Diego A Caicedo-Vierkant

Professor

  • 3773 Citations
1993 …2020

Research output per year

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Research Output

  • 3773 Citations
  • 60 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate
2020

A Nervous Breakdown that May Stop Autoimmune Diabetes

Makhmutova, M., Rodriguez-Diaz, R. & Caicedo, A., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 215-216 2 p.

Research output: Contribution to journalArticle

Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

Qadir, M. M. F., Álvarez-Cubela, S., Weitz, J., Panzer, J. K., Klein, D., Moreno-Hernández, Y., Cechin, S., Tamayo, A., Almaca, J., Hiller, H., Beery, M., Kusmartseva, I., Atkinson, M., Speier, S., Ricordi, C., Pugliese, A., Caicedo-Vierkant, D. A., Fraker, C., Pastori, R. & Dominguez-Bendala, J., Dec 1 2020, In : Nature communications. 11, 1, 3265.

Research output: Contribution to journalArticle

Open Access

Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

Panzer, J. K., Hiller, H., Cohrs, C. M., Almaça, J., Enos, S. J., Beery, M., Cechin, S., Drotar, D. M., Weitz, J. R., Santini, J., Huber, M. K., Qadir, M. M. F., Pastori, R. L., Domínguez-Bendala, J., Phelps, E. A., Atkinson, M. A., Pugliese, A., Caicedo, A., Kusmartseva, I. & Speier, S., Apr 23 2020, In : JCI Insight. 5, 8, e134525.

Research output: Contribution to journalArticle

Open Access

Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling

Weitz, J. R., Jacques-Silva, C., Qadir, M. M. F., Umland, O., Pereira, E., Qureshi, F., Tamayo, A., Dominguez-Bendala, J., Rodriguez-Diaz, R., Almaça, J. & Caicedo, A., Jun 1 2020, In : Diabetes. 69, 6, p. 1206-1218 13 p.

Research output: Contribution to journalArticle

The local paracrine actions of the pancreatic α-cell

Rodriguez-Diaz, R., Tamayo, A., Hara, M. & Caicedo, A., Apr 1 2020, In : Diabetes. 69, 4, p. 550-558 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells

Barro-Soria, R., Caicedo, A., Jägle, H., Merkel, L., Zhao, N., Knop, G., Gierke, K., Dannullis, A., Castrop, H., Brandstätter, J. H., Kirchhoff, F., Feigenspan, A. & Strauß, O., Dec 1 2019, In : Scientific reports. 9, 1, 19622.

Research output: Contribution to journalArticle

Open Access

Correction to: In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice (Diabetologia, (2019), 62, 7, (1237-1250), 10.1007/s00125-019-4879-0)

Abdulreda, M. H., Molano, R., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. S., Ricordi, C., Caicedo, A., Buchwald, P., Pileggi, A. & Berggren, P-O. Y., Jan 1 2019, In : Diabetologia.

Research output: Contribution to journalComment/debate

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice

Abdulreda, M. H., Molano, R. D., Faleo, G., Lopez-Cabezas, M., Shishido, A., Ulissi, U., Fotino, C., Hernandez, L. F., Tschiggfrie, A., Aldrich, V. R., Tamayo-Garcia, A., Bayer, A. S., Ricordi, C., Caicedo, A., Buchwald, P., Pileggi, A. & Berggren, P. O., Jul 1 2019, In : Diabetologia. 62, 7, p. 1237-1250 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Menegaz, D., Hagan, D. W., Almaça, J., Cianciaruso, C., Rodriguez-Diaz, R., Molina, J., Dolan, R. M., Becker, M. W., Schwalie, P. C., Nano, R., Lebreton, F., Kang, C., Sah, R., Gaisano, H. Y., Berggren, P-O. Y., Baekkeskov, S., Caicedo, A. & Phelps, E. A., Nov 1 2019, In : Nature Metabolism. 1, 11, p. 1110-1126 17 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity

Weitz, J. R., Makhmutova, M., Almaça, J., Stertmann, J., Aamodt, K., Brissova, M., Speier, S., Rodriguez-Diaz, R. & Caicedo, A., Jan 1 2018, In : Diabetologia. 61, 1, p. 182-192 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

