Feng-Chun Yang

Professor

  • 4907 Citations
1993 …2023
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Research Output 1993 2019

2013
31 Citations (Scopus)

Approaches to treating NF1 tibial pseudarthrosis: Consensus from the children's tumor foundation NF1 bone abnormalities consortium

Stevenson, D. A., Little, D., Armstrong, L., Crawford, A. H., Eastwood, D., Friedman, J. M., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D. L., Kolanczyk, M., Monsell, F., Oetgen, M., Richards, B. S., Schindeler, A., Schorry, E. K., Wilkes, D., Viskochil, D. H., Yang, F-C. & Elefteriou, F., Apr 2013, In : Journal of Pediatric Orthopaedics. 33, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Pseudarthrosis
Neurofibromatosis 1
Consensus
Bone and Bones
Neoplasms
26 Citations (Scopus)

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurobromin-decient mice

Sharma, R., Wu, X., Rhodes, S. D., Chen, S., He, Y., Yuan, J., Li, J., Yang, X., Li, X., Jiang, L., Kim, E. T., Stevenson, D. A., Viskochil, D., Xu, M. & Yang, F-C., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4818-4828 11 p., ddt333.

Research output: Contribution to journalArticle

Tibial Fractures
Mitogen-Activated Protein Kinases
Osteoblasts
Pseudarthrosis
Mitogen-Activated Protein Kinase Kinases
25 Citations (Scopus)

Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model

Rhodes, S. D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K. W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R., Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad, K. S., Xu, M., Guise, T. A. & Yang, F-C., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Transforming Growth Factors
Transforming Growth Factor beta
Osteoblasts
Pseudarthrosis
8 Citations (Scopus)

Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency

He, Y., Childress, P., Hood, M., Alvarez, M., Kacena, M. A., Hanlon, M., McKee, B., Bidwell, J. P. & Yang, F-C., Feb 1 2013, In : Stem Cells and Development. 22, 3, p. 492-500 9 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Mesenchymal Stromal Cells
Knockout Mice
Bone Marrow
Thigh
29 Citations (Scopus)

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk

Staser, K., Park, S. J., Rhodes, S. D., Zeng, Y., He, Y. Z., Shew, M. A., Gehlhausen, J. R., Cerabona, D., Menon, K., Chen, S., Sun, Z., Yuan, J., Ingram, D. A., Nalepa, G., Yang, F-C. & Clapp, D. W., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 329-334 6 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Hematopoiesis
Hematopoietic Stem Cells
Myelopoiesis
Juvenile Myelomonocytic Leukemia
109 Citations (Scopus)

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

Huang, H., Jiang, X., Li, Z., Li, Y., Song, C. X., He, C., Sun, M., Chen, P., Gurbuxani, S., Wang, J., Hong, G. M., Elkahloun, A. G., Arnovitz, S., Wang, J., Szulwach, K., Lin, L., Street, C., Wunderlich, M., Dawlaty, M., Neilly, M. B. & 9 others, Jaenisch, R., Yang, F-C., Mulloy, J. C., Jin, P., Liu, P. P., Rowley, J. D., Xu, M., He, C. & Chen, J., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 11994-11999 6 p.

Research output: Contribution to journalArticle

Leukemia
Myeloid-Lymphoid Leukemia Protein
Homeobox Genes
Genes
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
42 Citations (Scopus)

The tumor suppressor CDKN3 controls mitosis

Nalepa, G., Barnholtz-Sloan, J., Enzor, R., Dey, D., He, Y., Gehlhausen, J. R., Lehmann, A. S., Park, S. J., Yang, Y., Yang, X., Chen, S., Guan, X., Chen, Y., Renbarger, J., Yang, F-C., Parada, L. F. & Clapp, W., Jun 2013, In : Journal of Cell Biology. 201, 7, p. 997-1012 16 p.

