Anthony J Capobianco

Professor

  • 4399 Citations
1990 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 4399 Citations
  • 72 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Editorial
Filter
Article
2019

A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

Rodriguez-Blanco, J., Li, B., Long, J., Shen, C., Yang, F., Orton, D., Collins, S., Kasahara, N., Ayad, N. G., McCrea, H. J., Roussel, M. F., Weiss, W. A., Capobianco, A. J. & Robbins, D. J., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

Winterbottom, E. F., Moroishi, Y., Halchenko, Y., Armstrong, D. A., Beach, P. J., Nguyen, Q. P., Capobianco, A. J., Ayad, N. G., Marsit, C. J., Li, Z., Karagas, M. R. & Robbins, D. J., Feb 28 2019, In : Environmental Health: A Global Access Science Source. 18, 1, 18.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/ Km) of CK1α

Shen, C., Li, B., Astudillo, L., Deutscher, M. P., Cobb, M. H., Capobianco, A. J., Lee, E. & Robbins, D. J., Dec 24 2019, In : Biochemistry. 58, 51, p. 5102-5106 5 p.

Research output: Contribution to journalArticle

Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study

Winterbottom, E. F., Ban, Y., Sun, X., Capobianco, A. J., Marsit, C. J., Chen, X., Wang, L., Karagas, M. R. & Robbins, D. J., Nov 21 2019, In : Environmental Health: A Global Access Science Source. 18, 1, 100.

Research output: Contribution to journalArticle

Open Access
2018

Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1

Bhat, A. A., Lu, H., Soutto, M., Capobianco, A., Rai, P., Zaika, A. & El-Rifai, W., Nov 15 2018, In : Oncogene. 37, 46, p. 6011-6024 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C. R., Sep 1 2018, In : PLoS One. 13, 9, e0203173.

Research output: Contribution to journalArticle

2017

Acetylation of mastermind-like 1 by p300 drives the recruitment of NACK to initiate Notch-dependent transcription

Jin, K., Zhou, W., Han, X., Wang, Z., Li, B., Jeffries, S., Tao, W., Robbins, D. J. & Capobianco, A. J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4228-4237 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors

Li, B., Orton, D., Neitzel, L. R., Astudillo, L., Shen, C., Long, J., Chen, X., Kirkbride, K. C., Doundoulakis, T., Guerra, M. L., Zaias, J., Fei, D. L., Rodriguez-Blanco, J., Thorne, C., Wang, Z., Jin, K., Nguyen, D., Sands, L., Marchetti, F., Abreu, M. T. & 4 others, Cobb, M. H., Capobianco, A. J., Lee, E. & Robbin, D. J., Jun 27 2017, In : Science Signaling. 10, 485, aak9916.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

Rodriguez-Blanco, J., Pednekar, L., Penas, C., Li, B., Martin, V., Long, J., Lee, E., Weiss, W. A., Rodriguez, C., Mehrdad, N., Nguyen, D. M., Ayad, N. G., Rai, P., Capobianco, A. J. & Robbins, D. J., Nov 9 2017, In : Oncogene. 36, 45, p. 6306-6314 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Notch represses transcription by PRC2 recruitment to the ternary complex

Han, X., Ranganathan, P., Tzimas, C., Weaver, K. L., Jin, K., Astudillo, L., Zhou, W., Zhu, X., Li, B., Robbins, D. J. & Capobianco, A. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1173-1183 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

p16 loss rescues functional decline of Brca1-deficient mammary stem cells

Scott, A., Bai, F., Chan, H. L., Liu, S., Slingerland, J. M., Robbins, D. J., Capobianco, A. J. & Pei, X-H., Mar 10 2017, (Accepted/In press) In : Cell Cycle. p. 1-6 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Winterbottom, E. F., Koestler, D. C., Fei, D. L., Wika, E., Capobianco, A. J., Marsit, C. J., Karagas, M. R. & Robbins, D. J., Jun 14 2017, In : Environmental Health: A Global Access Science Source. 16, 1, 59.