Rodriguez-Diaz, R., Molano, R., Weitz, J. R., Abdulreda, M. H., Berman, D. M., Leibiger, B., Leibiger, I. B., Kenyon, N. S., Ricordi, C., Pileggi, A., Caicedo, A. & Berggren, P-O. Y., Mar 6 2018, In : Cell Metabolism. 27, 3, p. 549-558.e4

Research output: Contribution to journalArticle

36 Scopus citations

The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow

Almaca, J., Weitz, J., Rodriguez Diaz, R., Pereira, E. & Caicedo-Vierkant, D. A., Mar 6 2018, In : Cell Metabolism. 27, 3, p. 630-644.e4

Research output: Contribution to journalArticle

24 Scopus citations
2017

Confocal imaging of neuropeptide Y-pHluorin: A technique to visualize insulin granule exocytosis in intact murine and human islets

Makhmutova, M., Liang, T., Gaisano, H., Caicedo-Vierkant, D. A. & Almaca, J., Sep 13 2017, In : Journal of Visualized Experiments. 2017, 127, e56089.

Research output: Contribution to journalArticle

4 Scopus citations

Regulator of G protein signaling Gb5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion

Wang, Q., Pronin, A. N., Levay, K., Almaca, J., Fornoni, A., Caicedo, A. & Slepak, V. Z., Jul 2017, In : FASEB Journal. 31, 11

Research output: Contribution to journalArticle

7 Scopus citations

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Lenguito, G., Chaimov, D., Weitz, J. R., Rodriguez-Diaz, R., Rawal, S. A. K., Tamayo-Garcia, A., Caicedo, A., Stabler, C., Buchwald, P. & Agarwal, A., 2017, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 17, 5, p. 772-781 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

β-Arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Zhu, L., Almaca, J., Dadi, P. K., Hong, H., Sakamoto, W., Rossi, M., Lee, R. J., Vierra, N. C., Lu, H., Cui, Y., McMillin, S. M., Perry, N. A., Gurevich, V. V., Lee, A., Kuo, B., Leapman, R. D., Matschinsky, F. M., Doliba, N. M., Urs, N. M., Caron, M. G. & 3 others, Jacobson, D. A., Caicedo-Vierkant, D. A. & Wess, J., Feb 1 2017, In : Nature Communications. 8, 14295.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Almaça, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V., Berggren, P-O. Y. & Caicedo, A., Dec 20 2016, In : Cell Reports. 17, 12, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Liraglutide compromises pancreatic β cell function in a humanized mouse model

Abdulreda, M. H., Rodriguez-Diaz, R., Caicedo, A. & Berggren, P-O. Y., Mar 8 2016, In : Cell Metabolism. 23, 3, p. 541-546 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

The different faces of the pancreatic islet

Abdulreda, M. H., Rodriguez-Diaz, R., Cabrera, O., Caicedo, A. & Berggren, P-O. Y., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 938. p. 11-24 14 p. (Advances in Experimental Medicine and Biology; vol. 938).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2015

Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets

Almaça, J., Liang, T., Gaisano, H. Y., Nam, H. G., Berggren, P. O. & Caicedo, A., Dec 1 2015, In : Diabetologia. 58, 12, p. 2810-2818 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Control of insulin secretion by cholinergic signaling in the human pancreatic islet

Molina, J., Rodriguez-Diaz, R., Fachado, A., Jacques-Silva, M. C., Berggren, P-O. Y. & Caicedo, A., Aug 2014, In : Diabetes. 63, 8, p. 2714-2726 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

In vivo imaging of kidney glomeruli transplanted into the anterior chamber of the mouse eye

Kistler, A. D., Caicedo, A., Abdulreda, M. H., Faul, C., Kerjaschki, D., Berggren, P. O., Reiser, J. & Fornoni, A., Jan 27 2014, In : Scientific reports. 4, 3872.

