Feng-Chun Yang

Professor

  • 4861 Citations
1993 …2023
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Research Output 1993 2019

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Article
2019
2 Citations (Scopus)

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Primary Myelofibrosis

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., Dec 9 2019, In : Cancer Cell. 36, 6, p. 645-659.e8

Research output: Contribution to journalArticle

Long Noncoding RNA
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Genome
Growth
2018
1 Citation (Scopus)

Alteration in the cytokine secretion of bone marrow stromal cells from patients with chronic myelomonocytic leukemia contribute to impaired hematopoietic supportive activity

Shi, H., Wang, Y., Li, R., Xing, W., Yang, F-C., Bai, J. & Zhou, Y., Jan 1 2018, In : Stem Cells International. 2018, 5921392.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Mesenchymal Stromal Cells
Cytokines
Fetal Blood
Blood Cells
7 Citations (Scopus)

A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies

Inoue, D., Fujino, T., Sheridan, P., Zhang, Y. Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K. C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C. & 2 others, Oyama, M. & Kitamura, T., Mar 3 2018, (Accepted/In press) In : Leukemia. p. 1-11 11 p.

Research output: Contribution to journalArticle

Methylation
Transcriptional Activation
Neoplasms
Histone Code
Proteins
4 Citations (Scopus)

Cardiac Sca-1+ Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair

Zhang, L., Sultana, N., Yan, J., Yang, F., Chen, F., Chepurko, E., Yang, F-C., Du, Q., Zangi, L., Xu, M., Bu, L. & Cai, C. L., Dec 18 2018, In : Circulation. 138, 25, p. 2919-2930 12 p.

Research output: Contribution to journalArticle

Stem Cells
Endothelial Cells
Genetic Models
Cardiac Myocytes
Population
7 Citations (Scopus)

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis
2 Citations (Scopus)

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromatin
Mutation
Hematopoietic Stem Cells
Genes
9 Citations (Scopus)

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

Transcription
Acute Myeloid Leukemia
Gene expression
Chromatin
Genes
28 Citations (Scopus)

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

Comb and Wattles
Stem cells
Chromatin
Mass spectrometry
Neoplasms
6 Citations (Scopus)

Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates

Zhang, P., Chen, Z., Li, R., Guo, Y., Shi, H., Bai, J., Yang, H., Sheng, M., Li, Z., Li, Z., Li, J., Chen, S., Yuan, W., Cheng, T., Xu, M., Zhou, Y. & Yang, F-C., Dec 1 2018, In : Cell Discovery. 4, 1, 4.

Research output: Contribution to journalArticle

Comb and Wattles
RNA Polymerase II
Hematopoietic Stem Cells
Bone
Bone Marrow
4 Citations (Scopus)

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Guo, Y., Yang, H., Chen, S., Zhang, P., Li, R., Nimer, S. D., William Harbour, J., Xu, M. & Yang, F-C., Apr 2 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

Neoplasms
3 Citations (Scopus)

TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2−/−-Driven Myeloid Malignancy Progression

Li, R., Zhou, Y., Cao, Z., Liu, L., Wang, J., Chen, Z., Xing, W., Chen, S., Bai, J., Yuan, W., Cheng, T., Xu, M., Yang, F-C. & Zhao, Z., Jan 1 2018, In : Stem Cell Reports. 10, 1, p. 166-179 14 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone
Neoplasms
Osteoblasts
Cell proliferation
4 Citations (Scopus)

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

Chu, Y., Zhao, Z., Sant, D. W., Zhu, G., Greenblatt, S. M., Liu, L., Wang, J., Cao, Z., Tho, J. C., Chen, S., Liu, X., Zhang, P., Maciejewski, J. P., Nimer, S. D., Wang, G., Yuan, W., Yang, F-C. & Xu, M., Jan 1 2018, (Accepted/In press) In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticle

Osteoclasts
Genomics
Macrophage
Macrophages
Translocation
13 Citations (Scopus)

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia

Li, Y., Zhang, M., Sheng, M., Zhang, P., Chen, Z., Xing, W., Bai, J., Cheng, T., Yang, F-C. & Zhou, Y., Mar 28 2018, (Accepted/In press) In : Journal of Cancer Research and Clinical Oncology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Histone Demethylases
Acute Myeloid Leukemia
Myeloid Cells
Therapeutics
Histones
2017
14 Citations (Scopus)

