Feng-Chun Yang

Professor

  • 4907 Citations
1993 …2023
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Research Output 1993 2019

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2012
14 Citations (Scopus)

c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

He, Y., Rhodes, S. D., Chen, S., Wu, X., Yuan, J., Yang, X., Jiang, L., Li, X., Takahashi, N., Xu, M., Mohammad, K. S., Guise, T. A. & Yang, F-C., Nov 7 2012, In : PLoS One. 7, 11, e46900.

Research output: Contribution to journalArticle

osteoclasts
Neurofibromatosis 1
Osteoclasts
macrophage colony-stimulating factor
Macrophage Colony-Stimulating Factor
54 Citations (Scopus)

Hydroxylation of 5-methylcytosine by Tet2 maintains the active state of the mammalian Hoxa cluster

Bocker, M. T., Tuorto, F., Raddatz, G., Musch, T., Yang, F-C., Xu, M., Lyko, F. & Breiling, A., 2012, In : Nature Communications. 3, 818.

Research output: Contribution to journalArticle

5-Methylcytosine
Hydroxylation
genes
Genes
maintenance
97 Citations (Scopus)

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: A phase 2 trial

Robertson, K. A., Nalepa, G., Yang, F-C., Bowers, D. C., Ho, C. Y., Hutchins, G. D., Croop, J. M., Vik, T. A., Denne, S. C., Parada, L. F., Hingtgen, C. M., Walsh, L. E., Yu, M., Pradhan, K. R., Edwards-Brown, M. K., Cohen, M. D., Fletcher, J. W., Travers, J. B., Staser, K. W., Lee, M. W. & 5 others, Sherman, M. R., Davis, C. J., Miller, L. C., Ingram, D. A. & Clapp, D. W., Dec 2012, In : The Lancet Oncology. 13, 12, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Neurofibromatosis 1
Imatinib Mesylate
Neoplasms
Chemoradiotherapy
5 Citations (Scopus)

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J. P., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F. M., Kacena, M. A. & Yang, F-C., 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Zinc Fingers
Parathyroid Hormone
Proteins
Transcription Factors
42 Citations (Scopus)

Pathogenesis of plexiform neurofibroma: Tumor-stromal/hematopoietic interactions in tumor progression

Staser, K., Yang, F-C. & Clapp, D. W., 2012, In : Annual Review of Pathology: Mechanisms of Disease. 7, p. 469-495 27 p.

Research output: Contribution to journalArticle

pathogenesis
neoplasms
mast cells
stem cell factor
mutation
15 Citations (Scopus)

The Plexiform Neurofibroma Microenvironment

Yang, F-C., Staser, K. & Clapp, D. W., 2012, (Accepted/In press) In : Cancer Microenvironment. p. 1-4 4 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Schwann Cells
Mast Cells
Neurofibromatosis 1
Stem Cell Factor
2011
53 Citations (Scopus)

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F-C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

Bone Resorption
Mitogen-Activated Protein Kinases
Bone and Bones
Urine
Costello Syndrome
343 Citations (Scopus)

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C. L., Wang, J., Zhang, W., Petersen, B. E., Yang, F-C. & Xu, M., Oct 27 2011, In : Blood. 118, 17, p. 4509-4518 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
5-Methylcytosine
Neoplasms
Tumors
53 Citations (Scopus)

Erk1 positively regulates osteoclast differentiation and bone resorptive activity

He, Y., Staser, K., Rhodes, S. D., Liu, Y., Wu, X., Park, S. J., Yuan, J., Yang, X., Li, X., Jiang, L., Chen, S. & Yang, F-C., Sep 22 2011, In : PLoS One. 6, 9, e24780.

Research output: Contribution to journalArticle

osteoclasts
Osteoclasts
Bone
bones
Bone and Bones
1 Citation (Scopus)

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F-C. & Chan, R. J., Jul 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Protein Kinases
Hypersensitivity
Bone Marrow
KSR-1 protein kinase
26 Citations (Scopus)

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1

Stevenson, D. A., Yan, J., He, Y., Li, H., Liu, Y., Zhang, Q., Jing, Y., Guo, Z., Zhang, W., Yang, D., Wu, X., Hanson, H., Li, X., Staser, K., Viskochil, D. H., Carey, J. C., Chen, S., Miller, L., Roberson, K., Moyer-Mileur, L. & 4 others, Yu, M., Schwarz, E. L., Pasquali, M. & Yang, F-C., May 2011, In : American Journal of Medical Genetics, Part A. 155, 5, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Osteoclasts
Bone Resorption
Bone Density
Phenotype
17 Citations (Scopus)