Research output: Contribution to journalArticle

14 Scopus citations

Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis

Medina, M. C., Fonesca, T. L., Molina, J., Fachado, A., Castillo, M., Dong, L., Soares, R., Hernández, A., Caicedo, A. & Bianco, A., Aug 2014, In : Endocrinology. 155, 8, p. 3160-3171 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Neural control of the endocrine pancreas

Rodriguez Diaz, R. & Caicedo-Vierkant, D. A., Oct 1 2014, In : Best Practice and Research: Clinical Endocrinology and Metabolism. 28, 5, p. 745-756 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Neurotransmitters act as paracrine signals to regulate insulin secretion from the human pancreatic islet

Rodriguez-Diaz, R., Menegaz, D. & Caicedo, A., Aug 15 2014, In : Journal of Physiology. 592, 16, p. 3413-3417 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Young capillary vessels rejuvenate aged pancreatic islets

Almaça, J., Molina, J., Drigo, R. A., Abdulreda, M. H., Jeon, W. B., Berggren, P-O. Y., Caicedo, A. & Nam, H. G., Dec 9 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17612-17617 6 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser- induced choroidal neovascularization

Espinosa-Heidmann, D. G., Malek, G., Mettu, P. S., Caicedo, A., Saloupis, P., Gach, S., Dunnon, A. K., Hu, P., Spiga, M. G. & Cousins, S. W., Oct 17 2013, In : Investigative Ophthalmology and Visual Science. 54, 12, p. 7439-7449 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Coordination of hypothalamic and pituitary T3 production regulates TSH expression

Fonseca, T. L., Correa-Medina, M., Campos, M. P. O., Wittmann, G., Werneck-de-Castro, J. P., Drigo, R. A., Mora-Garzon, M., Ueta, C. B., Caicedo, A., Fekete, C., Gereben, B., Lechan, R. M. & Bianco, A. C., Apr 1 2013, In : Journal of Clinical Investigation. 123, 4, p. 1492-1500 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
17 Scopus citations

Paracrine and autocrine interactions in the human islet: More than meets the eye

Caicedo, A., Jan 2013, In : Seminars in Cell and Developmental Biology. 24, 1, p. 11-21 11 p.

Research output: Contribution to journalReview article

81 Scopus citations
15 Scopus citations
2012

Non-invasive in vivo imaging of pancreatic β-cell function and survival - a perspective

Leibiger, I. B., Caicedo, A. & Berggren, P-O. Y., Feb 1 2012, In : Acta Physiologica. 204, 2, p. 178-185 8 p.

Research output: Contribution to journalReview article

17 Scopus citations

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function

Rodriguez-Diaz, R., Speier, S., Molano, R. D., Formoso, A., Gans, I., Abdulreda, M. H., Cabrera, O., Molina, J., Fachado, A., Ricordi, C., Leibiger, I., Pileggi, A., Berggren, P. O. & Caicedo, A., Dec 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. 21456-21461 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Real-time detection of acetylcholine release from the human endocrine pancreas

Rodriguez-Diaz, R., Dando, R., Huang, Y. A., Berggren, P-O. Y., Roper, S. D. & Caicedo, A., Jun 1 2012, In : Nature protocols. 7, 6, p. 1015-1023 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

Rodriguez-Diaz, R., Dando, R., Jacques-Silva, M. C., Fachado, A., Molina, J., Abdulreda, M. H., Ricordi, C., Roper, S. D., Berggren, P-O. Y. & Caicedo, A., Jul 1 2011, In : Nature medicine. 17, 7, p. 888-892 5 p.

Research output: Contribution to journalArticle

155 Scopus citations

Donor islet endothelial cells in pancreatic islet revascularization

Nyqvist, D., Speier, S., Rodriguez-Diaz, R., Molano, R. D., Lipovsek, S., Rupnik, M., Dicker, A., Ilegems, E., Zahr-Akrawi, E., Molina, J., Lopez-Cabeza, M., Villate, S., Abdulreda, M. H., Ricordi, C., Caicedo, A., Pileggi, A. & Berggren, P-O. Y., Oct 1 2011, In : Diabetes. 60, 10, p. 2571-2577 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

High-resolution, noninvasive longitudinal live imaging of immune responses

Abdulreda, M. H., Faleo, G., Molano, R. D., Lopez-Cabezas, M., Molina, J., Tan, Y., Ron Echeverria, O. A., Zahr-Akrawi, E., Rodriguez-Diaz, R., Edlund, P. K., Leibiger, I., Bayer, A. L., Perez, V., Ricordi, C., Caicedo, A., Pileggi, A. & Berggren, P. O., Aug 2 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 31, p. 12863-12868 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Innervation patterns of autonomic axons in the human endocrine pancreas