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in fanconi anemia

Zhou, Y., He, Y., Xing, W., Zhang, P., Shi, H., Chen, S., Shi, J., Bai, J., Rhodes, S. D., Zhang, F., Yuan, J., Yang, X., Zhu, X., Li, Y., Hanenberg, H., Xu, M., Robertson, K. A., Yuan, W., Nalepa, G., Cheng, T. & 2 others, Clapp, D. W. & Yang, F-C., 2017, In : Haematologica. 102, 6, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Mesenchymal Stromal Cells
Bone Marrow
Inborn Genetic Diseases
Hematopoietic Stem Cells
12 Citations (Scopus)

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

Chromatids
Hematopoiesis
Gene Expression
Telophase
Chromatin Immunoprecipitation
9 Citations (Scopus)

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

Autophagy
Caspase 3
Modulation
Acute Myeloid Leukemia
Leukemia
3 Citations (Scopus)

Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism

Shao, Y., Hernandez-Buquer, S., Childress, P., Stayrook, K. R., Alvarez, M. B., Davis, H., Plotkin, L. I., He, Y., Condon, K. W., Burr, D. B., Warden, S. J., Robling, A. G., Yang, F-C., Wek, R. C., Allen, M. R. & Bidwell, J. P., Sep 1 2017, In : Endocrinology. 158, 9, p. 2722-2740 19 p.

Research output: Contribution to journalArticle

zoledronic acid
Parathyroid Hormone
Osteoporosis
Osteogenesis
Therapeutics
8 Citations (Scopus)

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, LL., Williams, S. L., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F-C., Jun 8 2017, In : Nature Communications. 8, 15456.

Research output: Contribution to journalArticle

stem cells
Hematopoietic Stem Cells
Stem cells
mice
deletion
11 Citations (Scopus)

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F. C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

CREB-Binding Protein
Myelodysplastic Syndromes
Hematopoietic Stem Cells
Histone Code
Neoplasms
9 Citations (Scopus)

PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia

Guo, H., Chu, Y., Wang, L., Chen, X., Chen, Y., Cheng, H., Zhang, L., Zhou, Y., Yang, F-C., Cheng, T., Xu, M., Zhang, X., Zhou, J. & Yuan, W., Jul 15 2017, In : International Journal of Cancer. 141, 2, p. 324-335 12 p.

Research output: Contribution to journalArticle

Leukemia
Stem Cells
Maintenance
Acute Myeloid Leukemia
Clustered Regularly Interspaced Short Palindromic Repeats
29 Citations (Scopus)

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., Nazha, A., Chen, L., Yao, B., Liu, C., Chen, S., Weeks, O., Ni, H., Phillips, B. L., Huang, S., Wang, J. & 8 others, He, C., Li, G. M., Radivoyevitch, T., Aifantis, I., MacIejewski, J. P., Yang, F-C., Jin, P. & Xu, M., Jan 1 2017, In : Nature Communications. 8, 15102.

Research output: Contribution to journalArticle

stem cells
mutations
Hematopoietic Stem Cells
Stem cells
Hematologic Neoplasms
2016
1 Citation (Scopus)

Aberrant Myeloid Differentiation Contributes to the Development of Osteoporosis in Neurofibromatosis Type 1

Rhodes, S. D. & Yang, F-C., Feb 1 2016, In : Current Osteoporosis Reports. 14, 1, p. 10-15 6 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Osteoporosis
Neurofibromin 1
Metabolic Bone Diseases
Osteoclasts
22 Citations (Scopus)

Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow

Lim, M., Pang, Y., Ma, S., Hao, S., Shi, H., Zheng, Y., Hua, C., Gu, X., Yang, F-C., Yuan, W. & Cheng, T., Jan 1 2016, In : Leukemia. 30, 1, p. 154-162 9 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Bone Marrow
Hematopoietic System
18 Citations (Scopus)

ASXL1 plays an important role in erythropoiesis

Shi, H., Yamamoto, S., Sheng, M., Bai, J., Zhang, P., Chen, R., Chen, S., Shi, L., Abdel-Wahab, O., Xu, M., Zhou, Y. & Yang, F-C., Jun 29 2016, In : Scientific Reports. 6, 28789.