Research output: Contribution to journalArticle

Mitosis
Phosphoric Monoester Hydrolases
Centrosome
Neoplasms
Kinetochores
2012
14 Citations (Scopus)

c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

He, Y., Rhodes, S. D., Chen, S., Wu, X., Yuan, J., Yang, X., Jiang, L., Li, X., Takahashi, N., Xu, M., Mohammad, K. S., Guise, T. A. & Yang, F-C., Nov 7 2012, In : PLoS One. 7, 11, e46900.

Research output: Contribution to journalArticle

osteoclasts
Neurofibromatosis 1
Osteoclasts
macrophage colony-stimulating factor
Macrophage Colony-Stimulating Factor
54 Citations (Scopus)

Hydroxylation of 5-methylcytosine by Tet2 maintains the active state of the mammalian Hoxa cluster

Bocker, M. T., Tuorto, F., Raddatz, G., Musch, T., Yang, F-C., Xu, M., Lyko, F. & Breiling, A., 2012, In : Nature Communications. 3, 818.

Research output: Contribution to journalArticle

5-Methylcytosine
Hydroxylation
genes
Genes
maintenance
97 Citations (Scopus)

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: A phase 2 trial

Robertson, K. A., Nalepa, G., Yang, F-C., Bowers, D. C., Ho, C. Y., Hutchins, G. D., Croop, J. M., Vik, T. A., Denne, S. C., Parada, L. F., Hingtgen, C. M., Walsh, L. E., Yu, M., Pradhan, K. R., Edwards-Brown, M. K., Cohen, M. D., Fletcher, J. W., Travers, J. B., Staser, K. W., Lee, M. W. & 5 others, Sherman, M. R., Davis, C. J., Miller, L. C., Ingram, D. A. & Clapp, D. W., Dec 2012, In : The Lancet Oncology. 13, 12, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Neurofibromatosis 1
Imatinib Mesylate
Neoplasms
Chemoradiotherapy
5 Citations (Scopus)

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J. P., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F. M., Kacena, M. A. & Yang, F-C., 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Zinc Fingers
Parathyroid Hormone
Proteins
Transcription Factors
42 Citations (Scopus)

Pathogenesis of plexiform neurofibroma: Tumor-stromal/hematopoietic interactions in tumor progression

Staser, K., Yang, F-C. & Clapp, D. W., 2012, In : Annual Review of Pathology: Mechanisms of Disease. 7, p. 469-495 27 p.

Research output: Contribution to journalArticle

pathogenesis
neoplasms
mast cells
stem cell factor
mutation

Role of mast cells in the neurofibromatosis type 1-associated neurofibroma

Staser, K., Clapp, D. W. & Yang, F-C., 2012, Advances in Neurofibromatosis Research. Nova Science Publishers, Inc., p. 43-58 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurofibroma
Neurofibromatosis 1
Mast Cells
Schwann Cells
Neurofibromin 1
15 Citations (Scopus)

The Plexiform Neurofibroma Microenvironment

Yang, F-C., Staser, K. & Clapp, D. W., 2012, (Accepted/In press) In : Cancer Microenvironment. p. 1-4 4 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Schwann Cells
Mast Cells
Neurofibromatosis 1
Stem Cell Factor
2011
53 Citations (Scopus)

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F-C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

Bone Resorption
Mitogen-Activated Protein Kinases
Bone and Bones
Urine
Costello Syndrome
343 Citations (Scopus)

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C. L., Wang, J., Zhang, W., Petersen, B. E., Yang, F-C. & Xu, M., Oct 27 2011, In : Blood. 118, 17, p. 4509-4518 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
5-Methylcytosine
Neoplasms
Tumors
53 Citations (Scopus)

Erk1 positively regulates osteoclast differentiation and bone resorptive activity

He, Y., Staser, K., Rhodes, S. D., Liu, Y., Wu, X., Park, S. J., Yuan, J., Yang, X., Li, X., Jiang, L., Chen, S. & Yang, F-C., Sep 22 2011, In : PLoS One. 6, 9, e24780.

