Claes R Wahlestedt

Professor

  • 29162 Citations
1976 …2020

Research output per year

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Research Output

2020

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

Andrade, N. S., Ramic, M., Esanov, R., Liu, W., Rybin, M. J., Gaidosh, G., Abdallah, A., Del'olio, S., Huff, T. C., Chee, N. T., Anatha, S., Gendron, T. F., Wahlestedt, C., Zhang, Y., Benatar, M., Mueller, C. & Zeier, Z., Feb 24 2020, In : Molecular Neurodegeneration. 15, 1, 13.

Research output: Contribution to journalArticle

Open Access
2019

BET bromodomain inhibitors which permit treg function enable a combinatorial strategy to suppress GVHD in pre-clinical allogeneic HSCT

Copsel, S. N., Lightbourn, C. O., Barreras, H., Lohse, I., Wolf, D., Bader, C. S., Manov, J., Kale, B. J., Shah, D., Brothers, S. P., Perez, V. L., Komanduri, K. V., Wahlestedt, C. & Levy, R. B., 2019, In : Frontiers in immunology. 10, JAN, 3104.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

CHAPTER 9: Oligonucleotide Targeting of Long Non-coding RNAs

Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Jan 1 2019, Therapies for Retinal Degeneration: Targeting Common Processes. Agrawal, S. & Gait, M. J. (eds.). 68 ed. Royal Society of Chemistry, p. 181-205 25 p. (RSC Drug Discovery Series; vol. 2019-January, no. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Argemi, J., Latasa, M. U., Atkinson, S. R., Blokhin, I. O., Massey, V., Gue, J. P., Cabezas, J., Lozano, J. J., Van Booven, D., Bell, A., Cao, S., Vernetti, L. A., Arab, J. P., Ventura-Cots, M., Edmunds, L. R., Fondevilla, C., Stärkel, P., Dubuquoy, L., Louvet, A., Odena, G. & 20 others, Gomez, J. L., Aragon, T., Altamirano, J., Caballeria, J., Jurczak, M. J., Taylor, D. L., Berasain, C., Wahlestedt, C., Monga, S. P., Morgan, M. Y., Sancho-Bru, P., Mathurin, P., Furuya, S., Lackner, C., Rusyn, I., Shah, V. H., Thursz, M. R., Mann, J., Avila, M. A. & Bataller, R., Dec 1 2019, In : Nature communications. 10, 1, 3126.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways

Johnstone, A. L., Andrade, N. S., Barbier, E., Khomtchouk, B. B., Rienas, C. A., Lowe, K., Van Booven, D. J., Domi, E., Esanov, R., Vilca, S., Tapocik, J. D., Rodriguez, K., Maryanski, D., Keogh, M. C., Meinhardt, M. W., Sommer, W. H., Heilig, M., Zeier, Z. & Wahlestedt, C., Jan 1 2019, (Accepted/In press) In : Addiction Biology. e12816.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins

Sartor, G., Malvezzi, A. M., Kumar, A., Andrade, N. S., Wiedner, H. J., Vilca, S. J., Janczura, K. J., Bagheri, A., Al-Ali, H., Powell, S. K., Brown, P. T., Volmar, C. H., Foster, T. C., Zeier, Z. & Wahlestedt, C., Jan 23 2019, In : Journal of Neuroscience. 39, 4, p. 612-626 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

HDAC inhibitors induce BDNF expression and promote neurite outgrowth in human neural progenitor cells-derived neurons

Bagheri, A., Habibzadeh, P., Razavipour, S. F., Volmar, C. H., Chee, N. T., Brothers, S. P., Wahlestedt, C., Mowla, S. J. & Faghihi, M. A., Mar 2019, In : International journal of molecular sciences. 20, 5, 1109.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Longevity-related molecular pathways are subject to midlife “switch” in humans

Timmons, J. A., Volmar, C. H., Crossland, H., Phillips, B. E., Sood, S., Janczura, K. J., Törmäkangas, T., Kujala, U. M., Kraus, W. E., Atherton, P. J. & Wahlestedt, C., Aug 2019, In : Aging Cell. 18, 4, e12970.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Cao, H., Salazar-García, L., Gao, F., Wahlestedt, T., Wu, C. L., Han, X., Cai, Y., Xu, D., Wang, F., Tang, L., Ricciardi, N., Cai, D. D., Wang, H., Chin, M. P. S., Timmons, J. A., Wahlestedt, C. & Kapranov, P., Dec 1 2019, In : Nature communications. 10, 1, 5799.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Optimized functional annotation of ChIP-seq data [version 1; peer review: 3 approved with reservations]

Khomtchouk, B. B., Koehler, W. C., Van Booven, D. J. & Wahlestedt, C., 2019, In : F1000Research. 8, 612.