Research output: Contribution to journalArticle

Erythropoiesis
Myelodysplastic Syndromes
Erythroblasts
Leukemia, Myelomonocytic, Chronic
Erythrocytes
6 Citations (Scopus)

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin

Man, N., Sun, X. J., Tan, Y., García-Cao, M., Liu, F., Cheng, G., Hatlen, M., Xu, H., Shah, R., Chastain, N., Liu, N., Huang, G., Zhou, Y., Sheng, M., Song, J., Yang, F-C., Benezra, R., Nimer, S. D. & Wang, L., 2016, In : Blood. 127, 19, p. 2322-2326 5 p.

Research output: Contribution to journalArticle

Leukemia
DNA
Liver
Bone
Bone Marrow Cells
9 Citations (Scopus)

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice

Zhang, P., Xing, C., Rhodes, S. D., He, Y., Deng, K., Li, Z., He, F., Zhu, C., Nguyen, L., Zhou, Y., Chen, S., Mohammad, K. S., Guise, T. A., Abdel-Wahab, O., Xu, M., Wang, Q. F. & Yang, F-C., Jan 26 2016, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone
Genes
Osteoblasts
Defects
7 Citations (Scopus)

Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas

Ferguson, M. J., Rhodes, S. D., Jiang, L., Li, X., Yuan, J., Yang, X., Zhang, S., Vakili, S. T., Territo, P., Hutchins, G., Yang, F-C., Ingram, D. A., Clapp, D. W. & Chen, S., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 206-213 8 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Mast Cells
Therapeutics
Neoplasms
Fibroblasts
14 Citations (Scopus)

Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion

Si, X., Zhang, X., Hao, X., Li, Y., Chen, Z., Ding, Y., Shi, H., Bai, J., Gao, Y., Cheng, T., Yang, F-C. & Zhou, Y., 2016, In : Oncotarget. 7, 47, p. 78095-78109 15 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Up-Regulation
Stem Cells
2015
29 Citations (Scopus)

A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation

Gehlhausen, J. R., Park, S. J., Hickox, A. E., Shew, M., Staser, K., Rhodes, S. D., Menon, K., Lajiness, J. D., Mwanthi, M., Yang, X., Yuan, J., Territo, P., Hutchins, G., Nalepa, G., Yang, F-C., Conway, S. J., Heinz, M. G., Stemmer-Rachamimov, A., Yates, C. W. & Clapp, D. W., Jan 1 2015, In : Human Molecular Genetics. 24, 1, p. 1-8 8 p., ddu414.

Research output: Contribution to journalArticle

Neurofibromatosis 2
Neurilemmoma
Vestibulocochlear Nerve
Neurofibromatosis 2 Genes
Cranial Nerves
46 Citations (Scopus)

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., Chen, S., Yuan, W., Qin, Z., Ni, H., Nimer, S. D., Yang, F-C., Jaenisch, R., Jin, P. & Xu, M., Nov 24 2015, In : Cell Reports. 13, 8, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Dioxygenases
Hematologic Neoplasms
Neoplasms
3 Citations (Scopus)

Dystrophic spinal deformities in a neurofibromatosis type 1 murine model

Rhodes, S. D., Zhang, W., Yang, D., Yang, H., Chen, S., Wu, X., Li, X., Yang, X., Mohammad, K. S., Guise, T. A., Bergner, A. L., Stevenson, D. A. & Yang, F-C., Mar 18 2015, In : PLoS One. 10, 3, e0119093.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Fusion reactions
animal models
intervertebral disks
Intervertebral Disc
5 Citations (Scopus)

