Guy Howard

Research Professor

  • 4428 Citations
1978 …2016

Research output per year

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Research Output

  • 4428 Citations
  • 84 Article
  • 1 Chapter
  • 1 Comment/debate
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Article
2016

Hepatocyte growth factor and alternative splice variants - expression, regulation and implications in osteogenesis and bone health and repair

Frisch, R. N., Curtis, K. M., Aenlle, K. K. & Howard, G., Mar 21 2016, (Accepted/In press) In : Expert Opinion on Therapeutic Targets. p. 1-12 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interactions between adipocytes and breast cancer cells stimulate cytokine production and drive Src/Sox2/miR-302b-mediated malignant progression

Picon-Ruiz, M., Pan, C., Drews-Elger, K., Jang, K., Besser, A. H., Zhao, D., Morata-Tarifa, C., Kim, M., Ince, T. A., Azzam, D. J., Wander, S. A., Wang, B., Ergonul, B., Datar, R. H., Cote, R. J., Howard, G. A., El-Ashry, D., Torné-Poyatos, P., Marchal, J. A. & Slingerland, J. M., Jan 15 2016, In : Cancer Research. 76, 2, p. 491-504 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Low Oxygen Modulates Multiple Signaling Pathways, Increasing Self-Renewal, while Decreasing Differentiation, Senescence, and Apoptosis in Stromal MIAMI Cells

Rios, C., D'Ippolito, G., Curtis, K. M., Delcroix, G. J-R., Gomez, L. A., El Hokayem, J., Rieger, M., Parrondo, R., De Las Pozas, A., Perez-Stable, C., Howard, G. A. & Schiller, P. C., Jun 1 2016, In : Stem Cells and Development. 25, 11, p. 848-860 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

TAp63γ and ΔNp63β promote osteoblastic differentiation of human mesenchymal stem cells: Regulation by vitamin D3 metabolites

Curtis, K. M., Aenlle, K. K., Frisch, R. N. & Howard, G. A., Apr 7 2015, In : PloS one. 10, 4, e0123642.

Research output: Contribution to journalArticle

7 Scopus citations
2014

24R,25-Dihydroxyvitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells

Curtis, K. M., Aenlle, K. K., Roos, B. A. & Howard, G. A., May 2014, In : Molecular Endocrinology. 28, 5, p. 644-658 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells

Aenlle, K. K., Curtis, K. M., Roos, B. A. & Howard, G. A., May 2014, In : Molecular Endocrinology. 28, 5, p. 722-730 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Progerin expression disrupts critical adult stem cell functions involved in tissue repair

Pacheco, L. M., Gomez, L. A., Dias, J., Ziebarth, N. M., Howard, G. A. & Schiller, P. C., 2014, In : Aging. 6, 12, p. 1049-1063 15 p.

Research output: Contribution to journalArticle

26 Scopus citations
2012

Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR

Chen, K., Aenlle, K. K., Curtis, K. M., Roos, B. A. & Howard, G. A., Jul 1 2012, In : Bone. 51, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Human bone marrow-derived stem cell proliferation is inhibited by hepatocyte growth factor via increasing the cell cycle inhibitors p53, p21 and p27

Chen, K., Perez-Stable, C., D'Ippolito, G., Schiller, P. C., Roos, B. A. & Howard, G. A., Dec 1 2011, In : Bone. 49, 6, p. 1194-1204 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
36 Scopus citations
2010

Changes in the expression of genes associated with intraneuronal amyloid-β and tau in Alzheimer's disease

Fujimura, R. K., Reiner, T., Ma, F., Phillips, V., De Las Pozas, A., Dickson, D. W., Roos, B. A., Howard, G. A. & Perez-Stable, C., 2010, In : Journal of Alzheimer's Disease. 19, 1, p. 97-109 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2006

Isolation and characterization of marrow-isolated adult multilineage inducible (MIAMI) cells

D'Ippolito, G., Howard, G. A., Roos, B. A. & Schiller, P. C., Nov 1 2006, In : Experimental Hematology. 34, 11, p. 1608-1610 3 p.

Research output: Contribution to journalArticle

53 Scopus citations

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

D'Ippolito, G., Diabira, S., Howard, G. A., Roos, B. A. & Schiller, P. C., Sep 1 2006, In : Bone. 39, 3, p. 513-522 10 p.