Research output: Contribution to journalArticle

10 Scopus citations

Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma

Sant, D. W., Tao, W., Field, M. G., Pelaez, D., Jin, K., Capobianco, A. J., Dubovy, S., Tse, D. & Wang, G., May 1 2017, In : Investigative ophthalmology & visual science. 58, 6, p. BIO240-BIO246

Research output: Contribution to journalArticle

6 Scopus citations
2016

Arsenic attenuates gli signaling, increasing or decreasing its transcriptional program in a context-dependent manner

Li, B., Giambelli, C., Tang, B., Winterbottom, E., Long, J., Jin, K., Wang, Z., Fei, D. L., Nguyen, D. M., Athar, M., Wang, B., Pochi, S., Wang, L., Rai, P., Ardalan, B., Capobianco, A. J. & Robbins, D. J., Feb 1 2016, In : Molecular Pharmacology. 89, 2, p. 226-232 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis

Liu, S., Chan, H. L., Bai, F., Ma, J., Scott, A., Robbins, D. J., Capobianco, A. J., Zhu, P. & Pei, X. H., Jan 1 2016, In : Oncotarget. 7, 39, p. 64007-64020 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Broadus, M. R., Chen, T. W., Neitzel, L. R., Ng, V. H., Jodoin, J. N., Lee, L. A., Salic, A., Robbins, D. J., Capobianco, A. J., Patton, J. G., Huppert, S. S. & Lee, E., May 31 2016, In : Cell Reports. 15, 9, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

p16INK4a suppresses BRCA1-deficient mammary tumorigenesis

Scott, A., Bai, F., Chan, H. L., Liu, S., Ma, J., Slingerland, J. M., Robbins, D. J., Capobianco, A. J. & Pei, X-H., 2016, In : Oncotarget. 7, 51, p. 84496-84507 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

The small molecule IMR-1 inhibits the notch transcriptional activation complex to suppress tumorigenesis

Astudillo, L., Da Silva, T. G., Wang, Z., Han, X., Jin, K., VanWye, J., Zhu, X., Weaver, K., Oashi, T., Lopes, P. E. M., Orton, D., Neitzel, L. R., Lee, E., Landgraf, R., Robbins, D. J., MacKerell, A. D. & Capobianco, A. J., Jun 15 2016, In : Cancer Research. 76, 12, p. 3593-3603 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. iii

Research output: Contribution to journalArticle

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth

Winterbottom, E. F., Fei, D. L., Koestler, D. C., Giambelli, C., Wika, E., Capobianco, A. J., Lee, E., Marsit, C. J., Karagas, M. R. & Robbins, D. J., Jun 1 2015, In : EBioMedicine. 2, 6, p. 536-543 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties

Long, J., Tokhunts, R., Old, W. M., Houel, S., Rodgriguez-Blanco, J., Singh, S., Schilling, N., Capobianco, A. J., Ahn, N. G. & Robbins, D. J., Mar 3 2015, In : Cell Reports. 10, 8, p. 1280-1287 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Notch1 pathway activity determines the regulatory role of cancer-associated fibroblasts in melanoma growth and invasion

Shao, H., Kong, R., Ferrari, M. L., Radtke, F., Capobianco, A. J. & Liu, Z. J., Nov 1 2015, In : PloS one. 10, 11, e0142815.

Research output: Contribution to journalArticle

9 Scopus citations

The notch signaling pathway in esophageal adenocarcinoma

Wang, Z., Chen, J. & Capobianco, A. J., 2015, In : Cellular and Molecular Biology. 61, 6, p. 24-32 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development

Bai, F., Chan, H. L., Scott, A., Smith, M. D., Fan, C., Herschkowitz, J. I., Perou, C. M., Livingstone, A. S., Robbins, D. J., Capobianco, A. J. & Pei, X. H., Nov 1 2014, In : Cancer Research. 74, 21, p. 6161-6172 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

NACK is an integral component of the notch transcriptional activation complex and is critical for development and tumorigenesis

Weaver, K. L., Alves-Guerra, M. C., Jin, K., Wang, Z., Han, X., Ranganathan, P., Zhu, X., DaSilva, T., Liu, W., Ratti, F., Demarest, R. M., Tzimas, C., Rice, M., Vasquez-Del Carpio, R., Dahmane, N., Robbins, D. J. & Capobianco, A. J., Sep 1 2014, In : Cancer Research. 74, 17, p. 4741-4751 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL

Pelullo, M., Quaranta, R., Talora, C., Checquolo, S., Cialfi, S., Felli, M. P. I., te Kronnie, G., Borga, C., Besharat, Z. M. E., Palermo, R., Di Marcotullio, L., Capobianco, A. J., Gulino, A., Screpanti, I. & Bellavia, D., Dec 1 2014, In : Neoplasia (United States). 16, 12, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma

