Anthony J Capobianco

Professor

  • 4430 Citations
1990 …2019

Research output per year

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Research Output

  • 4430 Citations
  • 72 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Editorial

Acetylation of mastermind-like 1 by p300 drives the recruitment of NACK to initiate Notch-dependent transcription

Jin, K., Zhou, W., Han, X., Wang, Z., Li, B., Jeffries, S., Tao, W., Robbins, D. J. & Capobianco, A. J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4228-4237 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

Rodriguez-Blanco, J., Li, B., Long, J., Shen, C., Yang, F., Orton, D., Collins, S., Kasahara, N., Ayad, N. G., McCrea, H. J., Roussel, M. F., Weiss, W. A., Capobianco, A. J. & Robbins, D. J., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

A conditional mutant of vrel containing sequences from the human estrogen receptor

Capobianco, A. J. & Gilmore, T. D., Mar 1993, In : Virology. 193, 1, p. 160-170 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression

Balint, K., Xiao, M., Pinnix, C. C., Soma, A., Veres, I., Juhasz, I., Brown, E. J., Capobianco, A. J., Herlyn, M. & Liu, Z. J., Nov 1 2005, In : Journal of Clinical Investigation. 115, 11, p. 3166-3176 11 p.

Research output: Contribution to journalArticle

253 Scopus citations

Active Notch1 confers a transformed phenotype to primary human melanocytes

Pinnix, C. C., Lee, J. T., Liu, Z. J., McDaid, R., Balint, K., Beverly, L. J., Brafford, P. A., Xiao, M., Himes, B., Zabierowski, S. E., Yashiro-Ohtani, Y., Nathanson, K. L., Bengston, A., Pollock, P. M., Weeraratna, A. T., Nickoloff, B. J., Pear, W. S., Capobianco, A. J. & Herlyn, M., Jul 1 2009, In : Cancer Research. 69, 13, p. 5312-5320 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

A Protein Kinase-A Recognition Sequence Is Structurally Linked to Transformation by p59v-rel and Cytoplasmic Retention of p68c-rel

Mosialos, G., Hamer, P., Capobianco, A. J., Laursen, R. A. & Gilmore, T. D., Dec 1991, In : Molecular and cellular biology. 11, 12, p. 5867-5877 11 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Arsenic attenuates gli signaling, increasing or decreasing its transcriptional program in a context-dependent manner

Li, B., Giambelli, C., Tang, B., Winterbottom, E., Long, J., Jin, K., Wang, Z., Fei, D. L., Nguyen, D. M., Athar, M., Wang, B., Subbarayan, P. R., Wang, L., Rai, P., Ardalan, B., Capobianco, A. J. & Robbins, D. J., Feb 1 2016, In : Molecular Pharmacology. 89, 2, p. 226-232 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Assembly of a notch transcriptional activation complex requires multimerization

Vasquez-Del Carpio, R., Kaplan, F. M., Weaver, K. L., VanWye, J. D., Alves-Guerra, M. C., Robbins, D. J. & Capobianco, A. J., Apr 1 2011, In : Molecular and cellular biology. 31, 7, p. 1396-1408 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development

Bai, F., Chan, H. L., Scott, A., Smith, M. D., Fan, C., Herschkowitz, J. I., Perou, C. M., Livingstone, A. S., Robbins, D. J., Capobianco, A. J. & Pei, X. H., Nov 1 2014, In : Cancer Research. 74, 21, p. 6161-6172 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Characterization of a chicken cDNA encoding the retinoblastoma gene product

Feinstein, R., Bolton, W. K., Quinones, J. N., Mosialos, G., Sif, S., Huff, J. L., Capobianco, A. J. & Gilmore, T. D., May 17 1994, In : BBA - Gene Structure and Expression. 1218, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
125 Scopus citations

Cloning and expression of a chicken c-rel cDNA: Unlike p59(v-rel), p68(c-rel) is a cytoplasmic protein in chicken embryo fibroblasts

Capobianco, A. J., Simmons, D. L. & Gilmore, T. D., Apr 3 1990, In : Oncogene. 5, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors

Li, B., Orton, D., Neitzel, L. R., Astudillo, L., Shen, C., Long, J., Chen, X., Kirkbride, K. C., Doundoulakis, T., Guerra, M. L., Zaias, J., Fei, D. L., Rodriguez-Blanco, J., Thorne, C., Wang, Z., Jin, K., Nguyen, D., Sands, L., Marchetti, F., Abreu, M. T. & 4 others, Cobb, M. H., Capobianco, A. J., Lee, E. & Robbin, D. J., Jun 27 2017, In : Science Signaling. 10, 485, aak9916.

