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Feng-Chun Yang

Professor

  • 4952 Citations
1993 …2023

Research output per year

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Research Output

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6 Scopus citations

Aberrant Myeloid Differentiation Contributes to the Development of Osteoporosis in Neurofibromatosis Type 1

Rhodes, S. D. & Yang, F-C., Feb 1 2016, In : Current Osteoporosis Reports. 14, 1, p. 10-15 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

Pulliam, A. C., Hobson, M. J., Ciccone, S. L., Li, Y., Chen, S., Srour, E. F., Yang, F-C., Broxmeyer, H. E. & Clapp, D. W., Sep 2008, In : Experimental Hematology. 36, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in fanconi anemia

Zhou, Y., He, Y., Xing, W., Zhang, P., Shi, H., Chen, S., Shi, J., Bai, J., Rhodes, S. D., Zhang, F., Yuan, J., Yang, X., Zhu, X., Li, Y., Hanenberg, H., Xu, M., Robertson, K. A., Yuan, W., Nalepa, G., Cheng, T. & 2 others, Clapp, D. W. & Yang, F-C., 2017, In : Haematologica. 102, 6, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Analysis of hemopoietic stem cell proliferation and differentiation using hg-csf receptor transgenic mice

Yang, F-C., Watanabeü, S., Ebihara, Y., Azusa Kaneko Mmg-Jiang, X. U., Kohichiro, T. S. U. J. I. & Nakahata, T., 1997, In : Experimental Hematology. 25, 8, p. 839 1 p.

Research output: Contribution to journalArticle

A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

Inoue, D., Fujino, T., Sheridan, P., Zhang, Y. Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K. C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C. & 2 others, Oyama, M. & Kitamura, T., Mar 3 2018, (Accepted/In press) In : Leukemia. p. 1-11 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Anti-mouse CD122 antibody promotes the hematopoietic repopulating capacity of cord blood CD34⁺ cells in NOD/SCID mice

Sheng, M. Y., Shi, H., Xing, W., Wang, W. J., Si, X. H., Bai, J., Yuan, W. P., Zhou, Y. & Yang, F-C., Dec 1 2014, In : Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology. 22, 6, p. 1673-1677 5 p.

Research output: Contribution to journalArticle

A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells

Staser, K., Shew, M. A., Michels, E. G., Mwanthi, M. M., Yang, F-C., Clapp, D. W. & Park, S. J., Jan 2013, In : Experimental Hematology. 41, 1

Research output: Contribution to journalArticle

19 Scopus citations

Approaches to treating NF1 tibial pseudarthrosis: Consensus from the children's tumor foundation NF1 bone abnormalities consortium

Stevenson, D. A., Little, D., Armstrong, L., Crawford, A. H., Eastwood, D., Friedman, J. M., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D. L., Kolanczyk, M., Monsell, F., Oetgen, M., Richards, B. S., Schindeler, A., Schorry, E. K., Wilkes, D., Viskochil, D. H., Yang, F-C. & Elefteriou, F., Apr 2013, In : Journal of Pediatric Orthopaedics. 33, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

4 Scopus citations

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

14 Scopus citations

ASXL1 plays an important role in erythropoiesis

Shi, H., Yamamoto, S., Sheng, M., Bai, J., Zhang, P., Chen, R., Chen, S., Shi, L., Abdel-Wahab, O., Xu, M., Zhou, Y. & Yang, F-C., Jun 29 2016, In : Scientific Reports. 6, 28789.

Research output: Contribution to journalArticle

19 Scopus citations

B cell subpopulations separated by CD27 and crucial collaboration of CD27 + B cells and helper T cells in immunoglobulin production

Agematsu, K., Nagumo, H., Yang, F-C., Nakazawa, T., Fukushima, K., Ito, S., Sugita, K., Mori, T., Kobata, T., Morimoto, C. & Komiyama, A., Aug 1997, In : European Journal of Immunology. 27, 8, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

229 Scopus citations

Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency

Gu, Y., Jia, B., Yang, F-C., D'Souza, M., Harris, C. E., Derrow, C. W., Zheng, Y. & Williams, D. A., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 15929-15938 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F-C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
5 Scopus citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

7 Scopus citations

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

CD27/CD70 interaction directly drives B cell IgG and IgM synthesis

Agematsu, K., Kobata, T., Yang, F-C., Nakazawa, T., Fukushima, K., Kitahara, M., Mori, T., Sugita, K., Morimoto, C. & Komiyama, A., Oct 1995, In : European Journal of Immunology. 25, 10, p. 2825-2829 5 p.

