Anthony J Capobianco

Professor

  • 4309 Citations
1990 …2019
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Research Output 1990 2019

  • 4309 Citations
  • 79 Article
  • 1 Editorial
2007
35 Citations (Scopus)

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas

Spaulding, C., Reschly, E. J., Zagort, D. E., Yashiro-Ohtani, Y., Beverly, L. J., Capobianco, A. J., Pear, W. S. & Kee, B. L., Oct 1 2007, In : Blood. 110, 7, p. 2650-2658 9 p.

Research output: Contribution to journalArticle

TCF Transcription Factors
T-cells
T-Cell Lymphoma
Survival
Cell death
126 Citations (Scopus)

Requirement for Rac1 in a K-ras-induced lung cancer in the mouse

Kissil, J. L., Walmsley, M. J., Hanlon, L., Haigis, K. M., Kim, C. F. B., Sweet-Cordero, A., Eckman, M. S., Tuveson, D. A., Capobianco, A. J., Tybulewicz, V. L. J. & Jacks, T., Sep 1 2007, In : Cancer Research. 67, 17, p. 8089-8094 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Carcinogenesis
Genetic Recombination
Cell Survival
Epithelial Cells
3 Citations (Scopus)

Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells

Beverly, L. J., Ascano, J. M. & Capobianco, A. J., Sep 1 2006, In : Genes and Immunity. 7, 6, p. 476-486 11 p.

Research output: Contribution to journalArticle

Stromal Cells
Epithelial Cells
Apoptosis
T-Lymphocytes
Thymus Gland
88 Citations (Scopus)

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

Liu, Z-J., Xiao, M., Balint, K., Soma, A., Pinnix, C. C., Capobianco, A. J., Velazquez, O. C. & Herlyn, M., May 1 2006, In : FASEB Journal. 20, 7

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Endothelial cells
phosphatidylinositol 3-kinase
Cell proliferation
Mitogen-Activated Protein Kinases
191 Citations (Scopus)

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

Sharma, V. M., Calvo, J. A., Draheim, K. M., Cunningham, L. A., Hermance, N., Beverly, L., Krishnamoorthy, V., Bhasin, M., Capobianco, A. J. & Kelliher, M. A., Nov 1 2006, In : Molecular and Cellular Biology. 26, 21, p. 8022-8031 10 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Amyloid Precursor Protein Secretases
Notch1 Receptor
T-Lymphocytes
2005
247 Citations (Scopus)

Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression

Balint, K., Xiao, M., Pinnix, C. C., Soma, A., Veres, I., Juhasz, I., Brown, E. J., Capobianco, A. J., Herlyn, M. & Liu, Z-J., Nov 1 2005, In : Journal of Clinical Investigation. 115, 11, p. 3166-3176 11 p.

Research output: Contribution to journalArticle

Catenins
Melanoma
Growth
Transcriptional Activation
Neoplasms
131 Citations (Scopus)

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice

Carlson, T. R., Yan, Y., Wu, X., Lam, M. T., Tang, G. L., Beverly, L. J., Messina, L. M., Capobianco, A. J., Werb, Z. & Wang, R., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9884-9889 6 p.

Research output: Contribution to journalArticle

Arteriovenous Malformations
Blood Vessels
Endothelium
Liver
Tetracycline
97 Citations (Scopus)

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein

Zhang, X. Y., DeSalle, L. M., Patel, J. H., Capobianco, A. J., Yu, D., Thomas-Tikhonenko, A. & McMahon, S. B., Sep 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 39, p. 13968-13973 6 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Neoplasm Metastasis
Nucleosomes
Proteins
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
124 Citations (Scopus)

Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression

Beverly, L. J., Felsher, D. W. & Capobianco, A. J., Aug 15 2005, In : Cancer Research. 65, 16, p. 7159-7168 10 p.

Research output: Contribution to journalArticle

Neoplasms
T-Cell Leukemia
T-Cell Lymphoma
Ionizing Radiation
Tetracycline
2004
13 Citations (Scopus)

Targeting promiscuous signaling pathways in cancer: Another Notch in the bedpost

Beverly, L. J. & Capobianco, A. J., Dec 1 2004, In : Trends in Molecular Medicine. 10, 12, p. 591-598 8 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Genetic Translocation
Mutation
Transcriptional Activation
Neoplasms
2003
118 Citations (Scopus)

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in NotchIC-induced T cell leukemogenesis

Beverly, L. J. & Capobianco, A. J., Jun 1 2003, In : Cancer Cell. 3, 6, p. 551-564 14 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Transgenic Mice
Protein Isoforms
T-Lymphocytes
Genetic Translocation
99 Citations (Scopus)

The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

Ascano, J. M., Beverly, L. J. & Capobianco, A. J., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8771-8779 9 p.

