Feng-Chun Yang

Professor

  • 4907 Citations
1993 …2023
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Research Output 1993 2019

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Article
2001
72 Citations (Scopus)

Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency

Gu, Y., Jia, B., Yang, F-C., D'Souza, M., Harris, C. E., Derrow, C. W., Zheng, Y. & Williams, D. A., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 15929-15938 10 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Cells
Guanine Nucleotide Exchange Factors
Guanosine Triphosphate
Bone
74 Citations (Scopus)

Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac

Xu, M., Matsuoka, S., Yang, F-C., Ebihara, Y., Manabe, A., Tanaka, R., Eguchi, M., Asano, S., Nakahata, T. & Tsuji, K., Apr 1 2001, In : Blood. 97, 7, p. 2016-2022 7 p.

Research output: Contribution to journalArticle

Yolk Sac
Megakaryocytes
Platelets
Thrombopoietin
Stem Cell Factor
148 Citations (Scopus)

Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

Yang, F-C., Atkinson, S. J., Gu, Y., Borneo, J. B., Roberts, A. W., Zheng, Y., Pennington, J. & Williams, D. A., May 8 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 10, p. 5614-5618 5 p.

Research output: Contribution to journalArticle

Cell Shape
GTP Phosphohydrolases
Hematopoietic Stem Cells
Cell Adhesion
Bone Marrow
2000
8 Citations (Scopus)

Cytokine requirement for the development of T-lymphoid lineage potential in clonal lymphohaematopoietic progenitors in vitro

Ma, F., Yang, F-C., Kaneko, A., Manabe, A., Tanaka, R., Asano, S., Nakahata, T. & Tsuji, K., 2000, In : British Journal of Haematology. 111, 4, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

Cytokines
T-Lymphocytes
Stem Cell Factor
Organ Culture Techniques
Fluorouracil
262 Citations (Scopus)

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

Williams, D. A., Tao, W., Yang, F-C., Kim, C., Gu, Y., Mansfield, P., Levine, J. E., Petryniak, B., Derrow, C. W., Harris, C., Jia, B., Zheng, Y., Ambruso, D. R., Lowe, J. B., Atkinson, S. J., Dinauer, M. C. & Boxer, L., Sep 1 2000, In : Blood. 96, 5, p. 1646-1654 9 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Phagocytes
Cells
Mutation
Neutrophils
146 Citations (Scopus)

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Ingram, D. A., Yang, F-C., Travers, J. B., Wenning, M. J., Hiatt, K., New, S., Hood, A., Shannon, K., Williams, D. A. & Clapp, D. W., Jan 3 2000, In : Journal of Experimental Medicine. 191, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Neurofibromatosis 1
Melanocytes
Tumor Suppressor Genes
Mast Cells
138 Citations (Scopus)

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F-C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Mast Cells
Actins
Intercellular Signaling Peptides and Proteins
rac1 GTP-Binding Protein
1999
23 Citations (Scopus)

Differential effects of human granulocyte colony-stimulating factor (hG- CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice

Yang, F-C., Tsuji, K., Oda, A., Ebihara, Y., Xu, M., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., Watanabe, S., Ikeda, Y. & Nakahata, T., Aug 1 1999, In : Blood. 94, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Thrombopoietin
Granulocyte Colony-Stimulating Factor
Platelets
Transgenic Mice
1998
37 Citations (Scopus)

Human granulocyte colony-stimulating factor (G-CSF) stimulates the in vitro and in vivo development but not commitment of primitive multipotential progenitors from transgenic mice expressing the human G-CSF receptor

Yang, F-C., Watanabe, S., Tsuji, K., Xu, M., Kaneko, A., Ebihara, Y. & Nakahata, T., Dec 15 1998, In : Blood. 92, 12, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Granulocyte Colony-Stimulating Factor
Transgenic Mice
Bone
Interleukin-3
131 Citations (Scopus)

Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines

Xu, M., Tsuji, K., Ueda, T., Mukouyama, Y. S., Hara, T., Yang, F-C., Ebihara, Y., Matsuoka, S., Manabe, A., Kikuchi, A., Ito, M., Miyajima, A. & Nakahata, T., Sep 15 1998, In : Blood. 92, 6, p. 2032-2040 9 p.