Rodriguez-Diaz, R., Abdulreda, M. H., Formoso, A. L., Gans, I., Ricordi, C., Berggren, P-O. Y. & Caicedo, A., Jul 6 2011, In : Cell Metabolism. 14, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

172 Scopus citations

The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: A study in a baboon model of diabetes

Perez, V. L., Caicedo, A., Berman, D. M., Arrieta, E., Abdulreda, M. H., Rodriguez-Diaz, R., Pileggi, A., Hernandez, E., Dubovy, S. R., Parel, J. M., Ricordi, C., Kenyon, N. M., Kenyon, N. S. & Berggren, P-O. Y., May 1 2011, In : Diabetologia. 54, 5, p. 1121-1126 6 p.

Research output: Contribution to journalArticle

52 Scopus citations
2010

ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell

Jacques-Silva, M. C., Correa-Medina, M., Cabrera, O., Rodriguez-Diaz, R., Makeeva, N., Fachado, A., Diez, J., Berman, D. M., Kenyon, N. S., Ricordi, C., Pileggi, A., Molano, R. D., Berggren, P-O. Y. & Caicedo, A., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6465-6470 6 p.

Research output: Contribution to journalArticle

88 Scopus citations
2008

Automated, high-throughput assays for evaluation of human pancreatic islet function

Cabrera, O., Jacques-Silva, M. C., Berman, D. M., Fachado, A., Echeverri, F., Poo, R., Khan, A., Kenyon, N. S., Ricordi, C., Berggren, P-O. Y. & Caicedo, A., May 30 2008, In : Cell Transplantation. 16, 10, p. 1039-1048 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Glutamate Is a Positive Autocrine Signal for Glucagon Release

Cabrera, O., Jacques-Silva, M. C., Speier, S., Yang, S. N., Köhler, M., Fachado, A., Vieira, E., Zierath, J. R., Kibbey, R., Berman, D. M., Kenyon, N. S., Ricordi, C., Caicedo, A. & Berggren, P-O. Y., Jun 4 2008, In : Cell Metabolism. 7, 6, p. 545-554 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice

Kim, J. W., Roberts, C. D., Berg, S. A., Caicedo, A., Roper, S. D. & Chaudhari, N., May 7 2008, In : PloS one. 3, 5, e2127.

Research output: Contribution to journalArticle

24 Scopus citations

Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye

Speier, S., Nyqvist, D., Köhler, M., Caicedo, A., Leibiger, I. B. & Berggren, P-O. Y., Sep 2 2008, In : Nature protocols. 3, 8, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Noninvasive in vivo imaging of pancreatic islet cell biology

Speier, S., Nyqvist, D., Cabrera, O., Yu, J., Molano, R. D., Pileggi, A., Moede, T., Köhler, M., Wilbertz, J., Leibiger, B., Ricordi, C., Leibiger, I. B., Caicedo, A. & Berggren, P-O. Y., May 1 2008, In : Nature medicine. 14, 5, p. 574-578 5 p.

Research output: Contribution to journalArticle

163 Scopus citations
2006
697 Scopus citations
2005

A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations

Ichii, H., Inverardi, L., Pileggi, A., Molano, R. D., Cabrera, O., Caicedo, A., Messinger, S., Kuroda, Y., Berggren, P-O. Y. & Ricordi, C., Jul 1 2005, In : American Journal of Transplantation. 5, 7, p. 1635-1645 11 p.

Research output: Contribution to journalArticle

154 Scopus citations

Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization

Caicedo, A., Espinosa-Heidmann, D. G., Piña, Y., Hernandez, E. P. & Cousins, S. W., Jul 1 2005, In : Experimental Eye Research. 81, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Photoreceptor synapses degenerate early in experimental choroidal neovascularization

Caicedo, A., Espinosa-Heidmann, D. G., Hamasaki, D., Piña, Y. & Cousins, S. W., Mar 14 2005, In : Journal of Comparative Neurology. 483, 3, p. 263-277 15 p.

Research output: Contribution to journalArticle

18 Scopus citations