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F-C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

Osteoblasts
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
Cell growth
24 Citations (Scopus)

Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model

Zhang, W., Rhodes, S. D., Zhao, L., He, Y., Zhang, Y., Shen, Y., Yang, D., Wu, X., Li, X., Yang, X., Park, S. J., Chen, S., Turner, C. & Yang, F-C., Jun 1 2011, In : Bone. 48, 6, p. 1378-1387 10 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Spine
Lumbar Vertebrae
Inborn Genetic Diseases
Photon Absorptiometry
22 Citations (Scopus)

The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1

Wu, X., Chen, S., He, Y., Rhodes, S. D., Mohammad, K. S., Li, X., Yang, X., Jiang, L., Nalepa, G., Snider, P., Robling, A. G., Clapp, D. W., Conway, S. J., Guise, T. A. & Yang, F-C., Sep 29 2011, In : PLoS One. 6, 9, e24917.

Research output: Contribution to journalArticle

Spontaneous Fractures
Neurofibromatosis 1
stem cells
Repair
animal models
29 Citations (Scopus)

The musculoskeletal phenotype of the RASopathies

Stevenson, D. A. & Yang, F-C., May 15 2011, In : American Journal of Medical Genetics, Part A. 157, 2, p. 90-103 14 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Phenotype
Costello Syndrome
Neurofibromatosis 1 Genes
Noonan Syndrome
2010
31 Citations (Scopus)

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Pulliam-Leath, A. C., Ciccone, S. L., Nalepa, G., Li, X., Si, Y., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., Orazi, A., Vance, G. H., Yang, F-C., Hanenberg, H., Bagby, G. C. & Clapp, D. W., Oct 21 2010, In : Blood. 116, 16, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Acute Myeloid Leukemia
Bone
Fanconi Anemia Complementation Group Proteins
Bone Marrow
4 Citations (Scopus)

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Hematopoietic Stem Cells
Hematopoiesis
Gene Expression
Small Interfering RNA
66 Citations (Scopus)

Mast cells and the neurofibroma microenvironment

Staser, K., Yang, F-C. & Clapp, D. W., Jul 15 2010, In : Blood. 116, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Cellular Microenvironment
Neurofibroma
Neurofibromatosis 1
Mast Cells
Plexiform Neurofibroma
11 Citations (Scopus)

Mechanical stimulation suppresses phosphorylation of eIF2α and PERK-mediated responses to stress to the endoplasmic reticulum

Hirasawa, H., Jiang, C., Zhang, P., Yang, F-C. & Yokota, H., Feb 2010, In : FEBS Letters. 584, 4, p. 745-752 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Endoplasmic Reticulum Stress
Ulna
Thapsigargin
Mortality
23 Citations (Scopus)

Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase

Chen, S., Burgin, S., McDaniel, A., Li, X., Yuan, J., Chen, M., Khalaf, W., Clapp, D. W. & Yang, F-C., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3125-3132 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cell Degranulation
Schwann Cells
Conditioned Culture Medium
Mast Cells
25 Citations (Scopus)

Plexiform neurofibroma genesis: Questions of Nf1 gene dose and hyperactive mast cells

Staser, K., Yang, F-C. & Clapp, D. W., 2010, In : Current Opinion in Hematology. 17, 4, p. 287-293 7 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1 Genes
Plexiform Neurofibroma
Mast Cells
Neurofibromatosis 1
Schwann Cells
Cell Growth Processes
Species Specificity
Neurofibromatosis 1
Tumor Microenvironment
Schwann Cells
2009
49 Citations (Scopus)

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg -/- mice in vivo

Li, Y., Chen, S., Yuan, J., Yang, Y., Li, J., Jin, M., Wu, X., Freund, M., Pollok, K., Hanenberg, H., Goebe, W. S. & Yang, F-C., Mar 5 2009, In : Blood. 113, 10, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Fanconi Anemia
Tibia
3 Citations (Scopus)

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F-C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Embryonic Stem Cells
Stromal Cells
Embryoid Bodies
Endoderm
19 Citations (Scopus)

Ras dependent paracrine secretion of osteopontin by nf1 +/- osteoblasts promote osteodast activation in a neurofibromatosis type i murine model

Li, H., Liu, Y., Zhang, Q., Jing, Y., Chen, S., Song, Z., Yan, J., Li, Y., Wu, X., Zhang, X., Zhang, Y., Case, J., Yu, M., Ingram, D. A. & Yang, F-C., Jun 2009, In : Pediatric Research. 65, 6, p. 613-618 6 p.