Research output: Contribution to journalArticle

279 Scopus citations

Sustained stromal stem cell self-renewal and osteoblastic differentiation during aging

D'Ippolito, G., Howard, G. A., Roos, B. A. & Schiller, P. C., Mar 1 2006, In : Rejuvenation Research. 9, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2005
22 Scopus citations
2004

Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential

D'Ippolito, G., Diabira, S., Howard, G. A., Menei, P., Roos, B. A. & Schiller, P. C., Jun 15 2004, In : Journal of Cell Science. 117, 14, p. 2971-2981 11 p.

Research output: Contribution to journalArticle

549 Scopus citations
2003

Autosomal dominant hyperostosis/osteosclerosis with high serum alkaline phosphatase activity

Hernandez-Cassis, C., Vogel, C. K., Hernandez, T. P., Econs, M. J., Iglesias, M., Iglesias, A., Levis, S., Roos, B. A., Howard, G. A. & Gamarra, A. I., Jun 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 6, p. 2650-2655 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2002
58 Scopus citations

The Gγ/T-15 transgenic mouse model of androgen-independent prostate cancer: Target cells of carcinogenesis and the effect of the vitamin D analogue EB 1089

Perez-Stable, C. M., Farinas, A., Howard, G. A., Roos, B. A., Perez-Stable, C. M., Howard, G. A., Roos, B. A., Howard, G. A., Roos, B. A., Perez-Stable, C. M., Howard, G. A., Roos, B. A., Schwartz, G. G., Finegold, M. & Binderup, L., Jan 1 2002, In : Cancer Epidemiology Biomarkers and Prevention. 11, 6, p. 555-563 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2001

2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer

Qadan, L. R., Perez-Stable, C. M., Anderson, C., D'Ippolito, G., Herron, A., Howard, G. A. & Roos, B. A., Jan 1 2001, In : Biochemical and biophysical research communications. 285, 5, p. 1259-1266 8 p.

Research output: Contribution to journalArticle

85 Scopus citations
30 Scopus citations

Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3-E1 osteoblasts in vitro

Fornoni, A., Cornacchia, F., Howard, G. A., Roos, B. A., Striker, G. E. & Striker, L. J., Jan 1 2001, In : Nephrology Dialysis Transplantation. 16, 3, p. 500-505 6 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Gap-junctional communication is required for the maturation process of osteoblastic cells in culture

Schiller, P. C., D'Ippolito, G., Balkan, W., Roos, B. A. & Howard, G. A., May 10 2001, In : Bone. 28, 4, p. 362-369 8 p.

Research output: Contribution to journalArticle

123 Scopus citations

Gap-junctional communication mediates parathyroid hormone stimulation of mineralization in osteoblastic cultures

Schiller, P. C., D'Ippolito, G., Balkan, W., Roos, B. A. & Howard, G. A., Feb 13 2001, In : Bone. 28, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Inhibition of Gap-Junctional Communication Induces the Trans-differentiation of Osteoblasts to an Adipocytic Phenotype in Vitro

Schiller, P. C., D'Ippolito, G., Brambilla, R., Roos, B. A. & Howard, G. A., Apr 27 2001, In : Journal of Biological Chemistry. 276, 17, p. 14133-14138 6 p.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations
2000

Hepatocyte growth factor and vitamin D cooperatively inhibit androgen-unresponsive prostate cancer cell lines

Qadan, L. R., Perez-Stable, C. M., Schwall, R. H., Burnstein, K. L., Ostenson, R. C., Howard, G. A. & Roos, B. A., Jan 1 2000, In : Endocrinology. 141, 7, p. 2567-2573 7 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
1999

Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow

D'Ippolito, G., Schiller, P. C., Ricordi, C., Roos, B. A. & Howard, G. A., Jul 17 1999, In : Journal of Bone and Mineral Research. 14, 7, p. 1115-1122 8 p.

Research output: Contribution to journalArticle

689 Scopus citations

Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment

Schiller, P. C., D'Ippolito, G., Roos, B. A. & Howard, G. A., Sep 13 1999, In : Journal of Bone and Mineral Research. 14, 9, p. 1504-1512 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein

Balkan, W., Oates, E. L., Howard, G. A. & Roos, B. A., Jan 1 1999, In : Endocrinology. 140, 3, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
1997

Absence of androgen-mediated transcriptional effects in osteoblastic cells despite presence of androgen receptors

Czerwiec, F. S., Liaw, J. J., Liu, S. B., Perez-Stable, C., Grumbles, R., Howard, G. A., Roos, B. A. & Burnstein, K. L., Jul 1 1997, In : Bone. 21, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
52 Scopus citations
1996

Calcitonin gene-related peptide is an adipose-tissue neuropeptide with lipolytic actions