Research output: Contribution to journalArticle

7 Scopus citations

Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. iii

Research output: Contribution to journalArticle

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice

Carlson, T. R., Yan, Y., Wu, X., Lam, M. T., Tang, G. L., Beverly, L. J., Messina, L. M., Capobianco, A. J., Werb, Z. & Wang, R., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9884-9889 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Enhanced tumor formation in mice heterozygous for Blm mutation

Goss, K. H., Risinger, M. A., Kordich, J. J., Sanz, M. H., Straughen, J. E., Slovek, L. E., Capobianco, A. J., German, J., Boivin, G. P. & Groden, J., Sep 20 2002, In : Science. 297, 5589, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

156 Scopus citations

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Epimorphic regeneration in mice is p53-independent

Arthur, L. M., Demarest, R. M., Clark, L., Gourevitch, D., Bedelbaeva, K., Anderson, R., Snyder, A., Capobianco, A. J., Lieberman, P., Feigenbaum, L. & Heber-Katz, E., Sep 15 2010, In : Cell Cycle. 9, 18, p. 3691-3697 7 p.

Research output: Contribution to journalReview article

16 Scopus citations

Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1

Bhat, A. A., Lu, H., Soutto, M., Capobianco, A., Rai, P., Zaika, A. & El-Rifai, W., Nov 15 2018, In : Oncogene. 37, 46, p. 6011-6024 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells

Beverly, L. J., Ascano, J. M. & Capobianco, A. J., Sep 1 2006, In : Genes and Immunity. 7, 6, p. 476-486 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C., Sep 2018, In : PloS one. 13, 9, e0203173.

Research output: Contribution to journalArticle

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis

Liu, S., Chan, H. L., Bai, F., Ma, J., Scott, A., Robbins, D. J., Capobianco, A. J., Zhu, P. & Pei, X. H., 2016, In : Oncotarget. 7, 39, p. 64007-64020 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth

Winterbottom, E. F., Fei, D. L., Koestler, D. C., Giambelli, C., Wika, E., Capobianco, A. J., Lee, E., Marsit, C. J., Karagas, M. R. & Robbins, D. J., Jun 1 2015, In : EBioMedicine. 2, 6, p. 536-543 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Guest editor

Capobianco, A. J., Sep 1 2008, In : Oncogene. 27, 38, p. 5081 1 p.

Research output: Contribution to journalEditorial

Hedgehog-producing cancer cells respond to and require autocrine hedgehog activity

Singh, S., Wang, Z., Fei, D. L., Black, K. E., Goetz, J. A., Tokhunts, R., Giambelli, C., Rodriguez-Blanco, J., Long, J., Lee, E., Briegel, K. J., Bejarano, P. A., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., Jul 1 2011, In : Cancer Research. 71, 13, p. 4454-4463 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hedgehog signaling regulates bladder cancer growth and tumorigenicity

Fei, D. L., Sanchez-Mejias, A., Wang, Z., Flaveny, C., Long, J., Singh, S., Rodriguez-Blanco, J., Tokhunts, R., Giambelli, C., Briegel, K. J., Schulz, W. A., Gandolfi, A. J., Karagas, M., Zimmers, T. A., Jorda, M., Bejarano, P., Capobianco, A. J. & Robbins, D. J., Sep 1 2012, In : Cancer Research. 72, 17, p. 4449-4458 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates notch transcriptional activity

Ranganathan, P., Vasquez-Del Carpio, R., Kaplan, F. M., Wang, H., Gupta, A., VanWye, J. D. & Capobianco, A. J., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 28844-28857 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties

Long, J., Tokhunts, R., Old, W. M., Houel, S., Rodgriguez-Blanco, J., Singh, S., Schilling, N., Capobianco, A. J., Ahn, N. G. & Robbins, D. J., Mar 3 2015, In : Cell Reports. 10, 8, p. 1280-1287 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Broadus, M. R., Chen, T. W., Neitzel, L. R., Ng, V. H., Jodoin, J. N., Lee, L. A., Salic, A., Robbins, D. J., Capobianco, A. J., Patton, J. G., Huppert, S. S. & Lee, E., May 31 2016, In : Cell Reports. 15, 9, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
312 Scopus citations

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

Liu, Z. J., Xiao, M., Balint, K., Soma, A., Pinnix, C. C., Capobianco, A. J., Velazquez, O. C. & Herlyn, M., May 1 2006, In : FASEB Journal. 20, 7, p. E201-E210

Research output: Contribution to journalArticle

88 Scopus citations

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

Rodriguez-Blanco, J., Pednekar, L., Penas, C., Li, B., Martin, V., Long, J., Lee, E., Weiss, W. A., Rodriguez, C., Mehrdad, N., Nguyen, D. M., Ayad, N. G., Rai, P., Capobianco, A. J. & Robbins, D. J., Nov 9 2017, In : Oncogene. 36, 45, p. 6306-6314 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

It's T-ALL about Notch

Demarest, R. M., Ratti, F. & Capobianco, A. J., Sep 1 2008, In : Oncogene. 27, 38, p. 5082-5091 10 p.