Genome-wide mapping and interrogation of the Nmp4 antianabolic bone axis

Childress, P., Stayrook, K. R., Alvarez, M. B., Wang, Z., Shao, Y., Hernandez-Buquer, S., Mack, J. K., Grese, Z. R., He, Y., Horan, D., Pavalko, F. M., Warden, S. J., Robling, A. G., Yang, F-C., Allen, M. R., Krishnan, V., Liu, Y. & Bidwell, J. P., Sep 1 2015, In : Molecular Endocrinology. 29, 9, p. 1269-1285 17 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Chromosome Mapping
Mesenchymal Stromal Cells
Bone and Bones
Osteoporosis
2 Citations (Scopus)

Hyperactive RAS/PI3-K/MAPK signaling cascade in migration and adhesion of Nf1 haploinsufficient mesenchymal stem/progenitor cells

Zhou, Y., He, Y., Sharma, R., Xing, W., Estwick, S. A., Wu, X., Rhodes, S. D., Xu, M. & Yang, F-C., 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12345-12359 15 p., A031.

Research output: Contribution to journalArticle

MAP Kinase Kinase 3
1-Phosphatidylinositol 4-Kinase
stem cells
Phosphatidylinositols
Mitogen-Activated Protein Kinases
3 Citations (Scopus)

Incidence and risk factors for myelofibrotic transformation among 272 Chinese patients with JAK2-mutated polycythemia vera

Bai, J., Ai, L., Zhang, L., Yang, F-C., Zhou, Y. & Xue, Y., Dec 1 2015, In : American Journal of Hematology. 90, 12, p. 1116-1121 6 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Primary Myelofibrosis
Incidence
Splenomegaly
Platelet Count
2 Citations (Scopus)

Nf1 haploinsufficiency alters myeloid lineage commitment and function, leading to deranged skeletal homeostasis

Rhodes, S. D., Yang, H., Dong, R., Menon, K., He, Y., Li, Z., Chen, S., Staser, K. W., Jiang, L., Wu, X., Yang, X., Peng, X., Mohammad, K. S., Guise, T. A., Xu, M. & Yang, F-C., Oct 1 2015, In : Journal of Bone and Mineral Research. 30, 10, p. 1840-1851 12 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Neurofibromatosis 1
Osteoclasts
Homeostasis
Osteogenesis
9 Citations (Scopus)

The TET2 interactors and their links to hematological malignancies

Pan, F., Weeks, O., Yang, F-C. & Xu, M., Jun 1 2015, In : IUBMB Life. 67, 6, p. 438-445 8 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Protein Transport
DNA
5-Methylcytosine
Dioxygenases
2014

Anti-mouse CD122 antibody promotes the hematopoietic repopulating capacity of cord blood CD34⁺ cells in NOD/SCID mice

Sheng, M. Y., Shi, H., Xing, W., Wang, W. J., Si, X. H., Bai, J., Yuan, W. P., Zhou, Y. & Yang, F-C., Dec 1 2014, In : Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology. 22, 6, p. 1673-1677 5 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Fetal Blood
Blood Cells
Antibodies
Natural Killer Cells
76 Citations (Scopus)

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

Wang, J., Li, Z., He, Y., Pan, F., Chen, S., Rhodes, S., Nguyen, L., Yuan, J., Jiang, L., Yang, X., Weeks, O., Liu, Z., Zhou, J., Ni, H., Cai, C. L., Xu, M. & Yang, F-C., Jan 23 2014, In : Blood. 123, 4, p. 541-553 13 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Apoptosis
Stem cells
Tumors
Neoplasms
Comb and Wattles
Mutation
Neoplasms
Repression (Psychology)
Leukemia, Myelomonocytic, Chronic
6 Citations (Scopus)

Whole exome sequencing reveals concomitant mutations of multiple FA genes in individual Fanconi anemia patients

Chang, L., Yuan, W., Zeng, H., Zhou, Q., Wei, W., Zhou, J., Li, M., Wang, X., Xu, M., Yang, F-C., Yang, Y., Cheng, T. & Zhu, X., May 15 2014, In : BMC Medical Genomics. 7, 1, 24.