Research output: Contribution to journalArticle

Open Access

Ovarian cancer treatment stratification using ex vivo drug sensitivity testing

Lohse, I., Azzam, D. J., Al-Ali, H., Volmar, C. H., Brothers, S. P., Ince, T. A. & Wahlestedt, C., 2019, In : Anticancer research. 39, 8, p. 4023-4030 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer

Yan, Y., Ma, J., Wang, D., Lin, D., Pang, X., Wang, S., Zhao, Y., Shi, L., Xue, H., Pan, Y., Zhang, J., Wahlestedt, C., Giles, F. J., Chen, Y., Gleave, M. E., Collins, C. C., Ye, D., Wang, Y. & Huang, H., Nov 7 2019, In : EMBO Molecular Medicine. 11, 11, e10659.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer

Mustafi, S., Camarena, V., Qureshi, R., Yoon, H., Volmar, C. H., Huff, T. C., Sant, D. W., Zheng, L., Brothers, S. P., Wahlestedt, C., Slingerland, J. & Wang, G., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

Timmons, J. A., Atherton, P. J., Larsson, O., Sood, S., Blokhin, I. O., Brogan, R. J., Volmar, C. H., Josse, A. R., Slentz, C., Wahlestedt, C., Phillips, S. M., Phillips, B. E., Gallagher, I. J. & Kraus, W. E., 2018, In : Nucleic acids research. 46, 15, p. 7772-7792 21 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cocaine exposure increases blood pressure and aortic stiffness via the mir-30c-5p-malic enzyme 1-reactive oxygen species pathway

Zhu, W., Wang, H., Wei, J., Sartor, G., Bao, M. M., Pierce, C. T., Wahlestedt, C. R., Dykxhoorn, D. M. & Dong, C., Jan 1 2018, In : Hypertension. 71, 4, p. 752-760 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Developments in lncRNA drug discovery: where are we heading?

Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Sep 2 2018, In : Expert Opinion on Drug Discovery. 13, 9, p. 837-849 13 p.

Research output: Contribution to journalReview article

7 Scopus citations

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

10 Scopus citations

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C., Sep 2018, In : PloS one. 13, 9, e0203173.

Research output: Contribution to journalArticle

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study

Swords, R. T., Azzam, D., Al-Ali, H., Lohse, I., Volmar, C. H., Watts, J., Perez, A., Rodriguez, A., Vargas, F., Elias, R., Vega, F., Zelent, A. Z., Brothers, S. P., Abbasi, T., Trent, J., Rangwala, S., Deutsch, Y., Conneally, E., Drusbosky, L., Cogle, C. R. & 1 others, Wahlestedt, C. R., Jan 1 2018, In : Leukemia Research. 64, p. 34-41 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia

Johnstone, A. L., O'Reilly, J. J., Patel, A. J., Guo, Z., Andrade, N. S., Magistri, M., Nathanson, L., Esanov, R., Miller, B. H., Turecki, G., Brothers, S. P., Zeier, Z. R. & Wahlestedt, C. R., Nov 1 2018, In : Neurobiology of Disease. 119, p. 149-158 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C., Xu, M. & 1 others, Yang, F. C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications

Khomtchouk, B. B., Weitz, E., Karp, P. D. & Wahlestedt, C. R., May 1 2018, In : Briefings in Bioinformatics. 19, 3, p. 537-543 7 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

Janczura, K. J., Volmar, C. H., Sartor, G. C., Rao, S. J., Ricciardi, N. R., Lambert, G., Brothers, S. P. & Wahlestedt, C., Nov 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 47, p. E11148-E11157

Research output: Contribution to journalArticle

21 Scopus citations

Precision medicine in the treatment stratification of AML patients: Challenges and progress

Lohse, I., Statz-Geary, K., Brothers, S. P. & Wahlestedt, C., Dec 1 2018, In : Oncotarget. 9, 102, p. 37790-37797 8 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Purification of H3 and H4 histone proteins and the quantification of acetylated histone marks in cells and brain tissue

Janczura, K. J., Volmar, C. H. & Wahlestedt, C. R., Nov 1 2018, In : Journal of Visualized Experiments. 2018, 141, e58648.

