Photo of Izidore Lossos

Izidore Lossos

  • 17305 Citations
1988 …2024

Research output per year

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Research Output

  • 17305 Citations
  • 272 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Chapter
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Article
2019
1 Scopus citations

Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling

Jiang, X., Lu, X., Zhang, Y., Lacaria, L., Schuchardt, B. J., Mikles, D. C., Magistri, M., García-Ramírez, I., Sanchez-Garcia, I., Farooq, A., Verdun, R. E., Abdulreda, M. H., Moy, V. T. & Lossos, I. S., Aug 13 2019, In : Blood Advances. 3, 15, p. 2286-2297 12 p.

Research output: Contribution to journalArticle

Open Access

LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL

Parvin, S., Ramirez-Labrada, A., Aumann, S., Lu, X. Q., Weich, N., Santiago, G., Cortizas, E. M., Sharabi, E., Zhang, Y., Sanchez-Garcia, I., Gentles, A. J., Roberts, E., Bilbao-Cortes, D., Vega, F., Chapman, J. R., Verdun, R. E. & Lossos, I. S., Sep 16 2019, In : Cancer Cell. 36, 3, p. 237-249.e6

Research output: Contribution to journalArticle

1 Scopus citations

Maintenance rituximab or observation after frontline treatment with bendamustine-rituximab for follicular lymphoma

Hill, B. T., Nastoupil, L., Winter, A. M., Becnel, M. R., Cerhan, J. R., Habermann, T. M., Link, B. K., Maurer, M. J., Fakhri, B., Reddy, P., Smith, S. D., Mukhija, D., Jagadeesh, D., Desai, A., Alderuccio, J. P., Lossos, I., Mehra, P., Portell, C. A., Goldman, M. L., Calzada, O. & 9 others, Cohen, J. B., Hussain, M. J., Ghosh, N., Caimi, P., Tiutan, T., Martin, P., Kodali, A., Evens, A. M. & Kahl, B. S., Feb 1 2019, In : British Journal of Haematology. 184, 4, p. 524-535 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Unusual Variants of Follicular Lymphoma: Case-based Review

Chapman, J. R., Alvarez, J. P., White, K., Sanchez, S., Khanlari, M., Algashaamy, K., Cassidy, D., Peng, J. H., Fan, Y. S., Alencar, A., Alderuccio, J. P., Lossos, I. S. & Vega, F., Jan 1 2019, (Accepted/In press) In : American Journal of Surgical Pathology.

Research output: Contribution to journalArticle

2018

CD4+/CD8+ immunophenotype switching as a marker for intraocular and CNS involvement in mycosis fungoides

Husnain, M., Mackrides, N., Vega, F., Paez-Escamilla, M., Markoe, A., William Harbour, J. & Lossos, I., Jan 1 2018, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

2 Scopus citations

Lmo2 expression defines tumor cell identity during T-cell leukemogenesis

García-Ramírez, I., Bhatia, S., Rodríguez-Hernández, G., González-Herrero, I., Walter, C., González de Tena-Dávila, S., Parvin, S., Haas, O., Woessmann, W., Stanulla, M., Schrappe, M., Dugas, M., Natkunam, Y., Orfao, A., Domínguez, V., Pintado, B., Blanco, O., Alonso-López, D., De Las Rivas, J., Martín-Lorenzo, A. & 8 others, Jiménez, R., García Criado, F. J., García Cenador, M. B., Lossos, I., Vicente-Dueñas, C., Borkhardt, A., Hauer, J. & Sánchez-García, I., Jul 13 2018, In : EMBO Journal. 37, 14, e98783.

Research output: Contribution to journalArticle

8 Scopus citations

MiR-181 family-specific behavior in different cancers: a meta-analysis view

Pop-Bica, C., Pintea, S., Cojocneanu-Petric, R., Del Sal, G., Piazza, S., Wu, Z. H., Alencar, A. J., Lossos, I., Berindan-Neagoe, I. & Calin, G. A., Jan 11 2018, (Accepted/In press) In : Cancer and Metastasis Reviews. p. 1-16 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prevalence, clinical characteristics and prognosis of EBV-positive follicular lymphoma

Mackrides, N., Chapman, J., Larson, M. C., Ramos, J. C., Toomey, N., Lin, P., Maurer, M. J., Rafaelle, M., Tan, Y., Ikpatt, O., Syrbu, S., Ansell, S. M., Habermann, T. M., Link, B. K., Feldman, A. L., Lossos, I. S., Cerhan, J. R. & Vega, F., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

