Feng-Chun Yang

Professor

  • 4907 Citations
1993 …2023
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Research Output 1993 2019

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1993
3 Citations (Scopus)

Hemophagocytic syndrome with high level of interferon-gamma in the advanced stage

Shiohara, M., Koike, K., Sawai, N., Kasai, S., Yang, F-C., Yabuhara, A., Nakahata, T. & Komiyama, A., Dec 1993, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 34, 12, p. 1573-1578 6 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Histiocytes
Natural Killer Cells
Interferon-gamma
Cytokines
1994
2 Citations (Scopus)
Recycling
Natural Killer Cells
Interferons
Interleukin-2
Infectious Mononucleosis
1995
75 Citations (Scopus)

CD27/CD70 interaction directly drives B cell IgG and IgM synthesis

Agematsu, K., Kobata, T., Yang, F-C., Nakazawa, T., Fukushima, K., Kitahara, M., Mori, T., Sugita, K., Morimoto, C. & Komiyama, A., Oct 1995, In : European Journal of Immunology. 25, 10, p. 2825-2829 5 p.

Research output: Contribution to journalArticle

Immunoglobulin M
B-Lymphocytes
Immunoglobulin G
Interleukin-2
T-Lymphocytes
7 Citations (Scopus)

Frequent natural killer cell abnormality in children in an area highly contaminated by the Chernobyl accident

Koike, K., Yabuhara, A., Yang, F-C., Shiohara, M., Sawai, N., Sugenoya, A., Iida, F., Koyama, Y., Takano, K., Takahashi, T., Kamata, M., Koizumi, Y., Anatoliebna, A. T., Skidanenko, G. I. & Komiyama, A., Apr 1995, In : International Journal of Hematology. 61, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Accidents
Radioisotopes
Radioactive Fallout
Republic of Belarus

Functional abnormalities of natural killer cells in childhood hemophagocytic syndrome

Yang, F-C., Yabuhara, A., Koike, K. & Komiyama, A., Feb 1995, In : Nihon Rinsho Men"eki Gakkai kaishi = Japanese journal of clinical immunology. 18, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Natural Killer Cells
Recycling
Lymphokines
Interleukin-2
1996
63 Citations (Scopus)

A killing defect of natural killer cells as an underlying immunologic abnormality in childhood systemic lupus erythematosus

Yabuhara, A., Yang, F-C., Nakazawa, T., Iwasaki, Y., Mori, T., Koike, K., Kawai, H. & Komiyama, A., 1996, In : Journal of Rheumatology. 23, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Systemic Lupus Erythematosus
Juvenile Arthritis
Recycling
Lymphocyte Subsets
52 Citations (Scopus)

CD27/CD70 interaction directly induces natural killer cell killing activity

Yang, F-C., Agematsu, K., Nakazawa, T., Mori, T., Ito, S., Kobata, T., Morimoto, C. & Komiyama, A., 1996, In : Immunology. 88, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Interleukin-12
Coculture Techniques
Interleukin-2
Flow Cytometry
1997

Analysis of hemopoietic stem cell proliferation and differentiation using hg-csf receptor transgenic mice

Yang, F-C., Watanabeü, S., Ebihara, Y., Azusa Kaneko Mmg-Jiang, X. U., Kohichiro, T. S. U. J. I. & Nakahata, T., 1997, In : Experimental Hematology. 25, 8, p. 839 1 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Transgenic Mice
Cell Differentiation
Stem Cells
Cell Proliferation
228 Citations (Scopus)

B cell subpopulations separated by CD27 and crucial collaboration of CD27 + B cells and helper T cells in immunoglobulin production

Agematsu, K., Nagumo, H., Yang, F-C., Nakazawa, T., Fukushima, K., Ito, S., Sugita, K., Mori, T., Kobata, T., Morimoto, C. & Komiyama, A., Aug 1997, In : European Journal of Immunology. 27, 8, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Immunoglobulins
B-Lymphocytes
Immunoglobulin D
Blood Cells
148 Citations (Scopus)

Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells

Umemoto, Y., Tsuji, K., Yang, F-C., Ebihara, Y., Kaneko, A., Furukawa, S. & Nakahata, T., 1997, In : Blood. 90, 9, p. 3438-3443 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Leptin
Stem Cell Factor
Bone Marrow Cells
Macrophages
1998
37 Citations (Scopus)

Human granulocyte colony-stimulating factor (G-CSF) stimulates the in vitro and in vivo development but not commitment of primitive multipotential progenitors from transgenic mice expressing the human G-CSF receptor

Yang, F-C., Watanabe, S., Tsuji, K., Xu, M., Kaneko, A., Ebihara, Y. & Nakahata, T., Dec 15 1998, In : Blood. 92, 12, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Granulocyte Colony-Stimulating Factor
Transgenic Mice
Bone
Interleukin-3
131 Citations (Scopus)

Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines

Xu, M., Tsuji, K., Ueda, T., Mukouyama, Y. S., Hara, T., Yang, F-C., Ebihara, Y., Matsuoka, S., Manabe, A., Kikuchi, A., Ito, M., Miyajima, A. & Nakahata, T., Sep 15 1998, In : Blood. 92, 6, p. 2032-2040 9 p.

