Anthony J Capobianco

Professor

  • 4344 Citations
1990 …2019

Research output per year

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Research Output

  • 4344 Citations
  • 78 Article
  • 1 Editorial
1990

Cloning and expression of a chicken c-rel cDNA: Unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts

Capobianco, A. J., Simmons, D. L. & Gilmore, T. D., Mar 1 1990, In : Oncogene. 5, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

74 Scopus citations
1991

A Protein Kinase-A Recognition Sequence Is Structurally Linked to Transformation by p59v-rel and Cytoplasmic Retention of p68c-rel

Mosialos, G., Hamer, P., Capobianco, A. J., Laursen, R. A. & Gilmore, T. D., Dec 1 1991, In : Molecular and Cellular Biology. 11, 12, p. 5867-5877 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Repression of the chicken c-rel promoter by vRel in chicken embryo fibroblasts is not mediated through a consensus NF-κB binding site

Capobianco, A. J. & Gilmore, T. D., Dec 1 1991, In : Oncogene. 6, 12, p. 2203-2210 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
1992

p105, the NF-κB p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells

Capobianco, A. J., Chang, D., Mosialos, G. & Gilmore, T. D., Jun 1 1992, In : Journal of Virology. 66, 6, p. 3758-3767 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
1993

A conditional mutant of vRel containing sequences from the human estrogen receptor

Capobianco, A. J. & Gilmore, T. D., Jan 1 1993, In : Virology. 193, 1, p. 160-170 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts

Sif, S., Capobianco, A. J. & Gilmore, T. D., Sep 1 1993, In : Oncogene. 8, 9

Research output: Contribution to journalArticle

38 Scopus citations
1994

Characterization of a chicken cDNA encoding the retinoblastoma gene product

Feinstein, R., Bolton, W. K., Quinones, J. N., Mosialos, G., Sif, S., Huff, J. L., Capobianco, A. J. & Gilmore, T. D., May 17 1994, In : BBA - Gene Structure and Expression. 1218, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Proto-oncogenes and plasticity in cell signaling

Bishop, J. M., Capobianco, A. J., Doyle, H. J., Finney, R. E., McMahon, M., Robbins, S. M., Samuels, M. L. & Vetter, M., Dec 1 1994, In : Cold Spring Harbor Symposia on Quantitative Biology. 59, p. 165-171 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
1997

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2

Capobianco, A. J., Zagouras, P., Blaumueller, C. M., Artavanis-Tsakonas, S. & Bishop, J. M., Nov 1 1997, In : Molecular and Cellular Biology. 17, 11, p. 6265-6273 9 p.

Research output: Contribution to journalArticle

209 Scopus citations
2000

Neoplastic transformation by Notch requires nuclear localization

Jeffries, S. & Capobianco, A. J., Jun 1 2000, In : Molecular and Cellular Biology. 20, 11, p. 3928-3941 14 p.

Research output: Contribution to journalArticle

98 Scopus citations

Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation

Ronchini, C. & Capobianco, A. J., Aug 10 2000, In : Oncogene. 19, 34, p. 3914-3924 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Suppression of erythroid but not megakaryocytic differentiation of human K562 Erythroleukemic cells by Notch-1

Lam, L. T., Ronchini, C., Norton, J., Capobianco, A. J. & Bresnick, E. H., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 19676-19684 9 p.

Research output: Contribution to journalArticle

78 Scopus citations
2001
310 Scopus citations
2002
125 Scopus citations

Enhanced tumor formation in mice heterozygous for Blm mutation

Goss, K. H., Risinger, M. A., Kordich, J. J., Sanz, M. H., Straughen, J. E., Slovek, L. E., Capobianco, A. J., German, J., Boivin, G. P. & Groden, J., Sep 20 2002, In : Science. 297, 5589, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

153 Scopus citations

Repression of activator protein-1-mediated transcriptional activation by the notch-1 intracellular domain

Chu, J., Jeffries, S., Norton, J. E., Capobianco, A. J. & Bresnick, E. H., Mar 1 2002, In : Journal of Biological Chemistry. 277, 9, p. 7587-7597 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2003

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in NotchIC-induced T cell leukemogenesis

Beverly, L. J. & Capobianco, A. J., Jun 1 2003, In : Cancer Cell. 3, 6, p. 551-564 14 p.

Research output: Contribution to journalArticle

119 Scopus citations

The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

Ascano, J. M., Beverly, L. J. & Capobianco, A. J., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8771-8779 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
2004

Targeting promiscuous signaling pathways in cancer: Another Notch in the bedpost

Beverly, L. J. & Capobianco, A. J., Dec 1 2004, In : Trends in Molecular Medicine. 10, 12, p. 591-598 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2005

Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression

Balint, K., Xiao, M., Pinnix, C. C., Soma, A., Veres, I., Juhasz, I., Brown, E. J., Capobianco, A. J., Herlyn, M. & Liu, Z-J., Nov 1 2005, In : Journal of Clinical Investigation. 115, 11, p. 3166-3176 11 p.