2 Scopus citations

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

Lu, X., Fernando, T. M., Lossos, C., Yusufova, N., Liu, F., Fontán, L., Durant, M., Geng, H., Melnick, J., Luo, Y., Vega, F., Moy, V. T., Inghirami, G., Nimer, S. D., Melnick, A. M. & Lossos, I., Nov 8 2018, In : Blood. 132, 19, p. 2026-2039 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2 Scopus citations

Risk factors for transformation to higher-grade lymphoma and its impact on survival in a large cohort of patients with marginal zone lymphoma from a single institution

Alderuccio, J. P., Zhao, W., Desai, A., Gallastegui, N., Ramdial, J., Kimble, E., De La Fuente, M. I., Rosenblatt, J. D., Chapman-Fredricks, J., Vega, F., Reis, I. & Lossos, I., Dec 1 2018, In : Journal of Clinical Oncology. 36, 34, p. 3370-3380 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Smoothened stabilizes and protects TRAF6 from degradation: A novel non-canonical role of smoothened with implications in lymphoma biology

Qu, C., Kunkalla, K., Vaghefi, A., Frederiksen, J. K., Liu, Y., Chapman-Fredricks, J., Blonska, M., Bernal-Mizrachi, L., Alderuccio, J. P., Lossos, I., Landgraf, R. & Vega, F., Nov 1 2018, In : Cancer Letters. 436, p. 149-158 10 p.

Research output: Contribution to journalArticle

2017

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

Abate, F., Da Silva-Almeida, A. C., Zairis, S., Robles-Valero, J., Couronne, L., Khiabanian, H., Quinn, S. A., Kim, M. Y., Laginestra, M. A., Kim, C., Fiore, D., Bhagat, G., Piris, M. A., Campo, E., Lossos, I., Bernard, O. A., Inghirami, G., Pileri, S., Bustelo, X. R., Rabadan, R. & 2 others, Ferrando, A. A. & Palomero, T., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. 764-769 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Anti-CD20-interleukin-21 fusokine targets malignant B cells via direct apoptosis and NK-cell–dependent cytotoxicity

Bhatt, S., Parvin, S., Zhang, Y., Cho, H. M., Kunkalla, K., Vega, F., Timmerman, J. M., Shin, S-U., Rosenblatt, J. D. & Lossos, I., Apr 20 2017, In : Blood. 129, 16, p. 2246-2256 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL

Pilichowska, M., Pittaluga, S., Ferry, J. A., Hemminger, J., Chang, H., Kanakry, J. A., Sehn, L. H., Feldman, T., Abramson, J. S., Kritharis, A., Hernandez-Ilizaliturri, F. J., Lossos, I. S., Press, O. W., Fenske, T. S., Friedberg, J. W., Vose, J. M., Blum, K. A., Jagadeesh, D., Woda, B., Gupta, G. K. & 3 others, Gascoyne, R. D., Jaffe, E. S. & Evens, A. M., Dec 12 2017, In : Blood Advances. 1, 26, p. 2600-2609 10 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Epstein-Barr virus-positive follicular lymphoma

Mackrides, N., Campuzano-Zuluaga, G., Maque-Acosta, Y., Moul, A., Hijazi, N., Ikpatt, O., Levy, R., Verdun, R. E., Kunkalla, K., Natkunam, Y., Lossos, I., Vega, F. & Chapman-Fredricks, J., Apr 1 2017, In : Modern Pathology. 30, 4, p. 519-529 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
5 Scopus citations

Long-term course of patients with primary ocular adnexal MALT lymphoma: a large single-institution cohort study

Desai, A., Joag, M. G., Lekakis, L., Chapman-Fredricks, J., Vega, F., Tibshirani, R., Tse, D., Markoe, A. & Lossos, I., Jan 19 2017, In : Blood. 129, 3, p. 324-332 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype

Guo, X., Koff, J. L., Moffitt, A. B., Cinar, M., Ramachandiran, S., Chen, Z., Switchenko, J. M., Mosunjac, M., Neill, S. G., Mann, K. P., Bagirov, M., Du, Y., Natkunam, Y., Khoury, H. J., Rossi, M. R., Harris, W., Flowers, C. R., Lossos, I. S., Boise, L. H., Dave, S. S. & 2 others, Kowalski, J. & Bernal-Mizrachi, L., Apr 3 2017, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

8 Scopus citations

Observational study of lenalidomide in patients with mantle cell lymphoma who relapsed/progressed after or were refractory/intolerant to ibrutinib (MCL-004)

Wang, M., Schuster, S. J., Phillips, T., Lossos, I., Goy, A., Rule, S., Hamadani, M., Ghosh, N., Reeder, C. B., Barnett, E., Bravo, M. L. C. & Martin, P., Nov 2 2017, In : Journal of Hematology and Oncology. 10, 1, 171.