Research output: Contribution to journalArticle

1 Scopus citations

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

Tan, S. K., Pastori, C., Penas, C., Komotar, R. J., Ivan, M. E., Wahlestedt, C. R. & Ayad, N., Mar 20 2018, In : Molecular Cancer. 17, 1, 74.

Research output: Contribution to journalLetter

61 Scopus citations

Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls

Cao, H., Wahlestedt, C. R. & Kapranov, P., Jan 1 2018, (Accepted/In press) In : Trends in Genetics.

Research output: Contribution to journalArticle

21 Scopus citations

Vitamin C sensitizes melanoma to BET inhibitors

Mustafi, S., Camarena, V., Volmar, C. H., Huff, T. C., Sant, D. W., Brothers, S. P., Liu, Z-J., Wahlestedt, C. R. & Wang, G., Jan 15 2018, In : Cancer Research. 78, 2, p. 572-583 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

Esanov, R., Cabrera, G. T., Andrade, N. S., Gendron, T. F., Brown, R. H., Benatar, M., Wahlestedt, C., Mueller, C. & Zeier, Z., Jun 12 2017, In : Molecular Neurodegeneration. 12, 1, 46.

Research output: Contribution to journalArticle

8 Scopus citations

Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens

Sartor, G., Powell, S. K., Velmeshev, D., Lin, D. Y., Magistri, M., Wiedner, H. J., Malvezzi, A. M., Andrade, N. S., Faghihi, M. A. & Wahlestedt, C. R., Dec 1 2017, In : Molecular and Cellular Neuroscience. 85, p. 183-189 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets

Wahlestedt, C. R., Jan 1 2017, In : Neuropsychopharmacology. 42, 1, p. 374-375 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Erratum: How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications (Briefings in bioinformatics (2016))

Khomtchouk, B. B., Weitz, E., Karp, P. D. & Wahlestedt, C., Sep 1 2017, In : Briefings in bioinformatics. 18, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer

Witt, A. E., Lee, C. W., Lee, T. I., Azzam, D. J., Wang, B., Caslini, C., Petrocca, F., Grosso, J., Jones, M., Cohick, E. B., Gropper, A. B., Wahlestedt, C., Richardson, A. L., Shiekhattar, R., Young, R. A. & Ince, T. A., Mar 23 2017, In : Oncogene. 36, 12, p. 1707-1720 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory

Volmar, C. H., Salah-Uddin, H., Janczura, K. J., Halley, P., Lambert, G., Wodrich, A., Manoah, S., Patel, N. H., Sartor, G. C., Mehta, N., Miles, N. T. H., Desse, S., Dorcius, D., Cameron, M. D., Brothers, S. P. & Wahlestedt, C., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. E9135-E9144

Research output: Contribution to journalArticle

15 Scopus citations

Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density

Seldeen, K. L., Halley, P. G., Volmar, C. H., Rodríguez, M. A., Hernandez, M., Pang, M., Carlsson, S. K., Suva, L. J., Wahlestedt, C. R., Troen, B. R. & Brothers, S. P., Jan 1 2017, (Accepted/In press) In : Neuropeptides.

Research output: Contribution to journalArticle

2 Scopus citations

Oligonucleotide therapies for disorders of the nervous system

Khorkova, O. & Wahlestedt, C. R., Mar 1 2017, In : Nature Biotechnology. 35, 3, p. 249-263 15 p.

Research output: Contribution to journalArticle

46 Scopus citations

Oxytocin and social functioning

Jones, C., Barrera, I. G., Brothers, S. P., Ring, R. & Wahlestedt, C. R., 2017, In : Dialogues in Clinical Neuroscience. 19, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Reprogramming of mPFC transcriptome and function in alcohol dependence

Heilig, M., Barbier, E., Johnstone, A. L., Tapocik, J., Meinhardt, M. W., Pfarr, S., Wahlestedt, C. R. & Sommer, W. H., Jan 1 2017, In : Genes, Brain and Behavior. 16, 1, p. 86-100 15 p.