Research output: Contribution to journalArticle

Mesonephros
Hematopoiesis
Gonads
Stromal Cells
Stem cells
1999
23 Citations (Scopus)

Differential effects of human granulocyte colony-stimulating factor (hG- CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice

Yang, F-C., Tsuji, K., Oda, A., Ebihara, Y., Xu, M., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., Watanabe, S., Ikeda, Y. & Nakahata, T., Aug 1 1999, In : Blood. 94, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Thrombopoietin
Granulocyte Colony-Stimulating Factor
Platelets
Transgenic Mice
2000
8 Citations (Scopus)

Cytokine requirement for the development of T-lymphoid lineage potential in clonal lymphohaematopoietic progenitors in vitro

Ma, F., Yang, F-C., Kaneko, A., Manabe, A., Tanaka, R., Asano, S., Nakahata, T. & Tsuji, K., 2000, In : British Journal of Haematology. 111, 4, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

Cytokines
T-Lymphocytes
Stem Cell Factor
Organ Culture Techniques
Fluorouracil
262 Citations (Scopus)

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

Williams, D. A., Tao, W., Yang, F-C., Kim, C., Gu, Y., Mansfield, P., Levine, J. E., Petryniak, B., Derrow, C. W., Harris, C., Jia, B., Zheng, Y., Ambruso, D. R., Lowe, J. B., Atkinson, S. J., Dinauer, M. C. & Boxer, L., Sep 1 2000, In : Blood. 96, 5, p. 1646-1654 9 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Phagocytes
Cells
Mutation
Neutrophils
146 Citations (Scopus)

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Ingram, D. A., Yang, F-C., Travers, J. B., Wenning, M. J., Hiatt, K., New, S., Hood, A., Shannon, K., Williams, D. A. & Clapp, D. W., Jan 3 2000, In : Journal of Experimental Medicine. 191, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Neurofibromatosis 1
Melanocytes
Tumor Suppressor Genes
Mast Cells
138 Citations (Scopus)

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F-C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Mast Cells
Actins
Intercellular Signaling Peptides and Proteins
rac1 GTP-Binding Protein
2001
72 Citations (Scopus)

Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency

Gu, Y., Jia, B., Yang, F-C., D'Souza, M., Harris, C. E., Derrow, C. W., Zheng, Y. & Williams, D. A., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 15929-15938 10 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Cells
Guanine Nucleotide Exchange Factors
Guanosine Triphosphate
Bone
74 Citations (Scopus)

Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac

Xu, M., Matsuoka, S., Yang, F-C., Ebihara, Y., Manabe, A., Tanaka, R., Eguchi, M., Asano, S., Nakahata, T. & Tsuji, K., Apr 1 2001, In : Blood. 97, 7, p. 2016-2022 7 p.

Research output: Contribution to journalArticle

Yolk Sac
Megakaryocytes
Platelets
Thrombopoietin
Stem Cell Factor
148 Citations (Scopus)

Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

Yang, F-C., Atkinson, S. J., Gu, Y., Borneo, J. B., Roberts, A. W., Zheng, Y., Pennington, J. & Williams, D. A., May 8 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 10, p. 5614-5618 5 p.

Research output: Contribution to journalArticle

Cell Shape
GTP Phosphohydrolases
Hematopoietic Stem Cells
Cell Adhesion
Bone Marrow
2002
32 Citations (Scopus)

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F-C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

Neurofibromin 1
T-cells
T-Lymphocytes
Defects
ras GTPase-Activating Proteins
49 Citations (Scopus)

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses

Croker, B. A., Handman, E., Hayball, J. D., Baldwin, T. M., Voigt, V., Cluse, L. A., Yang, F-C., Williams, D. A. & Roberts, A. W., 2002, In : Immunology and Cell Biology. 80, 3, p. 231-240 10 p.