Research output: Contribution to journalReview article

85 Scopus citations

Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival

Alves-Guerra, M. C., Ronchini, C. & Capobianco, A. J., Sep 15 2007, In : Cancer Research. 67, 18, p. 8690-8698 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein

Zhang, X. Y., DeSalle, L. M., Patel, J. H., Capobianco, A. J., Yu, D., Thomas-Tikhonenko, A. & McMahon, S. B., Sep 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 39, p. 13968-13973 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

NACK is an integral component of the notch transcriptional activation complex and is critical for development and tumorigenesis

Weaver, K. L., Alves-Guerra, M. C., Jin, K., Wang, Z., Han, X., Ranganathan, P., Zhu, X., DaSilva, T., Liu, W., Ratti, F., Demarest, R. M., Tzimas, C., Rice, M., Vasquez-Del Carpio, R., Dahmane, N., Robbins, D. J. & Capobianco, A. J., Sep 1 2014, In : Cancer Research. 74, 17, p. 4741-4751 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Neoplastic transformation by Notch requires nuclear localization

Jeffries, S. & Capobianco, A. J., Jun 1 2000, In : Molecular and cellular biology. 20, 11, p. 3928-3941 14 p.

Research output: Contribution to journalArticle

98 Scopus citations

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2

Capobianco, A. J., Zagouras, P., Blaumueller, C. M., Artavanis-Tsakonas, S. & Bishop, J. M., Nov 1997, In : Molecular and cellular biology. 17, 11, p. 6265-6273 9 p.

Research output: Contribution to journalArticle

209 Scopus citations

Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation

Ronchini, C. & Capobianco, A. J., Aug 10 2000, In : Oncogene. 19, 34, p. 3914-3924 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

Sharma, V. M., Calvo, J. A., Draheim, K. M., Cunningham, L. A., Hermance, N., Beverly, L., Krishnamoorthy, V., Bhasin, M., Capobianco, A. J. & Kelliher, M. A., Nov 2006, In : Molecular and cellular biology. 26, 21, p. 8022-8031 10 p.

Research output: Contribution to journalArticle

197 Scopus citations

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas

Spaulding, C., Reschly, E. J., Zagort, D. E., Yashiro-Ohtani, Y., Beverly, L. J., Capobianco, A., Pear, W. S. & Kee, B. L., Oct 1 2007, In : Blood. 110, 7, p. 2650-2658 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

Hanlon, L., Avila, J. L., Demarest, R. M., Troutman, S., Allen, M., Ratti, F., Rustgi, A. K., Stanger, B. Z., Radtke, F., Adsay, V., Long, F., Capobianco, A. J. & Kissil, J. L., Jun 1 2010, In : Cancer Research. 70, 11, p. 4280-4286 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53

Licciulli, S., Avila, J. L., Hanlon, L., Troutman, S., Cesaroni, M., Kota, S., Keith, B., Simon, M. C., Puré, E., Radtke, F., Capobianco, A. J. & Kissil, J. L., Oct 1 2013, In : Cancer Research. 73, 19, p. 5974-5984 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Notch1 pathway activity determines the regulatory role of cancer-associated fibroblasts in melanoma growth and invasion

Shao, H., Kong, R., Ferrari, M. L., Radtke, F., Capobianco, A. J. & Liu, Z. J., Nov 1 2015, In : PloS one. 10, 11, e0142815.

Research output: Contribution to journalArticle

9 Scopus citations

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL

Pelullo, M., Quaranta, R., Talora, C., Checquolo, S., Cialfi, S., Felli, M. P. I., te Kronnie, G., Borga, C., Besharat, Z. M. E., Palermo, R., Di Marcotullio, L., Capobianco, A. J., Gulino, A., Screpanti, I. & Bellavia, D., Dec 1 2014, In : Neoplasia (United States). 16, 12, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Mar 10 2011, In : Blood. 117, 10, p. 2901-2909 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia (Blood (2011) 117, 10, (2901-2909))

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Jun 16 2011, In : Blood. 117, 24, 1 p.

Research output: Contribution to journalComment/debate

Notch represses transcription by PRC2 recruitment to the ternary complex

Han, X., Ranganathan, P., Tzimas, C., Weaver, K. L., Jin, K., Astudillo, L., Zhou, W., Zhu, X., Li, B., Robbins, D. J. & Capobianco, A. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1173-1183 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma

Wang, Z., Da Silva, T. G., Jin, K., Han, X., Ranganathan, P., Zhu, X., Sanchez-Mejias, A., Bai, F., Li, B., Fei, D. L., Weaver, K., Vasquez-Del Carpio, R., Moscowitz, A. E., Koshenkov, V. P., Sanchez, L., Sparling, L., Pei, X. H., Franceschi, D., Ribeiro, A., Robbins, D. J. & 2 others, Livingstone, A. S. & Capobianco, A. J., Nov 1 2014, In : Cancer Research. 74, 21, p. 6364-6374 11 p.

Research output: Contribution to journalArticle

43 Scopus citations