Feng-Chun Yang

Professor

  • 4952 Citations
1993 …2023

Research output per year

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Research Output

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Article

Genome-wide mapping and interrogation of the Nmp4 antianabolic bone axis

Childress, P., Stayrook, K. R., Alvarez, M. B., Wang, Z., Shao, Y., Hernandez-Buquer, S., Mack, J. K., Grese, Z. R., He, Y., Horan, D., Pavalko, F. M., Warden, S. J., Robling, A. G., Yang, F-C., Allen, M. R., Krishnan, V., Liu, Y. & Bidwell, J. P., Sep 1 2015, In : Molecular Endocrinology. 29, 9, p. 1269-1285 17 p.

Research output: Contribution to journalArticle

5 Scopus citations

Hemophagocytic syndrome with high level of interferon-gamma in the advanced stage

Shiohara, M., Koike, K., Sawai, N., Kasai, S., Yang, F. C., Yabuhara, A., Nakahata, T. & Komiyama, A., Dec 1993, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 34, 12, p. 1573-1578 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., Dec 9 2019, In : Cancer Cell. 36, 6, p. 645-659.e8

Research output: Contribution to journalArticle

Human granulocyte colony-stimulating factor (G-CSF) stimulates the in vitro and in vivo development but not commitment of primitive multipotential progenitors from transgenic mice expressing the human G-CSF receptor

Yang, F. C., Watanabe, S., Tsuji, K., Xu, M. J., Kaneko, A., Ebihara, Y. & Nakahata, T., Dec 15 1998, In : Blood. 92, 12, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Hydroxylation of 5-methylcytosine by Tet2 maintains the active state of the mammalian Hoxa cluster

Bocker, M. T., Tuorto, F., Raddatz, G., Musch, T., Yang, F. C., Xu, M., Lyko, F. & Breiling, A., Oct 17 2012, In : Nature communications. 3, 818.

Research output: Contribution to journalArticle

55 Scopus citations

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Yang, F. C., Chen, S., Robling, A. G., Yu, X., Nebesio, T. D., Yan, J., Morgan, T., Li, X., Yuan, J., Hock, J., Ingram, D. A. & Clapp, D. W., Nov 1 2006, In : Journal of Clinical Investigation. 116, 11, p. 2880-2891 12 p.

Research output: Contribution to journalArticle

88 Scopus citations

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurobromin-decient mice

Sharma, R., Wu, X., Rhodes, S. D., Chen, S., He, Y., Yuan, J., Li, J., Yang, X., Li, X., Jiang, L., Kim, E. T., Stevenson, D. A., Viskochil, D., Xu, M. & Yang, F. C., Dec 1 2013, In : Human molecular genetics. 22, 23, p. 4818-4828 11 p., ddt333.

Research output: Contribution to journalArticle

26 Scopus citations

Hyperactive RAS/PI3-K/MAPK signaling cascade in migration and adhesion of Nf1 haploinsufficient mesenchymal stem/progenitor cells

Zhou, Y., He, Y., Sharma, R., Xing, W., Estwick, S. A., Wu, X., Rhodes, S. D., Xu, M. & Yang, F-C., 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12345-12359 15 p., A031.

Research output: Contribution to journalArticle

2 Scopus citations

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Rhodes, S. D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K. W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K. S., Xu, M., Guise, T. A. & Yang, F. C., Dec 1 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: A phase 2 trial

Robertson, K. A., Nalepa, G., Yang, F. C., Bowers, D. C., Ho, C. Y., Hutchins, G. D., Croop, J. M., Vik, T. A., Denne, S. C., Parada, L. F., Hingtgen, C. M., Walsh, L. E., Yu, M., Pradhan, K. R., Edwards-Brown, M. K., Cohen, M. D., Fletcher, J. W., Travers, J. B., Staser, K. W., Lee, M. W. & 5 others, Sherman, M. R., Davis, C. J., Miller, L. C., Ingram, D. A. & Clapp, D. W., Dec 1 2012, In : The Lancet Oncology. 13, 12, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism

Shao, Y., Hernandez-Buquer, S., Childress, P., Stayrook, K. R., Alvarez, M. B., Davis, H., Plotkin, L. I., He, Y., Condon, K. W., Burr, D. B., Warden, S. J., Robling, A. G., Yang, F-C., Wek, R. C., Allen, M. R. & Bidwell, J. P., Sep 1 2017, In : Endocrinology. 158, 9, p. 2722-2740 19 p.