Research output: Contribution to journalArticle

Ligands
Transcriptional Activation
Carcinogenesis
Proteins
Notch Receptors
2002
125 Citations (Scopus)
T-Cell Leukemia
Molecular Weight
Cell Line
Neoplastic Cell Transformation
Notch Receptors
153 Citations (Scopus)

Enhanced tumor formation in mice heterozygous for Blm mutation

Goss, K. H., Risinger, M. A., Kordich, J. J., Sanz, M. H., Straughen, J. E., Slovek, L. E., Capobianco, A. J., German, J., Boivin, G. P. & Groden, J., Sep 20 2002, In : Science. 297, 5589, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
RecQ Helicases
Bloom Syndrome
Haploinsufficiency
42 Citations (Scopus)

Repression of activator protein-1-mediated transcriptional activation by the notch-1 intracellular domain

Chu, J., Jeffries, S., Norton, J. E., Capobianco, A. J. & Bresnick, E. H., Mar 1 2002, In : Journal of Biological Chemistry. 277, 9, p. 7587-7597 11 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Transcriptional Activation
Chemical activation
Transcription
Notch Receptors
2001
309 Citations (Scopus)
Cyclin D1
Cell Cycle
Proteins
bcl-1 Genes
Hormones
2000
98 Citations (Scopus)

Neoplastic transformation by Notch requires nuclear localization

Jeffries, S. & Capobianco, A. J., Jun 1 2000, In : Molecular and Cellular Biology. 20, 11, p. 3928-3941 14 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Kidney
Cell Membrane
Notch Receptors
Oncogene Proteins
38 Citations (Scopus)

Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation

Ronchini, C. & Capobianco, A. J., Aug 10 2000, In : Oncogene. 19, 34, p. 3914-3924 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Hormones
Notch Receptors
Cell Nucleus
Oncogenes
77 Citations (Scopus)

Suppression of erythroid but not megakaryocytic differentiation of human K562 Erythroleukemic cells by Notch-1

Lam, L. T., Ronchini, C., Norton, J., Capobianco, A. J. & Bresnick, E. H., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 19676-19684 9 p.

Research output: Contribution to journalArticle

K562 Cells
Gene expression
Genes
Notch Receptors
Gene Expression
1997
208 Citations (Scopus)

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2

Capobianco, A. J., Zagouras, P., Blaumueller, C. M., Artavanis-Tsakonas, S. & Bishop, J. M., Nov 1 1997, In : Molecular and Cellular Biology. 17, 11, p. 6265-6273 9 p.

Research output: Contribution to journalArticle

Alleles
Proteins
Notch Receptors
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Genetic Translocation
1994
9 Citations (Scopus)

Characterization of a chicken cDNA encoding the retinoblastoma gene product

Feinstein, R., Bolton, W. K., Quinones, J. N., Mosialos, G., Sif, S., Huff, J. L., Capobianco, A. J. & Gilmore, T. D., May 17 1994, In : BBA - Gene Structure and Expression. 1218, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

Retinoblastoma Genes
Chickens
Complementary DNA
Genes
Proteins
9 Citations (Scopus)

Proto-oncogenes and plasticity in cell signaling

Bishop, J. M., Capobianco, A. J., Doyle, H. J., Finney, R. E., McMahon, M., Robbins, S. M., Samuels, M. L. & Vetter, M., Dec 1 1994, In : Cold Spring Harbor Symposia on Quantitative Biology. 59, p. 165-171 7 p.

Research output: Contribution to journalArticle

proto-oncogenes
cells
1993
13 Citations (Scopus)

A conditional mutant of vRel containing sequences from the human estrogen receptor

Capobianco, A. J. & Gilmore, T. D., Jan 1 1993, In : Virology. 193, 1, p. 160-170 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Chickens
Embryonic Structures
Fibroblasts

The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts

Sif, S., Capobianco, A. J. & Gilmore, T. D., Jan 1 1993, In : Oncogene. 8, 9, p. 2501-2509 9 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Chickens
Plasmids
Embryonic Structures
Fibroblasts
38 Citations (Scopus)

The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts

Sif, S., Capobianco, A. J. & Gilmore, T. D., Sep 1 1993, In : Oncogene. 8, 9

Research output: Contribution to journalArticle

Oncogene Proteins
Chickens
Plasmids
Embryonic Structures
Fibroblasts
1992
43 Citations (Scopus)

p105, the NF-κB p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells

Capobianco, A. J., Chang, D., Mosialos, G. & Gilmore, T. D., Jun 1 1992, In : Journal of Virology. 66, 6, p. 3758-3767 10 p.

Research output: Contribution to journalArticle

Protein Precursors
Oncogene Proteins
splenocytes
Chickens
Spleen
1991
91 Citations (Scopus)

A Protein Kinase-A Recognition Sequence Is Structurally Linked to Transformation by p59v-rel and Cytoplasmic Retention of p68c-rel

Mosialos, G., Hamer, P., Capobianco, A. J., Laursen, R. A. & Gilmore, T. D., Dec 1 1991, In : Molecular and Cellular Biology. 11, 12, p. 5867-5877 11 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Chickens
Embryonic Structures
Fibroblasts
23 Citations (Scopus)

Repression of the chicken c-rel promoter by vRel in chicken embryo fibroblasts is not mediated through a consensus NF-κB binding site

Capobianco, A. J. & Gilmore, T. D., Dec 1 1991, In : Oncogene. 6, 12, p. 2203-2210 8 p.

Research output: Contribution to journalArticle

Chickens
Embryonic Structures
Fibroblasts
Binding Sites
rel Genes
1990
73 Citations (Scopus)

Cloning and expression of a chicken c-rel cDNA: Unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts

Capobianco, A. J., Simmons, D. L. & Gilmore, T. D., Mar 1 1990, In : Oncogene. 5, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Organism Cloning
Chickens
Embryonic Structures
Complementary DNA
Fibroblasts