Wang, Z., Da Silva, T. G., Jin, K., Han, X., Ranganathan, P., Zhu, X., Sanchez-Mejias, A., Bai, F., Li, B., Fei, D. L., Weaver, K., Vasquez-Del Carpio, R., Moscowitz, A. E., Koshenkov, V. P., Sanchez, L., Sparling, L., Pei, X. H., Franceschi, D., Ribeiro, A., Robbins, D. J. & 2 others, Livingstone, A. S. & Capobianco, A. J., Nov 1 2014, In : Cancer Research. 74, 21, p. 6364-6374 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pyrvinium attenuates hedgehog signaling downstream of smoothened

Li, B., Fei, D. L., Flaveny, C. A., Dahmane, N., Baubet, V., Wang, Z., Bai, F., Pei, X. H., Rodriguez-Blanco, J., Hang, B., Orton, D., Han, L., Wang, B., Capobianco, A. J., Lee, E. & Robbins, D. J., Sep 1 2014, In : Cancer Research. 74, 17, p. 4811-4821 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis

Li, B., Flaveny, C. A., Giambelli, C., Liang Fei, D., Han, L., Hang, B. I., Bai, F., Pei, X. H., Nose, V., Burlingame, O., Capobianco, A. J., Orton, D., Lee, E. & Robbins, D. J., Jul 8 2014, In : PloS one. 9, 7, e101969.

Research output: Contribution to journalArticle

24 Scopus citations

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers

Long, J., Li, B., Rodriguez-Blanco, J., Pastori, C., Volmar, C. H., Wahlestedt, C., Capobianco, A., Bai, F., Pei, X. H., Ayad, N. G. & Robbins, D. J., Dec 19 2014, In : Journal of Biological Chemistry. 289, 51, p. 35494-35502 9 p., A32.

Research output: Contribution to journalArticle

57 Scopus citations
2013

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53

Licciulli, S., Avila, J. L., Hanlon, L., Troutman, S., Cesaroni, M., Kota, S., Keith, B., Simon, M. C., Puré, E., Radtke, F., Capobianco, A. J. & Kissil, J. L., Oct 1 2013, In : Cancer Research. 73, 19, p. 5974-5984 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

The Hedgehog processing pathway is required for NSCLC growth and survival

Rodriguez-Blanco, J., Schilling, N. S., Tokhunts, R., Giambelli, C., Long, J., Liang Fei, D., Singh, S., Black, K. E., Wang, Z., Galimberti, F., Bejarano, P. A., Elliot, S., Glassberg, M. K., Nguyen, D. M., Lockwood, W. W., Lam, W. L., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., May 2 2013, In : Oncogene. 32, 18, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

Azzam, D. J., Zhao, D., Sun, J., Minn, A. J., Ranganathan, P., Drews-Elger, K., Han, X., Picon-Ruiz, M., Gilbert, C. A., Wander, S. A., Capobianco, A. J., El-Ashry, D. & Slingerland, J. M., Oct 1 2013, In : EMBO Molecular Medicine. 5, 10, p. 1502-1522 21 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Hedgehog signaling regulates bladder cancer growth and tumorigenicity

Fei, D. L., Sanchez-Mejias, A., Wang, Z., Flaveny, C., Long, J., Singh, S., Rodriguez-Blanco, J., Tokhunts, R., Giambelli, C., Briegel, K. J., Schulz, W. A., Gandolfi, A. J., Karagas, M., Zimmers, T. A., Jorda, M., Bejarano, P., Capobianco, A. J. & Robbins, D. J., Sep 1 2012, In : Cancer Research. 72, 17, p. 4449-4458 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Assembly of a notch transcriptional activation complex requires multimerization

Vasquez-Del Carpio, R., Kaplan, F. M., Weaver, K. L., VanWye, J. D., Alves-Guerra, M. C., Robbins, D. J. & Capobianco, A. J., Apr 1 2011, In : Molecular and cellular biology. 31, 7, p. 1396-1408 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hedgehog-producing cancer cells respond to and require autocrine hedgehog activity