Research output: Contribution to journalArticle

249 Scopus citations

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice

Carlson, T. R., Yan, Y., Wu, X., Lam, M. T., Tang, G. L., Beverly, L. J., Messina, L. M., Capobianco, A. J., Werb, Z. & Wang, R., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9884-9889 6 p.

Research output: Contribution to journalArticle

132 Scopus citations

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein

Zhang, X. Y., DeSalle, L. M., Patel, J. H., Capobianco, A. J., Yu, D., Thomas-Tikhonenko, A. & McMahon, S. B., Sep 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 39, p. 13968-13973 6 p.

Research output: Contribution to journalArticle

98 Scopus citations

Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression

Beverly, L. J., Felsher, D. W. & Capobianco, A. J., Aug 15 2005, In : Cancer Research. 65, 16, p. 7159-7168 10 p.

Research output: Contribution to journalArticle

124 Scopus citations

Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells

Beverly, L. J., Ascano, J. M. & Capobianco, A. J., Sep 1 2006, In : Genes and Immunity. 7, 6, p. 476-486 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

Liu, Z-J., Xiao, M., Balint, K., Soma, A., Pinnix, C. C., Capobianco, A. J., Velazquez, O. C. & Herlyn, M., May 1 2006, In : FASEB Journal. 20, 7

Research output: Contribution to journalArticle

88 Scopus citations

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

Sharma, V. M., Calvo, J. A., Draheim, K. M., Cunningham, L. A., Hermance, N., Beverly, L., Krishnamoorthy, V., Bhasin, M., Capobianco, A. J. & Kelliher, M. A., Nov 1 2006, In : Molecular and Cellular Biology. 26, 21, p. 8022-8031 10 p.

Research output: Contribution to journalArticle

193 Scopus citations
2007

Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival

Alves-Guerra, M. C., Ronchini, C. & Capobianco, A. J., Sep 15 2007, In : Cancer Research. 67, 18, p. 8690-8698 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas

Spaulding, C., Reschly, E. J., Zagort, D. E., Yashiro-Ohtani, Y., Beverly, L. J., Capobianco, A. J., Pear, W. S. & Kee, B. L., Oct 1 2007, In : Blood. 110, 7, p. 2650-2658 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Requirement for Rac1 in a K-ras-induced lung cancer in the mouse

Kissil, J. L., Walmsley, M. J., Hanlon, L., Haigis, K. M., Kim, C. F. B., Sweet-Cordero, A., Eckman, M. S., Tuveson, D. A., Capobianco, A. J., Tybulewicz, V. L. J. & Jacks, T., Sep 1 2007, In : Cancer Research. 67, 17, p. 8089-8094 6 p.

Research output: Contribution to journalArticle

126 Scopus citations
2008

Guest editor

Capobianco, A. J., Sep 1 2008, In : Oncogene. 27, 38, p. 5081 1 p.

Research output: Contribution to journalEditorial

It's T-ALL about Notch

Demarest, R. M., Ratti, F. & Capobianco, A. J., Sep 1 2008, In : Oncogene. 27, 38, p. 5082-5091 10 p.

Research output: Contribution to journalArticle

85 Scopus citations
2009

Active Notch1 confers a transformed phenotype to primary human melanocytes

Pinnix, C. C., Lee, J. T., Liu, Z-J., McDaid, R., Balint, K., Beverly, L. J., Brafford, P. A., Xiao, M., Himes, B., Zabierowski, S. E., Yashiro-Ohtani, Y., Nathanson, K. L., Bengston, A., Pollock, P. M., Weeraratna, A. T., Nickoloff, B. J., Pear, W. S., Capobianco, A. J. & Herlyn, M., Jul 1 2009, In : Cancer Research. 69, 13, p. 5312-5320 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Notch signaling mediates G 1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

Joshi, I., Minter, L. M., Telfer, J., Demarest, R. M., Capobianco, A. J., Aster, J. C., Sicinski, P., Fauq, A., Golde, T. E. & Osborne, B. A., Feb 19 2009, In : Blood. 113, 8, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Rustighi, A., Tiberi, L., Soldano, A., Napoli, M., Nuciforo, P., Rosato, A., Kaplan, F., Capobianco, A. J., Pece, S., Di Fiore, P. P. & Del Sal, G., Jan 19 2009, In : Nature Cell Biology. 11, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

116 Scopus citations
2010

Epimorphic regeneration in mice is p53-independent

Arthur, L. M., Demarest, R. M., Clark, L., Gourevitch, D., Bedelbaeva, K., Anderson, R., Snyder, A., Capobianco, A. J., Lieberman, P., Feigenbaum, L. & Heber-Katz, E., Sep 15 2010, In : Cell Cycle. 9, 18, p. 3667-3673 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

Hanlon, L., Avila, J. L., Demarest, R. M., Troutman, S., Allen, M., Ratti, F., Rustgi, A. K., Stanger, B. Z., Radtke, F., Adsay, V., Long, F., Capobianco, A. J. & Kissil, J. L., Jun 1 2010, In : Cancer Research. 70, 11, p. 4280-4286 7 p.