Research output: Contribution to journalArticle

Exome
Fanconi Anemia
Mutation
Genes
Stanozolol
2013
6 Citations (Scopus)
Mesenchymal Stromal Cells
Bone Marrow
Density Gradient Centrifugation
Chondrocytes
Centrifugation
18 Citations (Scopus)

A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells

Staser, K., Shew, M. A., Michels, E. G., Mwanthi, M. M., Yang, F-C., Clapp, D. W. & Park, S. J., Jan 2013, In : Experimental Hematology. 41, 1

Research output: Contribution to journalArticle

p21-Activated Kinases
Protein Phosphatase 2
Mast Cells
Actins
Cell Degranulation
31 Citations (Scopus)

Approaches to treating NF1 tibial pseudarthrosis: Consensus from the children's tumor foundation NF1 bone abnormalities consortium

Stevenson, D. A., Little, D., Armstrong, L., Crawford, A. H., Eastwood, D., Friedman, J. M., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D. L., Kolanczyk, M., Monsell, F., Oetgen, M., Richards, B. S., Schindeler, A., Schorry, E. K., Wilkes, D., Viskochil, D. H., Yang, F-C. & Elefteriou, F., Apr 2013, In : Journal of Pediatric Orthopaedics. 33, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Pseudarthrosis
Neurofibromatosis 1
Consensus
Bone and Bones
Neoplasms
25 Citations (Scopus)

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurobromin-decient mice

Sharma, R., Wu, X., Rhodes, S. D., Chen, S., He, Y., Yuan, J., Li, J., Yang, X., Li, X., Jiang, L., Kim, E. T., Stevenson, D. A., Viskochil, D., Xu, M. & Yang, F-C., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4818-4828 11 p., ddt333.

Research output: Contribution to journalArticle

Tibial Fractures
Mitogen-Activated Protein Kinases
Osteoblasts
Pseudarthrosis
Mitogen-Activated Protein Kinase Kinases
25 Citations (Scopus)

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Rhodes, S. D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K. W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K. S., Xu, M., Guise, T. A. & Yang, F-C., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Transforming Growth Factors
Transforming Growth Factor beta
Osteoblasts
Pseudarthrosis
8 Citations (Scopus)

Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency

He, Y., Childress, P., Hood, M., Alvarez, M., Kacena, M. A., Hanlon, M., McKee, B., Bidwell, J. P. & Yang, F-C., Feb 1 2013, In : Stem Cells and Development. 22, 3, p. 492-500 9 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Mesenchymal Stromal Cells
Knockout Mice
Bone Marrow
Thigh
29 Citations (Scopus)

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk

Staser, K., Park, S. J., Rhodes, S. D., Zeng, Y., He, Y. Z., Shew, M. A., Gehlhausen, J. R., Cerabona, D., Menon, K., Chen, S., Sun, Z., Yuan, J., Ingram, D. A., Nalepa, G., Yang, F-C. & Clapp, D. W., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 329-334 6 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Hematopoiesis
Hematopoietic Stem Cells
Myelopoiesis
Juvenile Myelomonocytic Leukemia
108 Citations (Scopus)

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

Huang, H., Jiang, X., Li, Z., Li, Y., Song, C. X., He, C., Sun, M., Chen, P., Gurbuxani, S., Wang, J., Hong, G. M., Elkahloun, A. G., Arnovitz, S., Wang, J., Szulwach, K., Lin, L., Street, C., Wunderlich, M., Dawlaty, M., Neilly, M. B. & 9 others, Jaenisch, R., Yang, F-C., Mulloy, J. C., Jin, P., Liu, P. P., Rowley, J. D., Xu, M., He, C. & Chen, J., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 11994-11999 6 p.

Research output: Contribution to journalArticle

Leukemia
Myeloid-Lymphoid Leukemia Protein
Homeobox Genes
Genes
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
42 Citations (Scopus)

The tumor suppressor CDKN3 controls mitosis

Nalepa, G., Barnholtz-Sloan, J., Enzor, R., Dey, D., He, Y., Gehlhausen, J. R., Lehmann, A. S., Park, S. J., Yang, Y., Yang, X., Chen, S., Guan, X., Chen, Y., Renbarger, J., Yang, F-C., Parada, L. F. & Clapp, W., Jun 2013, In : Journal of Cell Biology. 201, 7, p. 997-1012 16 p.

Research output: Contribution to journalArticle

Mitosis
Phosphoric Monoester Hydrolases
Centrosome
Neoplasms
Kinetochores