Research output: Contribution to journalArticle

osteoclasts
Osteoclasts
Bone
bones
Bone and Bones
1 Citation (Scopus)

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F-C. & Chan, R. J., Jul 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Protein Kinases
Hypersensitivity
Bone Marrow
KSR-1 protein kinase
26 Citations (Scopus)

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1

Stevenson, D. A., Yan, J., He, Y., Li, H., Liu, Y., Zhang, Q., Jing, Y., Guo, Z., Zhang, W., Yang, D., Wu, X., Hanson, H., Li, X., Staser, K., Viskochil, D. H., Carey, J. C., Chen, S., Miller, L., Roberson, K., Moyer-Mileur, L. & 4 others, Yu, M., Schwarz, E. L., Pasquali, M. & Yang, F-C., May 2011, In : American Journal of Medical Genetics, Part A. 155, 5, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Osteoclasts
Bone Resorption
Bone Density
Phenotype
17 Citations (Scopus)

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F-C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

Osteoblasts
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
Cell growth
24 Citations (Scopus)

Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model

Zhang, W., Rhodes, S. D., Zhao, L., He, Y., Zhang, Y., Shen, Y., Yang, D., Wu, X., Li, X., Yang, X., Park, S. J., Chen, S., Turner, C. & Yang, F-C., Jun 1 2011, In : Bone. 48, 6, p. 1378-1387 10 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Spine
Lumbar Vertebrae
Inborn Genetic Diseases
Photon Absorptiometry
22 Citations (Scopus)

The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1

Wu, X., Chen, S., He, Y., Rhodes, S. D., Mohammad, K. S., Li, X., Yang, X., Jiang, L., Nalepa, G., Snider, P., Robling, A. G., Clapp, D. W., Conway, S. J., Guise, T. A. & Yang, F-C., Sep 29 2011, In : PLoS One. 6, 9, e24917.

Research output: Contribution to journalArticle

Spontaneous Fractures
Neurofibromatosis 1
stem cells
Repair
animal models
29 Citations (Scopus)

The musculoskeletal phenotype of the RASopathies

Stevenson, D. A. & Yang, F-C., May 15 2011, In : American Journal of Medical Genetics, Part A. 157, 2, p. 90-103 14 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Phenotype
Costello Syndrome
Neurofibromatosis 1 Genes
Noonan Syndrome
2010
31 Citations (Scopus)

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Pulliam-Leath, A. C., Ciccone, S. L., Nalepa, G., Li, X., Si, Y., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., Orazi, A., Vance, G. H., Yang, F-C., Hanenberg, H., Bagby, G. C. & Clapp, D. W., Oct 21 2010, In : Blood. 116, 16, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Acute Myeloid Leukemia
Bone
Fanconi Anemia Complementation Group Proteins
Bone Marrow
4 Citations (Scopus)

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Hematopoietic Stem Cells
Hematopoiesis
Gene Expression
Small Interfering RNA
66 Citations (Scopus)

Mast cells and the neurofibroma microenvironment

Staser, K., Yang, F-C. & Clapp, D. W., Jul 15 2010, In : Blood. 116, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Cellular Microenvironment
Neurofibroma
Neurofibromatosis 1
Mast Cells
Plexiform Neurofibroma
11 Citations (Scopus)

Mechanical stimulation suppresses phosphorylation of eIF2α and PERK-mediated responses to stress to the endoplasmic reticulum

Hirasawa, H., Jiang, C., Zhang, P., Yang, F-C. & Yokota, H., Feb 2010, In : FEBS Letters. 584, 4, p. 745-752 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Endoplasmic Reticulum Stress
Ulna
Thapsigargin
Mortality
23 Citations (Scopus)

Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase

Chen, S., Burgin, S., McDaniel, A., Li, X., Yuan, J., Chen, M., Khalaf, W., Clapp, D. W. & Yang, F-C., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3125-3132 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cell Degranulation
Schwann Cells
Conditioned Culture Medium
Mast Cells
25 Citations (Scopus)

Plexiform neurofibroma genesis: Questions of Nf1 gene dose and hyperactive mast cells

Staser, K., Yang, F-C. & Clapp, D. W., 2010, In : Current Opinion in Hematology. 17, 4, p. 287-293 7 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1 Genes
Plexiform Neurofibroma
Mast Cells
Neurofibromatosis 1
Schwann Cells
Cell Growth Processes
Species Specificity
Neurofibromatosis 1
Tumor Microenvironment
Schwann Cells
2009
49 Citations (Scopus)

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg -/- mice in vivo

Li, Y., Chen, S., Yuan, J., Yang, Y., Li, J., Jin, M., Wu, X., Freund, M., Pollok, K., Hanenberg, H., Goebe, W. S. & Yang, F-C., Mar 5 2009, In : Blood. 113, 10, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Fanconi Anemia
Tibia
3 Citations (Scopus)

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F-C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Embryonic Stem Cells
Stromal Cells
Embryoid Bodies
Endoderm
19 Citations (Scopus)

Ras dependent paracrine secretion of osteopontin by nf1 +/- osteoblasts promote osteodast activation in a neurofibromatosis type i murine model

Li, H., Liu, Y., Zhang, Q., Jing, Y., Chen, S., Song, Z., Yan, J., Li, Y., Wu, X., Zhang, X., Zhang, Y., Case, J., Yu, M., Ingram, D. A. & Yang, F-C., Jun 2009, In : Pediatric Research. 65, 6, p. 613-618 6 p.

Research output: Contribution to journalArticle

Neurofibromatoses
Osteopontin
Osteoblasts
Osteoclasts
Bone Resorption
78 Citations (Scopus)

Skeletal abnormalities in neurofibromatosis type 1: Approaches to therapeutic options

Elefteriou, F., Kolanczyk, M., Schindeler, A., Viskochil, D. H., Hock, J. M., Schorry, E. K., Crawford, A. H., Friedman, J. M., Little, D., Peltonen, J., Carey, J. C., Feldman, D., Yu, X., Armstrong, L., Birch, P., Kendler, D. L., Mundlos, S., Yang, F-C., Agiostratidou, G., Hunter-Schaedle, K. & 1 others, Stevenson, D. A., Oct 2009, In : American Journal of Medical Genetics, Part A. 149, 10, p. 2327-2338 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Clinical Trials
Bone and Bones
Natural History
Skeleton
2008
27 Citations (Scopus)

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

Pulliam, A. C., Hobson, M. J., Ciccone, S. L., Li, Y., Chen, S., Srour, E. F., Yang, F-C., Broxmeyer, H. E. & Clapp, D. W., Sep 2008, In : Experimental Hematology. 36, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Granulocyte Colony-Stimulating Factor
Knockout Mice
Stem Cells
Bone Marrow
150 Citations (Scopus)

Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use

Perry, B. C., Zhou, D., Wu, X., Yang, F-C., Byers, M. A., Chu, T. M. G., Hockema, J. J., Woods, E. J. & Goebel, W. S., 2008, In : Tissue Engineering - Part C: Methods. 14, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

Dental Pulp
Cryopreservation
Stem cells
Mesenchymal Stromal Cells
Pulp

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F-C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Medical Genetics
Osteoclasts
Molecular Biology
232 Citations (Scopus)

Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/-- and c-kit-Dependent Bone Marrow

Yang, F-C., Ingram, D. A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X., Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S. T., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L. F. & Clapp, D. W., Oct 31 2008, In : Cell. 135, 3, p. 437-448 12 p.