Research output: Contribution to journalArticle

102 Scopus citations

Sp100 as a potent tumor suppressor: Accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program

Negorev, D. G., Vladimirova, O. V., Kossenkov V, A., Nikonova V, E., Demarest, R. M., Capobianco, A. J., Showe, M. K., Rauscher, F. J., Showe, L. C. & Maul, G. G., Dec 1 2010, In : Cancer Research. 70, 23, p. 9991-10001 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2011

Assembly of a notch transcriptional activation complex requires multimerization

Vasquez-Del Carpio, R., Kaplan, F. M., Weaver, K. L., VanWye, J. D., Alves-Guerra, M. C., Robbins, D. J. & Capobianco, A. J., Apr 1 2011, In : Molecular and Cellular Biology. 31, 7, p. 1396-1408 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hedgehog-producing cancer cells respond to and require autocrine hedgehog activity

Singh, S., Wang, Z., Fei, D. L., Black, K. E., Goetz, J. A., Tokhunts, R., Giambelli, C., Rodriguez-Blanco, J., Long, J., Lee, E., Briegel, K., Bejarano, P. A., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., Jul 1 2011, In : Cancer Research. 71, 13, p. 4454-4463 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates notch transcriptional activity

Ranganathan, P., Vasquez-Del Carpio, R., Kaplan, F. M., Wang, H., Gupta, A., VanWye, J. D. & Capobianco, A. J., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 28844-28857 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Mar 10 2011, In : Blood. 117, 10, p. 2901-2909 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia (Blood (2011) 117, 10, (2901-2909))

Demarest, R. M., Dahmane, N. & Capobianco, A. J., Jun 16 2011, In : Blood. 117, 24

Research output: Contribution to journalArticle

Notch signalling in solid tumours: A little bit of everything but not all the time

Ranganathan, P., Weaver, K. L. & Capobianco, A. J., May 1 2011, In : Nature Reviews Cancer. 11, 5, p. 338-351 14 p.

Research output: Contribution to journalArticle

482 Scopus citations
2012

Hedgehog signaling regulates bladder cancer growth and tumorigenicity

Fei, D. L., Sanchez-Mejias, A., Wang, Z., Flaveny, C., Long, J., Singh, S., Rodriguez-Blanco, J., Tokhunts, R., Giambelli, C., Briegel, K., Schulz, W. A., Gandolfi, A. J., Karagas, M., Zimmers, T. A., Jorda, M., Bejarano, P., Capobianco, A. J. & Robbins, D. J., Sep 1 2012, In : Cancer Research. 72, 17, p. 4449-4458 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53

Licciulli, S., Avila, J. L., Hanlon, L., Troutman, S., Cesaroni, M., Kota, S., Keith, B., Simon, M. C., Puré, E., Radtke, F., Capobianco, A. J. & Kissil, J. L., Oct 1 2013, In : Cancer Research. 73, 19, p. 5974-5984 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

The Hedgehog processing pathway is required for NSCLC growth and survival

Rodriguez-Blanco, J., Schilling, N. S., Tokhunts, R., Giambelli, C., Long, J., Liang Fei, D., Singh, S., Black, K. E., Wang, Z., Galimberti, F., Bejarano, P. A., Elliot, S., Glassberg Csete, M. K., Nguyen, D., Lockwood, W. W., Lam, W. L., Dmitrovsky, E., Capobianco, A. J. & Robbins, D. J., May 2 2013, In : Oncogene. 32, 18, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

Azzam, D. J., Zhao, D., Sun, J., Minn, A. J., Ranganathan, P., Drews-Elger, K., Han, X., Picon-Ruiz, M., Gilbert, C. A., Wander, S. A., Capobianco, A. J., El-Ashry, D. & Slingerland, J. M., Oct 1 2013, In : EMBO Molecular Medicine. 5, 10, p. 1502-1522 21 p.

Research output: Contribution to journalArticle

42 Scopus citations
2014

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development

Bai, F., Chan, H. L., Scott, A., Smith, M. D., Fan, C., Herschkowitz, J. I., Perou, C. M., Livingstone, A., Robbins, D. J., Capobianco, A. J. & Pei, X-H., Nov 1 2014, In : Cancer Research. 74, 21, p. 6161-6172 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

NACK is an integral component of the notch transcriptional activation complex and is critical for development and tumorigenesis

Weaver, K. L., Alves-Guerra, M. C., Jin, K., Wang, Z., Han, X., Ranganathan, P., Zhu, X., DaSilva, T., Liu, W., Ratti, F., Demarest, R. M., Tzimas, C., Rice, M., Vasquez-Del Carpio, R., Dahmane, N., Robbins, D. J. & Capobianco, A. J., Sep 1 2014, In : Cancer Research. 74, 17, p. 4741-4751 11 p.

Research output: Contribution to journalArticle

13 Scopus citations