Research output: Contribution to journalArticle

9 Scopus citations

The genetic basis of hepatosplenic T-cell lymphoma

McKinney, M., Moffitt, A. B., Gaulard, P., Travert, M., Leval, L. D., Raffeld, A. N. M., Jaffe, E. S., Pittaluga, S., Xi, L., Heavican, T., Iqbal, J., Belhadj, K., Delfau-Larue, M. H., Fataccioli, V., Czader, M. B., Lossos, I., Chapman-Fredricks, J., Richards, K. L., Fedoriw, Y., Ondrejka, S. L. & 35 others, Hsi, E. D., Low, L., Weisenburger, D., Chan, W. C., Mehta-Shah, N., Horwitz, S., Bernal-Mizrachi, L., Flowers, C. R., Beaven, A. W., Parihar, M., Baseggio, L., Parrens, M., Moreau, A., Sujobert, P., Pilichowska, M., Evens, A. M., Chadburn, A., Au-Yeung, R. K. H., Srivastava, G., Choi, W. W. L., Goodlad, J. R., Aurer, I., Basic-Kinda, S., Gascoyne, R. D., Davis, N. S., Li, G., Zhang, J., Rajagopalan, D., Reddy, A., Love, C., Levy, S., Zhuang, Y., Datta, J., Dunson, D. B. & Davé, S. S., Apr 1 2017, In : Cancer Discovery. 7, 4, p. 369-379 11 p.

Research output: Contribution to journalArticle

59 Scopus citations
2016

Active IKKb promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

Agarwal, N. K., Kim, C. H., Kunkalla, K., Konno, H., Tjendra, Y., Kwon, D., Blonska, M., Kozloski, G. A., Moy, V. T., Verdun, R. E., Barber, G. N., Lossos, I. & Vega, F., Feb 4 2016, In : Blood. 127, 5, p. 605-615 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Characteristics and outcomes of lymphoblastic lymphoma – the University of Miami experience

Alderuccio, J. P., Amarapurkar, P., Chapman-Fredricks, J., Vega, F. & Lossos, I., Jun 1 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-4 4 p.

Research output: Contribution to journalArticle

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo

Healy, J. A., Nugent, A., Rempel, R. E., Moffitt, A. B., Davis, N. S., Jiang, X., Shingleton, J. R., Zhang, J., Love, C., Datta, J., McKinney, M. E., Tzeng, T. J., Wettschureck, N., Offermanns, S., Walzer, K. A., Chi, J. T., Rasheed, S. A. K., Casey, P. J., Lossos, I. & Dave, S. S., 2016, In : Blood. 127, 22, p. 2723-2731 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

MiR-181a negatively regulates NF-κB signaling and affects activated B-cell-like diffuse large B-cell lymphoma pathogenesis

Kozloski, G. A., Jiang, X., Bhatt, S., Ruiz, J., Vega, F., Shaknovich, R., Melnick, A. & Lossos, I., Jun 9 2016, In : Blood. 127, 23, p. 2856-2866 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

Matthews, J. M., Bhatt, S., Patricelli, M. P., Nomanbhoy, T. K., Jiang, X., Natkunam, Y., Gentles, A. J., Martinez, E., Zhu, D., Chapman-Fredricks, J., Cortizas, E., Shyam, R., Chinichian, S., Advani, R., Tan, L., Zhang, J., Choi, H. G., Tibshirani, R., Buhrlage, S. J., Gratzinger, D. & 3 others, Verdun, R. E., Gray, N. S. & Lossos, I., Jul 14 2016, In : Blood. 128, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

A roadmap for discovery and translation in lymphoma

Weinstock, D. M., Dalla-Favera, R., Gascoyne, R. D., Leonard, J. P., Levy, R., Lossos, I., Melnick, A. M., Nowakowski, G. S., Press, O. W., Savage, K. J., Shipp, M. A. & Staudt, L. M., Mar 26 2015, In : Blood. 125, 13, p. 2175-2177 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Chlamydophila psittaci-negative ocular adnexal marginal zone lymphomas express self polyreactive B-cell receptors

Zhu, D., Bhatt, S., Lu, X., Guo, F., Veelken, H., Hsu, D. K., Liu, F. T., Alvarez Cubela, S., Kunkalla, K., Vega, F., Chapman-Fredricks, J. & Lossos, I., Jul 13 2015, In : Leukemia. 29, 7, p. 1587-1599 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-κB pathway