Research output: Contribution to journalReview article

21 Scopus citations

Shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics

Khomtchouk, B. B., Hennessy, J. R. & Wahlestedt, C., May 2017, In : PloS one. 12, 5, e0176334.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Altering the course of schizophrenia: Progress and perspectives

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., Kahn, R., Krebs, M. O., Leboyer, M., Lewis, D., Marin, O., Marin, P., Meyer-Lindenberg, A., McGorry, P., McGuire, P., Owen, M. J. & 7 others, Patterson, P., Sawa, A., Spedding, M., Uhlhaas, P., Vaccarino, F., Wahlestedt, C. & Weinberger, D., Jun 30 2016, In : Nature Reviews Drug Discovery. 15, 7, p. 485-515 31 p.

Research output: Contribution to journalReview article

180 Scopus citations

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells

Esanov, R., Belle, K. C., van Blitterswijk, M., Belzil, V. V., Rademakers, R., Dickson, D. W., Petrucelli, L., Boylan, K. B., Dykxhoorn, D. M., Wuu, J., Benatar, M., Wahlestedt, C. & Zeier, Z., Mar 1 2016, In : Experimental neurology. 277, p. 171-177 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

Barbier, E., Johnstone, A. L., Khomtchouk, B. B., Tapocik, J. D., Pitcairn, C., Rehman, F., Augier, E., Borich, A., Schank, J. R., Rienas, C. A., van Booven, D. J., Sun, H., Nätt, D., Wahlestedt, C. R. & Heilig, M., Aug 30 2016, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

17 Scopus citations

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring

Silva, J. P., Lambert, G., van Booven, D. & Wahlestedt, C., Sep 8 2016, In : Genome Medicine. 8, 1, 93.

Research output: Contribution to journalArticle

6 Scopus citations

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach

Laurent, G. S., Vyatkin, Y., Antonets, D., Ri, M., Qi, Y., Saik, O., Shtokalo, D., De Hoon, M. J. L., Kawaji, H., Itoh, M., Lassmann, T., Arner, E., Forrest, A. R. R., Nicolas, E., McCaffrey, T. A., Carninci, P., Hayashizaki, Y., Wahlestedt, C. & Kapranov, P., Mar 21 2016, In : Nucleic acids research. 44, 7, p. 3233-3252 20 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation

Gidlöf, O., Johnstone, A. L., Bader, K., Khomtchouk, B. B., O'Reilly, J. J., Celik, S., Van Booven, D. J., Wahlestedt, C., Metzler, B. & Erlinge, D., Dec 2016, In : Journal of the American Heart Association. 5, 12, e004076.

Research output: Contribution to journalArticle

14 Scopus citations

MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps

Khomtchouk, B. B., Hennessy, J. R. & Wahlestedt, C., Sep 22 2016, In : BMC Bioinformatics. 17, 1, 390.

Research output: Contribution to journalArticle

5 Scopus citations

Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice

Sartor, G., Powell, S. K., Wiedner, H. J., Wahlestedt, C. R. & Brothers, S. P., Feb 1 2016, In : Brain Research. 1632, p. 34-41 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Seltene Krankheiten: Aktueller Stand der Pharmaforschung

Translated title of the contribution: Orphan diseases: state of the drug discovery artVolmar, C. H., Wahlestedt, C. R. & Brothers, S. P., Jan 27 2016, (Accepted/In press) In : Wiener Medizinische Wochenschrift. p. 1-8 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at ser396 in the brain of the 3xTg model of Alzheimer’s disease

Magistri, M., Velmeshev, D., Makhmutova, M., Patel, P., Sartor, G. C., Volmar, C. H., Wahlestedt, C. & Faghihi, M. A., Sep 1 2016, In : Current Alzheimer Research. 13, 9, p. 985-995 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients

Esanov, R., Andrade, N. S., Bennison, S., Wahlestedt, C. R. & Zeier, Z. R., Nov 15 2016, In : Human Molecular Genetics. 25, 22, p. 4870-4880 11 p.

Research output: Contribution to journalArticle

10 Scopus citations