Research output: Contribution to journalArticle

Neurofibroma
Tumors
Schwann Cells
Bone
Bone Marrow
38 Citations (Scopus)

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F-C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Osteoclasts
rho GTP-Binding Proteins
Bone Resorption
Osteoporosis
28 Citations (Scopus)

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F-C. & Kapur, R., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Osteoclasts
Gene Expression
Integrins
Cathepsin K
2007
15 Citations (Scopus)

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Li, B., Jia, N., Waning, D. L., Yang, F-C., Haneline, L. S. & Chun, K. T., Oct 1 2007, In : Blood. 110, 7, p. 2704-2707 4 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Ubiquitin
Stem cells
Ligases
Proteolysis
30 Citations (Scopus)

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells

Khalaf, W. F., Yang, F-C., Chen, S., White, H., Bessler, W., Ingram, D. A. & Clapp, D. W., Feb 15 2007, In : Journal of Immunology. 178, 4, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

Mast Cells
GTPase-Activating Proteins
Neurofibromin 1
ras Proteins
Protein Isoforms
7 Citations (Scopus)

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration - Implications for increased neurofibroma formation during pregnancy

Nebesio, T. D., Ming, W., Chen, S., Clegg, T., Yuan, J., Yang, Y., Estwick, S. A., Li, Y., Li, X., Hingtgen, C. M. & Yang, F-C., Apr 1 2007, In : GLIA. 55, 5, p. 527-536 10 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibroma
Schwann Cells
Neurofibromatosis 1
Pregnancy
2006
34 Citations (Scopus)

Continuous in vivo infusion of interferon-gamma (IFN-γ) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg -/- mice

Si, Y., Ciccone, S., Yang, F-C., Yuan, J., Zeng, D., Chen, S., Van De Vrugt, H. J., Critser, J., Arwert, F., Haneline, L. S. & Clapp, D. W., Dec 15 2006, In : Blood. 108, 13, p. 4283-4287 5 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Interferon-gamma
Stem cells
Bone
Stem Cells
24 Citations (Scopus)

Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L. S., White, H., Yang, F-C., Chen, S., Orschell, C., Kapur, R. & Ingram, D. A., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Fetal Movement
Hematopoiesis
Hematopoietic Stem Cells
Stem cells
88 Citations (Scopus)

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Yang, F-C., Chen, S., Robling, A. G., Yu, X., Nebesio, T. D., Yan, J., Morgan, T., Li, X., Yuan, J., Hock, J., Ingram, D. A. & Clapp, D. W., Nov 1 2006, In : Journal of Clinical Investigation. 116, 11, p. 2880-2891 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Osteoclasts
Phosphatidylinositol 3-Kinases
Macrophage Colony-Stimulating Factor Receptors
Proto-Oncogene Proteins p21(ras)
40 Citations (Scopus)

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Munchhof, A. M., Li, F., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Li, X., Yuan, J., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibroma
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Tumor Suppressor Genes
55 Citations (Scopus)

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Li, F., Munchhof, A. M., White, H. A., Mead, L. E., Krier, T. R., Fenoglio, A., Chen, S., Wu, X., Cai, S., Yang, F-C. & Ingram, D. A., Jun 2006, In : Human Molecular Genetics. 15, 11, p. 1921-1930 10 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Neurofibroma
63 Citations (Scopus)

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F-C., Oct 1 2006, In : Human Molecular Genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Osteoblasts
Mesenchymal Stromal Cells
Stem Cells
Fibroblasts
94 Citations (Scopus)

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling

Yang, F-C., Chen, S., Clegg, T., Li, X., Morgan, T., Estwick, S. A., Yuan, J., Khalaf, W., Burgin, S., Travers, J., Parada, L. F., Ingram, D. A. & Clapp, D. W., Aug 15 2006, In : Human Molecular Genetics. 15, 16, p. 2421-2437 17 p.

Research output: Contribution to journalArticle

Neurofibroma
Mast Cells
Transforming Growth Factor beta
Phenotype
Fibroblasts