Research output: Contribution to journalArticle

Neurofibromatoses
Osteopontin
Osteoblasts
Osteoclasts
Bone Resorption
78 Citations (Scopus)

Skeletal abnormalities in neurofibromatosis type 1: Approaches to therapeutic options

Elefteriou, F., Kolanczyk, M., Schindeler, A., Viskochil, D. H., Hock, J. M., Schorry, E. K., Crawford, A. H., Friedman, J. M., Little, D., Peltonen, J., Carey, J. C., Feldman, D., Yu, X., Armstrong, L., Birch, P., Kendler, D. L., Mundlos, S., Yang, F-C., Agiostratidou, G., Hunter-Schaedle, K. & 1 others, Stevenson, D. A., Oct 2009, In : American Journal of Medical Genetics, Part A. 149, 10, p. 2327-2338 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Clinical Trials
Bone and Bones
Natural History
Skeleton
2008
27 Citations (Scopus)

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

Pulliam, A. C., Hobson, M. J., Ciccone, S. L., Li, Y., Chen, S., Srour, E. F., Yang, F-C., Broxmeyer, H. E. & Clapp, D. W., Sep 2008, In : Experimental Hematology. 36, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Granulocyte Colony-Stimulating Factor
Knockout Mice
Stem Cells
Bone Marrow
150 Citations (Scopus)

Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use

Perry, B. C., Zhou, D., Wu, X., Yang, F-C., Byers, M. A., Chu, T. M. G., Hockema, J. J., Woods, E. J. & Goebel, W. S., 2008, In : Tissue Engineering - Part C: Methods. 14, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

Dental Pulp
Cryopreservation
Stem cells
Mesenchymal Stromal Cells
Pulp

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F-C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Medical Genetics
Osteoclasts
Molecular Biology
232 Citations (Scopus)

Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/-- and c-kit-Dependent Bone Marrow

Yang, F-C., Ingram, D. A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S. T., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L. F. & Clapp, D. W., Oct 31 2008, In : Cell. 135, 3, p. 437-448 12 p.

Research output: Contribution to journalArticle

Neurofibroma
Tumors
Schwann Cells
Bone
Bone Marrow
38 Citations (Scopus)

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F-C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Osteoclasts
rho GTP-Binding Proteins
Bone Resorption
Osteoporosis
28 Citations (Scopus)

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F-C. & Kapur, R., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Osteoclasts
Gene Expression
Integrins
Cathepsin K
2007
15 Citations (Scopus)

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Li, B., Jia, N., Waning, D. L., Yang, F-C., Haneline, L. S. & Chun, K. T., Oct 1 2007, In : Blood. 110, 7, p. 2704-2707 4 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Ubiquitin
Stem cells
Ligases
Proteolysis
30 Citations (Scopus)

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells

Khalaf, W. F., Yang, F-C., Chen, S., White, H., Bessler, W., Ingram, D. A. & Clapp, D. W., Feb 15 2007, In : Journal of Immunology. 178, 4, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

Mast Cells
GTPase-Activating Proteins
Neurofibromin 1
ras Proteins
Protein Isoforms
7 Citations (Scopus)

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration - Implications for increased neurofibroma formation during pregnancy

Nebesio, T. D., Ming, W., Chen, S., Clegg, T., Yuan, J., Yang, Y., Estwick, S. A., Li, Y., Li, X., Hingtgen, C. M. & Yang, F-C., Apr 1 2007, In : GLIA. 55, 5, p. 527-536 10 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibroma
Schwann Cells
Neurofibromatosis 1
Pregnancy
2006
34 Citations (Scopus)

Continuous in vivo infusion of interferon-gamma (IFN-γ) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg -/- mice