Research output: Contribution to journalArticle

75 Scopus citations

CD27/CD70 interaction directly induces natural killer cell killing activity

Yang, F-C., Agematsu, K., Nakazawa, T., Mori, T., Ito, S., Kobata, T., Morimoto, C. & Komiyama, A., 1996, In : Immunology. 88, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use

Perry, B. C., Zhou, D., Wu, X., Yang, F-C., Byers, M. A., Chu, T. M. G., Hockema, J. J., Woods, E. J. & Goebel, W. S., 2008, In : Tissue Engineering - Part C: Methods. 14, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

150 Scopus citations

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., Chen, S., Yuan, W., Qin, Z., Ni, H., Nimer, S. D., Yang, F-C., Jaenisch, R., Jin, P. & Xu, M., Nov 24 2015, In : Cell Reports. 13, 8, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Continuous in vivo infusion of interferon-gamma (IFN-γ) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg -/- mice

Si, Y., Ciccone, S., Yang, F-C., Yuan, J., Zeng, D., Chen, S., Van De Vrugt, H. J., Critser, J., Arwert, F., Haneline, L. S. & Clapp, D. W., Dec 15 2006, In : Blood. 108, 13, p. 4283-4287 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cytokine requirement for the development of T-lymphoid lineage potential in clonal lymphohaematopoietic progenitors in vitro

Ma, F., Yang, F-C., Kaneko, A., Manabe, A., Tanaka, R., Asano, S., Nakahata, T. & Tsuji, K., 2000, In : British Journal of Haematology. 111, 4, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C. L., Wang, J., Zhang, W., Petersen, B. E., Yang, F-C. & Xu, M., Oct 27 2011, In : Blood. 118, 17, p. 4509-4518 10 p.

Research output: Contribution to journalArticle

345 Scopus citations

Differential effects of human granulocyte colony-stimulating factor (hG- CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice

Yang, F-C., Tsuji, K., Oda, A., Ebihara, Y., Xu, M., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., Watanabe, S., Ikeda, Y. & Nakahata, T., Aug 1 1999, In : Blood. 94, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin

Man, N., Sun, X. J., Tan, Y., García-Cao, M., Liu, F., Cheng, G., Hatlen, M., Xu, H., Shah, R., Chastain, N., Liu, N., Huang, G., Zhou, Y., Sheng, M., Song, J., Yang, F-C., Benezra, R., Nimer, S. D. & Wang, L., 2016, In : Blood. 127, 19, p. 2322-2326 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
262 Scopus citations

Dystrophic spinal deformities in a neurofibromatosis type 1 murine model

Rhodes, S. D., Zhang, W., Yang, D., Yang, H., Chen, S., Wu, X., Li, X., Yang, X., Mohammad, K. S., Guise, T. A., Bergner, A. L., Stevenson, D. A. & Yang, F-C., Mar 18 2015, In : PLoS One. 10, 3, e0119093.

Research output: Contribution to journalArticle

4 Scopus citations

Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle

Li, B., Yang, F-C., Clapp, D. W. & Chun, K. T., Mar 1 2003, In : Blood. 101, 5, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Erk1 positively regulates osteoclast differentiation and bone resorptive activity

He, Y., Staser, K., Rhodes, S. D., Liu, Y., Wu, X., Park, S. J., Yuan, J., Yang, X., Li, X., Jiang, L., Chen, S. & Yang, F-C., Sep 22 2011, In : PLoS One. 6, 9, e24780.

Research output: Contribution to journalArticle

56 Scopus citations

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

Li, X., Le Beau, M. M., Ciccone, S., Yang, F-C., Freie, B., Chen, S., Yuan, J., Hong, P., Orazi, A., Haneline, L. S. & Clapp, D. W., May 1 2005, In : Blood. 105, 9, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Frequent natural killer cell abnormality in children in an area highly contaminated by the Chernobyl accident

Koike, K., Yabuhara, A., Yang, F-C., Shiohara, M., Sawai, N., Sugenoya, A., Iida, F., Koyama, Y., Takano, K., Takahashi, T., Kamata, M., Koizumi, Y., Anatoliebna, A. T., Skidanenko, G. I. & Komiyama, A., Apr 1995, In : International Journal of Hematology. 61, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional abnormalities of natural killer cells in childhood hemophagocytic syndrome

Yang, F-C., Yabuhara, A., Koike, K. & Komiyama, A., Feb 1995, In : Nihon Rinsho Men"eki Gakkai kaishi = Japanese journal of clinical immunology. 18, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F-C., White, H., Wenning, M. J., Orazi, A., Yoder, M. C., Kapur, R. & Ingram, D. A., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

34 Scopus citations
146 Scopus citations

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Pulliam-Leath, A. C., Ciccone, S. L., Nalepa, G., Li, X., Si, Y., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., Orazi, A., Vance, G. H., Yang, F-C., Hanenberg, H., Bagby, G. C. & Clapp, D. W., Oct 21 2010, In : Blood. 116, 16, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F-C. & Chan, R. J., Jul 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

1 Scopus citations