Research output: Contribution to journalArticle

Mesonephros
Hematopoiesis
Gonads
Stromal Cells
Stem cells
1997

Analysis of hemopoietic stem cell proliferation and differentiation using hg-csf receptor transgenic mice

Yang, F-C., Watanabeü, S., Ebihara, Y., Azusa Kaneko Mmg-Jiang, X. U., Kohichiro, T. S. U. J. I. & Nakahata, T., 1997, In : Experimental Hematology. 25, 8, p. 839 1 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Transgenic Mice
Cell Differentiation
Stem Cells
Cell Proliferation
228 Citations (Scopus)

B cell subpopulations separated by CD27 and crucial collaboration of CD27 + B cells and helper T cells in immunoglobulin production

Agematsu, K., Nagumo, H., Yang, F-C., Nakazawa, T., Fukushima, K., Ito, S., Sugita, K., Mori, T., Kobata, T., Morimoto, C. & Komiyama, A., Aug 1997, In : European Journal of Immunology. 27, 8, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Immunoglobulins
B-Lymphocytes
Immunoglobulin D
Blood Cells
148 Citations (Scopus)

Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells

Umemoto, Y., Tsuji, K., Yang, F-C., Ebihara, Y., Kaneko, A., Furukawa, S. & Nakahata, T., 1997, In : Blood. 90, 9, p. 3438-3443 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Leptin
Stem Cell Factor
Bone Marrow Cells
Macrophages
1996
63 Citations (Scopus)

A killing defect of natural killer cells as an underlying immunologic abnormality in childhood systemic lupus erythematosus

Yabuhara, A., Yang, F-C., Nakazawa, T., Iwasaki, Y., Mori, T., Koike, K., Kawai, H. & Komiyama, A., 1996, In : Journal of Rheumatology. 23, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Systemic Lupus Erythematosus
Juvenile Arthritis
Recycling
Lymphocyte Subsets
52 Citations (Scopus)

CD27/CD70 interaction directly induces natural killer cell killing activity

Yang, F-C., Agematsu, K., Nakazawa, T., Mori, T., Ito, S., Kobata, T., Morimoto, C. & Komiyama, A., 1996, In : Immunology. 88, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Interleukin-12
Coculture Techniques
Interleukin-2
Flow Cytometry
1995
75 Citations (Scopus)

CD27/CD70 interaction directly drives B cell IgG and IgM synthesis

Agematsu, K., Kobata, T., Yang, F-C., Nakazawa, T., Fukushima, K., Kitahara, M., Mori, T., Sugita, K., Morimoto, C. & Komiyama, A., Oct 1995, In : European Journal of Immunology. 25, 10, p. 2825-2829 5 p.

Research output: Contribution to journalArticle

Immunoglobulin M
B-Lymphocytes
Immunoglobulin G
Interleukin-2
T-Lymphocytes
7 Citations (Scopus)

Frequent natural killer cell abnormality in children in an area highly contaminated by the Chernobyl accident

Koike, K., Yabuhara, A., Yang, F-C., Shiohara, M., Sawai, N., Sugenoya, A., Iida, F., Koyama, Y., Takano, K., Takahashi, T., Kamata, M., Koizumi, Y., Anatoliebna, A. T., Skidanenko, G. I. & Komiyama, A., Apr 1995, In : International Journal of Hematology. 61, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Accidents
Radioisotopes
Radioactive Fallout
Republic of Belarus

Functional abnormalities of natural killer cells in childhood hemophagocytic syndrome

Yang, F-C., Yabuhara, A., Koike, K. & Komiyama, A., Feb 1995, In : Nihon Rinsho Men"eki Gakkai kaishi = Japanese journal of clinical immunology. 18, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Natural Killer Cells
Recycling
Lymphokines
Interleukin-2
1994
2 Citations (Scopus)
Recycling
Natural Killer Cells
Interferons
Interleukin-2
Infectious Mononucleosis
1993
3 Citations (Scopus)

Hemophagocytic syndrome with high level of interferon-gamma in the advanced stage

Shiohara, M., Koike, K., Sawai, N., Kasai, S., Yang, F-C., Yabuhara, A., Nakahata, T. & Komiyama, A., Dec 1993, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 34, 12, p. 1573-1578 6 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Histiocytes
Natural Killer Cells
Interferon-gamma
Cytokines