Singh, S., Wang, Z., Fei, D. L., Black, K. E., Goetz, J. A., Tokhunts, R., Giambelli, C., Rodriguez-Blanco, J., Long, J., Lee, E., Briegel, K. J., Bejarano, P. A., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., Jul 1 2011, In : Cancer Research. 71, 13, p. 4454-4463 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates notch transcriptional activity

Ranganathan, P., Vasquez-Del Carpio, R., Kaplan, F. M., Wang, H., Gupta, A., VanWye, J. D. & Capobianco, A. J., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 28844-28857 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Mar 10 2011, In : Blood. 117, 10, p. 2901-2909 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2010

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

Hanlon, L., Avila, J. L., Demarest, R. M., Troutman, S., Allen, M., Ratti, F., Rustgi, A. K., Stanger, B. Z., Radtke, F., Adsay, V., Long, F., Capobianco, A. J. & Kissil, J. L., Jun 1 2010, In : Cancer Research. 70, 11, p. 4280-4286 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Sp100 as a potent tumor suppressor: Accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program

Negorev, D. G., Vladimirova, O. V., Kossenkov V, A., Nikonova V, E., Demarest, R. M., Capobianco, A. J., Showe, M. K., Rauscher, F. J., Showe, L. C. & Maul, G. G., Dec 1 2010, In : Cancer Research. 70, 23, p. 9991-10001 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

Active Notch1 confers a transformed phenotype to primary human melanocytes

Pinnix, C. C., Lee, J. T., Liu, Z. J., McDaid, R., Balint, K., Beverly, L. J., Brafford, P. A., Xiao, M., Himes, B., Zabierowski, S. E., Yashiro-Ohtani, Y., Nathanson, K. L., Bengston, A., Pollock, P. M., Weeraratna, A. T., Nickoloff, B. J., Pear, W. S., Capobianco, A. J. & Herlyn, M., Jul 1 2009, In : Cancer Research. 69, 13, p. 5312-5320 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Notch signaling mediates G 1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

Joshi, I., Minter, L. M., Telfer, J., Demarest, R. M., Capobianco, A. J., Aster, J. C., Sicinski, P., Fauq, A., Golde, T. E. & Osborne, B. A., Feb 19 2009, In : Blood. 113, 8, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Rustighi, A., Tiberi, L., Soldano, A., Napoli, M., Nuciforo, P., Rosato, A., Kaplan, F., Capobianco, A., Pece, S., Di Fiore, P. P. & Del Sal, G., Jan 19 2009, In : Nature Cell Biology. 11, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

120 Scopus citations
2007

Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival

Alves-Guerra, M. C., Ronchini, C. & Capobianco, A. J., Sep 15 2007, In : Cancer Research. 67, 18, p. 8690-8698 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas

Spaulding, C., Reschly, E. J., Zagort, D. E., Yashiro-Ohtani, Y., Beverly, L. J., Capobianco, A., Pear, W. S. & Kee, B. L., Oct 1 2007, In : Blood. 110, 7, p. 2650-2658 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Requirement for Rac1 in a K-ras-induced lung cancer in the mouse

Kissil, J. L., Walmsley, M. J., Hanlon, L., Haigis, K. M., Kim, C. F. B., Sweet-Cordero, A., Eckman, M. S., Tuveson, D. A., Capobianco, A. J., Tybulewicz, V. L. J. & Jacks, T., Sep 1 2007, In : Cancer Research. 67, 17, p. 8089-8094 6 p.

Research output: Contribution to journalArticle

130 Scopus citations
2006

Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells

Beverly, L. J., Ascano, J. M. & Capobianco, A. J., Sep 1 2006, In : Genes and Immunity. 7, 6, p. 476-486 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

Liu, Z. J., Xiao, M., Balint, K., Soma, A., Pinnix, C. C., Capobianco, A. J., Velazquez, O. C. & Herlyn, M., May 1 2006, In : FASEB Journal. 20, 7, p. E201-E210

Research output: Contribution to journalArticle

88 Scopus citations

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

Sharma, V. M., Calvo, J. A., Draheim, K. M., Cunningham, L. A., Hermance, N., Beverly, L., Krishnamoorthy, V., Bhasin, M., Capobianco, A. J. & Kelliher, M. A., Nov 1 2006, In : Molecular and cellular biology. 26, 21, p. 8022-8031 10 p.

Research output: Contribution to journalArticle

196 Scopus citations