M., Nigh, E. D., Landin, A. M., Rodriguez, G. M., Hatzistergos, K. E., Schulman, I. H. & Hare, J. M., Jul 1 2018, In : Journal of the American Heart Association. 7, 14, e008460.

Research output: Contribution to journalArticle

5 Scopus citations

Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility

Mayourian, J., Ceholski, D. K., Gorski, P. A., Mathiyalagan, P., Murphy, J. F., Salazar, S. I., Stillitano, F., Hare, J. M., Sahoo, S., Hajjar, R. J. & Costa, K. D., Mar 30 2018, In : Circulation Research. 122, 7, p. 933-944 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Kidney-Derived c-Kit+ Cells Possess Regenerative Potential

Gomes, S. A., Hare, J. M. & Rangel, E. B., Apr 1 2018, In : Stem cells translational medicine. 7, 4, p. 317-324 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

Rangel, E. B., Gomes, S. A., Takeuchi, R., Saltzman, R. G., Wei, C., Ruiz, P., Reiser, J. & Hare, J., Dec 1 2018, In : Scientific Reports. 8, 1, 14723.

Research output: Contribution to journalArticle

4 Scopus citations

Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges

Bagno, L., Hatzistergos, K. E., Balkan, W. & Hare, J. M., Jan 1 2018, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

26 Scopus citations

Mesenchymal Stem Cell Therapy for Aging Frailty

Schulman, I. H., Balkan, W. & Hare, J. M., Nov 15 2018, In : Frontiers in Nutrition. 5, 108.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Preclinical Studies of Stem Cell Therapy for Heart Disease

Tompkins, B. A., Balkan, W., Winkler, J., Gyöngyösi, M., Goliasch, G., Fernández-Avilés, F. & Hare, J. M., Mar 30 2018, In : Circulation Research. 122, 7, p. 1006-1020 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Rationale and Design of the SENECA (StEm cell iNjECtion in cAncer survivors) Trial

Cardiovascular Cell Therapy Research Network (CCTRN), Jul 1 2018, In : American Heart Journal. 201, p. 54-62 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells

Hatzistergos, K. E., Jiang, Z., Valasaki, K., Takeuchi, L. M., Balkan, W., Atluri, P., Saur, D., Seidler, B., Tsinoremas, N., Difede, D. L. & Hare, J. M., Jun 1 2018, In : Stem Cells and Development. 27, 12, p. 819-830 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism

Masterson, T. A., Arora, H., Kulandavelu, S., Carroll, R. S., Kaiser, U. B., Gultekin, S. H., Hare, J. & Ramasamy, R., Jan 1 2018, (Accepted/In press) In : Journal of Sexual Medicine.

Research output: Contribution to journalArticle

5 Scopus citations

Subcutaneous Leydig Stem Cell Autograft: A Promising Strategy to Increase Serum Testosterone

Arora, H., Zuttion, M. S. S. R., Nahar, B., Lamb, D., Hare, J. & Ramasamy, R., Jan 1 2018, (Accepted/In press) In : Stem cells translational medicine.

Research output: Contribution to journalArticle

5 Scopus citations
2017
21 Scopus citations

Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty

Golpanian, S., DiFede, D. L., Khan, A., Schulman, I. H., Landin, A. M., Tompkins, B. A., Heldman, A. W., Miki, R., Goldstein, B. J., Mushtaq, M., Levis, S., Byrnes, J., Lowery, M., Natsumeda, M., Delgado, C., Saltzman, R., Vidro-Casiano, M., Pujol, M. V., Da Fonseca, M., Oliva, A. A. & 10 others, Green, G., Premer, C., Medina, A., Valasaki, K., Florea, V., Anderson, E., El-Khorazaty, J., Mendizabal, A., Goldschmidt-Clermont, P. & Hare, J., Oct 12 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 11, p. 1505-1512 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial

Glassberg Csete, M. K., Minkiewicz, J., Toonkel, R. L., Simonet, E. S., Rubio, G. A., DiFede, D., Shafazand, S., Khan, A., Pujol, M. V., LaRussa, V. F., Lancaster, L. H., Rosen, G. D., Fishman, J., Mageto, Y. N., Mendizabal, A. & Hare, J., May 1 2017, In : Chest. 151, 5, p. 971-981 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Tompkins, B. A., DiFede, D. L., Khan, A., Landin, A. M., Schulman, I. H., Pujol, M. V., Heldman, A. W., Miki, R., Goldschmidt-Clermont, P., Goldstein, B. J., Mushtaq, M., Levis, S., Byrnes, J., Lowery, M., Natsumeda, M., Delgado, C., Saltzman, R., Vidro-Casiano, M., Da Fonseca, M., Golpanian, S. & 10 others, Premer, C., Medina, A., Valasaki, K., Florea, V., Anderson, E., El-Khorazaty, J., Mendizabal, A., Green, G., Oliva, A. A. & Hare, J., Oct 12 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 11, p. 1513-1522 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cardiomyocyte Regeneration: A Consensus Statement

