Feng-Chun Yang

Professor

  • 4952 Citations
1993 …2023

Research output per year

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Research Output

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2012

c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

He, Y., Rhodes, S. D., Chen, S., Wu, X., Yuan, J., Yang, X., Jiang, L., Li, X., Takahashi, N., Xu, M., Mohammad, K. S., Guise, T. A. & Yang, F-C., Nov 7 2012, In : PLoS One. 7, 11, e46900.

Research output: Contribution to journalArticle

14 Scopus citations

Hydroxylation of 5-methylcytosine by Tet2 maintains the active state of the mammalian Hoxa cluster

Bocker, M. T., Tuorto, F., Raddatz, G., Musch, T., Yang, F-C., Xu, M., Lyko, F. & Breiling, A., 2012, In : Nature Communications. 3, 818.

Research output: Contribution to journalArticle

55 Scopus citations

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: A phase 2 trial

Robertson, K. A., Nalepa, G., Yang, F-C., Bowers, D. C., Ho, C. Y., Hutchins, G. D., Croop, J. M., Vik, T. A., Denne, S. C., Parada, L. F., Hingtgen, C. M., Walsh, L. E., Yu, M., Pradhan, K. R., Edwards-Brown, M. K., Cohen, M. D., Fletcher, J. W., Travers, J. B., Staser, K. W., Lee, M. W. & 5 others, Sherman, M. R., Davis, C. J., Miller, L. C., Ingram, D. A. & Clapp, D. W., Dec 2012, In : The Lancet Oncology. 13, 12, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J. P., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F. M., Kacena, M. A. & Yang, F-C., 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pathogenesis of plexiform neurofibroma: Tumor-stromal/hematopoietic interactions in tumor progression

Staser, K., Yang, F-C. & Clapp, D. W., 2012, In : Annual Review of Pathology: Mechanisms of Disease. 7, p. 469-495 27 p.

Research output: Contribution to journalArticle

42 Scopus citations

The Plexiform Neurofibroma Microenvironment

Yang, F-C., Staser, K. & Clapp, D. W., 2012, (Accepted/In press) In : Cancer Microenvironment. p. 1-4 4 p.

Research output: Contribution to journalArticle

15 Scopus citations
2011

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F-C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C. L., Wang, J., Zhang, W., Petersen, B. E., Yang, F-C. & Xu, M., Oct 27 2011, In : Blood. 118, 17, p. 4509-4518 10 p.

Research output: Contribution to journalArticle

345 Scopus citations

Erk1 positively regulates osteoclast differentiation and bone resorptive activity

He, Y., Staser, K., Rhodes, S. D., Liu, Y., Wu, X., Park, S. J., Yuan, J., Yang, X., Li, X., Jiang, L., Chen, S. & Yang, F-C., Sep 22 2011, In : PLoS One. 6, 9, e24780.

Research output: Contribution to journalArticle

56 Scopus citations

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F-C. & Chan, R. J., Jul 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1

Stevenson, D. A., Yan, J., He, Y., Li, H., Liu, Y., Zhang, Q., Jing, Y., Guo, Z., Zhang, W., Yang, D., Wu, X., Hanson, H., Li, X., Staser, K., Viskochil, D. H., Carey, J. C., Chen, S., Miller, L., Roberson, K., Moyer-Mileur, L. & 4 others, Yu, M., Schwarz, E. L., Pasquali, M. & Yang, F-C., May 2011, In : American Journal of Medical Genetics, Part A. 155, 5, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F-C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model

Zhang, W., Rhodes, S. D., Zhao, L., He, Y., Zhang, Y., Shen, Y., Yang, D., Wu, X., Li, X., Yang, X., Park, S. J., Chen, S., Turner, C. & Yang, F-C., Jun 1 2011, In : Bone. 48, 6, p. 1378-1387 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1

Wu, X., Chen, S., He, Y., Rhodes, S. D., Mohammad, K. S., Li, X., Yang, X., Jiang, L., Nalepa, G., Snider, P., Robling, A. G., Clapp, D. W., Conway, S. J., Guise, T. A. & Yang, F-C., Sep 29 2011, In : PLoS One. 6, 9, e24917.