Research output: Contribution to journalArticle

3 Scopus citations

Incidence and risk factors for myelofibrotic transformation among 272 Chinese patients with JAK2-mutated polycythemia vera

Bai, J., Ai, L., Zhang, L., Yang, F-C., Zhou, Y. & Xue, Y., Dec 1 2015, In : American Journal of Hematology. 90, 12, p. 1116-1121 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells

Khalaf, W. F., Yang, F. C., Chen, S., White, H., Bessler, W., Ingram, D. A. & Clapp, D. W., Feb 15 2007, In : Journal of Immunology. 178, 4, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells

Umemoto, Y., Tsuji, K., Yang, F. C., Ebihara, Y., Kaneko, A., Furukawa, S. & Nakahata, T., Nov 15 1997, In : Blood. 90, 9, p. 3438-3443 6 p.

Research output: Contribution to journalArticle

148 Scopus citations

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice

Zhang, P., Xing, C., Rhodes, S. D., He, Y., Deng, K., Li, Z., He, F., Zhu, C., Nguyen, L., Zhou, Y., Chen, S., Mohammad, K. S., Guise, T. A., Abdel-Wahab, O., Xu, M., Wang, Q. F. & Yang, F-C., Jan 26 2016, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

12 Scopus citations

Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates

Zhang, P., Chen, Z., Li, R., Guo, Y., Shi, H., Bai, J., Yang, H., Sheng, M., Li, Z., Li, Z., Li, J., Chen, S., Yuan, W., Cheng, T., Xu, M., Zhou, Y. & Yang, F-C., Dec 1 2018, In : Cell Discovery. 4, 1, 4.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

Wang, J., Li, Z., He, Y., Pan, F., Chen, S., Rhodes, S., Nguyen, L., Yuan, J., Jiang, L., Yang, X., Weeks, O., Liu, Z., Zhou, J., Ni, H., Cai, C. L., Xu, M. & Yang, F. C., Jan 23 2014, In : Blood. 123, 4, p. 541-553 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, LL., Williams, S. L., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F-C., Jun 8 2017, In : Nature Communications. 8, 15456.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F. C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

11 Scopus citations

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F. C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 1 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F. C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mechanical stimulation suppresses phosphorylation of eIF2α and PERK-mediated responses to stress to the endoplasmic reticulum

Hirasawa, H., Jiang, C., Zhang, P., Yang, F. C. & Yokota, H., Feb 1 2010, In : FEBS letters. 584, 4, p. 745-752 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg -/- mice in vivo

Li, Y., Chen, S., Yuan, J., Yang, Y., Li, J., Jin, M., Wu, X., Freund, M., Pollok, K., Hanenberg, H., Goebe, W. S. & Yang, F. C., Mar 5 2009, In : Blood. 113, 10, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1

Stevenson, D. A., Yan, J., He, Y., Li, H., Liu, Y., Zhang, Q., Jing, Y., Guo, Z., Zhang, W., Yang, D., Wu, X., Hanson, H., Li, X., Staser, K., Viskochil, D. H., Carey, J. C., Chen, S., Miller, L., Roberson, K., Moyer-Mileur, L. & 4 others, Yu, M., Schwarz, E. L., Pasquali, M. & Yang, F. C., May 1 2011, In : American Journal of Medical Genetics, Part A. 155, 5, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Munchhof, A. M., Li, F., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Li, X., Yuan, J., Yang, F. C. & Ingram, D. A., Jun 1 2006, In : Human molecular genetics. 15, 11, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration - Implications for increased neurofibroma formation during pregnancy

Nebesio, T. D., Ming, W., Chen, S., Clegg, T., Yuan, J., Yang, Y., Estwick, S. A., Li, Y., Li, X., Hingtgen, C. M. & Yang, F. C., Apr 1 2007, In : Glia. 55, 5, p. 527-536 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F. C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 1 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

152 Scopus citations

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Li, F., Munchhof, A. M., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Chen, S., Wu, X., Cai, S., Yang, F. C. & Ingram, D. A., Jun 1 2006, In : Human molecular genetics. 15, 11, p. 1921-1930 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F. C., Oct 1 2006, In : Human molecular genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase

Chen, S., Burgin, S., McDaniel, A., Li, X., Yuan, J., Chen, M., Khalaf, W., Clapp, D. W. & Yang, F. C., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3125-3132 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling

Yang, F. C., Chen, S., Clegg, T., Li, X., Morgan, T., Estwick, S. A., Yuan, J., Khalaf, W., Burgin, S., Travers, J., Parada, L. F., Ingram, D. A. & Clapp, D. W., Aug 15 2006, In : Human molecular genetics. 15, 16, p. 2421-2437 17 p.

Research output: Contribution to journalArticle

94 Scopus citations

Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/-- and c-kit-Dependent Bone Marrow

Yang, F. C., Ingram, D. A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S. T., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L. F. & Clapp, D. W., Oct 31 2008, In : Cell. 135, 3, p. 437-448 12 p.