Research output: Contribution to journalArticle

T-cells
Chemotaxis
T-Lymphocytes
Leishmania major
Ovalbumin
91 Citations (Scopus)

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

Croker, B. A., Tarlinton, D. M., Cluse, L. A., Tuxen, A. J., Light, A., Yang, F-C., Williams, D. A. & Roberts, A. W., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3376-3386 11 p.

Research output: Contribution to journalArticle

Antigen Receptors
Guanosine
Chemotaxis
B-Lymphocytes
Immunoglobulin M
2003
20 Citations (Scopus)

Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle

Li, B., Yang, F-C., Clapp, D. W. & Chun, K. T., Mar 1 2003, In : Blood. 101, 5, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

Cullin Proteins
Cell Cycle
Cells
Hematopoiesis
Myeloid Cells
27 Citations (Scopus)

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F-C., White, H., Wenning, M. J., Orazi, A., Yoder, M. C., Kapur, R. & Ingram, D. A., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Erythropoiesis
Phosphotransferases
Genes
Liver
152 Citations (Scopus)

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F-C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibromatosis 1
Schwann Cells
Neurofibroma
Mast Cells
2005
55 Citations (Scopus)

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

Li, X., Le Beau, M. M., Ciccone, S., Yang, F-C., Freie, B., Chen, S., Yuan, J., Hong, P., Orazi, A., Haneline, L. S. & Clapp, D. W., May 1 2005, In : Blood. 105, 9, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

Stem cells
Cell culture
Chromosome Aberrations
Stem Cells
Apoptosis
46 Citations (Scopus)

Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure

Jansen, M., Yang, F-C., Cancelas, J. A., Bailey, J. R. & Williams, D. A., Mar 2005, In : Stem Cells. 23, 3, p. 335-346 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Bone Marrow
Stem Cells
rho GTP-Binding Proteins
Cell Shape
2006
34 Citations (Scopus)

Continuous in vivo infusion of interferon-gamma (IFN-γ) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg -/- mice

Si, Y., Ciccone, S., Yang, F-C., Yuan, J., Zeng, D., Chen, S., Van De Vrugt, H. J., Critser, J., Arwert, F., Haneline, L. S. & Clapp, D. W., Dec 15 2006, In : Blood. 108, 13, p. 4283-4287 5 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Interferon-gamma
Stem cells
Bone
Stem Cells
24 Citations (Scopus)

Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L. S., White, H., Yang, F-C., Chen, S., Orschell, C., Kapur, R. & Ingram, D. A., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Fetal Movement
Hematopoiesis
Hematopoietic Stem Cells
Stem cells
88 Citations (Scopus)

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Yang, F-C., Chen, S., Robling, A. G., Yu, X., Nebesio, T. D., Yan, J., Morgan, T., Li, X., Yuan, J., Hock, J., Ingram, D. A. & Clapp, D. W., Nov 1 2006, In : Journal of Clinical Investigation. 116, 11, p. 2880-2891 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Osteoclasts
Phosphatidylinositol 3-Kinases
Macrophage Colony-Stimulating Factor Receptors
Proto-Oncogene Proteins p21(ras)
40 Citations (Scopus)

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Munchhof, A. M., Li, F., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Li, X., Yuan, J., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibroma
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Tumor Suppressor Genes
55 Citations (Scopus)

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Li, F., Munchhof, A. M., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Chen, S., Wu, X., Cai, S., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1921-1930 10 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Neurofibroma
63 Citations (Scopus)

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F-C., Oct 1 2006, In : Human Molecular Genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Osteoblasts
Mesenchymal Stromal Cells
Stem Cells
Fibroblasts
94 Citations (Scopus)

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling

Yang, F-C., Chen, S., Clegg, T., Li, X., Morgan, T., Estwick, S. A., Yuan, J., Khalaf, W., Burgin, S., Travers, J., Parada, L. F., Ingram, D. A. & Clapp, D. W., Aug 15 2006, In : Human Molecular Genetics. 15, 16, p. 2421-2437 17 p.

Research output: Contribution to journalArticle

Neurofibroma
Mast Cells
Transforming Growth Factor beta
Phenotype
Fibroblasts
2007
15 Citations (Scopus)

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Li, B., Jia, N., Waning, D. L., Yang, F-C., Haneline, L. S. & Chun, K. T., Oct 1 2007, In : Blood. 110, 7, p. 2704-2707 4 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Ubiquitin
Stem cells
Ligases
Proteolysis
30 Citations (Scopus)

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells

Khalaf, W. F., Yang, F-C., Chen, S., White, H., Bessler, W., Ingram, D. A. & Clapp, D. W., Feb 15 2007, In : Journal of Immunology. 178, 4, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