Research output: Contribution to journalArticle

22 Scopus citations

The musculoskeletal phenotype of the RASopathies

Stevenson, D. A. & Yang, F-C., May 15 2011, In : American Journal of Medical Genetics, Part A. 157, 2, p. 90-103 14 p.

Research output: Contribution to journalArticle

29 Scopus citations
2010

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Pulliam-Leath, A. C., Ciccone, S. L., Nalepa, G., Li, X., Si, Y., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., Orazi, A., Vance, G. H., Yang, F-C., Hanenberg, H., Bagby, G. C. & Clapp, D. W., Oct 21 2010, In : Blood. 116, 16, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mast cells and the neurofibroma microenvironment

Staser, K., Yang, F-C. & Clapp, D. W., Jul 15 2010, In : Blood. 116, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mechanical stimulation suppresses phosphorylation of eIF2α and PERK-mediated responses to stress to the endoplasmic reticulum

Hirasawa, H., Jiang, C., Zhang, P., Yang, F-C. & Yokota, H., Feb 2010, In : FEBS Letters. 584, 4, p. 745-752 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase

Chen, S., Burgin, S., McDaniel, A., Li, X., Yuan, J., Chen, M., Khalaf, W., Clapp, D. W. & Yang, F-C., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3125-3132 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Plexiform neurofibroma genesis: Questions of Nf1 gene dose and hyperactive mast cells

Staser, K., Yang, F-C. & Clapp, D. W., 2010, In : Current Opinion in Hematology. 17, 4, p. 287-293 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg -/- mice in vivo

Li, Y., Chen, S., Yuan, J., Yang, Y., Li, J., Jin, M., Wu, X., Freund, M., Pollok, K., Hanenberg, H., Goebe, W. S. & Yang, F-C., Mar 5 2009, In : Blood. 113, 10, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F-C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ras dependent paracrine secretion of osteopontin by nf1 +/- osteoblasts promote osteodast activation in a neurofibromatosis type i murine model

Li, H., Liu, Y., Zhang, Q., Jing, Y., Chen, S., Song, Z., Yan, J., Li, Y., Wu, X., Zhang, X., Zhang, Y., Case, J., Yu, M., Ingram, D. A. & Yang, F-C., Jun 2009, In : Pediatric Research. 65, 6, p. 613-618 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Skeletal abnormalities in neurofibromatosis type 1: Approaches to therapeutic options

Elefteriou, F., Kolanczyk, M., Schindeler, A., Viskochil, D. H., Hock, J. M., Schorry, E. K., Crawford, A. H., Friedman, J. M., Little, D., Peltonen, J., Carey, J. C., Feldman, D., Yu, X., Armstrong, L., Birch, P., Kendler, D. L., Mundlos, S., Yang, F-C., Agiostratidou, G., Hunter-Schaedle, K. & 1 others, Stevenson, D. A., Oct 2009, In : American Journal of Medical Genetics, Part A. 149, 10, p. 2327-2338 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
2008

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

Pulliam, A. C., Hobson, M. J., Ciccone, S. L., Li, Y., Chen, S., Srour, E. F., Yang, F-C., Broxmeyer, H. E. & Clapp, D. W., Sep 2008, In : Experimental Hematology. 36, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use

Perry, B. C., Zhou, D., Wu, X., Yang, F-C., Byers, M. A., Chu, T. M. G., Hockema, J. J., Woods, E. J. & Goebel, W. S., 2008, In : Tissue Engineering - Part C: Methods. 14, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

150 Scopus citations

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F-C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/-- and c-kit-Dependent Bone Marrow

Yang, F-C., Ingram, D. A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S. T., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L. F. & Clapp, D. W., Oct 31 2008, In : Cell. 135, 3, p. 437-448 12 p.