Chatzipanteli, K., Goldbergt, R. B., Howard, G. A. & Roos, B. A., Jan 1 1996, In : Endocrinology and Metabolism, Supplement. 3, 4, p. 235-242 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Calcitonin gene-related peptide rapidly inhibits calcium uptake in osteoblastic cell lines via activation of adenosine triphosphate-sensitive potassium channels

Kawase, T., Howard, G. A., Roos, B. A. & Burns, D. M., Jan 1 1996, In : Endocrinology. 137, 3, p. 984-990 7 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP

Mehta, P. P., Lokeshwar, B. L., Schiller, P. C., Bendix, M. V., Ostenson, R. C., Howard, G. A. & Roos, B. A., Jan 1 1996, In : Molecular Carcinogenesis. 15, 1, p. 18-32 15 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hepatocyte growth factor and its actions in growth plate chondrocytes

Grumbles, R. M., Howell, D. S., Wenger, L., Altman, R. D., Howard, G. A. & Roos, B. A., Sep 1996, In : Bone. 19, 3, p. 255-261 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
1995

Calcitonin gene-related peptide (cgrp) in the developing mouse limb

Bidegain, M., Roos, B. A., Hill, E. L., Howard, G. A. & Balkan, W., Jan 1995, In : Endocrine Research. 21, 4, p. 743-755 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cartilage metalloproteases in disuse atrophy

Grumbles, R. M., Howell, D. S., Howard, G. A., Roos, B. A., Setton, L. A., Mow, C., Ratcliffe, A., Muller, F. J. & Altman, R. D., Jan 1 1995, In : Journal of Rheumatology. 22, SUPPL. 43, p. 146-148 3 p.

Research output: Contribution to journalArticle

35 Scopus citations

Diverse actions of calcitonin gene-related peptide on intracellular free Ca2+ concentrations in UMR 106 osteoblastic cells

Kawase, T., Howard, G. A., Roos, B. A. & Burns, D. M., Apr 1995, In : Bone. 16, 4 SUPPL., p. S379-S384

Research output: Contribution to journalArticle

24 Scopus citations
1992

17β Estradiol stimulation of endosteal bone formation in the ovariectomized mouse: An animal model for the evaluation of bone-targeted estrogens

Edwards, M. W., Bain, S. D., Bailey, M. C., Lantry, M. M. & Howard, G. A., 1992, In : Bone. 13, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

An Assessment of the Anabolic Skeletal Actions of the Common‐Region Peptides Derived from the CGRP and Calcitonin Prohormones

BURNS, DOUGLAS. M., HOWARD, GUY. A. & Roos, B. A., Jun 1992, In : Annals of the New York Academy of Sciences. 657, 1, p. 50-62 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
Open Access
121 Scopus citations
1991

Bone‐cell changes in estrogen‐induced bone‐mass increase in mice: Dissociation of osteoclasts from bone surfaces

Liu, CC. C. & Howard, G. A., Feb 1991, In : The Anatomical Record. 229, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Ethanol inhibits human bone cell proliferation and function in vitro

Friday, K. E. & Howard, G. A., Jun 1991, In : Metabolism. 40, 6, p. 562-565 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Identification of a low molecular weight inhibitor of osteoblast mitogenesis in uremic plasma

Andress, D. L., Howard, G. A. & Birnbaum, R. S., May 1991, In : Kidney international. 39, 5, p. 942-945 4 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats

Spencer, E. M., Liu, C. C., Si, E. C. C. & Howard, G. A., 1991, In : Bone. 12, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

212 Scopus citations
1989

Acetate inhibition of chick bone cell proliferation and bone growth in vitro

Saitta, J. C., Lipkin, E. W. & Howard, G. A., Jun 1989, In : Journal of Bone and Mineral Research. 4, 3, p. 379-386 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Glycosylation reduces the bioactivity of calcitonin

Gkonos, P. J., Charbonneau, H., Lawson, P. T., Howard, G. A., Birnbaum, R. S. & Roos, B. A., Jan 1 1989, In : Peptides. 10, 1, p. 137-143 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
3 Scopus citations

Ontogeny of peptidylglycine alpha-amidating monooxygenase activity in rapidly mineralizing bone from neonatal mouse

Birnbaum, R. S., Howard, G. A. & Roos, B. A., Jun 1989, In : Endocrinology. 124, 6, p. 3134-3136 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Parathyroid hormone potentiates the effect of insulin-like growth factor-I on bone formation

Spencer, E. M., Si, E. C. C., Liu, C. C. & Howard, G. A., 1989, In : Acta endocrinologica. 121, 3, p. 435-442 8 p.

Research output: Contribution to journalArticle

20 Scopus citations