Claes R Wahlestedt

Professor

  • 24190 Citations
1976 …2021
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Projects 1976 2021

Epigenetic Signaling Pathways Contributing to Alcohol Dependence

Wahlestedt, C. R. & Heilig, M. A.

National Institutes of Health

9/24/158/31/20

Project: Research projectResearch Project

Epigenomics
Alcoholism
Alcohols
Reward
Drinking Behavior

Role of MicroRNAs in the Mechanisms of Drug Dependence

Wahlestedt, C. R. & Kenny, P.

National Institutes of Health

9/15/081/31/21

Project: Research projectResearch Project

MicroRNAs
Substance-Related Disorders
Cocaine
Neuronal Plasticity
Brain

Long noncoding RNAs and chromatin regulation in cocaine addiction

Wahlestedt, C. R.

National Institutes of Health

4/1/143/31/17

Project: Research projectExploratory/Developmental Grants

Long Noncoding RNA
Cocaine-Related Disorders
Cocaine
Chromatin
Self Administration
Antisense RNA
Brain-Derived Neurotrophic Factor
Epigenomics
Untranslated RNA
Rett Syndrome
Cocaine-Related Disorders
Cocaine
Therapeutics
Substance-Related Disorders
nociceptin receptor

Research Output 1982 2018

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

Timmons, J. A., Atherton, P. J., Larsson, O., Sood, S., Blokhin, I. O., Brogan, R. J., Volmar, C. H., Josse, A. R., Slentz, C., Wahlestedt, C. R., Phillips, S. M., Phillips, B. E., Gallagher, I. J. & Kraus, W. E., Jan 1 2018, In : Nucleic acids research. 46, 15, p. 7772-7792 21 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Genomics
Insulin Resistance
Genome-Wide Association Study
RNA
1 Citations

Cocaine exposure increases blood pressure and aortic stiffness via the mir-30c-5p-malic enzyme 1-reactive oxygen species pathway

Zhu, W., Wang, H., Wei, J., Sartor, G., Bao, M. M., Pierce, C. T., Wahlestedt, C. R., Dykxhoorn, D. M. & Dong, C., Jan 1 2018, In : Hypertension. 71, 4, p. 752-760 9 p.

Research output: Contribution to journalArticle

malate dehydrogenase (decarboxylating)
Vascular Stiffness
Cocaine
Reactive Oxygen Species
Blood Pressure

Developments in lncRNA drug discovery: where are we heading?

Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Sep 2 2018, In : Expert Opinion on Drug Discovery. 13, 9, p. 837-849 13 p.

Research output: Contribution to journalReview article

Long Noncoding RNA
Drug Discovery
Clustered Regularly Interspaced Short Palindromic Repeats
Biodiversity
Expert Testimony

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C. R., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schuerer, S. C. & Ayad, N., Dec 1 2018, In : Nature communications. 9, 1, 5315.

Research output: Contribution to journalArticle

Glioblastoma
drugs
signatures
Gene expression
Genes

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C. R., Sep 1 2018, In : PloS one. 13, 9, e0203173.

Research output: Contribution to journalArticle

Drug Repositioning
esophageal neoplasms
adenocarcinoma
Adenocarcinoma
Cells