Research output: Contribution to journalArticle

233 Scopus citations

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F-C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F-C. & Kapur, R., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

28 Scopus citations
2007

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Li, B., Jia, N., Waning, D. L., Yang, F-C., Haneline, L. S. & Chun, K. T., Oct 1 2007, In : Blood. 110, 7, p. 2704-2707 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells

Khalaf, W. F., Yang, F-C., Chen, S., White, H., Bessler, W., Ingram, D. A. & Clapp, D. W., Feb 15 2007, In : Journal of Immunology. 178, 4, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration - Implications for increased neurofibroma formation during pregnancy

Nebesio, T. D., Ming, W., Chen, S., Clegg, T., Yuan, J., Yang, Y., Estwick, S. A., Li, Y., Li, X., Hingtgen, C. M. & Yang, F-C., Apr 1 2007, In : GLIA. 55, 5, p. 527-536 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2006

Continuous in vivo infusion of interferon-gamma (IFN-γ) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg -/- mice

Si, Y., Ciccone, S., Yang, F-C., Yuan, J., Zeng, D., Chen, S., Van De Vrugt, H. J., Critser, J., Arwert, F., Haneline, L. S. & Clapp, D. W., Dec 15 2006, In : Blood. 108, 13, p. 4283-4287 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L. S., White, H., Yang, F-C., Chen, S., Orschell, C., Kapur, R. & Ingram, D. A., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Yang, F-C., Chen, S., Robling, A. G., Yu, X., Nebesio, T. D., Yan, J., Morgan, T., Li, X., Yuan, J., Hock, J., Ingram, D. A. & Clapp, D. W., Nov 1 2006, In : Journal of Clinical Investigation. 116, 11, p. 2880-2891 12 p.

Research output: Contribution to journalArticle

88 Scopus citations

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Munchhof, A. M., Li, F., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Li, X., Yuan, J., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Li, F., Munchhof, A. M., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Chen, S., Wu, X., Cai, S., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1921-1930 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F-C., Oct 1 2006, In : Human Molecular Genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling

Yang, F-C., Chen, S., Clegg, T., Li, X., Morgan, T., Estwick, S. A., Yuan, J., Khalaf, W., Burgin, S., Travers, J., Parada, L. F., Ingram, D. A. & Clapp, D. W., Aug 15 2006, In : Human Molecular Genetics. 15, 16, p. 2421-2437 17 p.

Research output: Contribution to journalArticle

94 Scopus citations
2005

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

Li, X., Le Beau, M. M., Ciccone, S., Yang, F-C., Freie, B., Chen, S., Yuan, J., Hong, P., Orazi, A., Haneline, L. S. & Clapp, D. W., May 1 2005, In : Blood. 105, 9, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure

Jansen, M., Yang, F-C., Cancelas, J. A., Bailey, J. R. & Williams, D. A., Mar 2005, In : Stem Cells. 23, 3, p. 335-346 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2003

Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle

Li, B., Yang, F-C., Clapp, D. W. & Chun, K. T., Mar 1 2003, In : Blood. 101, 5, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F-C., White, H., Wenning, M. J., Orazi, A., Yoder, M. C., Kapur, R. & Ingram, D. A., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F-C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

152 Scopus citations
2002

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F-C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses

Croker, B. A., Handman, E., Hayball, J. D., Baldwin, T. M., Voigt, V., Cluse, L. A., Yang, F-C., Williams, D. A. & Roberts, A. W., 2002, In : Immunology and Cell Biology. 80, 3, p. 231-240 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

Croker, B. A., Tarlinton, D. M., Cluse, L. A., Tuxen, A. J., Light, A., Yang, F-C., Williams, D. A. & Roberts, A. W., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3376-3386 11 p.

Research output: Contribution to journalArticle

91 Scopus citations