Ramachandiran, S., Adon, A., Guo, X., Wang, Y., Wang, H., Chen, Z., Kowalski, J., Sunay, U. R., Young, A. N., Brown, T., Mar, J. C., Du, Y., Fu, H., Mann, K. P., Natkunam, Y., Boise, L. H., Saavedra, H. I., Lossos, I. & Bernal-Mizrachi, L., May 15 2015, In : International Journal of Cancer. 136, 10, p. 2341-2351 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gene expression analysis of plasmablastic lymphoma identifies downregulation of B-cell receptor signaling and additional unique transcriptional programs

Chapman-Fredricks, J., Gentles, A. J., Sujoy, V., Vega, F., Dumur, C. I., Blevins, T. L., Bernal-Mizrachi, L., Mosunjac, M., Pimentel, A., Zhu, D. & Lossos, I., Nov 1 2015, In : Leukemia. 29, 11, p. 2270-2273 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

LymphomiRs: MicroRNAs with regulatory roles in lymphomas

Kozloski, G. A. & Lossos, I., Jul 1 2015, In : Current Opinion in Hematology. 22, 4, p. 362-368 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phase II study of <sup>90</sup>Y Ibritumomab tiuxetan (Zevalin) in patients with previously untreated marginal zone lymphoma

Lossos, I., Fabregas, J. C., Sengul, T., Miao, F., Goodman, D., Serafini, A. N., Hosein, P., Stefanovic, A., Rosenblatt, J. D. & Hoffman, J. E., Jun 1 2015, In : Leukemia and Lymphoma. 56, 6, p. 1750-1755 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient

Ruiz-Cordero, R., Lewis, J., Blieden, C., Campuzano-Zuluaga, G., Hernandez, J., Lossos, I., Ikpatt, O., Chapman-Fredricks, J. & Vega, F., Jun 1 2015, In : Human Pathology: Case Reports. 2, 2, p. 49-54 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

A multicentre study of primary breast diffuse large B-cell lymphoma in the rituximab era

Hosein, P., Maragulia, J. C., Salzberg, M. P., Press, O. W., Habermann, T. M., Vose, J. M., Bast, M., Advani, R. H., Tibshirani, R., Evens, A. M., Islam, N., Leonard, J. P., Martin, P., Zelenetz, A. D. & Lossos, I., Jan 1 2014, In : British Journal of Haematology. 165, 3, p. 358-363 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma: A multicentre phase II study

Evens, A. M., Smith, M. R., Lossos, I., Helenowski, I., Millenson, M., Winter, J. N., Rosen, S. T. & Gordon, L. I., Jan 1 2014, In : British Journal of Haematology. 166, 4, p. 514-520 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma

Lossos, C., Bayraktar, S., Weinzierl, E., Younes, S. F., Hosein, P., Tibshirani, R. J., Sutton Posthumus, J., Deangelis, L. M., Raizer, J., Schiff, D., Abrey, L., Natkunam, Y. & Lossos, I., Jan 1 2014, In : British Journal of Haematology. 165, 5, p. 640-648 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phase ii study of alisertib, a selective aurora a kinase inhibitor, in relapsed and refractory aggressive B- And T-cell non-Hodgkin lymphomas

Friedberg, J. W., Mahadevan, D., Cebula, E., Persky, D., Lossos, I., Agarwal, A. B., Jung, J., Burack, R., Zhou, X., Leonard, E. J., Fingert, H., Danaee, H. & Bernstein, S. H., Jan 1 2014, In : Journal of Clinical Oncology. 32, 1, p. 44-50 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Progressive leukemic non-nodal mantle cell lymphoma associated with deletions of TP53, ATM, and/or 13q14

Chapman-Fredricks, J., Sandoval-Sus, J., Vega, F. & Lossos, I., Jan 1 2014, In : Annals of Diagnostic Pathology. 18, 4, p. 214-219 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

Palomero, T., Couronné, L., Khiabanian, H., Kim, M. Y., Ambesi-Impiombato, A., Perez-Garcia, A., Carpenter, Z., Abate, F., Allegretta, M., Haydu, J. E., Jiang, X., Lossos, I., Nicolas, C., Balbin, M., Bastard, C., Bhagat, G., Piris, M. A., Campo, E., Bernard, O. A., Rabadan, R. & 1 others, Ferrando, A. A., Jan 1 2014, In : Nature Genetics. 46, 2, p. 166-170 5 p.

Research output: Contribution to journalArticle

290 Scopus citations