Research output: Contribution to journalArticle

233 Scopus citations

Nf1 haploinsufficiency alters myeloid lineage commitment and function, leading to deranged skeletal homeostasis

Rhodes, S. D., Yang, H., Dong, R., Menon, K., He, Y., Li, Z., Chen, S., Staser, K. W., Jiang, L., Wu, X., Yang, X., Peng, X., Mohammad, K. S., Guise, T. A., Xu, M. & Yang, F-C., Oct 1 2015, In : Journal of Bone and Mineral Research. 30, 10, p. 1840-1851 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J. P., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F. M., Kacena, M. A. & Yang, F. C., Nov 12 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency

He, Y., Childress, P., Hood, M., Alvarez, M., Kacena, M. A., Hanlon, M., McKee, B., Bidwell, J. P. & Yang, F. C., Feb 1 2013, In : Stem cells and development. 22, 3, p. 492-500 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk

Staser, K., Park, S. J., Rhodes, S. D., Zeng, Y., He, Y. Z., Shew, M. A., Gehlhausen, J. R., Cerabona, D., Menon, K., Chen, S., Sun, Z., Yuan, J., Ingram, D. A., Nalepa, G., Yang, F. C. & Clapp, D. W., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 329-334 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R. J., Jan 1 2009, In : Stem cells and development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F. C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia

Guo, H., Chu, Y., Wang, L., Chen, X., Chen, Y., Cheng, H., Zhang, L., Zhou, Y., Yang, F-C., Cheng, T., Xu, M., Zhang, X., Zhou, J. & Yuan, W., Jul 15 2017, In : International Journal of Cancer. 141, 2, p. 324-335 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas

Ferguson, M. J., Rhodes, S. D., Jiang, L., Li, X., Yuan, J., Yang, X., Zhang, S., Vakili, S. T., Territo, P., Hutchins, G., Yang, F-C., Ingram, D. A., Clapp, D. W. & Chen, S., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 206-213 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model

Zhang, W., Rhodes, S. D., Zhao, L., He, Y., Zhang, Y., Shen, Y., Yang, D., Wu, X., Li, X., Yang, X., Park, S. J., Chen, S., Turner, C. & Yang, F. C., Jun 1 2011, In : Bone. 48, 6, p. 1378-1387 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F. C., Apr 1 2008, In : Human molecular genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure

Jansen, M., Yang, F. C., Cancelas, J. A., Bailey, J. R. & Williams, D. A., Mar 1 2005, In : STEM CELLS. 23, 3, p. 335-346 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses

Croker, B. A., Handman, E., Hayball, J. D., Baldwin, T. M., Voigt, V., Cluse, L. A., Yang, F. C., Williams, D. A. & Roberts, A. W., Jun 26 2002, In : Immunology and Cell Biology. 80, 3, p. 231-240 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F. C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., Jan 1 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Open Access
138 Scopus citations

Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

Yang, F. C., Atkinson, S. J., Gu, Y., Borneo, J. B., Roberts, A. W., Zheng, Y., Pennington, J. & Williams, D. A., May 8 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 10, p. 5614-5618 5 p.

Research output: Contribution to journalArticle

148 Scopus citations

Ras dependent paracrine secretion of osteopontin by nf1 +/- osteoblasts promote osteodast activation in a neurofibromatosis type i murine model

Li, H., Liu, Y., Zhang, Q., Jing, Y., Chen, S., Song, Z., Yan, J., Li, Y., Wu, X., Zhang, X., Zhang, Y., Case, J., Yu, M., Ingram, D. A. & Yang, F. C., Jun 1 2009, In : Pediatric Research. 65, 6, p. 613-618 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Guo, Y., Yang, H., Chen, S., Zhang, P., Li, R., Nimer, S. D., William Harbour, J., Xu, M. & Yang, F-C., Apr 2 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines

Xu, M. J., Tsuji, K., Ueda, T., Mukouyama, Y. S., Hara, T., Yang, F. C., Ebihara, Y., Matsuoka, S., Manabe, A., Kikuchi, A., Ito, M., Miyajima, A. & Nakahata, T., Sep 15 1998, In : Blood. 92, 6, p. 2032-2040 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

Huang, H., Jiang, X., Li, Z., Li, Y., Song, C. X., He, C., Sun, M., Chen, P., Gurbuxani, S., Wang, J., Hong, G. M., Elkahloun, A. G., Arnovitz, S., Wang, J., Szulwach, K., Lin, L., Street, C., Wunderlich, M., Dawlaty, M., Neilly, M. B. & 9 others, Jaenisch, R., Yang, F. C., Mulloy, J. C., Jin, P., Liu, P. P., Rowley, J. D., Xu, M., He, C. & Chen, J., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 11994-11999 6 p.

Research output: Contribution to journalArticle

113 Scopus citations