Si, Y., Ciccone, S., Yang, F-C., Yuan, J., Zeng, D., Chen, S., Van De Vrugt, H. J., Critser, J., Arwert, F., Haneline, L. S. & Clapp, D. W., Dec 15 2006, In : Blood. 108, 13, p. 4283-4287 5 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Interferon-gamma
Stem cells
Bone
Stem Cells
24 Citations (Scopus)

Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L. S., White, H., Yang, F-C., Chen, S., Orschell, C., Kapur, R. & Ingram, D. A., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Fetal Movement
Hematopoiesis
Hematopoietic Stem Cells
Stem cells
88 Citations (Scopus)

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Yang, F-C., Chen, S., Robling, A. G., Yu, X., Nebesio, T. D., Yan, J., Morgan, T., Li, X., Yuan, J., Hock, J., Ingram, D. A. & Clapp, D. W., Nov 1 2006, In : Journal of Clinical Investigation. 116, 11, p. 2880-2891 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Osteoclasts
Phosphatidylinositol 3-Kinases
Macrophage Colony-Stimulating Factor Receptors
Proto-Oncogene Proteins p21(ras)
40 Citations (Scopus)

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Munchhof, A. M., Li, F., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Li, X., Yuan, J., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibroma
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Tumor Suppressor Genes
55 Citations (Scopus)

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Li, F., Munchhof, A. M., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Chen, S., Wu, X., Cai, S., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1921-1930 10 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Neurofibroma
63 Citations (Scopus)

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F-C., Oct 1 2006, In : Human Molecular Genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Osteoblasts
Mesenchymal Stromal Cells
Stem Cells
Fibroblasts
94 Citations (Scopus)

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling

Yang, F-C., Chen, S., Clegg, T., Li, X., Morgan, T., Estwick, S. A., Yuan, J., Khalaf, W., Burgin, S., Travers, J., Parada, L. F., Ingram, D. A. & Clapp, D. W., Aug 15 2006, In : Human Molecular Genetics. 15, 16, p. 2421-2437 17 p.

Research output: Contribution to journalArticle

Neurofibroma
Mast Cells
Transforming Growth Factor beta
Phenotype
Fibroblasts
2005
55 Citations (Scopus)

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

Li, X., Le Beau, M. M., Ciccone, S., Yang, F-C., Freie, B., Chen, S., Yuan, J., Hong, P., Orazi, A., Haneline, L. S. & Clapp, D. W., May 1 2005, In : Blood. 105, 9, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

Stem cells
Cell culture
Chromosome Aberrations
Stem Cells
Apoptosis
46 Citations (Scopus)

Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure

Jansen, M., Yang, F-C., Cancelas, J. A., Bailey, J. R. & Williams, D. A., Mar 2005, In : Stem Cells. 23, 3, p. 335-346 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Bone Marrow
Stem Cells
rho GTP-Binding Proteins
Cell Shape
2003
20 Citations (Scopus)

Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle

Li, B., Yang, F-C., Clapp, D. W. & Chun, K. T., Mar 1 2003, In : Blood. 101, 5, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

Cullin Proteins
Cell Cycle
Cells
Hematopoiesis
Myeloid Cells
27 Citations (Scopus)

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F-C., White, H., Wenning, M. J., Orazi, A., Yoder, M. C., Kapur, R. & Ingram, D. A., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Erythropoiesis
Phosphotransferases
Genes
Liver
152 Citations (Scopus)

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F-C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibromatosis 1
Schwann Cells
Neurofibroma
Mast Cells
2002
32 Citations (Scopus)

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F-C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

Neurofibromin 1
T-cells
T-Lymphocytes
Defects
ras GTPase-Activating Proteins
49 Citations (Scopus)

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses

Croker, B. A., Handman, E., Hayball, J. D., Baldwin, T. M., Voigt, V., Cluse, L. A., Yang, F-C., Williams, D. A. & Roberts, A. W., 2002, In : Immunology and Cell Biology. 80, 3, p. 231-240 10 p.

Research output: Contribution to journalArticle

T-cells
Chemotaxis
T-Lymphocytes
Leishmania major
Ovalbumin
91 Citations (Scopus)

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

Croker, B. A., Tarlinton, D. M., Cluse, L. A., Tuxen, A. J., Light, A., Yang, F-C., Williams, D. A. & Roberts, A. W., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3376-3386 11 p.

Research output: Contribution to journalArticle

Antigen Receptors
Guanosine
Chemotaxis
B-Lymphocytes
Immunoglobulin M