Eschenhagen, T., Bolli, R., Braun, T., Field, L. J., Fleischmann, B. K., Frisén, J., Giacca, M., Hare, J., Houser, S., Lee, R. T., Marbán, E., Martin, J. F., Molkentin, J. D., Murry, C. E., Riley, P. R., Ruiz-Lozano, P., Sadek, H. A., Sussman, M. A. & Hill, J. A., Jul 7 2017, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

128 Scopus citations

Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium

Kurtenbach, S., Ding, W., Goss, G. M., Hare, J., Goldstein, B. J. & Shehadeh, L., Nov 1 2017, In : PLoS One. 12, 11, e0187576.

Research output: Contribution to journalArticle

Dose Comparison Study of Allogeneic Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy (The TRIDENT Study)

Florea, V., Rieger, A. C., DiFede, D. L., El-Khorazaty, J., Natsumeda, M., Banerjee, M. N., Tompkins, B. A., Khan, A., Schulman, I. H., Landin, A. M., Mushtaq, M., Golpanian, S., Lowery, M., Byrnes, J., Hendel, R., Cohen, M. G., Valasaki, K., Pujol, M. V., Ghersin, E., Miki, R. & 11 others, Delgado, C., Abuzeid, F., Vidro-Casiano, M., Saltzman, R. G., DaFonseca, D., Caceres, L. V., Ramdas, K. N., Mendizabal, A., Heldman, A. W., Mitrani, R. & Hare, J., Nov 10 2017, In : Circulation Research. 121, 11, p. 1279-1290 12 p.

Research output: Contribution to journalArticle

44 Scopus citations
5 Scopus citations

Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN PACE Trial (Patients with Intermittent Claudication Injected with ALDH Bright Cells)

Perin, E. C., Murphy, M. P., March, K. L., Bolli, R., Loughran, J., Yang, P. C., Leeper, N. J., Dalman, R. L., Alexander, J., Henry, T. D., Traverse, J. H., Pepine, C. J., David Anderson, R., Berceli, S., Willerson, J. T., Muthupillai, R., Gahremanpour, A., Raveendran, G., Velasquez, O., Hare, J. & 35 others, Schulman, I. H., Kasi, V. S., Hiatt, W. R., Ambale-Venkatesh, B., Lima, J. A., Taylor, D. A., Resende, M., Gee, A. P., Durett, A. G., Bloom, J., Richman, S., G'Sell, P., Williams, S., Khan, F., Ross, E. G., Santoso, M. R., Goldman, J., Leach, D., Handberg, E., Cheong, B., Piece, N., Difede, D., Bruhn-Ding, B., Caldwell, E., Bettencourt, J., Lai, D., Piller, L., Simpson, L., Cohen, M., Sayre, S. L., Vojvodic, R. W., Moyé, L., Ebert, R. F., Simari, R. D. & Hirsch, A. T., Apr 11 2017, In : Circulation. 135, 15, p. 1417-1428 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Evidence for a retinal progenitor cell in the postnatal and adult mouse

Chen, X., Wang, S., Xu, H., Pereira, J. D., Hatzistergos, K. E., Saur, D., Seidler, B., Hare, J., Perrella, M. A., Yin, Z. Q. & Liu, X., Aug 1 2017, In : Stem Cell Research. 23, p. 20-32 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Experimental and Computational Insight into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity

Mayourian, J., Cashman, T. J., Ceholski, D. K., Johnson, B. V., Sachs, D., Kaji, D. A., Sahoo, S., Hare, J., Hajjar, R. J., Sobie, E. A. & Costa, K. D., Jun 23 2017, (Accepted/In press) In : Circulation Research.

Research output: Contribution to journalArticle

27 Scopus citations

Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure

Gesmundo, I., Miragoli, M., Carullo, P., Trovato, L., Larcher, V., Di Pasquale, E., Brancaccio, M., Mazzola, M., Villanova, T., Sorge, M., Taliano, M., Gallo, M. P., Alloatti, G., Penna, C., Hare, J., Ghigo, E., Schally, A. V., Condorelli, G. & Granata, R., Nov 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. 12033-12038 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
10 Scopus citations

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio, M. A., Pinto, M. T., Florea, V., Barrios, P. A., Taylor, C. N., Brown, A. B., Lamondin, C., Hare, J., Schulman, I. H. & Rodrigues, C. D., Dec 1 2017, In : Scientific Reports. 7, 1, 9702.

Research output: Contribution to journalArticle

3 Scopus citations