Mast Cells
GTPase-Activating Proteins
Neurofibromin 1
ras Proteins
Protein Isoforms
7 Citations (Scopus)

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration - Implications for increased neurofibroma formation during pregnancy

Nebesio, T. D., Ming, W., Chen, S., Clegg, T., Yuan, J., Yang, Y., Estwick, S. A., Li, Y., Li, X., Hingtgen, C. M. & Yang, F-C., Apr 1 2007, In : GLIA. 55, 5, p. 527-536 10 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibroma
Schwann Cells
Neurofibromatosis 1
Pregnancy
2008
27 Citations (Scopus)

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

Pulliam, A. C., Hobson, M. J., Ciccone, S. L., Li, Y., Chen, S., Srour, E. F., Yang, F-C., Broxmeyer, H. E. & Clapp, D. W., Sep 2008, In : Experimental Hematology. 36, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Granulocyte Colony-Stimulating Factor
Knockout Mice
Stem Cells
Bone Marrow
150 Citations (Scopus)

Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use

Perry, B. C., Zhou, D., Wu, X., Yang, F-C., Byers, M. A., Chu, T. M. G., Hockema, J. J., Woods, E. J. & Goebel, W. S., 2008, In : Tissue Engineering - Part C: Methods. 14, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

Dental Pulp
Cryopreservation
Stem cells
Mesenchymal Stromal Cells
Pulp

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F-C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Medical Genetics
Osteoclasts
Molecular Biology
232 Citations (Scopus)

Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/-- and c-kit-Dependent Bone Marrow

Yang, F-C., Ingram, D. A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S. T., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L. F. & Clapp, D. W., Oct 31 2008, In : Cell. 135, 3, p. 437-448 12 p.

Research output: Contribution to journalArticle

Neurofibroma
Tumors
Schwann Cells
Bone
Bone Marrow
38 Citations (Scopus)

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F-C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Osteoclasts
rho GTP-Binding Proteins
Bone Resorption
Osteoporosis
28 Citations (Scopus)

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F-C. & Kapur, R., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Osteoclasts
Gene Expression
Integrins
Cathepsin K
2009
49 Citations (Scopus)

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg -/- mice in vivo

Li, Y., Chen, S., Yuan, J., Yang, Y., Li, J., Jin, M., Wu, X., Freund, M., Pollok, K., Hanenberg, H., Goebe, W. S. & Yang, F-C., Mar 5 2009, In : Blood. 113, 10, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Fanconi Anemia
Tibia
3 Citations (Scopus)

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F-C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Embryonic Stem Cells
Stromal Cells
Embryoid Bodies
Endoderm
19 Citations (Scopus)

Ras dependent paracrine secretion of osteopontin by nf1 +/- osteoblasts promote osteodast activation in a neurofibromatosis type i murine model

Li, H., Liu, Y., Zhang, Q., Jing, Y., Chen, S., Song, Z., Yan, J., Li, Y., Wu, X., Zhang, X., Zhang, Y., Case, J., Yu, M., Ingram, D. A. & Yang, F-C., Jun 2009, In : Pediatric Research. 65, 6, p. 613-618 6 p.

Research output: Contribution to journalArticle

Neurofibromatoses
Osteopontin
Osteoblasts
Osteoclasts
Bone Resorption
78 Citations (Scopus)

Skeletal abnormalities in neurofibromatosis type 1: Approaches to therapeutic options

Elefteriou, F., Kolanczyk, M., Schindeler, A., Viskochil, D. H., Hock, J. M., Schorry, E. K., Crawford, A. H., Friedman, J. M., Little, D., Peltonen, J., Carey, J. C., Feldman, D., Yu, X., Armstrong, L., Birch, P., Kendler, D. L., Mundlos, S., Yang, F-C., Agiostratidou, G., Hunter-Schaedle, K. & 1 others, Stevenson, D. A., Oct 2009, In : American Journal of Medical Genetics, Part A. 149, 10, p. 2327-2338 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Clinical Trials
Bone and Bones
Natural History
Skeleton
2010
31 Citations (Scopus)

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Pulliam-Leath, A. C., Ciccone, S. L., Nalepa, G., Li, X., Si, Y., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., Orazi, A., Vance, G. H., Yang, F-C., Hanenberg, H., Bagby, G. C. & Clapp, D. W., Oct 21 2010, In : Blood. 116, 16, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Acute Myeloid Leukemia
Bone
Fanconi Anemia Complementation Group Proteins
Bone Marrow
4 Citations (Scopus)

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Hematopoietic Stem Cells
Hematopoiesis
Gene Expression
Small Interfering RNA